检索结果-南通市图书馆

Vascular occlusion to protect against intraoperative blood loss in liver surgeries: new perspectives on a traditional technique

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2021年第4期10卷 567-569页

作者： francesca Ratti Alessandro Nini Roberto Bertini Luca Aldrighetti Hepatobiliary Surgery Division IRCCS San Raffaele HospitalMilanItaly Department of Urology IRCCSSan Raffaele Scientific InstituteMilanItaly Division of Experimental Oncology/Unit of Urology URIIRCCS San Raffaele HospitalMilanItaly Department of Urology and Pediatric Urology Universitätsklinikum des SaarlandesHomburgGermany

The correlation between decreased blood loss and improved clinical and oncological outcomes has been described in liver surgery:considering that perioperative blood transfusions are associated with a higher rate of recurrence and lower survival after resection of colorectal liver metastases and hepatocellular carcinoma,any effort to address the task of bleeding control and reduce the need for blood transfusions is of outstanding importance(1).

关键词： transfusion liver clinical

Chemokine and chemotactic signals in dendritic cell migration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2018年第4期15卷 346-352页

作者： Laura Tiberio Annalisa Del Prete Tiziana Schioppa francesca Sozio Daniela Bosisio Silvano Sozzani Department of Molecular and Translational Medicine University of BresciaBresciaItaly Humanitas Clinical and Research Institute Rozzano-MilanoItaly

Dendritic cells (DCs) are professional antigen-presenting cells responsible for the activation of specific T-cell responses and for thedevelopment of immune tolerance. Immature DCs reside in peripheral tissues and specialize in antigen capture, whereas matureDCs reside mostly in the secondary lymphoid organs where they act as antigen-presenting cells. The correct localization of DCs isstrictly regulated by a large variety of chemotactic and nonchemotactic signals that include bacterial products, DAMPs (dangerassociated molecular patterns), complement proteins, lipids, and chemokines. These signals function both individually and inconcert, generating a complex regulatory network. This network is regulated at multiple levels through different strategies, such assynergistic interactions, proteolytic processing, and the actions of atypical chemokine receptors. Understanding this complexscenario will help to clarify the role of DCs in different pathological conditions, such as autoimmune diseases and cancers and willuncover new molecular targets for therapeutic interventions.

关键词： generating network mostly

High-risk HPVs, microbiota and epithelial carcinogenesis: state of the art and research contribution of in vitro 3D models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2019年第11期4卷 1-11页

作者： Diletta francesca Squarzanti Rita Sorrentino Barbara Azzimonti Laboratory of applied Microbiology Center for Translational Research on Allergic and Autoimmune DiseasesDepartment of Health SciencesMedical SchoolUniversitàdel Piemonte OrientaleNovara 28100Italy Department of Health Sciences Medical SchoolUniversitàdel Piemonte OrientaleNovara 28100Italy Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali Firenze 50121Italy(Local Unit of Universitàdel Piemonte OrientaleNovara 28100Italy

Persistent high-risk human papillomavirus (HR-HPV) infection is associated with anogenital and head & neck squamous epithelial (HNSCC) tumors, which altogether cause about 550,000 new cases every year. Several evidences suggest that the microbiota could have a role on the inflammatory, epithelial mesenchymal transition and tumorigenesis processes promoted by HR-HPV infection, yet the mechanisms involved remain to be clarified. In this review we report the state of the art on this topic and on the most promising in vitro developed models for studying the host-pathogen interactions. Using MEDLINE, several terms were searched and combined to select the most pertinent papers. The investigation was limited to the international indexed articles published in PubMed in the last 10 years. This review reports the latest knowledge in the field of the microbial-associated anogenital tumors and HNSCC. In addition, we also discuss the in vitro epithelial culture systems that reproduce the pathophysiological features of the tumoral microenvironment and the in vivo response to microbial agents, thus representing a useful tool for analyzing at cellular and molecular levels the role played by infective agents in tumorigenesis.

