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Occurrence and patterns of nutritional traits and polycyclic aromatic hydrocarbons(PAHs)in sea cucumber(Holothuria poli)tissues:benefits and risk for human health

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Food Quality and Safety 2022年第2期6卷 287-309页

作者： francesca Biandolino Isabella Parlapiano Lucia Spada Antonella Di Leo Maria Calo Giovanni Fanelli Ermelinda Prato Santina Giandomenico CNR-IRSA National Research CouncilWater Research Institute--Via Roma 3TarantoItaly

Objectives:The paper evaluates the benefit and risk for human health associated with consumption of sea cucumber Holothuria poli(*** from Italian coasts(Central Mediterranean Sea).Materials and Methods:Body wall(BW),internal tunic(ITu),muscle bands(MBs),alimentary canal(AC),gonad(Gd),and respiratory tree(RT)of *** were analyzed for proximate ***,amino acids(AAs),fatty acids(FAs)and polycyclic aromatic hydrocar bons(PAHs)were determined with high-performance liquid chromatography coupled with ultraviolet-visible spectroscopy(UPLC UV/Vis),gas chromatography-flame ionization detector(GC-FID)and gas chromatography mass spectrometry(GC-MS),***:Differences in the contents of total amino acids(TAAs)occurred based on tissue and sex,with AC and MB of female and Gd of male showing higher contents(range 47.8-60.2 g/kg we weight(ww)).Glycine and glutamic acid were the most *** fatty acid(PUFA)was the major class of FAs and arachidonic acid and eicosapentenoic acid(EPA)were the predominant PUFA.n-3 PUFA showed higher content in Gd,AC,and RT,indicating higher quality.A favorable n-3/n-6 in the range of 1.04-1.67 was *** showed values ranging from 23 to 207μg/kg ww with the highest levels in Gd and AC tissues and the lower in ***[alpyrene,the most toxic compound,was detected in all tissues,of both sexes,at levels of 1.5-18μg/kg ***:All tissues of ***,although with differences among them,are valuable food and can contribute for a healthy *** cancer risk(CR)values for Gd and AC tissues were above the considerable CR threshold of one in 10000 established by the United States Environmental Protection Agency(USEPA)for high ingestion rate of this seafood.

关键词： Holothuria poli,nutitional quality polycyclic aromatic hydrocarbons risk assessment estimated weekly intake cancer risk

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Acid-mediated decarboxylative C–H coupling between arenes and O-allyl carbamates

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Organic Chemistry Frontiers 2022年第6期9卷 1711-1718页

作者： Camilla Loro Julie Oble francesca Foschi Marta Papis Egle MBeccalli Sabrina Giofrè Giovanni Poli Gianluigi Broggini Dipartimento di Scienza e Alta Tecnologia Universitàdegli Studi dell’Insubriavia Valleggio 922100 ComoItaly Sorbonne Université Facultédes Sciences et IngénierieCNRSInstitut Parisien de Chimie MoléculaireIPCM4 place Jussieu75005 ParisFrance DISFARM Sezione di Chimica Generale e Organica“A.Marchesini”Universitàdegli Studi di Milanovia Venezian 2120133 MilanoItaly

Treatment of O-allyl N-tosyl carbamates with aromatic compounds in the presence of Cu(OTf)_(2) or TMSOTf as promoters affords N-substituted 1-arylpropan-2-amines,1,2-diarylpropanes,1,1-diarylpropanes,or indanes,depending on the nature of the promoter and of the aryl substrates.A full mechanistic rational allowing appreciation of the outcome of these novel C–H based cascades is *** initial acid promoted decarboxylative/deamidative Friedel–Crafts allylation takes *** protonation of the allylated arene,evolution of the resulting cation may follow different paths depending on the nature of the arene partner and of the allyl moiety in the carbamate.

关键词： allyl moiety coupling

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Thrombocytopenia in chronic liver disease:Physiopathology and new therapeutic strategies before invasive procedures

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World Journal of Gastroenterology 2022年第30期28卷 4061-4074页

作者： Paolo Gallo francesca Terracciani Giulia Di Pasquale Matteo Esposito Antonio Picardi Umberto Vespasiani-Gentilucci Clinical Medicine and Hepatology Unit Campus Bio-Medico UniversityRoma 00128Italy

Chronic liver disease is characterized by several hematological derangements resulting in a complex and barely rebalanced haemostatic *** is the most common abnormality observed in these patients and recent advances have led to researchers focus the attention on the multifactorial origin of thrombocytopenia and on the key role of thrombopoietin(TPO)in its *** thrombocytopenia(platelet count<50000/μL)complicates the management of patients with chronic liver disease by increasing the potential risk of bleeding for invasive procedures,which may be therefore delayed or canceled even if *** the very last years,the development of new drugs which exceed the limits of the current standard of care(platelet transfusions,either immediately before or during the procedure)paves the way to a new scenario in the management of this population of *** agents,such as the TPOreceptor agonists avatrombopag and lusutrombopag,have been developed in order to increase platelet production as an alternative to platelet *** agents have demonstrated a good profile in terms of efficacy and safety and will hopefully allow reducing limitations and risks associated with platelet transfusion,without any delay in scheduled ***,it is expected that patients with chronic liver disease will be able to face invasive procedures with one more string in their bow.

