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PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis

World Journal of Hepatology 2015年第29期7卷 2920-2926页

作者： Linda Pasta francesca Pasta Department of Medicine Clinica Candela

AIM To evaluate the different roles of thrombophiliain patients with and without viral etiology. The thrombophilicgenetic factors （THRGFs）, PAI-1 4G-4G, MTHFR677TT, V Leiden 506Q and prothrombin 20210A,were studied as risk factors in 1079 patients with livercirrhosis （LC）, enrolled from January 2000 to ***： All Caucasian LC patients consecutivelyobserved in a seven year period were included; thepresence of portal vein thrombosis （PVT） and BuddChiari syndrome （BCS） was registered. The differencesbetween the proportions of each THRGF with regardto the presence or absence of viral etiology and thefrequencies of the THRGF genotypes with those predictedin a population by the Hardy-Weinberg equilibriumwere ***： Four hundred and seventeen/one thousandand seventy-six patients （38.6%） showed thrombophilia：217 PAI-1 4G-4G, 176 MTHFR C677TT, 71 V Leidenfactor and 41 prothrombin G20210 A, 84 with morethan 1 THRGF; 350 presented with no viral liver cirrhosis（NVLC） and 729 with, called viral liver cirrhosis （VLC）,of whom 56 patients were hepatitis C virus ＋ hepatitisB virus. PAI-1 4G-4G, MTHFR C677TT, the presence ofat least one TRHGF and the presence of 〉 1 THRGF,were statistically more frequent in patients with NVLC vspatients with VLC： All χ 2 〉 3.85 and P 〈 0.05. Patientswith PVT and/or BCS with at least one TRHGF were189/352 （53.7%）. The Hardy-Weinberg of PAI-1 andMTHFR 677 genotypes deviated from that expectedfrom a population in equilibrium in patients with NVLC（respectively χ 2 = 39.3; P 〈 0.000 and χ 2 = 27.94; P 〈0.05）, whereas the equilibrium was respected in ***： MTHFR 677TT was nearly twofold andPAI-1 4G-4G more than threefold more frequently foundin NVLC vs patients with VLC; the Hardy-Weinbergequilibrium of these two polymorphisms confirms thisdata in NVLC. We suggest that PAI-1 4G-4G and MTHFR677TT could be considered as factors of fibrosis andthrombosis mechanisms, increasing the inflammationresponse, and causing the hepa

关键词： PAI-1 4G-4G MTHFR 677TT V Leiden506Q Prothrombin 20210A Liver cirrhosis Portal veinthrombosis Budd Chiari syndrome Fibrogenesis

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ON NONCOERCIVE (p,q)-EQUATIONS

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Acta Mathematica Scientia 2021年第5期41卷 1788-1808页

作者： Nikolaos S.PAPAGEORGIOU Calogero VETRO francesca VETRO Department of Mathematics National Technical UniversityZografou Campus15780AthensGreece Department of Mathematics and Computer Science University of PalermoVia Archirafi 3490123PalermoItaly 90123 PalermoItaly

We consider a nonlinear Dirichlet problem driven by a(p,q)-Laplace differential operator(1 详细信息

We consider a nonlinear Dirichlet problem driven by a(p,q)-Laplace differential operator(1

关键词： (p q)-Laplacian principal eigenvalue constant sign and nodal solutions extremal solutions nonlinear regularity

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Thermal ablation in colorectal liver metastases: Lack of evidence or lack of capability to prove the evidence?

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World Journal of Gastroenterology 2016年第13期22卷 3511-3515页

作者： Sergio Sartori Paola Tombesi francesca Di Vece Section of Interventional Ultrasound St Anna Hospital

Many studies suggest that combined multimodality treatments including ablative therapies may achieve better outcomes than systemic chemotherapy alone in patients with colorectal liver metastases. Nevertheless, ablative therapies are not yet considered as effective options because their efficacy has never been proved by randomized controlled trials (RCT). However, there are in literature no trials that failed in demonstrating the effectiveness of ablative treatments: what are lacking, are the trials. All the attempts to organize phase III studies on this topic failed as a result of non accrual. Just one prospective RCT comparing radiofrequency ablation combined with systemic chemotherapy vs chemotherapy alone has been published. It was designed as a phase III study, but it was closed early because of slow accrual, and was downscaled to phase II study, with the consequent limits in drawing definite conclusions on the benefit of combined treatment. However, the combination treatment met the primary end point of the study and obtained a significantly higher 3-year progression-free survival than systemic chemotherapy alone. It is very unlikely that ultimate efficacy of ablation treatments will ever be tested again, and the best available evidence points toward a benefit for the combination strategy using ablative treatments and chemotherapy.

