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Deep diving in the PACIFIC:Practical issues in stage III non-small cell lung cancer to avoid shipwreck

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World Journal of Clinical Oncology 2020年第11期11卷 898-917,I0003页

作者： Xabier Mielgo-Rubio Federico Rojo Laura Mezquita-Pérez francesc casas Amadeo Wals Manel Juan Carlos Aguado Javier Garde-Noguera David Vicente Felipe Couñago Department of Medical Oncology Hospital Universitario Fundación AlcorcónMadrid 28922Spain Department of Pathology IIS-Jiménez Díaz-CIBERONC FoundationMadrid 28040Spain Department of Medical Oncology Hospital ClinicLaboratory of Translational Genomics and Targeted Therapeutics in Solid TumorsIDIBAPSBarcelona 08036Spain Department of Radiation Oncology Hospital ClinicBarcelona 08036Spain Department of Radiation Oncology Hospital Universitario Virgen MacarenaSevilla 41009Spain Department of Immunology Service Hospital ClínicUniversitat de BarcelonaBarcelona 08036Spain Department of Medical Oncology Hospital Universitario Clínico San CarlosMadrid 28040Spain Department of Medical Oncology Hospital Universitario Virgen MacarenaSevilla 49001Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28028Spain

After publication of the PACIFIC trial results,immune checkpoint inhibitor-based immunotherapy was included in the treatment algorithm of locally advanced non-small cell lung cancer(NSCLC).The PACIFIC trial demonstrated that 12 mo of durvalumab consolidation therapy after radical-intent platinum doublet chemotherapy with concomitant radiotherapy improved both progression-free survival and overall survival in patients with unresectable stage III *** is the first treatment in decades to successfully improve survival in this clinical setting,with manageable toxicity and without deterioration in quality of *** integration of durvalumab in the management of locally advanced NSCLC accentuates the need for multidisciplinary,coordinated decision-making among lung cancer specialists,bringing new challenges and controversies as well as important changes in clinical work *** aim of the present article is to review—from a practical,multidisciplinary perspective—the findings and implications of the PACIFIC *** evaluate the immunobiological basis of durvalumab as well as practical aspects related to programmed cell death ligand 1 *** addition,we comprehensively assess the efficacy and toxicity data from the PACIFIC trial and discuss the controversies and practical aspects of incorporating durvalumab into routine clinical ***,we discuss unresolved questions and future *** short,the present document aims to provide clinicians with a practical guide for the application of the PACIFIC regimen in routine clinical practice.

关键词： Durvalumab Non-small cell lung cancer PACIFIC Immunotherapy Immune checkpoint inhibitors Anti-programmed cell death ligand 1 Consolidation therapy Unresectable stage III lung cancer

GOECP/SEOR clinical recommendations for lung cancer radiotherapy during the COVID-19 pandemic

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World Journal of Clinical Oncology 2020年第8期11卷 510-527页

作者： Felipe Couñago Arturo Navarro-Martin Javier Luna Nuria Rodríguez de Dios Aurora Rodríguez francesc casas Rafael García Antonio Gómez-Caamaño Jorge Contreras Javier Serrano Department of Radiation Oncology Hospital Universitario Quirónsalud MadridPozuelo de AlarcónMadrid 28223Spain Clinical Department Hospital La LuzMadridFaculty of BiomedicineUniversidad EuropeaMadrid 28223Spain Department of Radiation Oncology Institut Catalád’OncologiaL’Hospitalet de LlobregatBarcelona 08908Spain Department of Radiation Oncology Hospital Fundación Jiménez DíazMadrid 28040Spain Department of Radiation Oncology Hospital del MarBarcelona 08003Spain Department of Radiation Oncology Hospital Ruber InternacionalMadrid 28034Spain Department of Radiation Oncology Thoracic UnitHospital ClínicBarcelona 08036Spain Department of Radiaiton Oncology Hospital Ruber InternacionalMadrid 28034Spain Department of Radiation Oncology Hospital Clínico Universitario Santiago de CompostelaA Coruña 15706Spain Department of Radiation Oncology Hospital Regional Universitario de Málaga29010Spain Department of Radiation Oncology Clínica Universidad de NavarraMadrid 28027Spain

The coronavirus disease 2019 crisis has had a major and highly complex impact on the clinical practice of radiation oncology *** is one of the countries hardest hit by the virus,with devastating *** is an urgent need to share experiences and offer guidance on decision-making with regard to the indications and standards for radiation therapy in the treatment of lung *** the present article,the Oncological Group for the Study of Lung Cancer of the Spanish Society of Radiation Oncology reviews the literature and establishes a series of consensus-based recommendations for the treatment of patients with lung cancer in different clinical scenarios during the present pandemic.

