检索结果-南通市图书馆

Grain free diets for utility dogs during training work: Evaluation of the nutrient digestibility and faecal characteristics

引用

Animal Nutrition 2019年第3期5卷 297-306页

作者： Biagina Chiofalo Giulia De Vita Vittorio Lo Presti Salvatore Cucinotta Gabriella Gaglio francesco leone Ambra R.Di Rosa Department of Veterinary Sciences University of Messina Polo Universitario Annunziata

Two different diets characterized by the absence of cereals or by the presence of conventional cereals were evaluated on the nutrient digestibility and faecal characteristics and faecal fermentative endproduct concentrations of 8 neutered adult Labrador retrievers housed at the Regional Centre Helen Keller(Messina,Italy)during the training work for the service guide for the ***(age = 17 ± 1 months,initial body weight [BW]= 26.3 ± 1 *** body condition score [BCS]= 4.5 ± 0.11)were divided into 2 homogeneous groups for sex(half males and half females).Dogs in the grain free(GF)group were fed a commercial diet characterized by the absence of grain cereals,and dogs in the control(CTR)group were fed a super-premium pet food characterized by conventional grains as the carbohydrate *** trial lasted 84 *** by a 7-d of adaption *** examination,*** faecal characteristics were *** statistical model included the effects of diet(GF ***),time(from d 0 to *** of the trial)and the interaction(diet x time).The high-protein,lowcarbohydrate dry diet(GF)offered higher apparent nutrient digestibility of protein(+10%;P =0.002)and fat(+7%;P<0.001)and more stable large intestinal fermentation of carbohydrate compared to the commercial high-carbohydrate dry diet,enabling dogs to use nutrients from the diet more efficiently and thus requiring less food(-13%)to satisfy their nutrient requirements,producing less excrement(-33%;P= 0.033).and reaching a higher final BW(+8%;P<0.0001)and a higher final BCS(+15%;P= 0.003).Therefore,the GF diet appears the nutritional plan most suitable for these animals taking due account not only of the training work done by animals with their increased nutrient and energy needs,but also of the gastrointestinal disorders consequent to stress coming from work and life in kennels,which cause in the Labrador retrievers an unusual weight loss.

关键词： Utility dog Grain free diet Nutrient digestibility Faecal quality Training work

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Typing of Four Cases of Monoclonal Gammopathy: A Revival of Immunosubstraction Role

引用

Health 2017年第13期9卷 1852-1857页

作者： Marta Monari Paolo Bianchi Federica Maura Lucia Motta Giovanni Martellasio francesco Paolo leone Alessandro Montanelli Clinical Investigation Laboratory Humanitas Clinical and Research Hospital Rozzano Milano Laboratorio Analisi Cliniche Spedali Civili di Brescia Brescia Italy

Monoclonal gammopathy of undetermined significance (MGUS) is characterized by increased production of an immunoglobuling (Ig) from a clone of plasma cells and is a pre-malignant disorders in subjects older than 50 years. The prevalence of MGUS in Caucasian population is still not determined. MGUS is characterized by the presence of a monoclonal-protein(M-protein) (IgG and IgA) lower than 30 g/L, bone marrow plasma cell percentage lower than 10%, and absence of clinical signs related to multiple myeloma (MM). MGUS can be responsible for damage to organs through the production of toxic M proteins that may have autoantibody activity or deposit pathologically in the organ tissues. Many techniques are available for the characterization of M-proteins. These techniques can involve different expenses, skills, labor time, and sensitivity in detecting monoclonal proteins also at low-level. Detection of M-proteins needs of assays based on high-resolution electrophoresis and im-munofixation (or immunosubtraction). We show suggestive clinical cases where the subjects involved had not an apparent disease but they showed an interesting pattern in electrophoresis. All cases were investigated by capillary’s electrophoresis and immunofixation to confirm or not the clinical suspect, and then if the immunofixation is not exhaustive, additionally immunosubstraction is done. However in some cases, the interpretation of the peaks is not so easy. Clinical and scientific data provided evidences that immunofixaction technique can fail the identification of monoclonal components. In that cases, we opted for the immunosubtraction method as a third level test, in that cases when immunofixation failed the identification of a monoclonal protein.

