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The Genetic Variant c.553G>T in the Lipoprotein A5 Effects on Lipid Profile Parameters Levels

World Journal of Cardiovascular Diseases 2019年第2期9卷 122-131页

作者： Neda M. Bogari Ashwag Aljohani Amr A. Amin Faisal A. Al-Allaf Anas Dannoun Mohiuddin M. Taher Atalla Elsayed Dareen Ibrahim Rednah Osama Elkhatee Massimo Porqueddu francesco alamanni Ahmed Fawzy Medical Genetics Department Faculty of Medicine Umm Al-Qura University Makkah KSA Biochemistry Department Faculty of Medicine Umm Al-Qura University Makkah KSA Faculty of Medicine Ain Shams University Cairo Egypt Science and Technology Unit Umm Al-Qura University Makkah KSA St James’s Hospital Dublin UK Occupational Medicine The University of Manchester Manchester UK Fakeeh Hospital Jeddah KSA Department of Cardiology Dalhousie University Halifax Nova Scotia Canada Department of Cardiac Surgery King Fahd Armed Forces Hospital Jeddah KSA Department of Cardiac Surgery Monzino Heart Center University of Milan Milan Italy Division of Human Genetics and Genome Research Department of Molecular Genetics and human Enzymology National Research Centre Giza Egypt

Abnormal levels of plasma lipid have been linked to atherosclerosis, strokes and heart conditions. Variations in high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels are considered as risk factors for coronary artery disease (CAD). Furthermore, triglycerides are a leading cause of cardiovascular disease. Therefore, measurement of plasma lipid levels is an important mortality predictor. Several factors were associated with irregularity in plasma lipids such as genetic alterations. Recent researches have linked single nucleotides polymorphism (SNP) in ApoA5 gene with these deviations. In this study, we reported the effects of the genetic variant c.553G>T in ApoA5 on the levels of plasma lipids. To explore these effects, a case-control study including 280 male and female subjects (44 of them were assigned as CAD cases while the remaining subjects were categorized as control) was established. All patients in the study were recruited from the western region in KSA. The results have detected minor variations in LDL, HDL and cholesterol levels between CAD patients carrying T allele and CAD patients carrying the WT allele. However, there were no significant effects due to these variations. TG levels in the wild type carriers reached up to 291 mg/dl while T allele carriers, the cases, presented lower levels of TG (170 mg/dl and 71 mg/dl). Although, T allele showed no effects on plasma lipids with the exception of TG levels. We suggest by this study that T allele in this SNP might be considered as a valuable tool in the diagnosis of CAD.

关键词： APOA5 Gene Polymorphism Genetic Variation Coronary Artery Disease Kingdom of Saudi Arabia (KSA)

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