检索结果-南通市图书馆

Evidences on adaptive mechanisms for cardiorespiratory diseases regarding extreme temperatures and air pollution:A comparative systematic review

引用

Geography and Sustainability 2021年第3期2卷 182-194页

作者： Helena Madureira Maria Pacheco Carlos Sousa Ana Monteiro francesca de’-donato Manuela de-Sario department of Geography University of PortoCEGOTPorto 4150-564Portugal Faculty of Arts and Humanities University of PortoPorto 4150-564Portugal department of Geography University of PortoCEGOTCITTAPorto 4150-564Portugal department of Epidemiology Lazio Regional Health ServiceRome 00147Italy

The negative cardiorespiratory health outcomes due to extreme temperatures and air pollution are widely stud-ied,but knowledge about the effectiveness of the implementation of adaptive mechanisms remains *** objective of this paper is to explore the evidence of adaptive mechanisms for cardiorespiratory diseases regard-ing extreme temperatures and air pollution by comparing the results of two systematic literature review(SLR)processes sharing the same initial research question but led by two research groups with different academic back-grounds working in the same multidisciplinary *** start by presenting the methodological procedures and the results of the SLR triggered by the research group mainly composed by researchers with a background in ge-ography(named geographical strategy).We then compare these results with those achieved in the SLR led by the research group with a background in epidemiology(named epidemiological strategy).Both SLR were developed under the EU Horizon 2020 Project“EXHAUSTION”.The results showed:1)the lack of evidence regarding the effectiveness of adaptation measures,namely due to the limited number of studies about the topic,the prepon-derance of studies dedicated to heat extremes or the unbalance between different adaptation measures;2)that the choice of search terms in the geographical strategy,despite being more comprehensive at first sight,ended up retrieving less results,but it brought new studies that can complement the results of the epidemiological ***,it is suggested that to strengthen the empirical evidence of the effectiveness of adaptation measures,powerful multidisciplinary teams should work together in the preparation of SLR in topics of great complexity,such as the one presented in this paper.

关键词： Cardiopulmonary diseases Extreme temperatures Air pollution Adaptation Planning Systematic literature review(SLR)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fluctuating temperature modifies heat-mortality association around the globe

引用

The Innovation 2022年第2期3卷 65-72页

作者： Yao Wu Bo Wen Shanshan Li Antonio Gasparrini Shilu Tong Ala Overcenco Ales Urban Alexandra Schneider Alireza Entezari Ana Maria Vicedo-Cabrera Antonella Zanobetti Antonis Analitis Ariana Zeka Aurelio Tobias Barrak Alahmad Ben Armstrong Bertil Forsberg CarmenÍñiguez Caroline Ameling César de la Cruz Valencia ChristoferÅström Danny Houthuijs Do Van Dung Dominic Royé Ene Indermitte Eric Lavigne Fatemeh Mayvaneh Fiorella Acquaotta francesca de’donato Francesco Sera Gabriel Carrasco-Escobar Haidong Kan Hans Orru Ho Kim Iulian-Horia Holobaca Jan Kyselý Joana Madureira Joel Schwartz Klea Katsouyanni Magali Hurtado-Diaz Martina SRagettli Masahiro Hashizume Mathilde Pascal Micheline de Sousa Zanotti Stagliorio Coélho Noah Scovronick Paola Michelozzi Patrick Goodman Paulo Hilario Nascimento Saldiva Rosana Abrutzky Samuel Osorio Tran Ngoc Dang Valentina Colistro Veronika Huber Whanhee Lee Xerxes Seposo Yasushi Honda Michelle L.Bell Yuming Guo department of Epidemiology and Preventive Medicine School of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia department of Public Health Environments and SocietyLondon School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre for Statistical Methodology London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre on Climate Change&Planetary Health London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Shanghai Children’s Medical Centre Shanghai Jiao Tong UniversityShanghai 200025China School of Public Health Institute of Environment and Human HealthAnhui Medical UniversityHefei 230032China Center for Global Health Nanjing Medical UniversityNanjing 211166China School of Public Health and Social Work Queensland University of TechnologyBrisbane 4000Australia National Agency for Public Health of the Ministry of Health Labour and Social Protection of the Republic of MoldovaChisinau MD-2009Republic of Moldova Institute of Atmospheric Physics Czech Academy of SciencesPrague 14100Czech Republic Faculty of Environmental Sciences Czech University of Life SciencesPrague 16500Czech Republic Institute of Epidemiology Helmholtz Zentrum M€unchen-German Research Center for Environmental HealthNeuherberg 85747Germany Faculty of Geography and Environmental Sciences Hakim Sabzevari UniversitySabzevar ***Iran Institute of Social and Preventive Medicine University of BernBern 3012Switzerland Oeschger Center for Climate Change Research University of BernBern 3012Switzerland department of Environmental Health Harvard T.H.Chan School of Public HealthHarvard UniversityBostonMA 02115USA department of Hygiene Epidemiology and Medical StatisticsNational and Kapodistrian University of AthensAthens 11527Greece Institute for Environment Healthand SocietiesBrunel University LondonLondon UB83PNUK Institute of Environmental Assessment and