关键词： High risk human papillomavirus microbiota Fusobacterium nucleatum epithelial-mesenchymal transition anogenital cancer head&neck squamous cell carcinoma colorectal cancer transepithelial electrical resistance

Viral hepatitis and hepatocellular carcinoma:From molecular pathways to the role of clinical surveillance and antiviral treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第21期28卷 2251-2281页

作者： Leonardo Stella Francesco Santopaolo Antonio Gasbarrini Maurizio Pompili francesca Romana Ponziani Internal Medicine and Gastroenterology Hepatology UnitFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

Hepatocellular carcinoma(HCC)is a global health *** to the high prevalence in low-income countries,hepatitis B virus(HBV)and hepatitis C virus infections remain the main risk factors for HCC occurrence,despite the increasing frequencies of non-viral *** addition,hepatitis D virus coinfection increases the oncogenic risk in patients with HBV *** molecular processes underlying HCC development are complex and various,either independent from liver disease etiology or *** reciprocal interlinkage among non-viral and viral risk factors,the damaged cellular microenvironment,the dysregulation of the immune system and the alteration of gutliver-axis are known to participate in liver cancer induction and *** mechanisms and pathways change throughout the natural history of viral hepatitis with the worsening of liver *** high risk of cancer incidence in chronic viral hepatitis infected patients compared to other liver disease etiologies makes it necessary to implement a proper surveillance,both through clinical-biochemical scores and periodic ultrasound *** review aims to outline viral and microenvironmental factors contributing to HCC occurrence in patients with chronic viral hepatitis and to point out the importance of surveillance programs recommended by international guidelines to promote early diagnosis of HCC.

关键词： Hepatitis C virus Hepatitis B virus Hepatitis D virus Hepatocellular carcinoma Cirrhosis Liver

Primary vitreoretinal lymphoma masquerading as acute posterior multifocal placoid pigment epitheliopathy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2018年第7期11卷 1243-1244页

作者： francesca Frongia Claudio Iovino Nathalie Cassoux Enrico Peiretti Department of Surgical Sciences Eye Clinic University of Cagliari Radiation Oncology Department Institut Curie

Dear Editor,Primary vitreoretinal lymphoma（PVRL）is a rare form of ocular malignancy and it is usually considered as a subset of primary central nervous system lymphoma（PCNSL）.An insidious onset associated with del... 详细信息

关键词： Figure Primary vitreoretinal lymphoma masquerading as acute posterior multifocal placoid pigment epitheliopathy

Trends in tropospheric ozone concentrations and forest impact metrics in Europe over the time period 2000–2014

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2021年第2期32卷 543-551页

作者： Chiara Proietti Maria francesca Fornasier Pierre Sicard Alessandro Anav Elena Paoletti Alessandra De Marco Italian Institute for Environmental Protection and Research(ISPRA) via Brancati 4800144 RomeItaly ARGANS 260 route du Pin Montard06410 BiotFrance Italian National Agency for New Technologies Energy and the EnvironmentC.R.Casaccia00123 RomeItaly IRET-CNR Via Madonna del Piano 10Florence50019 Sesto FiorentinoItaly

In Europe,tropospheric ozone pollution appears as a major air quality issue,and ozone concentrations remain potentially harmful to *** this study we compared the trends of two ozone metrics widely used for forests protection in Europe,the AOT40(Accumulated Ozone over Threshold of 40 ppb)which only depends on surface air ozone concentrations,and the Phytotoxic Ozone Dose which is the accumulated ozone uptake through stomata over the growing season,and above a threshold Y of uptake(PODY).By using a chemistry transport model,we found that European-averaged ground-level ozone concentrations(−2%)and AOT40 metric(−26.5%)significantly declined from 2000 to 2014,due to successful control strategies to reduce the emission of ozone precursors in Europe since the early *** contrast,the stomatal ozone uptake by forests increased from 17.5 to 26.6 mmol O3 m^(−2)despite the reduction in ozone concentrations,leading to an increase of potential ozone damage on plants in *** a climate change context,a biologically-sound stomatal flux-based standard(PODY)as new European legislative standard is needed.

