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Retinal image quality with multifocal,EDoF,and accommodative intraocular lenses as studied by pyramidal aberrometry

Eye and Vision 2021年第6期8卷 374-384页

作者： Jorge l.Alio francesco D’Oria Francesca Toto Joan Balgos Antonio Palazon francesco Versaci Jorge l.Alio del Barrio Vissum Innovation AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezVissum Miranzac/Cabañal103016 AlicanteSpain Section of Ophthalmology Department of Basic Medical ScienceNeuroscience and Sense OrgansUniversity of BariBariItaly Department of Clinical Medicine Miguel Hernández UniversitySan Juan de AlicanteSpain R&D Department Costruzione Strumenti Oftalmici(CSO)FlorenceItaly

Background:To study and compare the clinical optical image quality following implantation with different premium IOls by analysing the point spread function(PSF)Strehl ratio using a pyramidal wavefront sensor(PWS)-based ***:This study included 194 eyes implanted with:(a)19 AcrySof SA60AT(control group);(b)19 Miniwell;(c)24 lENTIS Mplus lS-313 MF30;(d)33 lENTIS Mplus lS-313 MF15;(e)17 Akkolens lumina;(f)31 AT lISA Tri 839MP;(g)20 Precizon Presbyopic;(h)20 AcrySof IQ PanOptix;(i)11 Tecnis *** outcome measures were PSF Strehl ratio,PSF Strehl ratio excluding second-order aberrations(PSFw2),total root mean square(RMS),low-order aberration(lOA)and high-order aberration(HOA)RMS measured by PWS ***:AT lISA Tri had the highest PSFw2 Strehl ratio at both 3.0-and 4.0-mm pupil size(0.52±0.14 and 0.31±0.10;Pllowed by SA60AT(0.41±0.11 and 0.28±0.07)and PanOptix(0.4±0.07 and 0.26±0.04).AT lISA Tri was found to provide a significantly better retinal image quality than PanOptix at both 3.0 mm(Plus MF15 was found to be significantly better than Mplus MF30 at both 3.0 mm(Pl RMS,lOA RMS,HOA RMS,PSF Strehl ratio and PSFw2 varied significantly between the studied groups(Plusions:Far distance clinical image quality parameters measured by PWS aberrometer differed significantly according to the technology of the implanted *** lISA Tri,SA60AT and PanOptix showed the highest values of far distance retinal image quality,while the lowest PSFw2 Strehl ratios were displayed by Miniwell,Mplus MF30 and Precizon Presbyopic.

关键词： Cataract surgery Pyramidal aberrometry Multifocal IOl Extended depth of focus Accommodative IOl

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Reply to the letter to the editor

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Eye and Vision 2021年第1期8卷 462-463页

作者： Jorge l.Alio francesco Versaci francesco D’Oria Vissum Miranza AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain R&D Department Costruzione Strumenti Oftalmici(CSO)FlorenceItaly Section of Ophthalmology Department of Basic Medical ScienceNeuroscience and Sense OrgansUniversity of BariBariItaly

We appreciate the interest of Miguel Faria Ribeiro in our paper[1],as well as the comments made to *** interest of the topic is sound,as nowadays an enormous amount of new so-called“premium lenses”are appearing in the market,with different optical profiles which obviously lead to different light distributions and different quality of retinal *** is why our interest in this topic is longstanding and we have published extensive summaries about the outcomes and complications of multifocal lenses over the last years[2,3].

关键词： editor letter enormous

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Corneal collagen cross‑linking epithelium‑on ***‑off:a systematic review and meta‑analysis

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Eye and Vision 2021年第6期8卷 338-352页

作者： francesco D’Oria Antonio Palazón Jorge l.Alio Vissum Innovation c/Cabañal103016 AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain Section of Ophthalmology Department of Basic Medical ScienceNeuroscience and Sense OrgansUniversity of BariBariItaly Department of Clinical Medicine Miguel Hernández UniversitySan Juan de AlicanteSpain

