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Performance of QuantiFERON(R)-TB Gold In-Tube assay in children receiving disease modifying anti-rheumatic drugs

World Journal of Pediatrics 2017年第5期13卷 472-478页

作者： francesca gabriele Maria Trachana Maria Simitsopoulou Polixeni Pratsidou-Gertsi Elias Iosifidiso Zoi Dorothea Pana Emmanuel Roilides Infectious Diseases Unit 3rd Department of PediatricsAristotle UniversityThessalonikiGreece Pediatric Immunology and Rheumatology Referral Center 1st Department of PediatricsAristotle UniversityThessalonikiGreece

Background:To evaluate the performance of theQuantiferon(R)-TB Gold In-Tube (QFT-IT) interferon (IFN)-7 assay for the detection of latent tuberculosis infection (LTBI)in children receiving anti-rheumatic treatment in a tertiary referral hospital of Northern ***:A total of 79 consecutive children receiving anti-rheumatic treatment [of which 18 screened prior to antitumor necrosis factor (TNF)-α treatment] were tested using Mantoux tuberculin skin test (TST) and *** of both tests with risk factors for latent tuberculosis and Bacillus Calmette-Guerin immunization was *** of age,TNF-α inhibitors,systemic corticosteroids,conventional disease modifying anti-rheumatic drugs (DMARDs) and total duration of therapy on the QFT-IT mitogen-induced response was ***:Agreement between TST and QFT-IT results was moderate (k=0.38).Frequency of QFT-IT indeterminate results was low (2.5%).In patients with risk factors for LTBI,the odds of a positive IFN-7 assay was increased by a factor of 27.6 (P=0.002),whereas there was no positive *** was a significant difference in the mitogeninduced IFN-7 secretion among various treatments (P=0.038).TNF-α inhibitors were associated with increased mitogen-induced IFN-7 secretion compared to monotherapy with conventional DMARDs (P=0.008).All children screened prior to anti-TNF-a treatment exhibited a negative QFT-IT and no active TB disease was detected during a 2-year ***:QFT-IT may be a more reliable test than TST for detection of LTBI in children with rheumatic diseases receiving anti-rheumatic *** regimen might influence the mitogen-induced IFN-γ secretion and the effect of TNF-α inhibitors might vary according to the specific agent administered.

关键词： anti-tumor necrosis factor-α interferon-γ release assay latent tuberculosis rheumatic disease tuberculin

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This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco Maria Lisci Antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi Maria Chiara Spera Valeria De Masi Ester Maria Marzo francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna francesca Bardi Emanuela De Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression

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Cardiovascular injuries and SARS-COV-2 infection:focus on elderly people

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Journal of Geriatric Cardiology 2021年第7期18卷 534-548页

作者： Claudia Colombo Laura Garatti Giulia Ferrante francesca Casadei Claudio Montalto gabriele Crimi Chiara Cogliati Enrico Ammirati Stefano Savonitto Nuccia Morici Department of Cardiology De Gasperis Cardio Center ASST Grande Ospedale Metropolitano NiguardaMilanItaly School of Medicine and Surgery University of Milano BicoccaItaly Division of Cardiology Heart and Lung DepartmentSan Paolo HospitalASST Santi Paolo and CarloUniversity of MilanItaly Division of Cardiology University of PaviaPaviaLombardiaItaly Interventional Cardiology Unit Cardio Thoraco Vascular Department(DICATOV)IR-CCS Policlinico San MartinoGenovaItaly Internal Medicine Department of Medicine and RiabilitationASST Fatebenefratelli-SaccoLuigi Sacco HospitalMilanItaly De Gasperis Cardio Center and Transplant Center Niguarda HospitalMilanItaly Division of Cardiology Ospedale ManzoniLeccoItaly

The novel coronavirus disease(COVID-19)has hit the healthcare system *** risk of severe infection and mortality increases with advancing age,especially in subjects with comorbidities such as cardiovascular disease,hypertension,diabetes,obesity and ***,cardiovascular complications such as myocardial injury,heart failure and thromboembolism are frequently observed in COVID-19 cases,and several biomarkers(troponin,NTpro BNP and D-Dimer)have been identified as prognostic indicators of disease severity and worst ***,there is no specific therapy against SARS-Co V-2,although many medications are under *** aim of this review will be to explore the intertwined relationship between COVID-19 disease and the cardiovascular system,focusing on elderly *** available supportive treatments along with the related concerns in elderly patients,due to their comorbidities and polypharmacotherapy,will be explored.

