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莫高窟第85窟现状调查评估

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敦煌研究 2000年第1期 174-180页

作者：徐淑青王旭东孙洪才郦伟堂郑军 francesca pica 敦煌研究院保护研究所甘肃敦煌736200 中国文物研究所北京100029 美国盖蒂保护研究所

莫高窟第 85窟的保护是敦煌研究院与美国盖蒂保护所第二期合作项目。洞窟现状调查是该项目的重点内容之一。本文阐述了现状调查的目的及方法 ,并对调查结果进行了讨论 ,为探讨病害机理以及今后的保护规划提供了可靠的基础资料。

关键词：莫高窟 85窟现状调查

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Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives

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World Journal of Gastrointestinal Oncology 2016年第1期8卷 30-39页

作者： Roberta Gaziano Gabriella Moroni Cristina Buè Martino Tony Miele Paola Sinibaldi-Vallebona francesca pica Department of Experimental Medicine and Surgery University of Rome Tor Vergata

Historically, natural products have represented a significant source of anticancer agents, with plant-derived drugs becoming increasingly explored. In particular, sanguinarine is a benzophenanthridine alkaloid obtained from the root of Sanguinaria canadensis, and from other poppy Fumaria species, with recognized anti-microbial, anti-oxidant and anti-inflammatory properties. Recently, increasing evidence that sanguinarine exibits anticancer potential through its capability of inducing apoptosis and/or antiproliferative effects on tumor cells, has been proved. Moreover, its antitumor seems to be due not only to its pro-apoptotic and inhibitory effects on tumor growth, but also to its antiangiogenic and anti-invasive properties. Although the precise mechanisms underlying the antitumor activity of this compound remain not fully understood, in this review we will focus on the most recent findings about the cellular and molecular pathways affected by sanguinarine, together with the rationale of its potential application in clinic. The complex of data currently available suggest the potential application of sanguinarine as an adjuvant in the therapy of cancer, but further pre-clinical studies are needed before such an antitumor strategy can be effectively translated in the clinical practice.

关键词： Sanguinarine Cancer Apoptosis Cell-cycle Chemotherapy

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Mesenteric adenitis caused by Yersinia pseudotubercolosis in a patient subsequently diagnosed with Crohn's disease of the terminal ileum

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World Journal of Gastroenterology 2006年第24期12卷 3933-3935页

作者： Maddalena Zippi Maria Chiara Colaiacomo Adriana Marcheggiano Roberta pica Paolo Paoluzi Giancarlo Iaiani Renzo Caprilli francesca Maccioni Department of Clinical Sciences GI Unit Umberto Ⅰ Viale del Policlinico 15500161RomeItaly Department of Radiological Sciences Umberto Ⅰ Viale del Policlinico 155 00161RomeItaly Department of Infectious Diseases Umberto Ⅰ Viale del Policlinico 155 00161RomeItaly

Although the association between inflammatory bowel disease and gastrointestinal infections has been suggested, the mechanisms involved in the pathogenesis of Crohn＇s disease （CD） are still undetermined. We report the case of a man, who presented with mesenteric adenitis initially due to a Yersinia pseudotubercolosis infection, who was later diagnosed with Crohn＇s disease. This case is in keeping with recent evidence in the literature which suggests that CD is a disease linked to abnormal immune responses to enteric bacteria in genetically susceptible individuals.

关键词： Yersinia pseudotubercolosis Crohn's disease Ileitis

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