关键词： MGUS—Monoclona Gammopathy of Undetermined Significance Immunofixation Immunosubstraction Capillary’s Electrophoresis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

如何改善靶向药物在胆管癌中的疗效？

引用

中国普通外科杂志 2013年第8期22卷 973-975页

作者： Donatella Marino Federica Colombi Dario Ribero Massimo Aglietta francesco leone 王卓路(编译) 李新营(编译) 意大利坎迪奥洛医学癌症治疗研究所肿瘤科意大利都灵“翁贝托一世”Mauriziano医院普通外科与肿瘤外科不详

10年中胆管癌（CC）的处理方法已经有了巨大的改变。仅仅在几年前,胆管癌晚期患者还没有效的治疗方案,只有支持治疗。并且在没有有效证据及随机研究结果的情况下,常给予患者姑息化疗。

关键词：胆管肿瘤靶向治疗临床试验

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3

引用

Cancer Communications 2024年第2期44卷 282-286页

作者： Bianca Cesaro Alessia Iaiza Fabio Piscopo Marco Tarullo Eleonora Cesari Dante Rotili Antonello Mai Alberto Diana Michela Londero Luca Del Giacco Riccardo Masetti Alba Di leone Chiara Naro Silvia Masciarelli Giulia Fontemaggi Claudio Sette francesco Fazi Alessandro Fatica Department of Anatomical HistologicalForensic&Orthopedic SciencesSection of Histology&Medical EmbryologySapienza University of RomeRomeItaly Department of Biology and Biotechnologies“Charles Darwin” Sapienza University of RomeRomeItaly GSTeP Organoids Research Core Facility Fondazione Policlinico A.Gemelli Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)RomeItaly Department of Drug Chemistry and Technologies Sapienza University of RomeRomeItaly Pasteur Institute Cenci-Bolognetti FoundationSapienza University of RomeRomeItaly Department of BioSciences University of MilanMilanItaly Multidisciplinary Breast Center Dipartimento Scienze della Salute della Donna e del Bambino e di SanitàPubblicaCatholic University of the Sacred HeartRomeItaly Department of Neuroscience Section of Human AnatomyCatholic University of the Sacred HeartRomeItaly Oncogenomic and Epigenetic Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Dear Editor,N 6-methyladenosine(m^(6)A)is a critical mRNA modi-fication catalyzed by the enzyme methyltransferase-like 3(METTL3),with implications in RNA ***3 upregulation is associated with cancer progres-sion,metast... 详细信息

关键词： cancer methyltransferase metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

No evidence of circulating autoantibodies against osteoprotegerin in patients with celiac disease

引用

World Journal of Gastroenterology 2012年第14期18卷 1622-1627页

作者： Tiziana Larussa Evelina Suraci Immacolata Nazionale Isabella leone Tiziana Montalcini Ludovico Abenavoli Maria Imeneo Arturo Pujia francesco Luzza Department of Health Science University of Catanzaro "Magna Graecia"88100 CatanzaroItaly Department of Medical and Surgical Science University of Catanzaro "Magna Graecia"88100 CatanzaroItaly

AIM:To investigate risk factors for low bone mineral density(BMD) in celiac disease(CD) patients,focusing on circulating autoantibodies against osteoprotegerin(OPG).METHODS:Seventy asymptomatic CD adult patients on gluten-free diet(GFD) and harbouring persistent negative CD-related serology were *** risk factors for osteoporosis(e.g.,age,sex,menopausal status,history of fractures,smoke,and body mass index) were checked and BMD was assessed by dual energy X ray *** calcium and parathyroid hormone(PTH) levels were ***-eight patients underwent repeat duodenal *** samples from a selected sub-group of 30 patients,who were also typed for human leukocyte antigen(HLA) DQ2 and DQ8 haplotype,were incubatedwith homodimeric recombinant human OPG and tested by western blotting with an anti-OPG antibody after ***:Despite persistent negative CD-related serology and strict adherence to GFD,49 out of the 70(74%) patients displayed low *** these patients,13(24%) showed osteoporosis and 36(76%) *** the exception of age,conventional risk factors for osteoporosis did not differ between patients with normal and low *** serum calcium and PTH levels were normal in all *** mucosa healing was found in 31(82%) out of 38 patients who underwent repeat duodenal biopsy with 20(64%) still displaying low *** remaining 7 patients had an incomplete normalization of duodenal mucosa with 6(84%) showing low *** evidence of circulating antibodies against OPG was found in the serum of 30 celiac patients who were tested for,independent of BMD,duodenal histology,and HLA ***:If any,the role of circulating autoantibodies against OPG in the pathogenesis of bone derangement in patients with CD is not a major one.