Background:The purpose of the study was to determine the advantages and disadvantages of epi-on corneal crosslinking(CXl)techniques compared with standard epi-off ***:We searched MEDlINE and EMBASE for randomized controlled trials(RCTs)and non-randomized studies of interventions(NRSIs)and we evaluated the selected papers according to the Cochrane risk of bias *** considered,as primary outcomes,average Kmax flattening,changes in uncorrected and corrected distance visual acuity(UDVA and CDVA);as secondary outcomes,we considered changes in pachymetry values and endothelial cell density(ECD).We also investigated adverse events related to the treatments and treatment ***-analysis was conducted with a fixed or random-effects model using weighted mean difference(MD)with 95%confidence interval(CI)as the effect ***:A total of 15 studies were included and among these 15 trials,9 were RCTs and 6 were NRSIs,but only 4 studies showed no high risk of bias and were included in this *** analysis revealed significant postoperative differences in CDVA(MD=0.07;95%CI 0.04 to 0.10;Pl corneal thickness(CCT)and ECD(P>0.05).Epi-on CXl protocol was found to be significantly less prompt to have risks of delay in epithelial healing(P=0.035)and persistent stromal haze(P=0.026).Conclusion:Epi-on CXl is as effective as epi-off *** for a higher significant improvement in CDVA with current epi-on protocols,our meta-analysis demonstrates that epi-on and epi-off CXl have comparable effects on visual,topographic,pachymetric,and endothelial ***-on CXl has clinical advantages in terms of comfort and avoidance of complications as it reduces the risk of developing delay in epithelial healing and persistent stromal haze.

关键词： Corneal collagen cross-linking Keratoconus Transepithelial CXl Epithelium-off CXl Epithelium-on CXl Iontophoresis

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Organic chloramines in chlorine-based disinfected water systems： A critical review

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Journal of Environmental Sciences 2017年第8期29卷 2-18页

作者： Zuo Tong How Ina Kristiana francesco Busetti Kathryn l.linge Cynthia A.Joll Curtin Water Quality Research Centre Department of Chemistry Curtin University Perth Western Australia 6102 Australia

This paper is a critical review of current knowledge of organic chloramines in water systems,including their formation, stability, toxicity, analytical methods for detection, and their impact on drinking water treatment and quality. The term organic chloramines may refer to any halogenated organic compounds measured as part of combined chlorine（the difference between the measured free and total chlorine concentrations）, and may include N-chloramines,N-chloramino acids, N-chloraldimines and N-chloramides. Organic chloramines can form when dissolved organic nitrogen or dissolved organic carbon react with either free chlorine or inorganic chloramines. They are potentially harmful to humans and may exist as an intermediate for other disinfection by-products. However, little information is available on the formation or occurrence of organic chloramines in water due to a number of challenges. One of the biggest challenges for the identification and quantification of organic chloramines in water systems is the lack of appropriate analytical methods. In addition, many of the organic chloramines that form during disinfection are unstable, which results in difficulties in sampling and detection. To date research has focussed on the study of organic ***, given that breakpoint chlorination is commonly undertaken in water treatment systems, the formation of organic dichloramines should also be considered. Organic chloramines can be formed from many different precursors and pathways. Therefore, studying the occurrence of their precursors in water systems would enable better prediction and management of their formation.

关键词： Amino acids Disinfection by-products Organic chloramines N-chloramine Drinking water quality Organic bromamines Organic iodamines

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Many-body potential for simulating the self-assembly of polymer-grafted nanoparticles in a polymer matrix

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npj Computational Materials 2023年第1期9卷 71-84页

作者： Yilong Zhou Sigbjørn løland Bore Andrea R.Tao francesco Paesani Gaurav Arya Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA Materials Science Division Lawrence Livermore National LaboratoryLivermoreCA 94550USA Department of Chemistry and Biochemistry University of CaliforniaSan DiegoLa JollaCA 92093USA Department of Chemical and NanoEngineering University of CaliforniaSan DiegoLa JollaCA 92023USA

Many-body interactions between polymer-grafted nanoparticles(NPs)play a key role in promoting their assembly into low-dimensional structures within polymer melts,even when the particles are spherical and isotropically ***,capturing such interactions in simulations of NP assembly is very challenging because explicit modeling of the polymer grafts and melt chains is highly computationally expensive,even using coarse-grained ***,we develop a many-body potential for describing the effective interactions between spherical polymer-grafted NPs in a polymer matrix through a machine-learning *** approach involves using permutationally invariant polynomials to fit two-and three-body interactions derived from the potential of mean force *** potential developed here reduces the computational cost by several orders of magnitude,thereby,allowing us to explore assembly behavior over large length and time *** show that the potential not only reproduces previously known assembled phases such as 1D strings and 2D hexagonal sheets,which generally cannot be achieved using isotropic two-body potentials,but can also help discover interesting phases such as networks,clusters,and *** demonstrate how each of these assembly morphologies intrinsically arises from a competition between two-and three-body *** approach for deriving many-body effective potentials can be readily extended to other colloidal systems,enabling researchers to make accurate predictions of their behavior and dissect the role of individual interaction energy terms of the overall potential in the observed behavior.