Studies have investigated the effects of heat and temperature variability(TV)on ***,few assessed whether TV modifies the heat-mortality *** on daily temperature and mortality in the warm season were collected from 717 locations across 36 *** was calculated as the standard deviation of the average of the same and previous days’minimum and maximum temperatures.

关键词： deviation modif heat

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lighting the shades of hidden pain:a role for spinal cord neurons and microglia in vestibulodynia

引用

Neural Regeneration Research 2025年第10期20卷 2898-2900页

作者： Rosmara Infantino francesca Gargano Serena Boccella Carmela Belardo Andrea Maria Morace francesca Guida Sabatino Maione Livio Luongo department of Experimental Medicine Division of PharmacologyUniversitàdegli Studi della Campania“L.Vanvitelli”Italy UniversitàCampus Bio-medico di Roma RomeItaly

Vulvodynia,a chronic pain disorder affecting the vulvar region,represents a significant challenge in both diagnosis and treatment within the field of women’s *** condition is characterized by chronic pain that significantly affects the quality of life of afflicted *** present perspective paper examines the role of spinal sensitization and microglial activation in vulvodynia.

关键词： pain diagnosis activation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Wing-fanning frequency as a releaser boosting male mating success— High-speed video analysis of courtship behavior in Campoplex capitator, a parasitoid of Lobesia botrana

引用

Insect Science 2020年第6期27卷 1298-1310页

作者： Giovanni Benelli Renato Ricciardi donato Romano francesca Cosci Cesare Stefanini Andrea Lucchi department of Agriculture.Food and Environment University of PisaPisaItaly The BioRobotics Institute.Sant'Anna School of Advanced Studies PontederaPisaItaly department of Excellence in Robotics&A.I. Sant'Anna School of Advanced StudiesPisaItaly HEIC Center BME DepartmentKhalifa UniversityAbu DhabiUAE

Campoplex capitator is an ichneumonid parasitoid with a narrow host range,comprising grapevine moth *** being considered one of the possible candidates for biocontrol of Lobesia botrana,knowledge about its biology is limited and massrearing for commercial purposes is still *** research provides a quantitative analysis of the *** courtship and mating *** mating sequence was analyzed by high-speed video *** behavioral parameters,with special reference to male wing fanning and antennal tapping,were quantified and linked with mating ***,we analyzed the occurrence of population-level behavioral asymmetries during C capitator sexual interactions and their impact on male *** showed that male wing fanning was crucial to successfully approach the *** achieving higher mating success performed wing-fanning at higher frequencies over unsuccessful *** wing fanning,most of males palpated the females body with their antennae,before attempting *** overall mating success was>70%,with a rather long copula duration(254.76±14.21 s).Male wing-fanning was lateralized on the left at population level,while antennal tapping displays were *** male displays do not differ in terms of frequency and duration of their main *** research adds basic knowledge to the *** behavioral *** rearing protocols for *** are being developed male wing fanning frequency may represent a useful benchmark for monitoring mate quality over time,tackling mating success reductions due to prolonged mass-rearing.

