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Chemical characterization of submicron aerosol particles during wintertime in a northwest city of China using an Aerodyne aerosol mass spectrometry

Chemical characterization of submicron aerosol particles dur...

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第十五届海峡两岸气胶技术研讨会

作者： Xinghua Zhang Yangmei Zhang Junying Sun Yangchun Yu francesco canonaco Andre S.H.Prév?t Gang Li Key Laboratory of Arid Climatic Change and Reducing Disaster of Gansu Province Key Laboratory of Arid Climatic Change and Disaster Reduction of CMAInstitute of Arid MeteorologyChina Meteorological Administration State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences State Key Laboratory of Severe Weather & Key Laboratory of Atmospheric Chemistry of CMA Chinese Academy of Meteorological Sciences Shandong Academy for Environmental Planning Laboratory of Atmospheric Chemistry Paul Scherrer Institute (PSI) State Key Laboratory of Loess and Quaternary Geology and Key Laboratory of Aerosol Chemistry and Physics Institute of Earth EnvironmentChinese Academy of Sciences

An Aerodyne quadruple aerosol mass spectrometry(Q-AMS) was utilized to measure the size-resolved chemical composition of non-refractory submicron particles(NR-PM1) from October 27 to December 3,2014 at an urban site in Lanzhou,northwest *** average NR-PM1 mass concentration was 37.3 mg m(ranging from 2.9 to 128.2 mg m) under an AMS collection efficiency of unity and was composed of organics(48.4%),sulfate(17.8%),nitrate(14.6%),ammonium(13.7%),and chloride(5.7%).Positive matrix factorization(PMF) with the multi-linear engine(ME-2) solver identified six organic aerosol(OA) factors,including hydrocarbon-like OA(HOA),coal combustion OA(CCOA),cooking-related OA(COA),biomass burning OA(BBOA) and two oxygenated OA(OOA1 and OOA2),which accounted for 8.5%,20.2%,18.6%,12.4%,17.8% and 22.5% of the total organics mass on average,*** emissions were the major sources of fine particulate matter(PM) and played an important role in causing high chemically resolved PM pollution during wintertime in *** trajectory analysis indicated that the long-range regional transport air mass from the westerly was the key factor that led to severe submicron aerosol pollution during wintertime in Lanzhou.

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Single-cell pan-omics, environmental neurology, and artificial intelligence:the time for holistic brain health research

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Neural Regeneration Research 2025年第6期20卷 1703-1704页

作者： Paolo Abondio francesco Bruno IRCCS Istituto delle Scienze Neurologiche di Bologna BolognaItaly Association for Neurogenetic Research(ARN) Lamezia TermeCatanzaroItaly

The brain,with its trillions of neural connections,different cellular types,and molecular complexities,presents a formidable challenge for researchers aiming to comprehend the multifaceted nature of neural *** traditional methods have provided valuable insights,emerging technologies offer unprecedented opportunities to delve deeper into the underpinnings of brain *** the everevolving landscape of neuroscience,the quest to unravel the mysteries of the human brain is bound to take a leap forward thanks to new technological improvements and bold interpretative frameworks.

关键词： function artificial landscape

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Mechanisms behind elevated serum levels of plasminogen activator inhibitor-1 in frontotemporal lobar degeneration

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Neural Regeneration Research 2025年第8期20卷 2317-2318页

作者： francesco Angelucci Jakub Hort Memory Clinic Department of NeurologySecond Faculty of MedicineCharles University and Motol University HospitalPragueCzech Republic International Clinical Research Centre St.Anne’s University HospitalBrnoCzech Republic

Frontotemporal lobar degeneration(FTLD)is a form of progressive dementia characterized by degeneration of the frontal and temporal lobes of the *** pathology involves a series of cognitive,behavioral,and neurological ... 详细信息

关键词： degeneration elevated pathology

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Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： francesco Ferrini Esri H.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

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Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria Martinelli Jessica Mandrioli Andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari Cecilia Simonini francesco Cavallieri Franco Valzania Department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine Ph.D.Program University of Modena and Reggio EmiliaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

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Magnetron sputtered nickel oxide with suppressed interfacial defect states for efficient inverted perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang Ma Qin Tan Zhaoning Li Jingwei Xiu Jiafeng Wang Tianle Cheng Dong He Qiang Sun Xuhang Ma francesco Lamberti Zhubing He Department of Materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research Facilities Southern University of Science and Technology Department of Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells often suffer from severe interfacial reactions between the NiOxand adjacent perovskite layers due to surface defect states,which inherently impair device performance in a long-term view,even with surface molecule *** this study,we developed high-quality magnetron-sputtered NiOxthin films through detailed process optimization,and compared systematically sputtered and spin-coated NiOxthin film surfaces from materials to *** sputtered NiOxfilms exhibit improved crystallinity,smoother surfaces,and significantly reduced Ni3+or Ni vacancies compared to their spin-coated ***,the interface between the perovskite and sputtered NiOxfilm shows a substantially reduced density of defect *** solar cells （PSCs） fabricated with our optimally sputtered NiOxfilms achieved a high power conversion efficiency （PCE） of up to 19.93%and demonstrated enhanced stability,maintaining 86.2% efficiency during 500 h of maximum power point tracking under one standard sun ***,with the surface modification using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DMAcPA）,the device PCE was further promoted to 23.07%,which is the highest value reported for sputtered NiOxbased PSCs so far.