关键词： Liver metastases Colorectal cancer Thermal ablation Radiofrequency ablation Microwave ablation Laser ablation Systemic chemotherapy

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MicroRNAs and drug modulation in cancer:an intertwined new story

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Frontiers in Biology 2011年第5期6卷 351-356页

作者： francesca FANINI Ivan VANNINI Muller FABBRI Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Meldola47014Italy Department of Molecular Virology Immunologyand Medical Genetics and Comprehensive Cancer CenterOhio State UniversityColumbusOH 43210USA

MicroRNAs(miRNAs)are endogenous small non-coding RNAs(ncRNAs)which play important regulatory roles in physiological processes such as cellular differentiation,proliferation,development,apoptosis and stem cell *** increasing number of papers have clearly claimed their involvement in cancer,providing,in some cases,also the molecular mechanisms *** studies led to the conclusion that miRNAs can be effectively used as anticancer agents alone or in combination with existing anticancer *** particular,miRNAs can be effectively used to overcome drug resistance,one of the main factors responsible for anticancer treatment *** of the main questions remains how to modulate the expression of miRNAs in cancer ***,a few studies have shown that the expression of miRNAs is affected by drugs(including some drugs currently used as anticancer agents),therefore providing the rationale for an intertwined scenario in which miRNAs can be modulated by drugs and,in turn,can affect drug sensitivity of cancer cells.

关键词： miRNAs cancer multidrug resistance transcription factor chemotherapy

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Improving performance of robotic liver resections with high technical complexity by Robo-Lap approach

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 981-986页

作者： francesca Ratti Rebecca Marino Luca Aldrighetti Hepatobiliary Surgery Division IRCCS Ospedale San RaffaeleMilanItaly Vita-Salute San Raffaele University MilanItaly

Introduction The hybrid robotic-laparoscopic technique has been described-in the field of hepatic surgery-in order to overcome procedural challenges related to the lack of the robotic ultrasonic dissector(1-4):Robo-Lap approach hence combines the use of the robotic platform(specifically robotic bipolar forceps for coagulation and scissors)with the laparoscopic dissector handled by the surgeon at the table.

关键词： robotic handle approach

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Laparoscopic liver resections at the gates of 2020: a stand-alone field of hepatobiliary surgery

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Hepatobiliary Surgery and Nutrition 2020年第3期9卷 371-373页

作者： Federica Cipriani francesca Ratti Luca Aldrighetti Hepatobiliary Surgery Division IRCCS San Raffaele HospitalVia Olgettina 6020132 MilanItaly

We read with interest the review entitled"Laparoscopic liver resection:the current status and the future"written by *** Cai and published in Hepatobiliary Surgery and Nutrition(1).

关键词： Laparoscopic Surgery liver

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Bottom of the Pyramid and Reverse Innovation: an Exploration in the Food Indutry

Bottom of the Pyramid and Reverse Innovation: an Exploration...

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作者： francesca Arosio 复旦大学

学位级别：硕士

创新一直是企业的经济增长的基础，它被公认为是跨国公司的成功的主要支撑之一。在今天，随着新兴经济体打崛起和创新方向改变，从而改变过去的管理经验。在更广泛的意义上说，全球化的结果是一个平坦的世界经济中新兴市场不再是一个可... 详细信息