关键词： biological control European grapevine moth Ichneumonidae koinobiont parasitoid mass-rearing mating behavior

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Long-noncoding RNAs as epigenetic regulators in neurodegenerative diseases

引用

Neural Regeneration Research 2023年第6期18卷 1243-1248页

作者： Paola Ruffo francesca de Amicis Emiliano Giardina francesca Luisa Conforti Medical Genetics Laboratory Department of PharmacyHealth and Nutritional SciencesUniversity of CalabriaRendeItaly department of Pharmacy Health and Nutritional SciencesUniversity of CalabriaRendeItaly Genomic Medicine Laboratory UILDM IRCCS Fondazione Santa LuciaRomeItaly department of Biomedicine&Prevention Tor Vergata University of RomeRomeItaly

The growing and rapid development of high-throughput sequencing technologies have allowed a greater understanding of the mechanisms underlying gene expression *** the epigenome and epitranscriptome directs the fate of the transcript influencing the functional outcome of each *** this context,non-coding RNAs play a decisive role in addressing the expression regulation at the gene and chromosomal ***-noncoding RNAs,consisting of more than 200 nucleotides,have been shown to act as epigenetic regulators in several key molecular processes involving neurodegenerative disorders,such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis and Huntington’s ***-noncoding RNAs are abundantly expressed in the central nervous system,suggesting that their deregulation could trigger neuronal degeneration through RNA *** evaluation of their diagnostic significance and therapeutic potential could lead to new treatments for these diseases for which there is no cure.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis epigenetic mechanism Huntington’s disease long-noncoding RNAs neurodegenerative disease non-coding RNAs Parkinson’s disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

引用

Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Animal models of vascularized nerve grafts:a systematic review

引用

Neural Regeneration Research 2023年第12期18卷 2615-2618页

作者： francesca Toia Daniele Matta Federico de Michele Roberto Pirrello Adriana Cordova Plastic and Reconstructive Surgery.department of Surgical Oncological and Oral Sciences.University of PalermoPalermoItaly

The aim of this review is to present and compare the various animal models of vascularized nerve grafts described in the literature as well as to summarize preclinical evidence for superior functional results compared to non-vascularized free nerve grafts. We also will present the state of the art on prefabricated vascularized nerve grafts. A systematic literature review on vascularized nerve graft models was conducted via the retrieval with the Pub Med database on March 30, 2019. Data on the animal, nerve, and vascularization model, the recipient bed, the evaluation time points and methods, and the results of the study results were extracted and analyzed from selected articles. The rat sciatic nerve was the most popular model for vascularized nerve grafts, followed by the rabbit;however, rabbit models allow for longer nerve grafts, which are suitable for translational evaluation, and produced more cautious results on the superiority of vascularized nerve grafts. Compared to free nerve grafts, vascularized nerve grafts have better early but similar long-term results, especially in an avascular bed. There are few studies on avascular receiving beds and prefabricated nerve grafts. The clinical translation potential of available animal models is limited, and current experimental knowledge cannot fully support that the differences between vascularized nerve grafts and free nerve grafts yield a clinical advantage that justifies the complexity of the procedure.

关键词： nerve animal models nerve grafts nerve regeneration peripheral nerves prefabricated vascularized nerve grafts vascularized nerve grafts

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protein Domains Involved in Assembly in the Endoplasmic Reticulum Promote Vacuolar delivery when Fused to Secretory GFP, Indicating a Protein Quality Control Pathway for degradation in the Plant Vacuole

引用

Molecular Plant 2008年第6期1卷 1067-1076页

作者： Ombretta Foresti francesca de Marchis Maddalena de Virgilio Eva M. Klein Sergio Arcioni Michele Bellucci Alessandro Vitale Istituto di Biologia e Biotecnologia Agraria Consiglio Nazionale delle Ricerche via Bassini 15 20133 Milano Italy EU Istituto di Genetica Vegetale Consiglio Nazionale delle Ricerche via della Madonna Alta 130 06128 Perugia Italy EU