关键词： injuries cardiovascular infection

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Right sided diverticulitis in western countries:A review

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World Journal of Gastrointestinal Surgery 2021年第12期13卷 1721-1735页

作者： Angelo gabriele Epifani Diletta Cassini Roberto Cirocchi Caterina Accardo francesca Di Candido Massimiliano Ardu Gianandrea Baldazzi Complex Unit of General Minimally Invasive and Emergency SurgerySesto San Giovanni HospitalUniversity of MilanSesto San Giovanni 20099Italy Complex Unit of General Minimally Invasive and Emergency SurgerySesto San Giovanni HospitalSesto San Giovanni 20099Italy Department of General and Oncological Surgery University of PerugiaPerugia 06123Italy

BACKGROUND Although the treatment guidelines for left sided diverticulitis are clear,the management of right colonic diverticulitis is not well *** disease can no longer be ignored due to significant spread throughout *** To analyse epidemiology,diagnosis and treatment of right-sided diverticulitis in western *** MEDLINE and PubMed searches were performed using the key words "rightsided diverticulitis","right colon diverticulitis","caecal diverticulitis","ascending colon diverticulitis" and "caecum diverticula" in order to find relevant articles published until *** A total of 18 studies with 422 patients were *** diagnosis was made only in 32.2%,mostly intraoperatively or via CT *** main reason for misdiagnosis was a suspected acute appendicitis(56.8%).The treatment was a nonoperative management(NOM)in 184 patients(43.6%)and surgical in 238 patients(56.4%),seven of which after NOM *** rate was low(5.45%),similar to eastern studies and inferior to left-sided *** patients were successfully conservatively retreated in most *** The management of right-sided diverticulitis is not well clarified in the western world and no selective guidelines have been considered even if principles are similar to those with left-sided *** diagnosis is one of the most important problems and CT scan seems to be the best imaging *** offers a safe and effective treatment;surgery should be considered only in cases of complicated diverticulitis or if malignancy cannot be *** studies are needed to clarify the correct treatment.

关键词： Right-sided diverticulitis Cecal diverticulitis Right colonic diverticulitis Western countries Emergency surgery Diverticulitis

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Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation

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World Journal of Gastroenterology 2019年第33期25卷 4814-4834页

作者： Alberto Nicoletti francesca Romana Ponziani Marco Biolato Venanzio Valenza Giuseppe Marrone gabriele Sganga Antonio Gasbarrini Luca Miele Antonio Grieco Fondazione Policlinico Universitario A Gemelli IRCCS Rome 00168Italy UniversitàCattolica del Sacro Cuore Rome 00168Italy

The intimate connection and the strict mutual cooperation between the gut and the liver realizes a functional entity called gut-liver *** integrity of intestinal barrier is crucial for the maintenance of liver *** this mutual relationship,the liver acts as a second firewall towards potentially harmful substances translocated from the gut,and is,in turn,is implicated in the regulation of the *** evidence has highlighted the relevance of increased intestinal permeability and consequent bacterial translocation in the development of liver *** particular,in patients with non-alcoholic fatty liver disease recent hypotheses are considering intestinal permeability impairment,diet and gut dysbiosis as the primary pathogenic *** advanced liver disease,intestinal permeability is enhanced by portal *** clinical consequence is an increased bacterial translocation that further worsens liver ***,this pathogenic mechanism is implicated in most of liver cirrhosis complications,such as spontaneous bacterial peritonitis,hepatorenal syndrome,portal vein thrombosis,hepatic encephalopathy,and hepatocellular *** liver transplantation,the decrease in portal pressure should determine beneficial effects on the gut-liver axis,although are incompletely understood data on the modifications of the intestinal permeability and gut microbiota composition are still *** the modulation of the intestinal permeability could prevent the initiation and progression of liver disease is still an uncovered area,which deserves further attention.

