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The challenging management of malignant ureteral obstruction:Analysis of a series of 188 cases

Current Urology 2024年第1期18卷 34-42页

作者： Alberto Artiles Medina Inés Laso García Fernando González Tello Sara Álvarez Rodríguez Manuel Hevia Palacios Marina Mata Alcaraz César Mínguez Ojeda Fernando Arias Funez Victoria Gómez Dos Santos fran.isco javier burgos revilla Department of Urology Hospital Universitario Ramón y CajalMadridSpain Department of Radiology Hospital Universitario Ramón y CajalMadridSpain

Background:Malignant ureteral obstruction(MUO)is a common condition that complicates the course of advanced *** aims of this study are to analyze the causes,management,and survival of patients with obstructive nephropathy due to malignant ureteric obstruction and to determine prognostic ***,we studied the complications and outcomes in patients who underwent urinary *** and methods:A retrospective study was conducted on patients with computed tomography-confirmed MUO between January 2016 and November ***,clinical,radiological,laboratory,and management data were *** curves were estimated using the Kaplan-Meier method,and univariate and multivariate Cox proportional hazards models were used to test the association between parameters and ***:A total of 188 patients were *** mean age was 69.01 years(SD,14.95 years),and the majority(54.8%)were *** most common mechanism leading to MUO was compression by a pelvic mass(36.9%),and the 3 most frequent tumors causing MUO were prostate(17.6%),bladder(16.5%),and rectal cancer(11.7%).Forty-seven patients(25%)underwent urinary diversion:23(48.9%)underwent double-J stenting and 21(44.7%)underwent percutaneous *** most common reason for urinary diversion was acute kidney injury(53.3%).Recovery of renal function was observed in 55.8%of the patients after urinary *** most frequently identified complications after urinary diversion were urinary tract infection(24.4%),hematuria(17.0%),and urinary sepsis(14.9%).The median survival after hydronephrosis diagnosis was 6.43 months(interquartile range,1.91-14.81 months).In patients who underwent urinary decompression,the median survival after urinary diversion was 8.67 months(interquartile range,2.99-17.28 months).In the multivariate analysis,a lower grade of hydronephrosis and cancer cachexia negatively impacted ***:Cancer patients with MUO have a poor pro

关键词： Hydronephrosis Ureteral obstruction Neoplasms Urinary diversion Survival Prognosis

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The short form of the SUR1 and its functional implications in the damaged brain

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Neural Regeneration Research 2022年第3期17卷 488-496页

作者： Iván Alquisiras-burgos javier franco-Pérez Moisés Rubio-Osornio Penélope Aguilera Laboratorio de Patología Vascular Cerebral Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico Laboratorio de Formación Reticular Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico Laboratorio Experimental de Enfermedades Neurodegenerativas Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico.

Sulfonylurea receptor(SUR) belongs to the adenosine 5′-triphosphate(ATP)-binding cassette(ABC) transporter family;however,SUR is associated with ion channels and acts as a regulatory subunit determining the opening or closing of the ***8 and Abcc9 genes code for the proteins SUR1 and SUR2,*** SUR1 transcript encodes a protein of 1582 amino acids with a mass around 140–177 k Da expressed in the pancreas,brain,heart,and other *** is well known that SUR1 assembles with Kir6.2 and TRPM4 to establish K_(ATP) channels and non-selective cation channels,***8 and 9 are alternatively spliced,and the resulting transcripts encode different isoforms of SUR1 and SUR2,which have been detected by different experimental ***,the use of binding assays to sulfonylureas and Western blotting has allowed the detection of shorter forms of SUR(-65 k Da).Identity of the SUR1 variants has not been clarified,and some authors have suggested that the shorter forms are ***,immunoprecipitation assays have shown that SUR2 short forms are part of a functional channel even coexisting with the typical forms of the receptor in the *** evidence confirms that the structure of the short forms of the SURs is fully functional and does not lose the ability to interact with the *** structural changes in short forms of SUR modify its affinity to ATP,regulation of its expression might represent an advantage in pathologies where ATP concentrations decrease and a therapeutic target to induce ***,the expression of SUR1 variants might be induced by conditions associated to the decrease of energetic substrates in the brain(*** stroke and epilepsy).In this review,we want to contribute to the knowledge of SUR1 complexity by analyzing evidence that shows the existence of short SUR1 variants and its possible implications in brain function.