关键词： Celiac disease Osteoprotegerin Bone mineral density Gluten-free diet Osteoporosis Osteopenia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

非晶碳纳米球的低温石墨化(英文)

引用

催化学报 2014年第6期35卷 869-876页

作者： Katia Barbera leone Frusteri Giuseppe Italiano Lorenzo Spadaro francesco Frusteri Siglinda Perathoner Gabriele Centi University of Messina and INSTM/CASPE (Lab.of Catalysis for Sustainable Production and Energy) Department of Electronic Engineering Industrial Chemistry and Engineering-Contrada di Dio I-98166 Messina Italy Eco-Rigen S.r.l.R&D – Contrada Piana del Signore c/o Raffineria di Gela I-93012 Gela (CL) Italy Institute of Advanced Technologies for Energy "Nicola Giordano" (ITAE) Department of Energy and Transport (DET) National Council of Research (CNR) - Salita S.Lucia sopra Contesse 5 I-98126 Messina Italy

The investigation by SEM/TEM, porosity, and X-ray diffraction measurements of the graphitization process starting from amorphous carbon nanospheres, prepared by glucose carbonization, is reported. Aspects studied are the annealing temperature in the 750–1000 °C range, the type of inert carrier gas, and time of treatment in the 2–6 h range. It is investigated how these parameters influence the structural and morphological characteristics of the carbon materials obtained as well as their nanostructure. It is shown that it is possible to maintain after graphitization the round-shaped macro morphology, a high surface area and porosity, and especially a large structural disorder in the graphitic layers stacking, with the presence of rather small ordered domains. These are characteristics interesting for various catalytic applications. The key in obtaining these characteristics is the thermal treatment in a flow of N2. It was demonstrated that the use of He rather than N2 does not allow obtaining the same results. The effect is attributed to the presence of traces of oxygen, enough to create the presence of oxygen functional groups on the surface temperatures higher than 750 °C, when graphitization occurs. These oxygen functional groups favor the graphitization process.

关键词：石墨化过程无定形碳纳米球含氧官能团 X射线衍射测量低温纳米结构形态特征

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chronic functional constipation is strongly linked to vitamin D deficiency

引用

World Journal of Gastroenterology 2019年第14期25卷 1729-1740页

作者： Alba Panarese francesco Pesce Piero Porcelli Giuseppe Riezzo Palma Aurelia Iacovazzi Carla Maria leone Massimo De Carne Caterina Mammone Rinaldi Endrit Shahini Department of Gastroenterology and Digestive Endoscopy Scientific Institute for Digestive Disease "Saverio de Bellis" Hospital Nephrology section Department of Emergency and Organ TransplantationUniversity of Bari Department of Psychological Health and Territorial Sciences D'Annunzio University of Chieti-Pescara Department of Clinical Pathology Scientific Institute for Digestive Disease "Saverio de Bellis" Hospital Department of Radiology Scientific Institute for Digestive Disease "Saverio de Bellis" Hospital Department of Emergency and Organ Transplantation University of Bari

BACKGROUND Few studies have examined intestinal motility disorders, which are disabling conditions associated with chronic functional constipation, whose pathogenesis is actually not *** To investigate the relationship between serum 25-hydroxyvitamin D levels and functional chronic constipation associated to intestinal motility *** We performed a prospective case-control study, from May-June to November2017. Glucose/lactulose breath tests, radiopaque markers(multiple capsule techniques) and wireless motility capsule analysis were used to assess colonicand oro-cecal transit time, after excluding small-intestinal bacterial overgrowth condition. Then, we measured 25-hydroxyvitamin D levels in patients with intestinal motility disorders and we further evaluated the influence of intestinal motility disorders on psychological symptoms/quality of life using validated questionnaires, the Irritable Bowel Syndrome Quality of life(IBS-QOL), the Short Form Health Survey 12, and the Hospital Anxiety and Depression Scale 14(HADS-14 A and HADS-14 D).RESULTS We enrolled 86 patients with chronic functional constipation associated to intestinal motility disorders and 86 matched healthy subjects. Patients with intestinal motility disorders had lower 25-hydroxyvitamin D levels(P < 0.001), and they showed a significant impairment of all health-related quality of life and psychological tests(IBS-QOL, Short Form Health Survey 12-Physical Component Summary, Short Form Health Survey 12-Mental Component Summary, HADS-14 A and HADS-14 D), as compared to the control group(P < 0.001), which significantly correlated with low vitamin D levels(r =-0.57, P < 0.001; r = 0.21, P = 0.01; r =-0.48, P < 0.001; r =-0.57, P < 0.001; r =-0.29, P < 0.001, respectively). At multivariate analysis vitamin D low levels remained a significant independent risk factor for the occurrence of intestinal motility disorder(odds ratio = 1.19; 95% confidence interval: 1.14-1.26, P < 0.001).CONC

