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High-finesse Fabry-Perot cavities with bidimensional Si_(3)N_(4) photonic-crystal slabs

Light(Science & Applications) 2016年第1期5卷 320-327页

作者： Xu Chen Clément Chardin Kevin Makles Charles caër Sheon Chua Rémy Braive Isabelle Robert-Philip Tristan Briant Pierre-François Cohadon Antoine Heidmann Thibaut Jacqmin Samuel Deléglise Laboratoire Kastler Brossel UPMC-Sorbonne UniversitésCNRSENS-PSL Research UniversityCollège de France4 place JussieuCase 74F75252 ParisFrance Current address:IBM Research-Zürich Säumerstrasse 48803 RüschlikonSwitzerland Laboratoire de Photonique et de Nanostructures LPN-CNRS/CNRS Route de Nozay91460 MarcoussisFrance UniversitéParis Diderot Sorbonne Paris Cité75207 ParisFrance

Light scattering by a two-dimensional photonic-crystal slab(PCS)can result in marked interference effects associated with Fano *** devices offer appealing alternatives to distributed Bragg reflectors and filters for various applications,such as optical wavelength and polarization filters,reflectors,semiconductor lasers,photodetectors,bio-sensors and non-linear optical *** PCS also have natural applications in the field of optomechanics,where the mechanical modes of a suspended slab interact via radiation pressure with the optical field of a high-finesse *** reflectivity and transmission properties of a defect-free suspended PCS around normal incidence can be used to couple out-of-plane mechanical modes to an optical field by integrating it in a free-space *** we demonstrate the successful implementation of a PCS reflector on a high-tensile stress Si_(3)N_(4) *** illustrate the physical process underlying the high reflectivity by measuring the photonic-crystal band ***,we introduce a clear theoretical description of the membrane scattering properties in the presence of optical *** embedding the PCS inside a high-finesse cavity,we fully characterize its optical *** spectrally,angular-and polarization-resolved measurements demonstrate the wide tunability of the membrane’s reflectivity,from nearly 0 to 99.9470±0.0025%,and show that material absorption is not the main source of optical ***,the cavity storage time demonstrated in this work exceeds the mechanical period of low-order mechanical drum *** so-called resolved-sideband condition is a prerequisite to achieve quantum control of the mechanical resonator with light.

关键词： Fano resonance high-reflectivity membrane low-loss optical reflector nanomembrane resonator photonic-crystal slab quantum optomechanics

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Endoscopic ultrasonography guided biliary drainage: Summary of consortium meeting, May 7^(th) , 2011, Chicago

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World Journal of Gastroenterology 2013年第9期19卷 1372-1379页

作者： Michel Kahaleh Everson LA Artifon Manuel Perez-Miranda Kapil Gupta Takao Itoi Kenneth F Binmoeller california Pacific Medical Center San Francisco ca 94115 United States Marc Giovannini Division of Gastroenterology and Hepatology Weill Cornell Medical College New York NY 10021 United States Department of Gastroenterology University of So Paulo Medical School So Paulo 05403-000 Brazil Endoscopy Unit Hospital Universitario Rio Hortega 47012 Valladolid Spain Pancreatic Biliary Department Cedars-Sinai Medical Center Beverly Hills CA 90048 United States Department of Gastroenterology and Hepatology Tokyo Medical University Tokyo 160-0023 Japan Department of Gastroenterology Paolicalmettes Institute 13273 Marseille France

Endoscopic retrograde cholangiopancreatography (ERCP) has become the preferred procedure for biliary or pancreatic drainage in various pancreatico-biliary disorders. With a success rate of more than 90%, ERCP may not achieve biliary or pancreatic drainage in cases with altered anatomy or with tumors obstructing access to the duodenum. In the past those failures were typically managed exclusively by percutaneous approaches by interventional radiologists or surgical intervention. The morbidity associated was significant especially in those patients with advanced malignancy, seeking minimally invasive interventions and improved quality of life. With the advent of biliary drainage via endoscopic ultrasound (EUS) guidance, EUS guided biliary drainage has been used more frequently within the last decade in different countries. As with any novel advanced endoscopic procedure that encompasses various approaches, advanced endoscopists all over the world have innovated and adopted diverse EUS guided biliary and pancreatic drainage techniques. This diversity has resulted in variations and improvements in EUS Guided biliary and pancreatic drainage; and over the years has led to an extensive nomenclature. The diversity of techniques, nomenclature and recent progress in our intrumentation has led to a dedicated meeting on May 7 th , 2011 during Digestive Disease Week 2011. More than 40 advanced endoscopists from United States, Brazil, Mexico, Venezuela, Colombia, Italy, france, Austria, Germany, Spain, Japan, China, South Korea and India attended this pivotal meeting. The meeting covered improved EUS guided biliary access and drainage procedures, terminology, nomenclature, training and credentialing; as well as emerging devices for EUS guided biliary drainage. This paper summarizes the meeting's agenda and the conclusions generated by the creation of this consortium group.

