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MEDICATION USE AND THE RISK OF STEVENS-JOHNSON SYNDROME OR TOXIC EPIDERMAL NECROLYSIS

IEEE/CAA Journal of Automatica Sinica 2020年第5期

作者： Giuseppe Franzè Senior Member IEEE Domenico Famularo Walter Lucia Member IEEE francesco Tedesco Member IEEE

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MEDICATION USE AND THE RISK OF STEVENS-JOHNSON SYNDROME OR T...

Boceprevir or telaprevir in hepatitis C virus chronic infection:The Italian real life experience

中成药上市后药物流行病学评价培训会议

作者： JEAN-CLAUDE ROUJEAU JUDITH P.KELLY LUIGI NALDI BERTHOLD RZANY ROBERT S.STERN THERESA ANDERSON ARIANE AUQUIER SYLVIE BASTUJI-GARIN OSVALDO CORREIA francesco LOCATI MAJA MOCKENHAUPT CATHERINE PAOLETTI SAMUEL SHAPIRO NEIL SHEAR ERWIN SCHPF DAVID W.KAUFMAN Department of Dermatology Universite Paris Ⅻ CreteilFrance M.D. the Slone Epidemiology Unit Boston University School of MedicineBostonM.S. Gruppo Italiano Studi Epidemiologici in Dermatologia Department of DermatologyUniversita degli Studi di MilanoBergamoItalyM.D. the Department of Dermatology Beth Israel HospitalHarvard Medical SchoolBostonM.D. the Slone Epidemiology Unit Boston University School of MedicineBostonR.N. the Department of Biostatistics and Epidemiology INSERM Unite 351Institut Gustave-RoussyVillejuifFranceM.S. the Department of Public Health Universite Paris Ⅻ CreteilFranceM.D. Grupo Portugues EIYS Department of Dermatology and ImmunologyHospital S.JoaoFaculdade de MedicinaPortoPortugalM.D. the Department of Biostatistics and Epidemiology INSERM Unite 351Institut Gustave-RoussyVillejuifFrance the Slone Epidemiology Unit Boston University School of MedicineBostonM.B.F.R.C.P.(E.) the Department of Pharmacology Sunnybrook Health Science CentreTorontoM.D. the Slone Epidemiology Unit Boston University School of MedicineBostonSC.D.

*** epidermal necrolysis and Stevens-Johnson syndrome are rare,life-threatening, drug-induced cutaneous *** conducted a case-control study to quantify the risks associated with the use of specific drugs. *** were obtained through surveillance networks in France,Germany,Italy,and *** use before the onset of disease was compared in 245 people who were hospitalized because of toxic epidermal necrolysis or Stevens-Johnson syndrome and 1147 patients hospitalized for other reasons(controls).Crude relative risks were calculated and adjusted for confounding by multivariate methods when numbers were large enough. *** drugs usually used for short periods, the risks were increased for trimethoprim-sulfamethoxazole and other sulfonamide antibiotics(crude relative risk,172;95 percent confidence interval,75 to 396), chlormezanone(crude relative risk,62;21 to 188),aminopenicillins (multivariate relative risk,6.7;2.5 to 18), quinolones(multivariate relative risk,10;2.6 to 38),and cephalosporins(multivariate relative risk,14;3.2 to 59). For acetaminophen,the multivariate relative risk was 0.6 (95 percent confidence interval,0.2 to 1.3) in France but 9.3(3.9 to 22) in the other *** drugs usually used for months or years,the increased risk was confined largely to the first two months of treatment, when crude relative risks were as follows:carbamazepine, 90(95 percent confidence interval,19 to∞);phenobarbital, 45(19 to 108);phenytoin,53(11 to∞);valproic acid,25(4.3 to∞);oxicam nonsteroidal antiinflammatory drugs(NSAIDs),72(25 to 209);allopurinol,52(16 to 167);and corticosteroids,54(23 to 124).For many drugs,including thiazide diuretics and oral hypoglycemic agents,there was no significant increase in risk. *** use of antibacterial sulfonamides, anticonvulsant agents,oxicam NSAIDs,allopurinol,chlormezanone, and corticosteroids is associated with large increases in the risk of Stevens-Johnson syndrome or toxic epi

