检索结果-南通市图书馆

Improving performance of robotic liver resections with high technical complexity by Robo-Lap approach

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2023年第6期12卷 981-986页

作者： francesca Ratti Rebecca Marino luca Aldrighetti Hepatobiliary Surgery Division IRCCS Ospedale San RaffaeleMilanItaly Vita-Salute San Raffaele University MilanItaly

Introduction The hybrid robotic-laparoscopic technique has been described-in the field of hepatic surgery-in order to overcome procedural challenges related to the lack of the robotic ultrasonic dissector(1-4):Robo-Lap approach hence combines the use of the robotic platform(specifically robotic bipolar forceps for coagulation and scissors)with the laparoscopic dissector handled by the surgeon at the table.

关键词： robotic handle approach

Laparoscopic liver resections at the gates of 2020: a stand-alone field of hepatobiliary surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2020年第3期9卷 371-373页

作者： Federica Cipriani francesca Ratti luca Aldrighetti Hepatobiliary Surgery Division IRCCS San Raffaele HospitalVia Olgettina 6020132 MilanItaly

We read with interest the review entitled"Laparoscopic liver resection:the current status and the future"written by *** Cai and published in Hepatobiliary Surgery and Nutrition(1).

关键词： Laparoscopic Surgery liver

ZrB_(2)-SiC ceramics toughened with oriented paper-derived graphite for a sustainable approach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Advanced Ceramics 2024年第2期13卷 207-219页

作者： luca Zoli francesca Servadei Simone Failla Matteo Mor Antonio Vinci Pietro Galizia Diletta Sciti CNR-ISSMC Institute of ScienceTechnology and Sustainability for CeramicsFaenza I-48018Italy

Carbon fibre-reinforced ultra-high temperature ceramics(UHTCs)are considered a class of promising materials for several applications,the most appealing ones being in the aerospace *** is necessary to overcome the brittleness and low thermal shock resistance of ceramics and is often provided through the addition of carbon fibres or other carbon-based phases,such as nanotubes,graphene,and *** present work is focused on the toughening of UHTCs through incorporation of 30-50 vol% thin,ordered graphite layers from conventional filter paper followed by hot pressing *** filter paper was selected because it undergoes thermolysis with no melting stage forming a strong carbonaceous residue that can be used as *** and mechanical properties of toughened composites were compared to those of other materials reinforced with short carbon fibres and the effect of different distribution of graphite was *** of graphite allowed toughness to be increased from 3−4 MPa·m^(1/2)(for unreinforced materials)to 5.1−5.5 MPa·m^(1/2),similar to results obtained with short fibre *** high-temperature properties,such as strength and toughness as well as oxidation resistance at 1500℃,were also examined.

关键词： borides paper-derived graphite microstructure toughness sustainability

HER2 heterogeneity in gastric/gastroesophageal cancers: From benchside to practice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第26期22卷 5879-5887页

作者： Federica Grillo Matteo Fassan francesca Sarocchi Roberto Fiocca luca Mastracci Department of Surgical and Diagnostic Sciences Pathology Unit University of Genoa 16132 Genoa Italy Institute for Research and Cure of Cancer (IRCCS) S. Martino-IST University Hospital 16132 Genoa Italy Department of Medicine (DIMED) Surgical Pathology Unit University of Padua 35121 Padua Italy

HER2 is overexpressed in approximately 10%-20% of gastric and gastroesophageal junction carcinomas. In these types of cancer, accurate assessment of HER2 status is mandatory, for selecting patients who may benefit from targeted therapies with anti-HER2 drugs such as Trastuzumab. This manuscript focuses on HER2 in gastric carcinogenesis, on optimal evaluation of HER2 and on the possible causes which may contribute to inaccurate HER2 evaluation. Similarly to breast cancer HER2 evaluation, standardization of HER2 testing in gastric cancer is necessary in diagnostic practice. The three principle aspects which require consideration are:(1) the choice of sample with regards to cancer morphology- intestinal vs diffuse areas;(2) the choice of scoring criteria- use of HER2 scoring criteria specific for gastric cancer; and(3) the choice of HER2 evaluation methods- use of an algorithm in which both immunohistochemistry and in situ hybridization play a role. Problematic issues include:(1) pre-analytic variables with particular emphasis on fixation;(2) recommended methodology for HER2 assessment(immunohistochemistry vs in situ hybridization);(3) HER2 heterogeneity both within the primary tumor and between primary tumor and metastases;(4) reliability of biopsies in HER 2 evaluation; and(5) quantity of sample(FFPE blocks from surgical specimens or endoscopic biopsies) necessary for an adequate assessment.

关键词： Gastric cancer HER2 Heterogeneity Immunohistochemistry FISH

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

Proteomic insights on the metabolism in inflammatory bowel disease

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第7期26卷 696-705页

作者： Laura francesca Pisani Manuela Moriggi Cecilia Gelfi Maurizio Vecchi luca Pastorelli Gastroenterology and Digestive Endoscopy Unit IRCCS Policlinico San DonatoSan Donato Milanese 20097Italy Department of Biomedical Science for Health University of the Study of MilanIRCCS Istituto Ortopedico GaleazziMilan 20122Italy Gastroenterology and Endoscopy Unit IRCCS Ca'Granda FoundationPoliclinico HospitalUniversity of the Study of MilanMilan 20122Italy Department of Biomedical Science for Health University of the Study of MilanMilan 20122Italy

Inflammatory bowel diseases(IBD)are chronic and relapsing inflammatory conditions of the gut that include Crohn's disease and ulcerative *** pathogenesis of IBD is not completely unraveled,IBD are multi-factorial diseases with reported alterations in the gut microbiota,activation of different immune cell types,changes in the vascular endothelium,and alterations in the tight junctions’structure of the colonic epithelial *** represents a useful tool to enhance our biological understanding and to discover biomarkers in blood and intestinal *** is expected to provide reproducible and quantitative data that can support clinical assessments and help clinicians in the diagnosis and treatment of *** a differential diagnosis of Crohn's disease and ulcerative colitis and the prediction of treatment response can be deducted by finding meaningful *** some non-invasive biomarkers have been described,none can be considered as the“gold standard”for IBD diagnosis,disease activity and therapy *** these reason new studies have proposed an“IBD signature”,which consists in a panel of biomarkers used to assess *** above described approach characterizes“omics”and in this review we will focus on proteomics.

