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Efficacy of long term cyclic administration of the poorly absorbed antibiotic Rifaximin in symptomatic,uncomplicated colonic diverticular disease

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World Journal of Gastroenterology 2007年第2期13卷 264-269页

作者： Antonio Colecchia Amanda Vestito francesca Pasqui Giuseppe Mazzella Enrico Roda francesca pistoia Giovanni Brandimarte Davide Festi Department of Internal Medicine and Gastroenterology University of Bologna Cristo Re Hospital Rome Italy Department of Surgery University of L’Aq- uila Cristo Re Hospital Rome Italy Department of Internal Medicine Cristo Re Hospital Rome Italy

AIM： To comparatively evaluate the long term efficacy of Rifaximin and dietary fibers in reducing symptoms and/or complication frequency in symptomatic, uncomplicated diverticular disease,METHODS： 307 patients （118 males, 189 females, age range： 40-80 years） were enrolled in the study and randomly assigned to： Rifaximin （400 mg bid for 7 d every month） plus dietary fiber supplementation （at least 20 gr/d） or dietary fiber supplementation alone. The study duration was 24 mo; both clinical examination and symptoms＇ questionnaire were performed every two months. RESULTS： Both treatments reduced symptom frequency, but Rifaximin at a greater extent, when compared to basal values. Symptomatic score declined during both treatments, but a greater reduction was evident in the Rifaximin group （6.4±2.8 and 6.2 ± 2.6 at enrollment, P = NS, 1.0 ±0.7 and 2.4±1.7 after 24 mo, P 〈 0.001, respectively）. Probability of symptom reduction was higher and complication frequency lower （Kaplan-Meyer method） in the Rifaximin group （P 〈 0.0001 and 0.028, respectively）.CONCLUSION： In patients with symptomatic, uncomplicated diverticular disease, cyclic administration of RJfaximin plus dietary fiber supplementation is more effective in reducing both symptom and complication frequency than simple dietary fiber *** term administration of the poorly absorbed antibiotic Rifaximin is safe and well tolerated by the patients,confirming the usefulness of this therapeutic strategy in the overall management of diverticular disease.

关键词： Dietary fiber Antibiotics Abdominal symptoms Diverticulitis

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Isochronous singing in 3 crested gibbon species(Nomascus spp.)

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Current Zoology 2024年第3期70卷 291-297页

作者： Chiara De Gregorioa Teresa Raimondi Valeria Bevilacqua Chiara Pertosa Daria Valente Filippo Carugati francesca Bandoli Livio Favaro Brice Lefaux Andrea Ravignani Marco Gamba Department of Life Sciences and Systems Biology University of Turinvia Accademia Albertina 13Torino 10125Italy Department of Biology University of PaduaVia VIII Febbraio2Padova 35122Italy Giardino Zoologico di pistoia Via Pieve a Celle160/APistoia 5110Italy Botanical and Zoological Garden of Mulhouse 11 Av.de la 1ère Division BlindéeMulhouse 68100France Comparative Bioacoustics Group Max Planck Institute for PsycholinguisticsWundtlaan 1Nijmegen 6525 XDThe Netherlands Center for Music in the Brain Department of Clinical MedicineAarhus UniversityBuilding 1710Universitetsbyen 38000AarhusDenmark Department of Human Neuroscience Sapienza University of RomeViale Regina Elena 334Rome 00185Italy

The search for common characteristics between the musical abilities of humans and other animal species is still taking its frst *** of the most promising aspects from a comparative point of view is the analysis of rhythmic components,which are crucial features of human communicative performance but also well-identifable patterns in the vocal displays of other ***,the study of rhythm is becoming essential to understand the mechanisms of singing behavior and the evolution of human *** fndings provided evidence that particular rhythmic structures occur in human music and some singing animal species,such as birds and rock hyraxes,but only 2 species of nonhuman primates have been investigated so far(Indri indri and Hylobates lar).Therefore,our study aims to consistently broaden the list of species studied regarding the presence of rhythmic *** investigated the temporal organization in the singing of 3 species of crested gibbons(Nomascus gabriellae,Nomascus leucogenys,and Nomascus siki)and found that the most prominent rhythmic category was ***,we found slight variation in songs’tempo among species,with *** and *** singing with a temporal pattern involving a gradually increasing tempo(a musical accelerando),and *** with a more regular ***,we show how the prominence of a peak at the isochrony establishes itself as a shared characteristic in the small apes considered so far.

关键词： accelerando isochrony music rhythm singing primates song tempo

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