关键词： grafted polymer potential

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Addressing the impact of canine distemper spreading on an isolated tiger population in northeast Asia

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Integrative Zoology 2023年第6期18卷 994-1008页

作者： Dawei WANG James l.D.SMITH francesco ACCATINO Jianping GE Tianming WANG Ministry of Education Key laboratory for Biodiversity Science and Engineering NFGA Key Laboratory for Conservation Ecology of Northeast Tiger and Leopard&College of Life SciencesBeijing Normal UniversityBeijingChina Department of Fisheries Wildlife and Conservation BiologyUniversity of MinnesotaSt.PaulMNUSA UMR SADAPT INRAEAgroParisTechUniversitéParis-SaclayPALAISEAU CedexFrance

The continuation of the isolated Amur tiger(Panthera tigris altaica)population living along the China-Russia border is facing serious challenges due to factors such as its small size(including 38 individuals)and canine distemper virus(CDV).We use a population viability analysis metamodel,which consists of a traditional individual-based demographic model linked to an epidemiological model,to assess options for controlling the impact of negative factors through domestic dog management in protected areas,increasing connectivity to the neighboring large population(including more than 400 individuals),and habitat *** intervention,under inbreeding depression of 3.14,6.29,and 12.26 lethal equivalents,our metamodel predicted the extinction within 100 years is 64.4%,90.6%,and 99.8%,*** addition,the simulation results showed that dog management or habitat expansion independently will not ensure tiger population viability for the next 100 years,and connectivity to the neighboring population would only keep the population size from rapidly ***,when the above three conservation scenarios are combined,even at the highest level of 12.26 lethal equivalents inbreeding depression,population size will not decline and the probability of extinction will belight that protecting the Amur tiger necessitates a multifaceted synergistic *** key management recommendations for this population underline the importance of reducing CDV threats and expanding tiger occupancy to its former range in China,but re-establishing habitat connectivity to the neighboring population is an important long-term objective.

关键词： Amur tiger canine distemper virus habitat connectivity metamodel population viability analysis(PVA)

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Role of one-step nucleic acid amplification in colorectal cancer lymph node metastases detection

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World Journal of Gastroenterology 2022年第30期28卷 4019-4043页

作者： francesco Crafa Serafino Vanella Onofrio A Catalano Kelsey l Pomykala Mario Baiamonte Division of General and Surgical Oncology St.Giuseppe Moscati HospitalCenter of National Excellence and High SpecialtyAvellino 83100Italy Department of Radiology Athinoula A.Martinos Center for Biomedical ImagingMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States Department of Nuclear Medicine Department of Radiological SciencesDavid Geffen School of Medicine at University of CaliforniaLos AngelesUniversity Hospital EssenUniversity of Duisburg-EssenEssen 45141Germany

Current histopathological staging procedures in colorectal cancer(CRC)depend on midline division of the lymph nodes(lNs)with one section of hematoxylin and eosin *** cells outside this transection line may be missed,which could lead to understaging of Union for International Cancer Control Stage II high-risk *** one-step nucleic acid amplification(OSNA)assay has emerged as a rapid molecular diagnostic tool for lN metastases *** is a molecular technique that can analyze the entire lN tissue using a reversetranscriptase loop-mediated isothermal amplification reaction to detect tumorspecific cytokeratin 19 *** findings suggest that the OSNA assay has a high diagnostic accuracy in detecting metastatic lNs in CRC and a high negative predictive *** is a standardized,observer-independent technique,which may lead to more accurate *** has been suggested that in stage II CRC,the upstaging can reach 25%and these patients can access postoperative adjuvant ***,intraoperative OSNA sentinel node evaluation may allow early CRC to be treated with organ-preserving surgery,while in more advanced-stage disease,a tailored lymphadenectomy can be performed considering the presence of aberrant lymphatic drainage and skip metastases.