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World Journal of Hepatology 2016年第22期8卷 949-956页

作者： Antonio Ascione Luigi Elio Adinolfi Pietro Amoroso Angelo Andriulli Orlando Armignacco Tiziana Ascione Sergio Babudieri Giorgio Barbarini Michele Brogna francesco Cesario Vincenzo Citro Ernesto Claar Raffaele Cozzolongo Giuseppe D’Adamo Emilio D’Amico Pellegrino Dattolo Massimo De Luca Vincenzo De Maria Massimo De Siena Giuseppe De Vita Antonio Di Giacomo Rosanna De Marco Giorgio De Stefano Giulio De Stefano Sebastiano Di Salvo Raffaele Di Sarno Nunzia Farella Laura Felicioni Basilio Fimiani Luca Fontanella Giuseppe Foti Caterina Furlan Francesca Giancotti Giancarlo Giolitto Tiziana Gravina Barbara Guerrera Roberto Gulminetti Angelo Iacobellis Michele Imparato Angelo Iodice Vincenzo Iovinella Antonio Izzi Alfonso Liberti Pietro Leo Gennaro Lettieri Ileana Luppino Aldo Marrone Ettore Mazzoni Vincenzo Messina Roberto Monarca Vincenzo Narciso Lorenzo Nosotti Adriano Maria Pellicelli Alessandro Perrella Guido Piai Antonio Picardi Paola Pierri Grazia Pietromatera francesco Resta Luca Rinaldi Mario Romano Angelo Rossini Maurizio Russello Grazia Russo Rodolfo Sacco Vincenzo Sangiovanni Antonio Schiano Antonio Sciambra Gaetano Scifo Filomena Simeone Annarita Sullo Pierluigi Tarquini Paolo Tundo Alfredo Vallone Depart-ment of Medicine Center for Liver Diseases "Buon Consiglio" -Fatebenefratelli Hospital Internal Medicine Unit Second University of Naples VI Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Division of Gastro- enterology Casa Sollievo Sofferenza Hospital IRCCS Division of Infectious Diseases Belcolle Hospital IX Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Clinical of Infectious Disease University of Sassari Infectious Disease IRCCS San Matteo Division of Infectious Diseases and Liver Unit "G. Iazzolino" Hospital Division of Infectious Diseases "Annunziata" Hospital Depart-ment of Internal Medicine Umberto I Hospital Internal Medicine Ospedale Evangelico Villa Betania Division of Gastroenterology IRCCS "S.de Bellis" Hospital Internal Medicine Unit Pescara-Penne Hospital Gastroenterology Unit Marcianise Hospital Liver Unit AORN Cardarelli Liver Unit Policlinico "Mater Domini" Service of Medical Day Hospital "Rummo" Hospital Internal Medicine Regina Margherita Hospital Division of Gastroenterology "Annunziata" Hospital Infectious Disease Matera Hospital First Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Division of Infectious Diseases AO Melacrino- Bianchi-Morelli Infectious and Tropical Disease Policlinico Umberto I Division of Infectious Disease Maria SS Addolorata Hospital Division of Infectious Diseases S. Anna and S. Sebastiano Hospital Outpatients Service for Liver Diseases "Loreto Crispi" Hospital V Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Department of Medical Surgical Neurological Geriatric and Metabolic Sciences Second Univer-sity of Naples Liver Unit Policlinico Casilino Medicine and Health Unit for Prisoners Belcolle Hospital Internal Medicine Unit "Ascalesi" Hospital Gastrointestinal and Liver Department National Institute for Health Migration and Poverty Liver Unit Azienda Ospedaliera San Camillo Forlanini VII Division of Infectious Diseases

