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An Assessment of Cardiovascular Functional Capacity of a Group of Chronic Heart Failure Patients Using the 6-Minute Walk Test in a Cameroonian Urban Setting

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World Journal of Cardiovascular Diseases 2023年第6期13卷 275-282页

作者： Félicité Kamdem Chris Nadège Nganou-Gnindjio Dieudonné Danwe franc.Christ-Roi Soemessabot Elysée Claude Bika Léle Ba Hamadou Sidick Mouliom Lade Viché Henri Ngoté Caroline Kenmegne Marie Solange Ndom Ebongue Siddikatou Djibrilla William Ngatchou Department of Internal Medicine Douala General Hospital Douala Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Faculty of Sciences University of Douala Douala Cameroon Faculty of Medicine and Biomedical Sciences University of Garoua Garoua Cameroon Faculty of Health Sciences University of Buea Cameroon

Background: Chronic heart failure is a public health problem worldwide. It has a high mortality rate and is accompanied by a decreased functional capacity and alteration of the quality of life. Objective: This study aimed to assess the cardiovascular functional capacity of a group of patients suffering from heart failure using the 6-minute walk test (6 MWT). Methods: This was a cross-sectional study carried out in the cardiology unit of Douala’s general hospital for 4 months. We included all eligible patients aged 18 years or more who had stable chronic heart failure and gave informed consent. Those who had an acute coronary syndrome (≤1 month), tachycardia (HR ≥ 120 bpm), high blood pressure (SBP ≥ 180 mmHg and/or DBP ≥ 100 mmHg) and reduced mobility due to orthopaedic reasons were excluded. A 6 MWT was done according to the American Thoracic Society guidelines. The 6 MWT result was considered poor for - 450 m and good for >450 m. Results: We recruited a total of 81 patients (61.7% women) with a mean age of 65.9 ± 10.6 years. The most frequent risk factor for heart failure was high blood pressure (77.8%), alcohol consumption(69.1%) and a sedentary lifestyle (53.1%). The left ventricular ejection fraction was mostly preserved (42.0%) or mildly altered (46.9). The 6 MWT results were poor in 55.6% of cases, average in 19.8% of cases and good in only 24.7% of cases. More than half (59.3%) of the participants perceived the effort as being difficult. The cardiovascular functional capacity was significantly associated with age, heart failure stage and physical activity (p Conclusion: Most patients suffering from chronic stable heart failure in the general hospital of Douala have poor cardiovascular functional capacity.

关键词： Cardiovascular Functional Capacity Chronic Heart Failure 6-Minute Walk Test Cameroon

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掌上电脑＋手机＝Nokia9210

新潮电子 2001年第1期 47-47页

作者： franc

屈光性角膜切削术后病毒性角膜结膜炎导致上皮下浸润

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世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 48-49页

作者： Arcieri E.S. Arcieri R.S. franc.a E.T. RochaF.J. 陈立军 Rua Corcovado no 155 38411-092 Uberlandia Minas Gerais Brazil

Purpose. To report three cases of adenoviral keratoconjunctivitis in patients who have undergone photorefractive keratectomy and that just developed subepithe lial infiltrates. Methods. Description of patients that developed postoperative adenoviral keratoconjunctivitis after photorefractive keratectomy without influe nce in the final visual outcome. Results. All patients presented adenoviral kera toconjunctivitis 2-3 months after refractive surgery. They developed multiple p inpoint subepithelial infiltrates in six eyes, without haze development. The final uncorrected visual acuity was better or equal to 20/30. Conclusion. Although patients undergoing photorefractive ker atectomy might develop severe corneal scarring following ocular infections, such events may follow their natural evolution.

关键词：角膜切削术屈光性角膜屈光手术角膜切除术眼部感染腺病毒角膜结膜炎角膜瘢痕自然演变点样

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奥迪

Canonical Workflows to Make Data FAlR

作者： (德)马提亚斯·布劳恩(Matthias Braun) (德)亚历山大·弗兰斯·施多尔茨(Alexander franc.Storz)

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Data Intelligence 2022年第2期4卷 286-305页

作者： Peter Wittenburg Alex Hardisty Yann Le franc.Amirpasha Mozaffari Limor Peer Nikolay A.Skvortsov Zhiming Zhao Alessandro Spinuso FDO Forum Gemeindweg 5547533 KleveGermany Cardiff University CardiffWales CF103ATUK eScience Factory 75570 Paris Cedex 12France Forschungszentrum Julich GmbH 52425 JulichGermany Yale University New HavenCT 06520USA Russian Academy of Sciences 121351 MoscowRussia University of Amsterdam PO-Box 943231090 GH AmsterdamThe Netherlands Royal Netherlands Meteorological Institute(KNMI) Utrechtseweg 2973731 GA De BiltThe Netherlands