创新一直是企业的经济增长的基础，它被公认为是跨国公司的成功的主要支撑之一。在今天，随着新兴经济体打崛起和创新方向改变，从而改变过去的管理经验。在更广泛的意义上说，全球化的结果是一个平坦的世界经济中新兴市场不再是一个可以被忽略打购买力，但是与此相反的是，他们可以成为的下一个创新的源泉和新机会的贡献者。这项研究开始处假设了属于新兴经济体的消费者不应该被视为社会的负担，相反的是，必须让他们成为潜在市场中创新的来源．此外，为了更好地了解这些市场的潜力，我们将分析新兴国家的消费者和他们消费的过程，并且能使他们能够转化为真正的消费者的特点。这将提供一个框架，以更好地理解的焦点的大小和属于它的底部的世界人口的潜力的经济发展和经济金字塔的功能的需求。此外，在本研究中，我們將探討創新的新動力，重點對食品行業。事實上，同時牢記反向創新是一個現象，涉及許多行業，我們希望更好地了解創新流動有關的食品工業和涉案司機。在這種模式中，將重點分析兩個主要的集群創新：涓滴和扭轉。第一，包括創新產品，從發達國家向新興經濟體流動，而第二個將調查從發展中國家向發達國家流動相反。这一篇沦文的目的是在于分析在当今打创新年革新的潮流在全球化当中扮演打角色和位置，分析现在当今打发展以及描述一副未来创新和革新打潮流在世界经济中所扮演打角色。这篇论文背后的众多原因之一是由于全球一体化现象以及越发占有重要地位的新兴经济体在当今快速发展并且不断发展变化的经济环境。作为创新经济，而不是只利用市场瞬息万变的经济环境。首先，我们在这篇沦文中指出了金字塔底部(BOP)的作用以及金字塔底部在新兴市场和经济休是一个具有极高利润空间的市场;然后，我们将论文打方向放在创新流动涉及发展中国家作为创新打领导者，而不是仅作为创新打受惠人。在事实上，我们强调了增加相关的反向创新流量，以及这方面的发展背后的原因。此外，我们专注于在过程和组织一个跨国企业的需求，和在一个新兴发达郭嘉成功地推出新产品。其次，我们指出，关于两类食品行业：烘培食物和婴幼儿食品产品的创新传统和反向扩散类型的经验证据。在这个框架内，我们的目标是调查反向创新的特点比较涓滴流量的扩散速度和价格定位的变化。更特别的是，我们会依靠经验验证反向创新普及的速度比创新的传统路径和下游的产品具有较高的价格定位比那些上游的产品。最后，通过推测比较的事实，在新兴经济体需要适应的营销策略的主要需求，我们将提供证据，一个简单方法的反向创新流动比传统的创新要来的更加容易扩散．此外，在本研究中，我們將探討創新的新動力，重點對食品行業。事實上，同時牢記反向創新是一個現象，涉及許多行業，我們希望更好地了解創新流動有關的食品工業和涉案司機。在這種模式中，將重點分析兩個主要的集群創新;涓滴和扭轉。第一，包括創新產品，從發達國家向新興經濟體流動，而第二個將調查從發展巾國家向發達國家流動相反．研究的口的是提供一個問题的答案，但與此相反，以減輕涓滴和反向創新以及缺乏有關食品行業的研究，其最新的流量差距最近的貢獻研究創新。在這個框架内，我們將確定四個集群創新的特點：首先，創新是發展富裕的經濟體，而且不流外人這個邊界，我們將定義集群“只開發了”創新流動。其次，創新，在新興經濟體開始，沒有達到西方世界的， “新興”創新,第三“涓滴”創新傳統路徑，從發達國家到新興國家，最後，那些出生於發展中經濟體和應用，後來在發達國家，這個被稱為“反向”创新流量。

关键词：反向创新金字塔的底部扩散类型的创新价格定位扩散速度全球化

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Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 3-16页

作者： Sara Mattana Silvia Caponi Francesco Tamagnini Daniele Fioretto francesca Palombo Department of Physics and Geology University of Perugia Perugia I-06123Italy Istituto Officina dei Materiali del CNR(CNR-IOM)-Unita di Perugia Department of Physics and Geology University of Perugia Perugia I-06123Italy Hatherly Laboratories Medical School University of ExeterExeter EX44PSUK School of Physics and Astronomy University of Exeter Exeter EX44QLUK