The correct folding and assembly of newly synthesized secretory proteins are monitored by the protein quality control system of the endoplasmic reticulum （ER）. Through interactions with chaperones such as the binding protein （BiP） and other folding helpers, quality control favors productive folding and sorts for degradation defective proteins. A major route for quality control degradation identified in yeast, plants, and animals is constituted by retrotranslocation from the ER to the cytosol and subsequent disposal by the ubiquitin/proteasome system, but alternative routes involving the vacuole have been identified in yeast. In this study, we have studied the destiny of sGFP418, a fusion between a secretory form of GFP and a domain of the vacuolar protein phaseolin that is involved in the correct assembly of phaseolin and in BiP recognition of unassembled subunits. We show that sGFP418, despite lacking the phaseolin vacuolar sorting signal, is delivered to the vacuole and fragmented, in a process that is inhibited by the secretory traffic inhibitor brefeldin A. Moreover, a fusion between GFP and a domain of the maize storage protein γ-zein involved in zein polymerization also undergoes post-translational fragmentation similar to that of sGFP418. These results show that defective secretory proteins with permanently exposed sequences normally involved in oligomerization can be delivered to the vacuole by secretory traffic. This strongly suggests the existence of a plant vacuolar sorting mechanism devoted to the disposal of defective secretory proteins.

关键词： Endoplasmic reticulum protein degradation protein traffic vacuole.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aberrant Notch signaling in gliomas: a potential landscape of actionable converging targets for combination approach in therapies resistance

引用

Cancer Drug Resistance 2022年第4期5卷 939-953页

作者： Maria D’Amico francesca de Amicis department of Pharmacy Health and Nutritional SciencesUniversity of CalabriaVia P.BucciRende 87036Italy Health Center University of CalabriaVia P.BucciRende 87036Italy.

The current therapeutic protocols and prognosis of gliomas still depend on clinicopathologic and radiographiccharacteristics. For high-grade gliomas, the standard of care is resection followed by radiotherapy plustemozolomide chemotherapy. However, treatment resistance develops due to different mechanisms, among whichis the dynamic interplay between the tumor and its microenvironment. Different signaling pathways cause theproliferation of so-called glioma stem cells, a minor cancer cell population with stem cell-like characteristics andaggressive phenotype. In the last decades, numerous studies have indicated that Notch is a crucial pathway thatmaintains the characteristics of resistant glioma stem cells. Data obtained from preclinical models indicate thatdownregulation of the Notch pathway could induce multifaceted drug sensitivity, acting on the expression of drugtransporterproteins, inducing epithelial–mesenchymal transition, and shaping the tumor microenvironment. Thisreview provides a brief overview of the published data supporting the roles of Notch in drug resistance anddemonstrates how potential novel strategies targeting Notch could become an efficacious action to improve thetherapy of high-grade glioma to overcome drug resistance.

关键词： Tumor microenvironment notch inhibitors stem cells brain tumors drug resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neoadjuvant chemoradiotherapy for locally advanced rectal cancer:The debate continues

引用

World Journal of Gastrointestinal Oncology 2014年第12期6卷 438-440页

作者： francesca de Felice Daniela Musio Luciano Izzo Vincenzo Tombolini department of Radiotherapy Policlinico Umberto I "Sapienza" University of Rome department of Surgery "Pietro Valdoni" Policlinico Umberto I "Sapienza" University of Rome Spencer-Lorillard Foundation 00161 Rome Italy

Rectal carcinoma represents the 30% of all colorectal cancers, with about 40000 new cases/years. In the past two decades, the management of rectal cancer has made important progress, highlighting the main role of a multimodality strategy approach, combining surgery, radiation therapy and chemotherapy. Nowadays, surgery remains the primary treatment and neoadjuvant chemoradiotherapy, based on fluoropyrimidine(5-FU) continuous infusion, is considered the standard in locally advanced rectal carcinoma. The aim is to reduce the incidence of local recurrence and to perform a conservative surgery. To improve these purposes different drugs combination have been tested in the neo-adjuvant setting. At American Society of Clinical Oncology 2014 an important abstract was presented focusing on the role of adding oxaliplatin to concomitant treatment, in patients with locally advanced rectal carcinoma. Rodel et al reported on the CAO/ARO/AIO-04 randomized phase Ⅲ trial that compared standard treatment with 5-FU and radiation therapy, to oxaliplatin plus 5-FU inassociation with radiation therapy. The addition of oxaliplatin to the neo-adjuvant treatment has been shown to improve disease-free survival from 71.2% to 75.9%(P = 0.03). This editorial was planned to clarify the optimal treatment in patients with locally advanced rectal cancer, considering the results from CAO/ARO/AIO-04 study.

关键词： Chemoradiotherapy Rectal cancer Locally advanced disease Neoadjuvant debate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：