关键词： Bacterial translocation Gut microbiota Gut-liver axis Liver disease Cirrhosis Mediterranean diet Personalized medicine

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An Unusual Case of Functional Neurological Disorders and Psychogenic Coma following Physical Assault:Clinical and Medico-Legal Considerations

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Journal of Forensic Science and Medicine 2021年第1期7卷 36-38页

作者： Fiorella Caputo Rosario Barranco Pietrantonio Ricci Santo Gratteri francesca Maria Elena Frigiolini gabriele Rocca Francesco Ventura Department of Legal and Forensic Medicine University of GenovaGenovaItaly Department of Legal and Forensic Medicine Institute of Legal MedicineMagna Grsecia University of CatanzaroCatanzaroItaly

Functional neurological disorders can have different clinical manifestations,including coma,in the setting of an unknown *** this article,we present a case of a young man affected by intellectual disabilities who,after a physical assault reported serious neurological alterations and a functional *** case shows how a stressful psychophysical event can bring acute and variable neurological manifestations of functional significance to a victim with previous intellectual *** the growing interest in this field,research is still very limited and studies in this field could better explain the nature of the psychogenic *** a medico-legal point of view,problems of evaluation may emerge for these disorders emerge as a result of acute psycho-physical stress and without any detectable structural alterations.

关键词： Functional coma functional neurological disorder psychogenic disorders stressful events

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Mallory-Weiss syndrome from giant gastric trichobezoar: A case report

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 972-977页

作者： Eva Lieto Annamaria Auricchio Maria Paola Belfiore Giovanni Del Sorbo gabriele De Sena Vincenzo Napolitano Alessio Ruggiero Gennaro Galizia francesca Cardella Department of Translational Medical Sciences University of Campania L.VanvitelliNapoli 80138CampaniaItaly Department of Precision Medicine University of Campania L.VanvitelliNapoli 80138CampaniaItaly

BACKGROUND Mallory-Weiss syndrome(MWS),representing a linear mucosal laceration at the gastroesophageal junction,is a quite frequent cause of upper gastrointestinal bleeding,usually induced by habitual *** subsequent cardiac ulceration in this condition is likely due to the concomitance of increased intragastric pressure and inappropriate closure of the gastroesophageal sphincter,collectively inducing ischemic mucosal ***,MWS is associated with all vomiting conditions,but it has also been described as a complication of prolonged endoscopic procedures or ingested foreign *** SUMMARY We described herein a case of upper gastrointestinal bleeding in a 16-year-old girl with MWS and chronic psychiatric distress,the latter of which deteriorated following her parents’*** patient,who was residing on a small island during the coronavirus disease 2019 pandemic lockdown period,presented with a 2-mo history of habitual vomiting,hematemesis,and a slight depressive ***,a huge intragastric obstructive trichobezoar was detected and discovered to be due to a hidden habit of continuously eating her own hair;this habit had persisted for the past 5 years until a drastic reduction in food intake and corresponding weight loss *** relative isolation in her living status without school attendance had worsened her compulsory *** hair agglomeration had reached such enormous dimensions and its firmness was so hard that its potential for endoscopic treatment was judged to be *** patient underwent surgical intervention instead,which culminated in complete removal of the *** According to our knowledge,this is the first-ever described case of MWS due to an excessively large trichobezoar.