关键词： Thrombocytopenia Chronic liver disease Thrombopoietin agonists Platelet transfusions Avatrombopag Lusutrombopag

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Analysis of a load application point in spline coupling teeth

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第4期15卷 302-308页

作者： francesca CURA Andrea MURA Department of Mechanical and Aerospace Engineering Politecnico di Torino C.so Duca degli Abruzzi 24 10129 Torino Italy

研究目的:研究理想和偏差条件下接触压力分布导致的花键联接渐开线齿的合力位置。创新要点:分别给出了额定条件和两轴偏移条件下载荷直径和节径的偏差,并分析了荷载点齿轮刚度和接触压力分布的影响。研究方法:运用有限元模型分别分析在... 详细信息

研究目的:研究理想和偏差条件下接触压力分布导致的花键联接渐开线齿的合力位置。创新要点:分别给出了额定条件和两轴偏移条件下载荷直径和节径的偏差,并分析了荷载点齿轮刚度和接触压力分布的影响。研究方法:运用有限元模型分别分析在理想条件和两轴偏移条件下花键联接的影响。重要结论:验证了传统上应用于径节的花键联接啮合齿接触合力的近似法。在额定条件下,载荷直径和径节的偏差随载荷等级的增加而增加。在0.08 mm两轴偏移模型下,有限元法获得的结果与理论径节的最大偏差为2.94%。一般的,在理想联接和两轴偏移花键联接条件下,载荷直径和径节的偏差并不大。径节处载荷和实际荷载点所获得的刚度偏差接近15%。荷载点变化的影响与轴向压力分布相关,即该参数受荷载点位置的影响。

关键词：花键联接负载点应用接触压力分布有限元法渐开线理想接触线

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Have we really understood when the efforts of laparoscopic liver resection are justified?-a complexity-based appraisal of the differential benefit

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 363-374页

作者： francesca Ratti Federica Cipriani Guido Fiorentini Marco Catena Michele Paganelli Luca Aldrighetti Hepatobiliary Surgery Division IRCCS San Raffaele HospitalMilanoItaly

Background:The implementation of minimally invasive liver resection surgery(MILS)programs starts from procedures with a low degree of technical *** regarding the real short-term advantage of laparoscopy according to technical difficulty are still *** aim of the present study is to evaluate the differential benefit of laparoscopic over open technique according to the technical difficulty of the procedures and to investigate if efforts associated with laparoscopic approach are always ***:Nine hundred and thirty-six MILS resections performed between 2005 and 2018 were stratified according to technical complexity(low,intermediate and high difficulty)and to approach(MILS or open)and matched in a 1:1 ratio using propensity scores to obtain three pairs of groups(Pair 1:Low-MILS and Low-Open,including 274 cases respectively;Pair 2:Int-MILS and Int-Open,including 237 patients respectively;Pair 3:High-MILS and High-Open,including 226 patients respectively).Results:MILS approach resulted in a statistically significant lower blood loss,reduced morbidity,reduced and shorter time for functional recover and length of stay within all *** evaluation of the differential benefit showed a greater advantage of laparoscopic approach in high degree procedures compared with intermediate and low degree,both in terms of blood loss(-250 and-200 mL respectively)and morbidity rate(-5.7%and-4.1%respectively).Conclusions:The favorable biological scenario associated with laparoscopic approach allows to obtain significant benefits in the setting of technically complex *** commitment towards MILS approach should be therefore stronger in this setting,where the advantage of laparoscopy seems to be enhanced.

关键词： Laparoscopic liver complexity outcomes

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The boys are back in town: Rethinking the function of ribosomal DNA repeats in the genomic era

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Molecular Plant 2023年第3期16卷 514-516页

作者： francesca B.Lopez Peter C.McKeown Antoine Fort Galina Brychkova Charles Spillane Genetics and Biotechnology Laboratory Plant&AgriBiosciences Research Centre(PABC)Ryan InstituteUniversity of GalwayH91 REW4 GalwayIreland Present address:Department of Plant Biology and Genome Center University of CaliforniaDavisUC Davis Genome CenterDavisCA 95616USA

Next-generation sequencing technological advances,affording high-throughput,scalable,and fast assemblies,have enabled genome editing techniques that allow us to remove,insert,and modify genes for rapid and precise fun... 详细信息

关键词： remove precise function

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B cells in pancreatic cancer stroma

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World Journal of Gastroenterology 2022年第11期28卷 1088-1101页

作者： francesca Romana Delvecchio Michelle R Goulart Rachel Elizabeth Ann Fincham Michele Bombadieri Hemant M Kocher William Harvey Research Institute Queen Mary University of LondonLondon EC1M 6BQUnited Kingdom Barts Cancer Institute Queen Mary University of LondonLondon EC1M 6BQUnited Kingdom Barts and the London HPB Centre Barts Health NHS TrustLondon E11BBUnited Kingdom