AIM: To check the safety and efficacy of boceprevir/telaprevir with peginterferon/ribavirin for hepatitis C virus(HCV) genotype 1 in the real-world settings. METHODS: This study was a non-randomized, observational, prospective, multicenter. This study involved 47 centers in Italy. A database was prepared for the homogenous collection of the data, was used by all of the centers for data collection, and was updated continuously. All of the patients enrolled in this study were older than 18 years of age and were diagnosed with chronic infection due to HCV genotype 1. The HCV RNA testing was performed using COBAS-Taq Man2.0(Roche, LLQ 25 IU/m L). RESULTS: All consecutively treated patients were included. Forty-seven centers enrolled 834 patients as follows: Male 64%; median age 57(range 18-78), of whom 18.3% were over 65; mean body mass index 25.6(range 16-39); genotype 1b(79.4%); diagnosis of cirrhosis(38.2%); and fibrosis F3/4(71.2%). The following drugs were used: Telaprevir(66.2%) and PEG-IFN-alpha2a(67.6%). Patients were na?ve(24.4%), relapsers(30.5%), partial responders(14.8%) and null responders(30.3%). Overall, adverse events(AEs) occurred in 617 patients(73.9%) during the treatment. Anemia was the most frequent AE(52.9% of cases), especially in cirrhotic. The therapy was stopped for 14.6% of the patients because of adverse events or virological failure(15%). Sustained virological response was achieved in 62.7% of the cases, but was 43.8% in cirrhotic patients over 65 years of age. CONCLUSION: In everyday practice, triple therapy is safe but has moderate efficacy, especially for patients over 65 years of age, with advanced fibrosis, nonresponders to peginterferon + ribavirin.

关键词： Boceprevir Telaprevir Chronic hepatitis Antiviral therapy Peg-interferon Ribavirin

Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a Delphi consensus project

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Asian Journal of Urology 2024年第2期11卷 271-279页

作者： Andrea Cocci Marta Pezzoli Fernando Bianco Franco Blefari Pierluigi Bove Francois Cornud Gaetano De Rienzo Paolo Destefanis Danilo Di Trapani Alessandro Giacobbe Luca Giovanessi Antonino Laganà Giovanni Lughezzani Guglielmo Manenti Gianluca Muto Gianluigi Patelli Novello Pinzi Stefano Regusci Giorgio I.Russo Juan I.M.Salamanca Matteo Salvi Luigi Silvestri Fabrizio Verweij Eric Walser Riccardo GBertolo Valerio Iacovelli Alessandro Bertaccini Debora Marchiori Hugo Davila Pasquale Ditonno Paolo Gontero Gennaro Iapicca Theo M De Reijke Vito Ricapito Pierluca Pellegrini Andrea Minervini Sergio Serni francesco Sessa Department of Urology Careggi HospitalUniversity of FlorenceFlorenceItaly Urology Section University of FlorenceFlorenceItaly Urological Research Network MiamiFLUSA Urology Section Prato HospitalPratoItaly Torvergata Oncoscience Research Centre of Excellence TORDepartment of Experimental MedicineUniversity of Rome Tor VergataRomeItaly Department of Urology San Carlo di Nancy HospitalRomeItaly Department of Radiology Hôpital CochinParis Descartes UniversityParisFrance Urology and Andrology Unit II Department of Emergency and Organ TransplantationUniversity of BariBariItaly Unit of Urology Cittàdella Salute e della Scienza HospitalUniversity of TurinTurinItaly Urology Unit Buccheri La Ferla Fatebenefratelli HospitalPalermoItaly Department of Urology Humanitas Gradenigo HospitalTurinItaly Urology Unit Surgical DepartmentFondazione Poliambulanza Istituto OspedalieroBresciaItaly Departement of Urology “S.Giovanni Evangelista”HospitalTivoliItaly Humanitas Clinical and Research CentereIRCCS Department of UrologyRozzanoItaly Department of Biomedical Sciences Humanitas UniversityPieve EmanueleItaly Department of Biomedicine and Prevention University of Rome“Tor Vergata”RomeItaly Department of Diagnostic Imaging and Interventional Radiology University of Rome“Tor Vergata”RomeItaly Department of Interventional Radiology Pesenti-Fenaroli Hospital-ASST Bergamo EstAlzano LombardoItaly Department of Urology University of SienaSienaItaly Swiss International Prostate Center GenevaSwitzerland Clinique Générale Beaulieu GenevaSwitzerland Department of Urology University of CataniaItaly Department of Urology Puerta de Hierro-Majadahonda University HospitalMadridSpain Lyx Institute of Urology Universidad Francisco de VitoriaMadridSpain Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of RomeFaculty of Pharmacy and MedicineUrology Unit ICOTLatinaItaly Department of Urology European Institute of Oncology(IEO)IRCCSMilanItaly Department of Radiology D