The FAIR principles have been accepted globally as guidelines for improving data-driven science and data management practices,yet the incentives for researchers to change their practices are presently *** addition,data-driven science has been slow to embrace workflow technology despite clear evidence of recurring *** overcome these challenges,the Canonical Workflow Frameworks for Research(CWFR)initiative suggests a large-scale introduction of self-documenting workflow scripts to automate recurring processes or fragments *** standardised approach,with FAIR Digital Objects as anchors,will be a significant milestone in the transition to FAIR data without adding additional load onto the researchers who stand to benefit most from *** paper describes the CWFR approach and the activities of the CWFR initiative over the course of the last year or so,highlights several projects that hold promise for the CWFR approaches,including Galaxy,Jupyter Notebook,and RO Crate,and concludes with an assessment of the state of the field and the challenges ahead.

关键词： Workflow Data management FAIR Principles Digital Objects

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大黄芩鱼散半仿生提取及其活性成分的检测

中国饲料 2022年第7期 63-66页

作者：古玛纳姚丹王宏军周丽芹博意李虹颖张达锦州医科大学畜牧兽医学院辽宁锦州121001

为获得大黄芩鱼散半仿生提取物的制备工艺,本研究以均匀实验设计U5(53)安排实验,考察提取溶媒pH、料液比、提取时间对提取物抗鹅沙门氏菌最小抑菌浓度(MIC)的影响,以乙腈-0.1%磷酸水为流动相梯度洗脱,高效液相色谱法检测提取物中的活性... 详细信息

为获得大黄芩鱼散半仿生提取物的制备工艺,本研究以均匀实验设计U5(53)安排实验,考察提取溶媒pH、料液比、提取时间对提取物抗鹅沙门氏菌最小抑菌浓度(MIC)的影响,以乙腈-0.1%磷酸水为流动相梯度洗脱,高效液相色谱法检测提取物中的活性成分。结果显示:大黄芩鱼散半仿生提取最优的工艺为pH 8.3,料液比1:40,提取时间0.5 h,对鹅沙门氏菌的MIC为(9.10±0.11)mg/mL,HPLC可以同步检测提取物中的活性成分有黄芩苷、槲皮素、芦荟大黄素和大黄素。

关键词：大黄芩鱼散半仿生提取均匀实验设计

抗乳腺癌单抗CDI315B可变区基因的序列分析

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广西医科大学学报 2000年第1期17卷 53-55页

作者：樊晓晖 Natasa Kopitar-Jerala franc.Gubensek 广西医科大学微生物学与免疫学教研室南宁530021 Dept.of Biochemistry and Molecular Biology Jozef StefanIn stitute

目的 :克隆抗乳腺癌 CDI315 B单抗可变区基因 ,并对其进行序列分析。方法 :利用前导肽序列设计引物 ,采用 RT-PCR技术从分泌抗人乳腺癌单克隆抗体的杂交瘤细胞株 CDI315 B分离克隆了抗体轻重链可变区基因 ,用 Sanger双脱氧末端终止法测... 详细信息

目的 :克隆抗乳腺癌 CDI315 B单抗可变区基因 ,并对其进行序列分析。方法 :利用前导肽序列设计引物 ,采用 RT-PCR技术从分泌抗人乳腺癌单克隆抗体的杂交瘤细胞株 CDI315 B分离克隆了抗体轻重链可变区基因 ,用 Sanger双脱氧末端终止法测定扩增的 CDI315 B单抗 VK 和 VH 基因的序列 ,对其进行序列分析。结果 :和国际标准的小鼠 Kabat分类体系进行对比分析 ,CDI315 B单抗的 VK属于第 4或第 5组的第 6亚组 (VI) ;CDI315 B单抗的 VH 则属于第 2族 (VH2 )。结论 :抗乳腺癌 CDI315 B单抗可变区基因的克隆及序列分析为构建人鼠嵌合轻链和人鼠嵌合重链打下基础。

关键词：抗乳腺癌单克隆抗体可变区基因乳腺癌

因特网视频编解码器的主观品质——采用SAMVIQ进行第二阶段评估

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世界宽带网络 2005年第8期12卷 44-48页

作者：弗兰克·科扎莫尼克（franc.Kozamernik） Paloa Sunna Emmanuel Wyckens Dag Inge Pettersen 和颜洁（译）欧洲广播聪明EBU技术部高级工程师 RAI CRIT成员法国电信研发部FTRD成员挪威公共广播电视公司NRK成员不详

通常来说．评价音视频压缩技术的性能是一个颇有争议的主题。不过，设计用于互联网和网播的商用化音视频编解码器才是实事。有些人认为它是一门科学，但是还有一些人则说它是“妖术”。随着编解码器市场的发展，投资逐渐增多．也有些人... 详细信息

