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Chronic kidney disease as a predictor of clinical risk in the elderly

Journal of Geriatric Cardiology 2016年第3期13卷 199-201页

作者： francesca Viazzi francesca cappadona Barbara Bonino Roberto Pontremoli University of Genoa and IRCCS AOU San Martino-IST Genoa Italy

Facing the needs of an increasingly ageing population is rapidly becoming a major public health issue in western countries, Chronic kidney disease （CKD）, whose current prevalence is estimated around 10%-15% in the general population, with considerably higher figures in at-risk groups, is widely known to increase with age. In the elderly, renal impairment is often concomitant or secondary to several other systemic disorders such as hypertension, atherosclerosis,

关键词： Albuminuria Chronic kidney disease Glomerular filtration rate Risk assessment The elderly

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Multifaceted relationship between diabetes and kidney diseases:Beyond diabete

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World Journal of Diabetes 2023年第10期14卷 1450-1462页

作者： Pasquale Esposito Daniela Picciotto francesca cappadona francesca Costigliolo Elisa Russo Lucia Macciò francesca Viazzi Department of Internal Medicine and Medical Specialties(DiMI) University of GenoaGenoa 16132Italy Unit of Nephrology Dialysis and TransplantationIRCCS Ospedale Policlinico San MartinoGenoa 16132Italy

Diabetes mellitus is one of the most common causes of chronic kidney *** involvement in patients with diabetes has a wide spectrum of clinical presentations ranging from asymptomatic to overt proteinuria and kidney *** development of kidney disease in diabetes is associated with structural changes in multiple kidney compartments,such as the vascular system and *** alterations include thickening of the glomerular basement membrane,loss of podocytes,and segmental mesangiolysis,which may lead to microaneurysms and the development of pathognomonic Kimmelstiel-Wilson *** lesions directly related to diabetes,awareness of the possible coexistence of nondiabetic kidney disease in patients with diabetes is *** nondiabetic lesions include focal segmental glomerulosclerosis,IgA nephropathy,and other primary or secondary renal *** diagnosis of these conditions is crucial in guiding clinical management and therapeutic ***,the relationship between diabetes and the kidney is bidirectional;thus,new-onset diabetes may also occur as a complication of the treatment in patients with renal ***,we review the complex and multifaceted correlation between diabetes and kidney diseases and discuss clinical presentation and course,differential diagnosis,and therapeutic opportunities offered by novel drugs.

关键词： Diabetes Diabetic kidney disease Nondiabetic kidney disease Biomarkers Glomerular disease Kidney biopsy Sodium-glucose cotransporter-2 inhibitors

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Kidney and cardiovascular risk in primary hypertension

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World Journal of Hypertension 2015年第4期5卷 115-118页

作者： francesca Viazzi francesca cappadona Barbara Bonino Roberto Pontremoli Università degli Studi di Genova IRCCS Azienda Ospedaliera Universitaria San Martino IST

In patients with primary hypertension,therapeutic strategies should be based on global cardiovascular risk profile rather than on the severity of blood pressure *** assessment of concomitant risk factors and especially of the presence and extent of subclinical organ damage is of paramount importance in definingindividual *** the high prevalence of hypertension in the population at large,however,extensive diagnostic evaluation is often impractical or unfeasible in clinical *** cost,easy to use markers of risk are needed to improve the clinical management of patients with *** renal abnormalities such as a slight reduction in glomerular filtration rate and/or the presence of microalbuminuria are well known and powerful predictors of cardio-renal morbidity and mortality and provide a useful,low cost tools to optimize cardiovascular risk assessment.A greater use of these tests should therefore be implemented in clinical practice in order to optimize the management of hypertensive patients.

关键词： Hypertension Albuminuria Cardiovascular risk Glomerular filtration rate Risk assessment Kidney

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