关键词： Perovskite

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A new three-dimensional finite-volume non-hydrostatic shock-capturing model for free surface flow

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Journal of Hydrodynamics 2017年第4期29卷 552-566页

作者： francesco Gallerano Giovanni Cannata francesco Lasaponara Chiara Petrelli Department of Civil Constructional and Environmental Engineering Sapienza University of Rome

In this paper a new finite-volume non-hydrostatic and shock-capturing three-dimensional model for the simulation of wave-structure interaction and hydrodynamic phenomena（wave refraction, diffraction, shoaling and breaking） is proposed. The model is based on an integral formulation of the Navier-Stokes equations which are solved on a time dependent coordinate system： a coordinate transformation maps the varying coordinates in the physical domain to a uniform transformed space. The equations of motion are discretized by means of a finite-volume shock-capturing numerical procedure based on high order WENO reconstructions. The solution procedure for the equations of motion uses a third order accurate Runge-Kutta（SSPRK） fractional-step method and applies a pressure corrector formulation in order to obtain a divergence-free velocity field at each stage. The proposed model is validated against several benchmark test cases.

关键词： Three-dimensional simulation non-hydrostatic wave-structure interaction flow-structure interaction shock-capturing

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Automated classification of civil structure defects based on convolutional neural network

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Frontiers of Structural and Civil Engineering 2021年第2期15卷 305-317页

作者： Pierclaudio SAVINO francesco TONDOLO Department of Structural Geotechnical and building EngineeringPolitecnico di TorinoTorino10129Italy

Today,the most commonly used civil infrastructure inspection method is based on a visual assessment conducted by certified inspectors following prescribed ***,the increase in aggressive environmental and load conditions,coupled with the achievement of many structures of the life-cycle end,has highlighted the need to automate damage identification and satisfy the number of structures that need to be *** overcome this challenge,this paper presents a method for automating concrete damage classification using a deep convolutional neural *** convolutional neural network was designed after an experimental investigation of a wide number of pretrained networks,applying the transfer-learning *** and validation were conducted using a database built with 1352 images balanced between“undamaged”,“cracked”,and“delaminated”concrete *** increase the network robustness compared to images in real-world situations,different image configurations have been collected from the Internet and on-field bridge *** GoogLeNet model,with the highest validation accuracy of approximately 94%,was selected as the most suitable network for concrete damage *** results confirm that the proposed model can correctly classify images from real concrete surfaces of bridges,tunnels,and pavement,resulting in an effective alternative to the current visual inspection techniques.

关键词： concrete structure infrastructures visual inspection convolutional neural network artificial intelligence

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Mechanisms and significance of liver steatosis in hepatitis C virus infection

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World Journal of Gastroenterology 2006年第42期12卷 6756-6765页

作者： francesco Negro Services de Gastroentérologie et d'Hépatolo- gie et de Pathologie Clinique H?pitaux Universitaires Genève 1205 Switzerland

The pathogenesis of liver damage associated with chronic hepatitis C virus （HCV） infection is thought to be largely immunomediated. However, some frequent histoo pathological features, such as steatosis, suggest a direct cytopathic effect of HCV. The direct responsibility of HCV in the pathogenesis of steatosis is shown by：（1） the association with HCV genotype 3 infection, suggesting that some viral sequences are involved in the intracellular aco cumulation of lipids; （2） the correlation between severity of steatosis and HCV replication levels; （3） association between response to treatment and disappearance of steatosis. Experimental studies have shown that the nuo cleocapsid protein of HCV （core protein） is capable and sufficient to induce lipid accumulation in hepatocytes. Moreover, the observation that chronic hepatitis C pao tients have reduced serum levels of ApoB suggests an interference with the very-low density lipoprotein （VLDL） assembly, although other mechanisms are possible. In patients with sustained virological response induced by antiviral therapy, such levels are normalized. Other obo servations suggest that the pathogenesis of steatosis in chronic hepatitis C is not solely due to HCV. The origin of the mild steatosis observed in most patients may be metabolic, since its severity correlates with body mass index and insulin resistance. Most studies have shown a correlation between presence and/or severity of steatosis and fibrosis stage, but it is unclear whether this effect is direct or mediated by the associated insulin resistance, increased susceptibility to apoptosis, or by inflammao tory cytokines. Finally, steatosis negatively influences the rate of response to antiviral treatment, as confirmed by large clinical trials. Management of steatosis in chronic hepatitis C requires knowledge of its pathogenesis and may involve both life-style changes and pharmacological interventions, although the latter remain largely experio mental.

关键词： Hepatitis C Fibrosis Insulin Resistance Insulin signaling

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Metamaterials and plasmonics: From nanoparticles to nanoantenna arrays, metasurfaces, and metamaterials

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Chinese Physics B 2014年第4期23卷 64-75页

作者： francesco Monticone Andrea Alù Department of Electrical and Computer Engineering The University of Texas at Austin 1 University Station C0803Austin Texas 78712 USA

The rise of plasmonic metamaterials in recent years has unveiled the possibility of revolutionizing the entire field of optics and photonics, challenging well-established technological limitations and paving the way to innovations at an unprecedented level To capitalize the disruptive potential of this rising field of science and technology, it is important to be able to combine the richness of optical phenomena enabled by nanoplasmonics in order to realize metamaterial components, devices, and systems of increasing complexity. Here, we review a few recent research directions in the field of plasmonic metamaterials, which may foster further advancements in this research area. We will discuss the anomalous scattering features enabled by plasmonic nanoparticles and nanoclusters, and show how they may represent the fundamental building blocks of complex nanophotonic architectures. Building on these concepts, advanced components can be designed and operated, such as optical nanoantennas and nanoantenna arrays, which, in turn, may be at the basis of metasurface devices and complex systems. Following this path, from basic phenomena to advanced functionalities, the field of plasmonic metamaterials offers the promise of an important scientific and technological impact, with applications spanning from medical diagnostics to clean energy and information processing.

关键词： plasmonics metamaterials nanoparticles scattering

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