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From purines to purinergic signalling:molecular functions and human diseases

Signal Transduction and Targeted Therapy 2021年第5期6卷 1463-1482页

作者： Zhao Huang Na Xie Peter Illes francesco di virgilio Henning Ulrich Alexey Semyanov Alexei Verkhratsky Beata Sperlagh Shu-Guang Yu Canhua Huang Yong Tang State Key Laboratory of Biotherapy and Cancer Center West China Hospitaland West China School of Basic Medical Sciences&Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengduChina International Collaborative Centre on Big Science Plan for Purinergic Signalling Chengdu University of Traditional Chinese MedicineChengduChina Rudolf-Boehm-Institut für Pharmakologie und Toxikologie Universitaet LeipzigLeipzigGermany Department of Medical Sciences University of FerraraFerraraItaly Department of Biochemistry Institute of ChemistryUniversity of São PauloSão PauloBrazil Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of SciencesMoscowRussia Sechenov First Moscow State Medical University MoscowRussia Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Department of Pharmacology Institute of Experimental MedicineHungarian Academy of SciencesBudapestHungary Acupuncture and Chronobiology Key Laboratory of Sichuan Province ChengduChina School of Basic Medical Sciences Chengdu University of Traditional Chinese MedicineChengduChina

Purines and their derivatives,most notably adenosine and ATP,are the key molecules controlling intracellular energy homoeostasis and nucleotide ***,these purines support,as chemical messengers,purinergic transmission throughout tissues and *** act as endogenous ligands that bind to and activate plasmalemmal purinoceptors,which mediate extracellular communication referred to as“purinergic signalling”.Purinergic signalling is cross-linked with other transmitter networks to coordinate numerous aspects of cell behaviour such as proliferation,differentiation,migration,apoptosis and other physiological processes critical for the proper function of *** deregulation of purinergic signalling contributes to various diseases including neurodegeneration,rheumatic immune diseases,inflammation,and ***,gout is one of the most prevalent purine-related disease caused by purine metabolism disorder and consequent *** evidence indicates that purinoceptors are potential therapeutic targets,with specific purinergic agonists and antagonists demonstrating prominent therapeutic ***,dietary and herbal interventions help to restore and balance purine metabolism,thus addressing the importance of a healthy lifestyle in the prevention and relief of human *** understanding of molecular mechanisms of purinergic signalling provides new and exciting insights into the treatment of human diseases.

关键词： metabolism diseases urine

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