Objective: To evaluate transperineal laser ablation (TPLA) with Echolaser® (Echolaser® TPLA, Elesta S.p.A., Calenzano, Italy) as a treatment for benign prostatic hyperplasia (BPH) and prostate cancer (PCa) using the Delphi consensus ***: Italian and international experts on BPH and PCa participated in a collaborative consensus project. During two rounds, they expressed their opinions on Echolaser® TPLA for the treatment of BPH and PCa answering online questionnaires on indications, methodology, and potential complications of this technology. Level of agreement or disagreement to reach consensus was set at 75%. If the consensus was not achieved, questions were modified after each round. A final round was performed during an online meeting, in which results were discussed and ***: Thirty-two out of forty invited experts participated and consensus was reached on all topics. Agreement was achieved on recommending Echolaser® TPLA as a treatment of BPH in patients with ample range of prostate volume, from 80 mL (80%), comorbidities (100%), antiplatelet or anticoagulant treatment (96%), indwelling catheter (77%), and strong will of preserving ejaculatory function (100%). Majority of respondents agreed that Echolaser® TPLA is a potential option for the treatment of localized PCa (78%) and recommended it for low-risk PCa (90%). During the final round, experts concluded that it can be used for intermediate-risk PCa and it should be proposed as an effective alternative to radical prostatectomy for patients with strong will of avoiding urinary incontinence and sexual dysfunction. Almost all participants agreed that the transperineal approach of this organ-sparing technique is safer than transrectal and transurethral approaches typical of other techniques (97% of agreement among experts). Pre-procedural assessment, technical aspects, post-procedural catheterization, pharmacological therapy, and expected outcomes were discussed, leading t

关键词： Transperineal laser ablation Prostatecancer Benignprostatic hyperplasia Delphi consensus

Redefining pandemic preparedness:Multidisciplinary insights from the CERP modelling workshop in infectious diseases,workshop report

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Infectious Disease Modelling 2024年第2期9卷 501-518页

作者： Marta C.Nunes Edward Thommes Holger Fröhlich Antoine Flahault Julien Arino Marc Baguelin Matthew Biggerstaff Gaston Bizel-Bizellot Rebecca Borchering Giacomo Cacciapaglia Simon Cauchemez Alex Barbier-Chebbah Carsten Claussen Christine Choirat Monica Cojocaru Catherine Commaille-Chapus Chitin Hon Jude Kong Nicolas Lambert Katharina B.Lauer Thorsten Lehr Cédric Mahe Vincent Marechal Adel Mebarki Seyed Moghadas Rene Niehus Lulla Opatowski francesco Parino Gery Pruvost Andreas Schuppert Rodolphe Thiébaut Andrea Thomas-Bachli Cecile Viboud Jianhong Wu Pascal Crépey Laurent Coudeville Center of Excellence in Respiratory Pathogens(CERP) Hospices Civils de Lyon(HCL)and Centre International de Recherche en Infectiologie(CIRI)Équipe SantéPubliqueÉpidémiologie etÉcologieÉvolutive des Maladies Infectieuses(PHE3ID)Inserm U1111CNRS UMR5308ENS de LyonUniversitéClaude Bernard Lyon 1LyonFrance South African Medical Research Council Vaccines&Infectious Diseases Analytics Research UnitFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa New Products and Innovation(NPI) Sanofi Vaccines(Global)TorontoOntarioCanada Department of Mathematics and Statistics University of GuelphGuelphOntarioCanada Fraunhofer Institute for Algorithms and Scientific Computing(SCAI) Department of BioinformaticsSchloss BirlinghovenSankt AugustinGermany University of Bonn Bonn-Aachen International Center for IT(b-it)BonnGermany Institute of Global Health Faculty of MedicineUniversity of GenevaGenevaSwitzerland and Swiss School of Public HealthZürichSwitzerland Department of Mathematics University of ManitobaWinnipegManitobaCanada MRC Centre for Global Infectious Disease Analysis School of Public HealthImperial College LondonLondonUK Centre for Mathematical Modelling of Infectious Diseases Department of Infectious Disease EpidemiologyLondon School of Hygiene&Tropical MedicineLondonUK National Center for Immunization and Respiratory Diseases(NCIRD) US Centers for Disease Control and Prevention(CDC)AtlantaGAUSA Departement of Computational Biology Departement of Global HealthInstitut PasteurParisFrance Institut de Physique des Deux Infinis de Lyon(IP2I) UMR5822IN2P3/CNRSUniversitéClaude Bernard Lyon 1VilleurbanneFrance Mathematical Modelling of Infectious Diseases Unit Institut PasteurUniversitéParis CitéUMR2000 CNRSParisFrance Decision and Bayesian Computation Institut PasteurUniversitéParis CitéCNRS UMR 3571France Fraunhofer-Institute for Translational Medicine and Pharmacology HamburgGermany Institute of Global Health Faculty of MedicineUniversity of

