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Relevance of Spike/Estrogen Receptor-αinteraction for endothelial-based coagulopathy induced by SARS-CoV-2

Signal Transduction and Targeted Therapy 2023年第6期8卷 2459-2462页

作者： Silvia Stella Barbieri Franca Cattani Leonardo Sandrini Magda Maria Grillo Alessandra Amendola Carmen Valente Carmine Talarico Daniela Iaconis Gabriele Turacchio Miriam Lucariello Lucia Lione Erika Salvatori Patrizia Amadio Gloria Garoffolo Mariano Maffei francesca galli Andrea Rosario Beccari Giuseppe Sberna Emanuele Marra Marica Zoppi Michael Michaelides Giuseppe Roscilli Luigi Aurisicchio Riccardo Bertini Marcello Allegretti Maurizio Pesce Centro Cardiologico Monzino IRCCSMilanoItaly Dompéfarmaceutici S.p.A. L’AquilaItaly Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani RomaItaly Institute of Experimental Endocrinology and Oncology“G.Salvatore”(IEOS) National Research CouncilNaplesItaly EXSCALATE DompéFarmaceutici S.p.ANapoliItaly Takis S.r.l. RomeItaly National Institute on Drug Abuse Intramural Research Program Baltimore21224MDUSA Johns Hopkins School of Medicine BaltimoreMDUSA Atreius S.a.s. L’AquilaItaly

Dear Editor,The severe coagulation syndrome in numerous organs is the major life-threatening conditions characterizing the acute infection by *** inflammation/dysfunction,platelet hyper-reactivity,generation of neutro... 详细信息

关键词： organs infection acute

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seventh tumor-node-metastasis staging of gastric cancer: Five-year follow-up

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World Journal of Gastroenterology 2016年第34期22卷 7748-7753页

作者： Stefano Rausei Laura Ruspi Federica galli Vincenzo Pappalardo Giuseppe Di Rocco Francesco Martignoni Francesco Frattini francesca Rovera Luigi Boni Gianlorenzo Dionigi Department of Surgery University of Insubria

Seventh tumor-node-metastasis(TNM) classification for gastric cancer,published in 2010,introduced changes in all of its three parameters with the aim to increase its accuracy in prognostication. The aim of this review is to analyze the efficacy of these changes and their implication in clinical practice. We reviewed relevant Literature concerning staging systems in gastric cancer from 2010 up to March 2016. Adenocarcinoma of the esophago-gastric junction still remains a debated entity,due to its peculiar anatomical and histological situation: further improvement in its staging are required. Concerning distant metastases,positive peritoneal cytology has been adopted as a criterion to define metastatic disease: however,its search in clinical practice is still far from being routinely performed,as staging laparoscopy has not yet reached wide diffusion. Regarding definition of T and N: in the era of multimodal treatment these parameters should more influence both staging and surgery. The changes about T-staging suggested some modifications in clinical practice. Differently,many controversies on lymph node staging are still ongoing,with the proposal of alternative classification systems in order to minimize the extent of lymphadenectomy. The next TNM classification should take into account all of these aspects to improve its accuracy and the comparability of prognosis in patients from both Eastern and Western world.

关键词： Gastric cancer Staging system Tumor node-metastasis Prognostic factors Clinical practice

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Multimodal treatment of gastric cancer

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World Journal of Gastrointestinal Surgery 2014年第4期6卷 55-58页

作者： Ilaria Proserpio Stefano Rausei Sabrina Barzaghi Francesco Frattini Federica galli Domenico Iovino francesca Rovera Luigi Boni Gianlorenzo Dionigi Graziella Pinotti Department of Oncology Ospedale di Circolo and University of Insubria Department of Surgery Ospedale di Circolo and University of Insubria

Gastric cancer is the second leading cause of death from malignant disease *** complete surgical resection remains the only curative modality for early stage gastric cancer,surgery alone only provides long-term survival in 20%of patients with advancedstage *** improve current results,it is necessary to consider multimodality treatment,including chemotherapy,radiotherapy and *** clinical trials have shown survival benefit of combining different neoadjuvant or adjuvant protocols compared with surgery with curative ***,the implementation of chemotherapy with novel targeted agents could play an important role in the multimodal management of advanced gastric *** this paper,we focus on a multidisciplinary approach in the treatment of gastric cancer and discuss future strategies to improve the outcome for these patients.

关键词： Gastric cancer Gastrectomy Lymphadenectomy Multimodal treatment Adjuvant therapy Neoadjuvant therapy Chemotherapy Radiotherapy Targeted therapy

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