关键词： Mallory-Weiss syndrome Upper gastrointestinal bleeding Trichobezoar Ringworm Psychiatric distress Case report

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A new approach for the treatment of CLL using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles

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Nano Research 2016年第2期9卷 537-548页

作者： Sara Capolla Nelly Mezzaroba Sonia Zorzet Claudio Tripodo Ramiro Mendoza-Maldonado Marilena Granzotto francesca Vita Ruben Spretz Gustavo Larsen Sandra Noriega Eduardo Mansilla Michele Dal Bo Valter Gattei gabriele Pozzato Luis Nunez Paolo Macor Department of Life Sciences University of Trieste 34127 Trieste Italy Department of Human Pathology University of Palermo 90133 Sicilia Italy Molecular Oncology Unit National Laboratory Consorzio Interuniversitatio per le Biotecnologie (CIB) 34012 Trieste Italy Dipartimento Universitario Clinico di Scienze mediche Chirurgiche e della Salute University of Trieste 34149 Trieste Italy LNK Chemsolutions LLC Lincoln NE 68521 USA Bio-Target Inc. Chicago IL 60637 USA Centro Unico Coordinador de Ablacion e Implante Provincia de Buenos Aires (C.U.CA.I.B.A.) Ministry of Health La Plata Buenos AiresArgentina Clinical and Experimental Onco-Hematology Unit Centro di Riferimento Oncologico Istituto di Ricerca e Cura a Carattere Scientifico(I.R.C.C.S.) 33081 Aviano Italy Callerio Foundation Onlus Institutes of Biological Researches 34127 Trieste Italy

Current approaches for the treatment of chronic lymphocytic leukemia （CLL） have greatly improved the prognosis for survival, but some patients remain refractive to these therapeutic regimens. Hence, in addition to reducing the long-term side- effects of therapeutics for all leukemia patients, there is an urgent need for novel therapeutic strategies for difficult-to-treat leukemia cases. Due to the cytotoxicity of drugs, the major challenge currently is to deliver the therapeutic agents to neoplastic cells while preserving the viability of non-malignant ceils. In this study, we propose a therapeutic approach in which high doses of hydroxychloroquine and chlorambucil were loaded into biodegradable polymeric nanopartides coated with an anti-CD20 *** first demonstrated the ability of the nanoparticles to target and internalize in tumor B-cells. Moreover, these nanoparticles could kill not only p53-mutated]deleted leukemia cells expressing a low amount of CD20, but also circulating primary ceils isolated from chronic lymphocytic leukemia patients. The safety of these nanoparticles was also demonstrated in healthy mice, and their therapeutic effects were shown in a new model of aggressive leukemia. These results showed that anti-CD20 nanoparticles containing hydroxychloroquine and chlorambucil can be effective in controlling aggressive leukemia and provided a rationale for adopting this approach for the treatment of other B-cell disorders.

关键词： chronic lymphocytic leukemia immune targeted nanoparticles treatment xenograft model

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Acute heart failure in the elderly:setting related differences in clinical features and management

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Journal of Geriatric Cardiology 2021年第6期18卷 407-415页

作者： Francesco Orso Alessandra Pratesi Andrea Herbst Anna Chiara Baroncini francesca Bacci gabriele Ciuti Andrea Berni Camilla Tozzetti Carlo Nozzoli Alberto Moggi Pignone Loredana Poggesi Luciano Gabbani Mauro Di Bari Francesco Fattirolli Massimo Milli Andrea Ungar NiccolòMarchionni Samuele Baldasseroni Heart Failure Clinic Division of Geriatric Medicine and Intensive Care UnitAzienda Ospedaliero-Universitaria CareggiFlorenceItaly Department of Experimental and Clinical Medicine University of FlorenceFlorenceItaly Divisions of Internal Medicine 1 Azienda Ospedaliero-Universitaria CareggiFlorenceItaly Divisions of Internal Medicine 4 Azienda Ospedaliero-Universitaria CareggiFlorenceItaly Divisions of Internal Medicine 3 Azienda Ospedaliero-Universitaria CareggiFlorenceItaly Division of Medical-Geriatric Department Azienda Ospedaliero-Universitaria CareggiFlorenceItaly Department of Cardiothoracovascular Medicine Azienda Ospedaliero-Universitaria CareggiFlorenceItaly Division of Cardiology Santa Maria Nuova HospitalFlorenceItaly