关键词： Lung cancer COVID-19 Pandemic Radiotherapy Recommendations

GOECP/SEOR radiotherapy guidelines for small-cell lung cancer

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World Journal of Clinical Oncology 2021年第3期12卷 115-143页

作者： Felipe Couñago Carolina de la Pinta Susana Gonzalo Castalia Fernández Piedad Almendros Patricia Calvo Begoña Taboada Antonio Gómez-Caamaño JoséLuis López Guerra Marisa Chust JoséAntonio GonzálezFerreira AnaÁlvarez González francesc casas Department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28223MadridSpain Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Radiation Oncology Hospital Universitario La PrincesaMadrid 28006Spain Department of Radiation Oncology GenesisCare MadridMadrid 28043Spain Department of Radiation Oncology Hospital General UniversitarioValencia 46014Spain Department of Radiation Oncology Hospital Clínico Universitario Santiago de CompostelaSantiago de Compostela 15706Spain Department of Radiation Oncology Hospital Universitario Virgen del RocíoSevilla 41013Spain Department of Radiation Oncology Fundación Instituto Valenciano de OncologíaValencia 46009Spain Department of Radiation Oncology GenesisCare-SpainSevilla 41092Spain Department of Radiation Oncology HGU Gregorio MarañónMadrid 28007Spain Department of Radiation Oncology Thoracic UnitHospital ClinicBarcelona 08036Spain

Small cell lung cancer(SCLC)accounts for approximately 20%of all lung *** main treatment is chemotherapy(Ch).However,the addition of radiotherapy significantly improves overall survival(OS)in patients with non-metastatic SCLC and in those with metastatic SCLC who respond to *** cranial irradiation reduces the risk of brain metastases and improves OS in both metastatic and non-metastatic *** 5-year OS rate in patients with limited-stage disease(non-metastatic)is slightly higher than 30%,but less than 5%in patients with extensive-stage disease(metastatic).The present clinical guidelines were developed by Spanish radiation oncologists on behalf of the Oncologic Group for the Study of Lung Cancer/Spanish Society of Radiation Oncology to provide a current review of the diagnosis,planning,and treatment of *** guidelines emphasise treatment fields,radiation techniques,fractionation,concomitant treatment,and the optimal timing of Ch and ***,we discuss the main indications for reirradiation in local recurrence.

关键词： Small cell lung cancer Chemotherapy Hyperfractionated radiation therapy Prophylactic brain irradiation Brain metastases Reirradiation

Pathological response to neoadjuvant therapy with chemotherapy vs chemoradiotherapy in stage III NSCLC-contribution of IASLC recommendations

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World Journal of Clinical Oncology 2021年第11期12卷 1047-1063页

作者： Diego Muñoz-Guglielmetti David Sanchez-Lorente Roxana Reyes Daniel Martinez Carmen Lucena Marc Boada Pilar Paredes Marta Parera-Roig Ivan Vollmer Joel Mases Roberto Martin-Deleon Sergi Castillo Mariana Benegas Silvia Muñoz Maria Mayoral Carla Cases Meritxell Mollà francesc casas Radiation Oncology Department Hospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Thoracic Surgery Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Medical Oncology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Pathology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Pneumology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Nuclear Medicine Department Faculty of Medicine of University of BarcelonaInstitut d'Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)Barcelona 08036CataluñaSpain Medical Oncology Department Hospital Comarcal de VicVic 08500CataluñaSpain Radiology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Pneumology Department Hospital Universitario Reina SofiaCórdoba 14004AndalucíaSpain Medical Oncology Department Hospital de MolletMollet 08100CataluñaSpain Medical Oncology Department Hospital General de GranollersGranollers 08402CataluñaSpain Nuclear Medicine Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Radiation Oncology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain

BACKGROUND Neoadjuvant treatment(NT)with chemotherapy(Ch)is a standard option for resectable stage III(N2)*** studies have suggested benefits with the addition of radiotherapy(RT)to NT *** International Association for the Study of Lung Cancer(IASLC)published recommendations for the pathological response(PHR)of NSCLC resection specimens after *** To contribute to the IASLC recommendations showing our results of PHR to NT Ch vs NT chemoradiotherapy(ChRT).METHODS We analyzed 67 consecutive patients with resectable stage III NSCLC with positive mediastinal nodes treated with surgery after NT Ch or NT ChRT between 2013 and *** NT,all patients were evaluated for radiological response(RR)according to Response Evaluation Criteria in Solid Tumours criteria and evaluated for surgery by a specialized group of thoracic *** histological samples were examined by the same two *** was evaluated by the percentage of viable cells in the tumor and the resected lymph *** Forty patients underwent NT ChRT and 27 NT ***-six(83.6%)patients underwent surgery(35 ChRT and 21 Ch).The median time from ChRT to surgery was 6 wk(3-19)and 8 wk(3-21)for Ch *** observed significant differences in RR,with disease progression in 2.5%and 14.8%of patients with ChRT and Ch,respectively,and partial response in 62.5%ChRT vs 29.6%Ch(P=0.025).In PHR we observed≤10%viable cells in the tumor in 19(54.4%)and 2 cases(9.5%),and in the resected lymph nodes(RLN)30(85.7%)and 7(33.3%)in ChRT and Ch,respectively(P=0.001).Downstaging was greater in the ChRT compared to the Ch group(80%vs 33.3%;P=0.002).In the univariate analysis,NT ChRT had a significant impact on partial RR[odds ratio(OR)12.5;95%confidence interval(CI):1.21-128.61;P=0.034],a decreased risk of persistence of cancer cells in the tumor and RLN and an 87.5%increased probability for achieving downstaging(OR 8;95%CI:2.34-27.32;P=0.001).CONCLUSION We found significant benefits in RR and PHR

关键词： Non-small cell lung cancer Chemotherapy Chemoradiotherapy Neoadjuvant treatment Resectable stage III Pathological response

Network-centric medicine for peripheral nerve injury:treating the whole to boost endogenous mechanisms of neuroprotection and regeneration

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Neural Regeneration Research 2019年第7期14卷 1122-1128页

作者： David Romeo-Guitart Caty casas Institut de Neurociències(INc) and Department of Cell Biology Physiology and ImmunologyUniversitat Autònoma de Barcelona (UAB) & Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas(CIBERNED)

Peripheral nerve injuries caused by accidents may lead to paralysis,sensory disturbances,anaesthesia,and lack of autonomic *** recovery after disconnection of the motoneuronal soma from target tissue with proximal rupture of axons is determined by several factors:motoneuronal soma viability,proper axonal sprouting across inhibitory zones and elongation toward specific muscle,effective synapse contact rebuilding,and prevention of muscle ***,such as adjuvant drugs with pleiotropic effects,that promote functional recovery after peripheral nerve injury are *** this aim,we designed a drug discovery workflow based on a network-centric molecular vision using unbiased proteomic data and neural artificial computational *** focus is on boosting intrinsic capabilities of neurons for neuroprotection;this is in contrast to the common approach based on suppression of a pathobiological pathway known to be associated with disease *** our workflow,we discovered neuroheal,a combination of two repurposed drugs that promotes motoneuronal soma neuroprotection,is anti-inflammatory,enhances axonal regeneration after axotomy,and reduces muscle *** drug discovery workflow has thus yielded a therapy that is close to its clinical application.

关键词： motoneuron neurodegeneration axonal regeneration muscle atrophy systems biology neuroheal PI3K/AKT sirtuin 1 motor function recovery

Iterated Inverse Images of Plane Curve Singularities

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Acta Mathematica Sinica,English Series 2011年第12期27卷 2319-2328页

作者： Eduardo casas-ALVERO Joaquim ROE Departament d＇Algebra i Geometria Universitat de Barcelona Gran Via 585 08007 Barcelona Spain Departament de Matematiques Universitat Autonoma de Barcelona 08193 Bellaterra （Barcelona） Spain

We describe the evolution of certain multiplicities and intersection numbers of plane curve singularities under the iterated action of an analytic morphism.

关键词： Plane curve singularity analytic morphism dynamics of intersection

Neural functions of small heat shock proteins

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Neural Regeneration Research 2022年第3期17卷 512-515页

作者： Teresa de los Reyes Sergio casas-Tintó Instituto Cajal CSICMadridSpain

Stress response is a cellular widespread mechanism encoded by a common protein program composed by multiple cellular factors that converge in a defense reaction to protect the cell against *** many mechanisms described,heat shock proteins were proposed as universally conserved protective factors in the stress core proteome,coping with different stress stimuli through its canonical role in protein ***,emerging evidences reveal non-canonical roles of heat shock proteins relevant for physiological and pathological ***,we review the implications of inducible heat shock proteins in the central nervous system *** particular,we discuss the relevance of heat shock proteins in the maintenance of synapses,as a balanced protective mechanism in central nervous system development,pathological conditions and aging.