In July 2023,the Center of Excellence in Respiratory Pathogens organized a two-day workshop on infectious diseases modelling and the lessons learnt from the Covid-19 *** report summarizes the rich discussions that occurred during the *** workshop participants discussed multisource data integration and highlighted the benefits of combining traditional surveillance with more novel data sources like mobility data,social media,and wastewater *** advancements were noted in the development of predictive models,with examples from various countries showcasing the use of machine learning and artificial intelligence in detecting and monitoring disease *** role of open collaboration between various stakeholders in modelling was stressed,advocating for the continuation of such partnerships beyond the pandemic.A major gap identified was the absence of a common international framework for data sharing,which is crucial for global pandemic ***,the workshop underscored the need for robust,adaptable modelling frameworks and the integration of different data sources and collaboration across sectors,as key elements in enhancing future pandemic response and preparedness.

关键词： Modelling Covid-19 Infectious diseases Pandemic preparedness Workshop

Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease

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Journal of Geriatric Cardiology 2016年第08期 701-711页

作者： Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli francesco S Dioguardi Department of Clinical & Experimental Sciences Division of Human Anatomy & PhysiopathologyUniversity of Brescia "S.Maugeri Foundation" IRCCSCardiology DivisionMedical Centre of Lumezzane Zena and Michael A Wiener Cardiovascular InstituteMount Sinai Medical Center Center for Heart and Vessel Preclinical Studies St.John Hospital & Medical CenterWayne State University School of Medicine VA Ann Arbor Health Care System University of Michigan Department of Cardiovascular Surgery "San Rocco" Hospital Department of Biotechnological and Applied Clinical Sciences University of L'Aquila Division of Sport-Internal Medicine Department of Clinical & Experimental SciencesUniversity of Brescia Department of Clinical Sciences and Community Health University of Milan

Background Klotho proteins(α-and β) are membrane-based circulating proteins that regulate cell metabolism,as well as the lifespan modulating activity of Fibroblast Growth Factors(FGFs).Recent data has shown that higher plasma circulating Klotho levels reduce cardiovascular risk,suggesting Klotho has a protective role in cardiovascular ***,although so far it has been identified in various organs,it is unknown whether cardiomyocytes express Klotho and FGFs,and whether high cardiovascular risk could affect cardiac expression of Klotho,FGFs and other *** We selected 20 patients with an estimated 10-year high atherosclerotic cardiovascular disease and 10 age-matched control subjects with an estimated 10-year low risk undergone cardiac surgery for reasons other than coronary artery *** myocardial biopsies,we evaluated by immuno-histochemistry whether Klotho and FGFs were expressed in cardiomyocytes,and whether higher cardiovascular risk influenced the expression of other molecules involved in endoplasmic reticulum stress,oxidative stress,inflammation and *** Only cardiomyocytes of patients with a higher cardiovascular risk showed lower expression of Klotho,but higher expressions of ***,higher cardiovascular risk was associated with increased expression of oxidative and endoplasmic reticular stress,inflammation and *** This study showed for the first time that Klotho proteins are expressed in human cardiomyocytes and that cardiac expression of Klotho is down-regulated in higher cardiovascular risk patients,while expression of stress-related molecules were significantly increased.