BACKGROUND Administrative data show that acute heart failure(HF)patients are older than those enrolled in clinical registries and frequently admitted to non-cardiological settings of *** purpose of this study was to describe clinical characteristics of old patients hospitalised for acute HF in Cardiology,Internal Medicine or Geriatrics *** Data came from ATHENA(AcuTe Heart failurE in advaNced Age)registry which included elderly patients(≥65 years)admitted to the above mentioned settings of care from December 1,2014 to December 1,*** We enrolled 396 patients,15.4%assigned to Cardiology,69.7%to Internal Medicine,and 14.9%to a Geriatrics *** age was 83.5±7.6 years(51.8%of patients≥85 years)and was higher in patients admitted to Geriatrics(P<0.001);more than half were *** treatments did not differ significantly among settings of care(in a context of a low prescription rate of renin-angiotensin-aldosterone system inhibitors)whereas significant differences were observed in comorbidity patterns and management guidelines recommendation adherence for decongestion evaluation with comparison of weight and N-terminal pro-B-type natriuretic peptide levels on admission and at discharge(both P=0.035 and P<0.001),echocardiographic evaluation(P<0.001)and follow-up visits planning(P<0.001),all higher in *** in-hospital length of stay was 9±5.9 days,significantly higher in Geriatrics(13.7±6.5 days)and Cardiology(9.9±6.7 days)compared to Internal Medicine(8±5.2 days),P<***-hospital mortality was 9.3%,resulting higher in Geriatrics(18.6%)and Cardiology(16.4%)than Internal Medicine(5.8%),P=*** In elderly patients hospitalised for acute HF,clinical characteristics and management differ significantly according to the setting of admission.

关键词： admitted clinical acute

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Maxillofacial and concomitant serious injuries： An eight-year single center experience

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Chinese Journal of Traumatology 2017年第1期20卷 4-8页

作者： Fausto Fama Marco Cicciu Alessandro Sindoni Enrico Nastro-Siniscalchi Roberto Falzea gabriele Cervino francesca Polito Francesco De Ponte Maria Gioffre-Florio Department of Human Pathology University Hospital of Messina 98125 Messina Italy Department of Biomedical and Dental Sciences Morphological and Functional Images University Hospital of Messina 98125 Messina Italy Department of Clinical and Experimental Medicine University Hospital of Messina 98125 Messina Italy

Purpose： Maxillofacial injuries are frequently associated with multiple trauma and can determine func- tional and aesthetic bad *** severity ofmaxillofacial injuries may be considerable and can divert clinicians＇ attention from other concomitant injuries which is less evident but potentially life-threatening. The aim of this study was to find out the concomitant injuries in patients referred to the Emergency Department （ED） of the University Hospital of Messina （North-East Sicily, Italy） for maxillofacial traumas. Methods： We retrospectively evaluated data of 240,833 patients admitted at the ED of the University Hospital of Messina from January 2008 to December 2015 because of maxillofacial injuries leading to hospitalization and surgical treatment. Patients who primarily received treatment care at different in- stitutions, pediatric trauma patients and adult patients who were transferred in accordance with pre- existing agreements in case of paucity of beds were excluded. Finally we included 447 （0.2%） patients over the 8 years. Data were evaluated with emphasis on epidemiology （age, gender, mechanism of trauma）, primary survey and abnormalities and pattern of trauma. Results： The most frequent cause of maxillofacial trauma was road accidents （319 patients, 71.4%）, among which motorcycle ones were prevalent. The maxillofacial injured who presented major lesions were 98 patients and minor lesions occurred in 349 patients： 443 （99.1%） patients underwent maxillofacial surgery, immediate or delayed depending on the severity of concomitant injuries （x^2 = 557.2, p 〈 0.0001）. Five concomitant neglected lesions were found to be associated with severe maxillofacial traumas （x^2 = 17.13, p 〈 0.0001 vs minor lesions）. All of the neglected lesions occurred in pauci- symptomatic patients who showed painless abdomen, no hemodynamic instability, no signs of hema- toma of anterior and posterior abdominal wall or other suspicious clinical signs and symptoms. Conclusion： A

关键词： Maxillofacial injuries Concomitant lesions Multiple trauma Emergency department

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