关键词： colorectal malignancies One-step nucleic acid amplification Diagnostic accuracy Negative predictive value Upstaging Organ-sparing surgery Tailored lymphadenectomy

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Surgery for Residual Inferior left-to-Right Atrial Shunt

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Congenital Heart Disease 2021年第1期16卷 39-43页

作者： francesco Bertelli Claudia Cattapan Alvise Guariento Vladimiro l.Vida Paediatric and Congenital Cardiac Surgery Unit Department of CardiacThoracicVascular Sciences and Public HealthUniversity of PaduaPaduaItaly Department of Cardiovascular Surgery The Hospital for Sick ChildrenUniversity of TorontoTorontoCanada

We report the case of three female patients who were scheduled for surgical correction of residual left-to-right shunt after initial repair of sinus venosus atrial septal defect(SV-ASD)during *** excluding the possibility of an hemodynamic intervention,all three patients underwent a successful surgical closure through a right mini sub-axillary approach by using total peripheral cannulation for cardiopulmonary bypass and leaving the inferior vena cava completely un-snared allowing for an optimal visualization of the residual atrial septal communication and avoiding extensive dissection of mediastinal structures.

关键词： Residual sinus venosus-ASD un-snared vena cavae minimally invasive cardiac surgery inferior ASD

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length–mass allometries in amphibians

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Integrative Zoology 2018年第1期13卷 36-45页

作者： luca SANTINI Ana BENÍTEZ-lÓPEZ Gentile francesco FICETOlA Mark A.J.HUIJBREGTS Department of Environmental Science Institute for Wetland and Water ResearchFaculty of ScienceRadboud UniversityNijmegenthe Netherlands Department of Bioscience University of MilanMilanItaly Alpine Ecology laboratory Grenoble Alpes UniversityGrenobleFrance PBl Netherlands Environmental Assessment Agency The Haguethe Netherlands

Body mass is rarely recorded in amphibians,and other body measurements(*** to vent length,SVl)are generally collected ***,length measurements,when used as proxies of body mass in comparative analyses,are problematic if different taxa and morphotypes are *** developed allometric relationships to derive body mass from SVl *** fitted phylogenetic generalized least square models for frogs(Anura)and salamanders(Caudata)and for several families *** tested whether allometric relationships differed between species with different habitat preferences and between morphs in *** were fitted with SVl-mass measurements for 88 frog and 42 salamander *** assessed the predictive performance of the models by ***,the models showed high explained variance and low forecasting *** differed among semi-aquatic,terrestrial and arboreal frogs,and between paedomorphic and non-paedomorphic *** mass estimates derived from our models allow for comparability of studies on multiple taxa and can be used for testing theories built upon evolutionary and ecological processes which are directly related to body mass.

关键词： Anura body size body weight Caudata SVl

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3-Phase hierarchical graphene-based epoxy nanocomposite laminates for automotive applications

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Journal of Materials Science & Technology 2019年第10期35卷 2169-2177页

作者： Ahmed Elmarakbi Panagiotis Karagiannidis Alessandra Ciappa Franco Innocente francesco Galise Brunetto Martorana francesco Bertocchi francesco Cristiano Elvira Villaro Abalos Julio Gomez Department of Mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastleNE18STUnited Kingdom School of Engineering Faculty of TechnologyUniversity of SunderlandSunderlandSR6 ODDUnited Kingdom Delta-Tech S.pA. localita Rifoglieto 60/a-int.155011AltopascioLUItaly Fiat Research Center via ex Aeroporto80038 Pomigliano d'ArcoNaplesItaly Nanesa srl.Via Del Gavardello 59/c 52100 ArezzoARItaly Instituto de Tecnologfas Quimicas Emergences de la Rioja Antonio de Nebrija826006 LogronoSpain Avanzare Innovacion Tecnologica S.l Avda.lentiscares 4-626370 NavarreteSpain

Two different types of graphene flakes were produced following solution processing methods and dispersed using shear mixing in a bifunctional(A) and a multifunctional(B) epoxy resin at a concentration of 0.8 and 0.6 wt%, respectively. The graphene/epoxy resin mixtures were used to impregnate unidirectional carbon fibre tapes. These prepregs were stacked(seven plies) and cured to produce *** interlaminar fracture toughness(mode-I) of the carbon fiber/graphene epoxy laminates with resin B showed over 56% improvement compared with the laminate without graphene. Single lap joints were prepared using the laminates as adherents and polyurethane adhesives(Sika 7666 and Sika 7888). The addition of graphene improved considerably the adhesion strength from 3.3 to 21 MPa(sample prepared with resin A and Sika 7888) highlighting the potential of graphene as a secondary filler in carbon fibre reinforced polymer composites.

关键词： Graphene Carbon fibre reinforced polymer(CFRP) Fracture toughness Shear lap joints

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