Pancreatic cancer is a disease with high unmet clinical *** cancer is also characterised by an intense fibrotic stroma,which harbours many immune *** in both human and animal models have demonstrated that the immune system plays a crucial role in modulating tumour onset and *** human pancreatic ductal adenocarcinoma,high B-cell infiltration correlates with better patient ***,B cells have received recent interest in pancreatic cancer as potential therapeutic ***,the data on the role of B cells in murine models is unclear as it is dependent on the pancreatic cancer model used to ***,it appears that B cells do organise along with other immune cells such as a network of follicular dendritic cells(DCs),surrounded by T cells and DCs to form tertiary lymphoid structures(TLS).TLS are increasingly recognised as sites for antigen presentation,T-cell activation,Bcell maturation and differentiation in plasma *** this review we dissect the role of B cells and provide directions for future studies to harness the role of B cells in treatment of human pancreatic cancer.

关键词： B cells Pancreatic cancer Cancer immunology Tertiary lymphoid structures Anti-tumour immunoglobulins Plasma cells

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Female representation in intensive care medicine:Challenges and perspectives from China

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Journal of Intensive Medicine 2022年第2期2卷 89-91页

作者： Xuelian Liao Yi Yang Rubulotta francesca Yan Kang Jordi Rello Department of Critical Care Medicine West China HospitalSichuan University.ChengduSichuan 610044China Department of Critical Care Medicine West China Tianfu HospitalSichuan University.ChengduSichuan 610213China Department of Critical Care Medicine Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Intensive Care Medicine McGill UniversityMontreal H3A 0G4Canada Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias Instituto de Salud Carlos IIIand Infections AreaVall d’Hebron Institute of ResearchBarcelona 08035Spain

The gender gap in the practice of intensive care medicine has increasingly been recognized as a problem in recent *** limited information,the available data suggest that representation of women in the physician workforce,academic positions,and leadership roles in intensive care is inadequate *** this article,we describe the situation of female intensive care unit(ICU)physicians from the perspective of Chinese *** proportion of female ICU physicians in China has been increasing in recent *** biggest challenges faced by female ICU physicians include balance of work and life,difficulties in career planning,and lack of academic *** attention and policy support should be provided to help them play a better role in intensive care medicine.

关键词： Gender gap Female Critical care

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Simulation of unconventional well tests with the finite volume method

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Petroleum Science 2012年第3期9卷 317-329页

作者： CANCELLIERE Michel VERGA francesca Politecnico di Torino DITAGTorino (TO) 10129 Italy

The finite volume method has been successfully applied in several engineering fields and has shown outstanding performance in fluid dynamics simulation. In this paper, the general framework for the simulation ofnear-wellbore systems using the finite volume method is described. The mathematical model and the numerical model developed by the authors are presented and discussed. A radial geometry in the vertical plane was implemented so as to thoroughly describe near-wellbore phenomena. The model was then used to simulate injection tests in an oil reservoir through a horizontal well and proved very powerful to correctly reproduce the transient pressure behavior. The reason for this is the robustness of the method, which is independent of the gridding options because the discretization is performed in the physical space. The model is able to describe the phenomena taking place in the reservoir even in complex situations, i.e. in the presence of heterogeneities and permeability barriers, demonstrating the flexibility of the finite volume method when simulating non-conventional tests. The results are presented in comparison with those obtained with the finite difference numerical approach and with analytical methods, if possible.

关键词： Finite volume method numerical methods horizontal well modeling injection testing gridding

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Occult Cytomegalovirus Cholangitis and Pancreatic Adenocarcinoma: A Case Report

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Infectious Diseases & Immunity 2023年第3期3卷 140-141页

作者： Antonio Mastroianni Sonia Greco Valeria Vangeli Maria Vittoria Mauro francesca Greco Roberto Manfredi Infectious&Tropical Diseases Unit "Annunziata"Hub HospitalAzienda Ospedaliera di CosenzaCosenzaItaly Microbiology&Virology Unit "Annunziata"Hub HospitalAzienda Ospedaliera di CosenzaCosenzaItaly University of Bologna BolognaItaly

A rare case of occult cytomegalovirus(CMV)cholangitis along with an updated literature review is *** patient had not undergone solid organ-bone marrow transplantation and had no chronic autoimmune biliary tract disorder or obvious *** patient had underwent a pyloric-sparing duodenocephalopancreasectomy,and the postoperative histopathologic examination revealed multiple ulcerative lesions and an occult CMV *** copy number of CMV DNA was high(38,000 copies/μg DNA)in common bile duct surgical specimens measured by real-time quantitative polymerase chain *** was not detected in blood and urine samples from the patient after full doses of intravenous ganciclovir and full doses of oral valganciclovir antiviral *** report recapitulates the role of CMV in causing severe cholangiopathy in the absence of obvious immunosuppression or autoimmune disorder of the biliary tract.

关键词： Cholangitis Bile cytomegalovirus-DNA detection Biliary complications Cytomegalovirus

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