关键词： Tropospheric ozone AOT40 POD Trendm Mann-Kendall test

Effect of corneal light scatter on vision: a review of the literature

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2016年第3期9卷 459-464页

作者： Leopoldo Spadea Giorgia Maraone francesca Verboschi Enzo Maria Vingolo Daniele Tognetto Department of Biotechnology and Medical-Surgical Sciences "Sapienza" University of Rome Eye Clinic Ospedale MaggioreUniversity of Trieste

The cornea is the transparent connective tissue window at the front of the *** physiological role of the cornea is to conduct external light into the eye,focus it,together with the lens,onto the retina,and to provide rigidity to the entire ***,good vision requires maintenance of the transparency and proper refractive shape of the *** surface structures irregularities can be associated with wavefront aberrations and scattering *** scattering in the human cornea causes a reduction of visual *** fact,the cornea must be transparent and maintain a smooth and stable curvature since it contributes to the major part of the focusing power of the *** most cases,a simple examination of visual acuity cannot demonstrate the reduction of visual quality secondary light *** fact,clinical techniques for examining the human cornea in vivo have greatly expanded over the last few *** measurement of corneal back scattering qualifies the degree of corneal *** measurement of corneal forward-scattering quantifies the amount of visual impairment that is produced by the alteration of *** aim of this study was to review scattering in the human cornea and methods of measuring it.

关键词： cornea haze light photorefraetive keratectomy scattering vision

Service design for climate-smart agriculture

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Information Processing in Agriculture 2021年第2期8卷 328-340页

作者： Michael O’Grady David Langton francesca Salinari Peter Daly Gregory O’Hare School of Computer Science University College DublinBelfieldDublin 4Ireland Origin Enterprises plc 4-6 RiverwalkCitywest Business CampusDublin 24Ireland

Holistic information systems for climate-smart agriculture demands the seamless integration of various categories of climate,meteorological and weather *** actor in the agricultural value chain may harness weather forecasts at the short and medium-range,local weather history,and prevailing climatic conditions,to inform *** is fundamental to many day-to-day operations,especially at farm-level,influencing decision-making at various spatial and temporal *** operational decisions ideally require hyper-localized service *** practice,integrating weather information into decision-support services demands a comprehensive understanding of various categories of weather-related data,their genesis,as well as the specific standards and data formats used by the meteorological *** paper considers the weather as a crucial context for the delivery of farm-level operational services in smart agriculture,highlighting critical issues for reflection by system designers during the service design and implementation phases.

关键词： Smart agriculture Climate services Agrometeorology Precision agriculture

Liquid biopsy in endometrial cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2020年第1期6卷 399-416页

作者： francesca Malentacchi Chiara Sgromo Lorenzo Antonuzzo Serena Pillozzi Department of Clinical Experimental and Biomedical Sciences University of FlorenceFlorence 50134Italy Clinical Oncology Unit Careggi University HospitalFlorence 50134Italy

Liquid biopsy(LB)is an emerging tool for the evaluation of relapse in several cancers and nowadays is used in lung cancer for primary detection and molecular characterization when tumoral tissue is not *** can represent an innovative biospecimen for the screening,diagnosis,and monitoring of all types of cancer and for monitoring of therapeutic *** includes several biofluids such as blood,urine,peritoneal fluid/lavage,and analytes(circulating tumor cells,circulating tumor DNA,long noncoding RNA,microRNA,vesicles,mRNA,and protein)that can play different roles in diagnosis,prognosis,and patient management as well as in the improvement of the knowledge of cancer *** cancer(EC)is a tumor usually detected at low stage with a good prognosis,but few low risk cases,unexpectedly,can evolve to bad *** to now,no molecular target exists to treat advanced stage or to define the evolution of low stage *** review focuses on how the LB may help in the management and characterization of patients affected by EC.

关键词： Endometrial cancer liquid biopsy long noncoding RNA circular RNA circulating tumor DNA circulating tumor cell extracellular vesicle peritoneal lavage