关键词： Chronic constipation Intestinal motility Vitamin D Quality of life Anxiety Depression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Strategies for Countering Freezing in Police Operational Activities

引用

Sociology Study 2023年第2期13卷 49-62页

作者： Franco Posa Jessica leone francesco Sclavi Nicolas Poncini Christian Musso NeuroIntelligence Private Institute of Research in Forensic Neuroscience and CriminologyVareseItaly Nicolas PonciniChristian Musso Department of Public Security Chiasso Local Police-Region I ChiassoSwitzerland

The term“freezing”refers to an innate defensive reaction characterized by the sudden cessation of all movements(Stote&Fanselow,2004;Eilam,2005).The freezing effect involving a police officer exposes him to a risk to himself and *** and Methods:400 anonymous questionnaires administered to law enforcement personnel in Switzerland were evaluated with the aim of testing their knowledge about the freezing *** addition,semi-structured interviews involving police personnel were *** authors also analyzed two cases of police officers who had experienced *** and Conclusions:From the results obtained,it emerges that freezing is not known to most of the police officers ***,specific and innovative training seems to be *** authors described the brain mechanisms that are involved in *** integrated training modules have been proposed by applying some neuroscientific knowledge,particularly using the potential of mirror *** authors propose a strategy for supporting police officers who have experienced an episode of *** ultimate goal is to provide more scientific tools to protect police officers and civilians.

关键词： freezing police survey

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ventricular repolarization measures for arrhythmic risk stratification

引用

World Journal of Cardiology 2016年第1期8卷 57-73页

作者： francesco Monitillo Marta leone Caterina Rizzo Andrea Passantino Massimo Iacoviello Cardiology Unit Department of Emergency and Organ Transplantation University of Bari Division of Cardiology and Cardiac Rehabilitation "S. Maugeri" Foundation IRCCS Institute of Cassano Murge

Ventricular repolarization is a complex electrical phenomenon which represents a crucial stage in electrical cardiac activity. It is expressed on the surface electrocardiogram by the interval between the start of the QRS complex and the end of the T wave or U wave(QT). Several physiological, pathological and iatrogenic factors can influence ventricular repolarization. It has been demonstrated that small perturbations in this process can be a potential trigger of malignant arrhythmias, therefore the analysis of ventricular repolarization represents an interesting tool to implement risk stratification of arrhythmic events in different clinical settings. The aim of this review is to critically revise the traditional methods of static analysis of ventricular repolarization as well as those for dynamic evaluation, their prognostic significance and the possible application in daily clinical practice.

关键词： Ventricular repolarization Arrhythmias QT interval Cardiovascular diseases Drugs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscientific Evidence in the Strategic Exploit of the Disabled as a Fighter in the Islamic State

引用

Sociology Study 2022年第1期12卷 1-6页

作者： Franco Posa Jessica leone Valeria Rondinelli francesco Sclavi Stefano Piazza Franco Iacch NeuroIntelligence(Private Institute of Research in Forensic Neuroscience and Criminology) VareseItaly Independent Researcher Italy

In this paper we aim to address,through an innovative neuroscientific view,a significant recruitment strategy implemented by ISIS targeting individuals with *** use of strategies that reinforce empathy and the encouragement of the belief that one is capable of achieving a given goal,are strategically effective messages in terms of ***-efficacy,which is the set of beliefs the individual holds about his or her own abilities,is another tool used to effectively recruit someone with a *** use of media messages also reinforces the“know how”and the feeling of“being”,that is,recognizing oneself in rewarding *** analyzing the Entertainment-Education method,we identified some elements of persuasive storytelling that even in people with disabilities has led to success in terms of *** innovative multidisciplinary contrast activity with the contribution of neuroscience may therefore be effective in identifying behaviors and recruitment strategies that are effective with people with disabilities.

关键词： Islamic State recruitment disabled terrorism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：