通常来说．评价音视频压缩技术的性能是一个颇有争议的主题。不过，设计用于互联网和网播的商用化音视频编解码器才是实事。有些人认为它是一门科学，但是还有一些人则说它是“妖术”。随着编解码器市场的发展，投资逐渐增多．也有些人或许赞成编解码器厂商大胆的观点．认为其编解码器明显位于他们之前的版本，

关键词：视频编解码器因特网音视频压缩技术评估二阶品质商用化互联网

Genetic causes of macrozoospermia and proposal for an optimized genetic diagnosis strategy based on sperm parameters

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Journal of Genetics and Genomics 2023年第7期50卷 536-540页

作者： Alicia Coudert Caroline Cazin Amir Amiri-Yekta Selima Fourati Ben Mustapha Raoudha Zouari Julien Bessonat Abdelali Zoghmar Antoine Clergeau Catherine Metzler-Guillemain Chema Triki Herve Lejeune Nathalie Sermondade Eva Pipiras Nadia Prisant Isabelle Cedrin Leila Keskes Florence Lestrade Laetitia Hesters Nathalie Rives Beatrice Dorphin Agnes Guichet Catherine Patrat Emmanuel Dulioust Aur elie Feraille franc.ois Robert Eric Bieth Arthur Sorlin Jean-Pierre Siffroi Mariem Ben Khelifa Florence Boiterelle Sylvianne Hennebicq Veronique Satre Christophe Arnoult Charles Coutton Anne-Laure Barbotin Nicolas Thierry-Mieg Zine-Eddine Kherraf Pierre F.Ray Genetic Epigenetic and Therapies of Infertility Team Institute for Advanced BiosciencesInserm U 1209CNRS UMR 5309Universite Grenoble Alpes38000GrenobleFrance CHU Grenoble Alpes UM GI-DPI38000GrenobleFrance CHU Grenoble Alpes UM de Genetique Chromosomique38000GrenobleFrance Department of Genetics Reproductive Biomedicine Research CenterRoyan Institute for Reproductive BiomedicineACECRTehranIran Polyclinique les Jasmins Centre d’Aide M edicale a la Procr eationCentre Urbain Nord1003TunisTunisia CHU Grenobles Alpes UF de Biologie de la Procr eation38000GrenobleFrance Reproduction Sciences and Surgery Clinique Ibn RochdConstantineAlgeria CHU Caen CECOS de CaenD epartement de BiologieUnit e de Biologie de la Reproduction14033CaenFrance APHM Hopital La-Conception P^ole Femmes-parents-enfantsCentre Clinico-biologique d’assistance M edicale a la Procr eation-CECOS13385 MarseilleFrance Aix-Marseille Univ InsermMMGU125113385 Marseille Medical Genetics13385 MarseilleFrance Clinique Hannibal Centre d’AMPLes Berges du Lac1053TunisTunisia Reproductive Medicine Department Hospices Civil de LyonLyonFrance Hopital Jean Verdier Universit e Sorbonne Paris NordParisFrance CHU de Pointe-a-Pitre/Abymes GuadeloupeFrance Service de Medecine de la Reproduction CHU Jean VerdierParisFrance Faculte de M edecine de Sfax SfaxTunisia CHR Metz-Thionville Service d’Assistance Medicale a la Procr eation57530Ars-LaquenexyFrance Unit of Reproductive Biology Antoine B ecl ere University HospitalUniversity Paris SudClamartParis-Sud UniversityLe Kremlin Bic^etreFrance Univ Rouen Normandie Inserm U1239NorDICAdrenal and Gonadal PathophysiologyReproductive Biology Laboratory-CECOSRouen University Hospital76031Rouen CedexFrance CHAL Centre Hospitalier Alpes Leman Centre AMP7474130Contamine-sur-ArveFrance CHU Angers Service de Gen etique49933AngersINSERM U1083France Service de Biologie de la Reproduction-CECOS Hopital Cochin 74014ParisFrance IRH Medicentre Clinique du Val d’Ouest39

Macrozoospermia,characterized by the presence of largeheaded spermatozoa usually carrying several flagella,is one of the most severe phenotypes of male *** in most cases,the gametes are chromosomally abnormal and cannot be used for assisted reproductive technologies(ART)(Ray et al.,2017).In 2007,subjects from consanguineous families were shown to carry the same homozygous deleterious AURKC variant(NM_001015878.2:c.144delC,later renamed c.145delC,***49TrpfsTer23),establishing AURKC as the first and main gene associated with macrozoospermia(Dieterich et al.,2007).Using flow cytometry,all spermatozoa from patients homozygous for the c.145delC variant were shown to be tetraploid,highlighting a cytokinesis blockage of the first meiotic divisions thus confirming that ART cannot be successful for these patients(Dieterich et al.,2009).

关键词： diagnosis establishing