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Inhibin B:are modified ranges needed for orchiectomised testicular cancer patients?

Asian Journal of Andrology 2019年第4期21卷 332-336页

作者： Alessandra Petrozzi Francesco Pallotti Marianna Pelloni Antonella Anzuini Antonio francesco Radicioni Andrea Lenzi Donatella Paoli francesco Lombardo Laboratory of Seminology Sperm Bank "Loredana Gandini" Department of Experimental Medicine Medical Pathophysiology Section"Sapienza" University of Rome Rome 00161 Italy Hormone Laboratory Department of Experimental Medicine Medical Pathophysiology Section"Sapienza" University of Rome Rome 00161 Italy

Inhibin B is a gon adal horm one that down regulates the pituitary production of follicle-stimulati ng horm one (FSH). In recent years, inhibin B has proved to be an excellent marker of spermatogenesis and even a predictive factor for the recovery of fertility in patients undergoing orchiectomy and antineoplastic treatments. We propose to study inhibin B levels in orchiectomised testicular cancer patients, in order to identify a minimum value representative of normal semen quality. This retrospective study evaluates horm onal and semen parameters of 290 no rmozoospermic patie nts atte nding the Laboratory of Semi no logy - Sperm Bank "Loredana Gandini"(Rome, Italy) for cryopreservation of seminal fluid following a diagnosis of testicular cancer (TC group) and 117 healthy, normozoospermic men as a control group (CTR group). The percentile distribution of gonadotropin and inhibin B values in the TC and CTR groups was analyzed. There was a statistically significant differenee between the two groups in the levels of all hormones (P ≤ 0.001) and in all semen parameters (P 95^th percentile of CTR group. Orchiectomised patients for testicular cancer presented inhibin B levels lower than healthy patients, despite normozoospermia. Our study revealed the poor sensitivity of the current inhibin B reference range when applied to monorchidic patients, suggesting the need to establish more representative ranges to enable more appropriate counseling in relation to the patienfs new endocrine condition.

关键词： inhibin B orchiectomy referenee range testicular cancer

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A decade of WH02010:total sperm number temporal trend and role of lifestyle factors

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Asian Journal of Andrology 2023年第5期25卷 572-577页

作者： francesco Cargnelutti Francesco Pallotti Tania Carlini Fabiana Faja Anna Rita Vestri Danilo Alunni Fegatelli Andrea Lenzi francesco Lombardo Donatella Paoli Laboratory of Seminology-Sperm Bank"Loredana Gandini" Department of Experimental MedicineSapienza University of RomeViale del Pliclinico 155Roma 00161Italy Department of Public Health and Infectious Disease Sapienza University of RomeViale del Polclinico 155Roma 00161Italy

After a huge decline in sperm concentration between 1938 and 1991 was reported,many researchers investigated the possibility of a worsening of human sperm quality.Despite massive efforts,published evidence is still controversial.Similarly,the role of lifestyle factors on semen parameters is debated.We conducted a monocentric Italian study to evaluate the total sperm number trend over the last 10 years(from 2010 to 2019).Additionally,we evaluated the association between lifestyle factors and total sperm number in order to identify possible damaging factors.We performed a retrospective study analyzing subjects aged 18-55 years who had their semen analyzed between 2010 and 2019.A total of 3329 subjects were included:1655 subjects referred to our department(Department of Experimental Medicine,Sapienza University of Rome,Roma,Italy)for idiopathic infertility and 1674 subjects referred for preconceptional or andrological screening with no confirmed andrological diseases.Semen samples were examined according to World Health Organization(WHO)2010 criteria by two seminologists with the same training and the same equipment.For statistical evaluations,only total sperm number(×10^(6)per ejaculate)was taken into consideration.We detected no significant changes in mean total sperm number during the last decade,in either the entire population or the two subgroups(infertile group and control group).In a multivariate analysis total sperm number was significantly associated with the history of infertility,body mass index(BMI)and cigarette smoking.Our results suggest that infertile men are"vulnerable"subjects,particularly susceptible to several negative factors,many of which still remain unknown.Our study highlights the need for studies addressing men's lifestyle in order to find and reduce deleterious agents.

关键词： aging male infertility obesity smoking sperm decline

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