关键词： Endoscopic ultrasound Biliary drainage Endosonography-guided cholangiopancreatography Endoscopic ultrasound guided Pancreatic drainage Endoscopic retrograde cholangiopancreatography

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DET1-mediated COP1 regulation avoids HY5 activity over second-site gene targets to tune plant photomorphogenesis

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Molecular Plant 2021年第6期14卷 963-982页

作者： Esther canibano Clara Bourbousse Marta Garcia-Leon Borja Garnelo Gomez Lea Wolff camila Garcia-Baudino Rosa Lozano-Duran Fredy Barneche Vicente Rubio Sandra Fonseca Centro Nacional de Biotecnología CNB-CSICMadrid 28049Spain Institut de biologie de l’École normale supérieure(IBENS) École normale supérieureCNRSINSERMUniversitéPSLParis 75005France Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China Department of Plant Biochemistry Centre for Plant Molecular Biology(ZMBP)Eberhard Karls University72076 TübingenGermany

DE-ETIOLATED 1(DET1)and CONSTITUTIVE PHOTOMORPHOGENESIS 1(COP1)are two essential repressors of Arabidopsis *** proteins can associate with CULLIN4 to form independent CRL4-based E3 ubiquitin ligases that mediate the degradation of several photomorphogenic transcription factors,including ELONGATED HYPOCOTYL 5(HY5),thereby controlling multiple gene-regulatory *** extensive biochemical and genetic analyses of their multi-subunit complexes,the functional links between DET1 and COP1 have long remained ***,we report that DET1 associates with COP1 in vivo,enhances COP1-HY5 interaction,and promotes COP1 destabilization in a process that dampens HY5 protein *** regulating its accumulation,DET1 avoids HY5 association with hundreds of second-site genomic loci,which are also frequently targeted by the skotomorphogenic transcription factor PHYTOCHROME-INTERACTING FACTOR ***,ectopic HY5 chromatin enrichment favors local gene repression and can trigger fusca-like *** study therefore shows that DET1-mediated regulation of COP1 stability tunes down the HY5 cistrome,avoiding hyper-photomorphogenic responses that might compromise plant viability.

关键词： HY5 DET1 COP1 photomorphogenesis light signaling fusca

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机械通气重症患者所呼出一氧化碳的检测:吸入氧浓度的影响

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德国医学 2001年第5期18卷 255-256页

作者： R.Zegdi R.ca(?)d A.VanDeLouw D.Perrin M.Burdin R.Boiteau A.Tenaillon 贾红轩 Department of Intensive care Louise Michel HospitalQuartier du Canal91080 Courcouronnes France 华中科技大学同济医学院附属同济医院

最近一些研究显示,支气管-肺的炎症性疾患患者的呼出气CO浓度增加.这与氧化应激有关,氧化应激能上调血红素氧合酶的表达,此酶能在细胞内合成C0.据笔者所知,到目前为止还未见到有关机械通气治疗的重症成年患者呼出气CO浓度进行检测的文... 详细信息

最近一些研究显示,支气管-肺的炎症性疾患患者的呼出气CO浓度增加.这与氧化应激有关,氧化应激能上调血红素氧合酶的表达,此酶能在细胞内合成C0.据笔者所知,到目前为止还未见到有关机械通气治疗的重症成年患者呼出气CO浓度进行检测的文献报道.为了对在氧化应激情况下重症患者呼出气CO浓度监测的意义作出评价,应首先得到一个标准.众所周知,增加FIO2会使呼出的CO增加,这正是治疗CO中毒的依据.本研究的目的是评估机械通气的重症患者呼出气CO检测的可行性,了解FIO2对呼出气CO的影响.