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陡峭且地震活跃的西北地中海利古里亚陆缘海底失稳和沉积物运移

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海洋地质 2009年第1期25卷 62-63页

作者： Antonio Cattaneo Sebastien Migeon Christophe Larroque Etienne Ruellan Franqoise Sage Marc Sosson Nicola Corradi Yves Le Gonidec francesco Fanucci 杨丽娟（译）闫章存（校对）海洋开发研究院法国尼斯地球科学实验室法国热那亚大学意大利雷恩第一大学法国的里雅斯特大学意大利不详

利古里亚陆缘地形陡峭，表现为复杂的继承性地壳运动构造、易变的下切谷以及众多的海底滑坡。这部分陆缘经常受到地震（历史上有四次地震，分别是公元1564年、1644年、1817年和1887年）和海啸（公元1564年、1817年、1887年和1979年）的... 详细信息

利古里亚陆缘地形陡峭，表现为复杂的继承性地壳运动构造、易变的下切谷以及众多的海底滑坡。这部分陆缘经常受到地震（历史上有四次地震，分别是公元1564年、1644年、1817年和1887年）和海啸（公元1564年、1817年、1887年和1979年）的影响。在这个人口密集的海岸带，人们对地震和海啸的高度关注是实施两次海上计划（Malisarl和Malisar2），对沉积物滑坡触发机制进行调查的深层次的原因。2006年采集到的资料包括尼斯到热那亚之间水深100～2500m的EM300多波束资料、3—5kHz浅层剖面以及24道或72道地震剖面。

关键词：地震剖面沉积物运移海底滑坡陆缘地中海失稳地壳运动

梵文《七百颂般若经》：转写本第一部分（英文）

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China Tibetology 2021年第2期 105-120页

作者：李学竹法兰西斯柯·比安齐尼 China Tibetology Research center Heidelberg University

INTRODUCTION The present paper offers a diplomatic edition of the first half of the Sanskrit Sapta?atikā Praj?āpāramitā as preserved in a Pāla manuscript made accessible by the CTRC(Beijing). This is a composite manuscript containing various Praj?āpāramitā and related texts. It has been previously described in detail by Toru Tomabechi, who inspected it for his critical edition of the Adhyardha?atikā Praj?āpāramitā(2009: xxivxxxii).

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原油结垢沉积表征、测量和模拟

国外科技新书评介 2016年第1期 16-16页

作者： francesco Coletti 陈宏刚不详华北电力大学

石油炼制是典型的高能耗过程，炼油过程的节能降耗减排任务艰巨。随着原油资源日益重质化劣质化和页岩油的开采，石油加工设备和管道特别是常减压蒸馏装置中换热器的结垢问题日益突出。

关键词：原油资源结垢常减压蒸馏装置表征沉积模拟测量石油加工设备

梵文《七百颂般若经》转写本第二部分（英文）

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China Tibetology 2022年第2期 41-58页

作者：法兰西斯柯·比安齐尼李学竹 Mahidol University China Tibetology Research center

本文是基于保存在西藏布达拉宫《七百颂般若经》梵文写本所作的转写。《七百颂般若经》有三个汉文译本和一个藏译本。1923年意大利学者图齐曾校勘出该经梵文本,但图齐所依梵文写本多有残缺,并不是一个理想的校本,故本文的发表可修正和... 详细信息

本文是基于保存在西藏布达拉宫《七百颂般若经》梵文写本所作的转写。《七百颂般若经》有三个汉文译本和一个藏译本。1923年意大利学者图齐曾校勘出该经梵文本,但图齐所依梵文写本多有残缺,并不是一个理想的校本,故本文的发表可修正和补充图齐校本中的错误和不足。

关键词：《七百颂般若经》梵文写本般若思想