关键词： Proteomics Inflammatory bowel disease Cronh’s disease Ulcerative colitis Proteins Biomarkers discovery

Vascular occlusion to protect against intraoperative blood loss in liver surgeries: new perspectives on a traditional technique

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2021年第4期10卷 567-569页

作者： francesca Ratti Alessandro Nini Roberto Bertini luca Aldrighetti Hepatobiliary Surgery Division IRCCS San Raffaele HospitalMilanItaly Department of Urology IRCCSSan Raffaele Scientific InstituteMilanItaly Division of Experimental Oncology/Unit of Urology URIIRCCS San Raffaele HospitalMilanItaly Department of Urology and Pediatric Urology Universitätsklinikum des SaarlandesHomburgGermany

The correlation between decreased blood loss and improved clinical and oncological outcomes has been described in liver surgery:considering that perioperative blood transfusions are associated with a higher rate of recurrence and lower survival after resection of colorectal liver metastases and hepatocellular carcinoma,any effort to address the task of bleeding control and reduce the need for blood transfusions is of outstanding importance(1).

关键词： transfusion liver clinical

Genome Res:科学家发现遗传突变和环境暴露或可明显影响机体健康

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现代生物医学进展 2016年第35期16卷 I0004-I0004页

作者： Gregory A. Moyerbrailean,4 Allison L. Richards,4 Daniel Kurtz,4 Cynthia A. Kalita,4 Gordon O. Davis Chris T. Harvey Adnan Alazizi Donovan Watza Yoram Sorokin Nancy Hauff Xiang Zhou Xiaoquan Wen Roger Pique-Regi francesca luca Center for Molecular Medicine and Genetics Wayne State University Detroit Michigan 48201 USA Department of Obstetrics and Gynecology Wayne State University Detroit Michigan 48201 USA Department of Biostatistics University of Michigan Ann Arbor Michigan 48109 USA Corresponding authors: fluca{at}wayne.edu rpique{at}wayne.edu

日前，一项发表在国际杂志Genome Research上的研究报告中。来自韦恩州立大学医学中心的研究人员通过研究首次揭示了环境暴罐和遗传突变之间的相互作用如何对机体健康和诸如糖尿病等多种疾病产生明显的影响，该研究或将加速未来精准医... 详细信息

日前，一项发表在国际杂志Genome Research上的研究报告中。来自韦恩州立大学医学中心的研究人员通过研究首次揭示了环境暴罐和遗传突变之间的相互作用如何对机体健康和诸如糖尿病等多种疾病产生明显的影响，该研究或将加速未来精准医学的研究步伐。

关键词：机体健康环境暴露遗传突变科学家 Res 显影相互作用研究人员

Non-anatomical liver resection for hepatocellular carcinoma:the SegSubTe classification to overcome the problem of heterogeneity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 265-271页

作者： Mattia Garancini Alessandro Fogliati Mauro Alessandro Scotti Cristina Ciulli francesca Carissimi Antonio Rovere luca Gianotti Fabrizio Romano Unit of Hepatobiliopancreatic Surgery Department of SurgeryASST-MonzaSan Gerardo HospitalUniversity of Milano-Bicoccavia Pergolesi 33MonzaMB 20052Italy Interventional Radiology Department of RadiologyASST-MonzaSan Gerardo HospitalMilano-Bicocca Universityvia Pergolesi 33MonzaMB 20052Italy

Background:The superiority of anatomical resection(AR)***-anatomical resection(NAR)in the surgical management of hepatocellular carcinoma(HCC)is *** are well-defined procedures,whereas the lack of NAR standardization results in heterogeneous *** study aimed to introduce the SegSubTe classification for NAR detailing the appropriateness of the level of surgical section of the Glissonean pedicles feeding the ***:A single-center retrospective analysis of pre-and postoperative imaging of consecutive patients treated with NAR for single HCC between 2012 and 2020 was *** quality of surgery was assessed classifying the type of vascular supply and the level of surgical section(segmental,subsegmental or terminal next to the tumor)of vascular pedicles feeding the HCCs;then,the population was divided in“SegSubTe-IN”or“SegSubTe-OUT”groups,and the tumor recurrence and survival were ***:Ninety-seven patients who underwent NAR were included;76%were SegSubTe-IN and 24%were *** disease recurrence,local recurrence and cut-edge recurrence in the SegSubTe-IN ***-OUT groups were 50%vs.83%(P=0.006),20%vs.52%(P=0.003)and 16%vs.39%(P=0.020),***-OUT odds ratio for local recurrence was 4.1 at univariate regression ***-,three-,and five-year disease-free survival rates in the SegSubTe-IN ***-OUT groups were 81%,58%and 35%vs.46%,21%and 11%,respectively(P<0.001).Conclusions:The SegSubTe classification is a useful tool to stratify and standardize NAR for HCC,aiming at improving long-term oncological outcomes and reducing the heterogeneity of quality of NAR for HCC.

关键词： Hepatocellular carcinoma Intraoperative ultrasound Liver surgery Computed tomography Surgical procedure