A myloidopathy is one of the most prominent hallmarks of Alkheimer's disease(AD),the leading cause of dementia worldwide,and is characterized by the accumulation of amyloid plaques in the brain *** plaques consist of abnornal deposits mainly composed of an aggregation-prone protein fragment,B-amyloid 140/1-42,into the extracellular *** micro-spectroscopy is an all-optical contactless technique that is based on the interaction between visible light and longitudinal acoustic waves or phonons,giving access to the viscoelasticity of a sample on a subcellular ***,we describe the first application of micromechanical mapping based on Brillouin scattering spectroscopy to probe the stifness of individual amyloid plaques in the hippocampal part of the brain of a B-amyloid overexpressi ng transgenic *** analysis based on Brillouin and Raman microspectroscopy showed that amyloid plaques have a complex structure with a rigid core of B-pleated shoet conformation(B-aryloid)protein sur-rounded by a softer ring-shaped region richer in lipids and other protein *** preliminary results give a new insight into the plaque biophysics and biomechanics,and a valuable contrast mechanism for the study and diagnosis of amnyloidopathy.

关键词： Alzheimer's imaging vibrational spectrosecopy protein misfolding light scattering

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Modeling shoreline sand waves on the coasts of Namibia and Angola

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International Journal of Sediment Research 2013年第3期28卷 338-348页

作者： francesca RIBAS Albert FALQUES Niels VAN DEN BERG Miquel CABALLERIA Department of Applied Physics Universitat Politecnica de CatalunyaSpain

The southwestern（SW） coast of Africa（Namibia and Angola） features long sandy beaches and a wave climate dominated by energetic swells from the Southsouthwest（SSW）,therefore approaching the coast with a very high *** images reveal that along that coast there are many shoreline sand waves with wavelengths ranging from 2 to 8 km.A more detailed study,including a Fourier analysis of the shoreline position,yields the wavelengths（among this range） with the highest spectral density ***,it becomes apparent that at least some of the sand waves are dynamically active rather than being controlled by the geological setting.A morphodynamic model is used to test the hypothesis that these sand waves could emerge as free morphodynamic instabilities of the coastline due to the obliquity in wave *** is found that the period of the incident water waves,T;,is crucial to establish the tendency to stability or instability,instability increasing for decreasing period,whilst there is some discrepancy in the observed *** results for T;= 7-8 s clearly show the tendency for the coast to develop free sand waves at about 4 km wavelength within a few years,which migrate to the north at rates of 0.2-0.6 km yr;.For larger T;or steeper profiles,the coast is stable but sand waves originated by other mechanisms can propagate downdrift with little decay.

关键词： Shoreline evolution Shoreline sand waves High angle wave instability Longshore sediment transport

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Toward the use of smartphones for mobile mapping

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Geo-Spatial Information Science 2016年第3期19卷 210-221页

作者： Andrea Masiero francesca Fissore Francesco Pirotti Alberto Guarnieri Antonio Vettore Interdepartmental Research Center of Geomatics(CIRGEO) University of PadovaPadovaItaly

This paper considers the use of a low cost mobile device in order to develop a mobile mapping system(MMS),which exploits only sensors embedded in the *** goal is to make this MMS usable and reliable even in difficult environments(*** conditions,when also WiFi connection might not work).For this aim,a navigation system able to deal with the unavailability of the GNSS(***)is proposed *** is achieved by a pedestrian dead reckoning approach,i.e.a specific particle filter has been designed to enable good position estimations by a small number of particles(e.g.100).This specific characteristic enables its real time use on the standard mobile ***,3D reconstruction of the scene can be achieved by processing multiple images acquired with the standard camera embedded in the *** most of the vision-based 3D reconstruction systems are recently proposed in the literature,this work considers the use of structure from motion to estimate the geometrical structure of the *** detail level of the reconstructed scene is clearly related to the number of images processed by the reconstruction ***,the execution of a 3D reconstruction algorithm on a mobile device imposes several restrictions due to the limited amount of available energy and computing *** consideration motivates the search for new methods to obtain similar results with less computational *** paper proposes a novel method for feature matching,which allows increasing the number of correctly matched features between two images according to our simulations and can make the matching process more robust.

关键词： Mobile mapping positioning feature matching smartphone

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