关键词：机械通气一氧化碳氧浓度

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大麻抑制β淀粉样多肽导致的星形胶质细胞半通道激活:一种神经元保护机制

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神经损伤与功能重建 2017年第1期12卷 F0003-F0003页

作者： Gajardo-Gómez R Labra VC Maturana CJ Shoji KF Santiba?ez ca Sáez JC Giaume C Orellana JA 唐颖馨 Departamento de Neurología Escuela de Medicina Pontificia Universidad Católica de Chile Departamento de Fisiología Pontificia Universidad Católica de ChileSantiago de ChileChile and Instituto MilenioCentro Interdisciplinario de Neurociencias de Valparaíso Center for Interdisciplinary Research in Biology Collège de France/Centre National de la Recherche ScientifiqueUnité Mixte de Recherche 7241Institut National de la Santé et de la Recherche Médicale U1050

阿尔茨海默病(AD)的机制尚不完全清楚,星形胶质细胞及其信号传导在AD中的作用也有待进一步研究。既往研究表明,β淀粉样多肽(Aβ)会导致神经元死亡,其可能的机制为Aβ导致星形胶质细胞半通道开放,并由此增加兴奋性毒性ATP和谷氨酸释放... 详细信息

阿尔茨海默病(AD)的机制尚不完全清楚,星形胶质细胞及其信号传导在AD中的作用也有待进一步研究。既往研究表明,β淀粉样多肽(Aβ)会导致神经元死亡,其可能的机制为Aβ导致星形胶质细胞半通道开放,并由此增加兴奋性毒性ATP和谷氨酸释放。本课题组的既往研究显示,激活的小胶质细胞或炎症介质可导致星形胶质细胞上缝隙连接43半通道开放;而外源性或内源性大麻均可以减少这种开放。但尚不清楚大麻是否可以减少由Aβ激活星形胶质细胞半通道导致的神经元死亡。本研究培养星形胶质细胞及海马脑片,分别单用Aβ处理或用Aβ及大麻(WIN,2-AG,或甲酰胺基)联合处理。采用单通道膜片钳及延时乙啡啶摄取法记录胶质细胞半通道的活动,采用Fluoro-Jade C染色检测神经元死亡。结果显示,大麻完全抑制了由Aβ导致的星形胶质细胞半通道的活性及炎症反应。而且,大麻完全抑制了由Aβ导致的星形胶质细胞缝隙连接43半通道开放而引起的兴奋毒性谷氨酸及ATP的释放,大麻也可以很大程度上减少由Aβ导致的海马脑片神经元的损伤。通过调节星形胶质细胞的功能来保护神经元是目前治疗AD的新策略,本研究结果为此提供了新思路。

关键词：阿尔茨海默病缝隙连接蛋白43 胶质细胞神经炎症反应神经元

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卒中介入治疗培训指南：国际多学会共识文件

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国际脑血管病杂志 2017年第5期25卷 396-399页

作者： Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo ca Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩孙瑞郭芮兵 From the American Association of Neurological Surgeons/Congress of Neurological Surgeons (AANS/CNS) Rolling Meadows IL USA American Society of Neuroradiology (ASNR) Oak Brook IL USA Asian Australasian Federation of lnterventional and Therapeutic Neuroradiology (AAFITN) Bali Indonesia Australian and New Zealand Society of Neuroradiobgy-Conjomt Committee for Recognition of Training in Interventional Neuroradiology (CCINR) representing the RANZCR (ANZSNR) ANZAN and NSA Sydney Australia canadian Interventional Neuro Group (CING) Edmonton AB Canada World Federation of Interventional and Therapeutic Neuroradiology (WFITN) Gold Coast Australia European Society of Neuroradiology (ESNR) Milan Italy European Society of Minimally Invasive Neurologic Therapy (ESMINT) Nice France Japanese Society for Neuroendovascular therapy (JSNET) Okayama Japan Sociedad Ibero Latino Americana de Neuroradiologica (SILAN) Cartagena Colombia Society of Neurolnterventional Surgery (SNIS) Washington DC USA Society of Vascular and Interventional Neurology (SVIN) Brooklyn NY USA 南京大学医学院附属金陵医院(南京军区南京总医院)神经内科 210002 解放军第一0一医院(无锡太湖医院)神经内科无锡214004

1背景缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞（emergent large vesselocclusion，ELVO）患者都会遗留长期残疾。事实上，这些颅内大动脉闭塞经常会导致大面积脑损伤，进而造成患者死亡或严重致残。

关键词：缺血性卒中培训指南介入治疗文件学会国际血管闭塞动脉闭塞

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