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Hepatitis delta virus: From infection to new therapeutic strategies

World Journal of Gastroenterology 2021年第24期27卷 3530-3542页

作者： Grazia A Niro Arianna Ferro francesca cicerchia Isabella Brascugli Marilena Durazzo Department of Gastroenterology IRCCS Casa Sollievo della Sofferenza Hospital FoundationSan Giovanni Rotondo 71013Italy Department of Medical Sciences University of TurinTurin 10126Italy

The hepatitis delta virus(HDV)is a small RNA virus that encodes a single protein and which requires the hepatitis B virus(HBV)-encoded hepatitis B surface antigen(HBsAg)for its assembly and ***/HDV co-infections exist worldwide and show a higher prevalence among selected groups of HBV-infected populations,specifically intravenous drug users,practitioners of high-risk sexual behaviours,and patients with cirrhosis and hepatocellular *** chronic form of HDV-related hepatitis is usually severe and rapidly *** of the viral infection itself,including the status of co-infection or super-infection,virus genotypes(both for HBV and HDV),and persistence of the virus’replication,influence the outcome of the accompanying and manifested liver ***,disease severity is burdened by the lack of an effective cure for either virus *** decades,the main treatment option has been interferon,administered as mono-therapy or in combination with nucleos(t)ide *** its efficacy has been reported for different doses,durations and courses,only a minority of patients achieve a sustained response,which is the foundation of eventual improvement in related liver *** need for an efficient therapeutic alternative *** efforts towards this end have led to new treatment options that target specific steps in the HDV life cycle;the most promising among these are myrcludex B,which inhibits virus entry into hepatocytes,lonafarnib,which inhibits farnesylation of the viral-encoded LHDAg large hepatitis D antigen,and REP-2139,which interferes with HBsAg release and assembly.

关键词： Hepatitis delta virus Hepatitis B virus Myrcludex Lonafarnib REP 2139

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