关键词： aging central nervous system chaperones environment neuroprotection pathology stress synapses

西南极利文斯顿岛汉那角火山岩地质及火山活动

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南极研究 1994年第2期6卷 1-12页

作者：郑祥身 francesc Sabat Josep M casas Ranimon Pallas 中国科学院地质研究所岩石圈构造演化开放研究实验室巴塞罗那大学地质系

本文以野外地质资料为基础，并结合岩相学特征，论述了西南极南设得兰群岛利文斯顿岛汉那角（ＨａｎｎａｈＰｏｉｎｔ）火山岩地层及岩石的基本特征，初步讨论了该地火山活动过程。该地互层状产出的火山角砾岩和熔岩，为南极半岛火山岩... 详细信息

本文以野外地质资料为基础，并结合岩相学特征，论述了西南极南设得兰群岛利文斯顿岛汉那角（ＨａｎｎａｈＰｏｉｎｔ）火山岩地层及岩石的基本特征，初步讨论了该地火山活动过程。该地互层状产出的火山角砾岩和熔岩，为南极半岛火山岩组的一部分。剖面上出露的三个火山岩地层旋回分别是三期火山作用的产物。第一、二旋回岩层产状的变化记录了火山作用过程中的一次活动间歇。第一旋回的英安岩和含有流纹岩质熔岩夹层的凝灰角砾岩仅为第一期火山活动末的产物；第二旋回为三次较强喷发活动的产物，从安山岩质火山碎屑岩为主，经玄武岩－安山岩质熔岩为主，过渡为含有安山岩或流纹岩质熔浆团的火山角砾岩。第三期火山活动可能更强烈，大面积分布的厚层玄武质熔岩无论从产状上还是在岩石学特征方面都有别于其他旋回。火山岩地层总体产状稳定，平缓地倾向北西，表明该区未受到过明显的构造影响，火山活动中心可能有逐步向北西迁移的趋势，与南设得兰群岛岩浆弧演变趋势一致。次火山岩主要为玄武岩质小岩墙，集中在第二旋回底部。第一、二旋回接触界线两侧凝灰角砾岩表现较强的沸石化。这些现象说明该接触面附近为一薄弱带，侵入活动和蚀变均较易发生。

关键词：火山岩地层火山活动岩相学利文斯顿岛

Hyperparameter optimization of YOLOv8 for smoke and wildfire detection:Implications for agricultural and environmental safety

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Artificial Intelligence in Agriculture 2024年第2期12卷 109-126页

作者： Leo Ramos Edmundo casas Eduardo Bendek Cristian Romero Francklin Rivas-Echeverría Kauel Inc. Menlo Park(Silicon Valley)CA 94025USA Computer Vision Center Universitat Autònoma de BarcelonaBellaterra 08193Spain Faculty of Engineering University of DeustoBilbao 48007Spain Jet Propulsion Laboratory NASAPasadenaCA 91109USA

In this study,we extensively evaluated the viability of the state-of-the-art YOLOv8 architecture for object detec-tion tasks,specifically tailored for smoke and wildfire identification with a focus on agricultural and environmen-tal *** available versions of YOLOv8 were initially fine-tuned on a domain-specific dataset that included a variety of scenarios,crucial for comprehensive agricultural ***‘large’version(YOLOv8l)was se-lected for further hyperparameter tuning based on its performance *** model underwent a detailed hyperparameter optimization using the One Factor At a Time(OFAT)methodology,concentrating on key param-eters such as learning rate,batch size,weight decay,epochs,and *** from the OFAT study were used to define search spaces for a subsequent Random Search(RS).The final model derived from RS demon-strated significant improvements over the initial fine-tuned model,increasing overall precision by 1.39%,recall by 1.48%,F1-score by 1.44%,mAP@0.50 by 0.70%,and mAP@0.50:0.95 by 5.09%.We validated the enhanced model's efficacy on a diverse set of real-world images,reflecting various agricultural settings,to confirm its ro-bustness in detecting smoke and *** results underscore the model's reliability and effectiveness in scenar-ios critical to agricultural safety and environmental *** work,representing a significant advancement in the field of fire and smoke detection through machine learning,lays a strong foundation for fu-ture research and solutions aimed at safeguarding agricultural areas and natural environments.

关键词： Agricultural safety Wildfire detection Smoke detection Object detection Computer vision YOL