关键词： brain edema epilepsy Parkinson's disease stroke sulfonylurea receptor 1 SUR1 traumatic brain injury TRPM4

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Diagnostic-therapeutic management of bile duct cancer

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World Journal of Clinical Cases 2019年第14期7卷 1732-1752页

作者： José María Huguet Miriam Lobo José Mir Labrador Carlos Boix Cecilia Albert Luis Ferrer-Barceló Ana B Durá Patricia Suárez Isabel Iranzo Mireia Gil-Raga Celia Baez de burgos javier Sempere Digestive Disease Department General University Hospital of ValenciaValencia 46014Spain Medical Oncology Department General University Hospital of ValenciaValencia 46014Spain Unidad Hepática Avanzada Servicio de Cirugía General y DigestivaGeneral University Hospital of ValenciaValencia 46014Spain Medical Oncology Department Hospital de RequenaRequena 46340Spain

Biliary tract cancer, or cholangiocarcinoma, comprises a heterogeneous group of malignant tumors that can emerge at any part of the biliary tree. This group is the second most common type of primary liver cancer. Diagnosis is usually based on symptoms, which may be heterogeneous, and nonspecific biomarkers in serum and biopsy specimens, as well as on imaging techniques. Endoscopy-based diagnosis is essential, since it enables biopsy specimens to be taken. In addition, it can help with locoregional staging of distal tumors. Endoscopic retrograde cholangiopancreatography is a key technique for the evaluation and treatment of malignant biliary tumors. Correct staging of cholangiocarcinoma is essential in order to be able to determine the degree of resectability and assess the results of treatment. The tumor is staged based on the TNM classification of the American Joint Committee on Cancer. The approach will depend on the classification of the tumor. Thus, some patients with early-stage disease could benefit from surgery;complete surgical resection is the cornerstone of cure. However, only a minority of patients are diagnosed in the early stages and are suitable candidates for resection. In the subset of patients diagnosed with locally advanced or metastatic disease, chemotherapy has been used to improve outcome and to delay tumor progression. The approach to biliary tract tumors should be multidisciplinary, involving experienced endoscopists, oncologists, radiologists, and surgeons.

关键词： Bile duct cancer Cholangiocarcinoma Management Diagnosis Incidence Multidisciplinary treatment

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Spectral analysis of new black hole candidate AT2019wey observed by NuSTAR

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Science China(Physics,Mechanics & Astronomy) 2022年第1期65卷 92-102页

作者： Ye Feng XueShan Zhao LiJun Gou YuFeng Li James FSteiner javier AGarc´ıa Yuan Wang Nan Jia ZhenXuan Liao HuiXian Li Key Laboratory for Computational Astrophysics National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100012China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China Harvard-Smithsonian Center for Astrophysics Cambridge MA 02138USA Cahill Centre for Astronomy and Astrophysics California Institute of TechnologyPasadena CA 91125USA Dr.Karl Remeis-Observatory and Erlangen Centre for Astroparticle Physics Bamberg 96052Germany School of Science Jimei UniversityXiamen 361021China

AT2019 wey is a new galactic X-ray binary that was first discovered as an optical transient by the Asteroid Terrestrial-impact Last Alert System(ATLAS)on December 7,***2019 wey consists of a black hole candidate as well as a low-mass companion star(M_(star)≤1.0 M_(■))and is likely to have a short orbital period(P_(orb)≤16h).Although AT2019 wey began activation in the X-ray band on March 8,2020,it did not enter the soft state during almost the entire *** this study,we present a detailed spectral analysis of AT2019 wey in the low/hard state during its X-ray outburst on the basis of Nuclear Spectroscopic Telescope Array(Nu S T AR)*** obtain tight constraints on several of its important physical parameters by applying the state of the art relxill relativistic reflection model *** particular,we determine that the measured inner radius of the accretion disk is most likely to have extended to the innermost stable circular orbit(isco)radius,i.e.,R_(in)=1.38^(+0.23)_(-0.16)R_(isco).Hence,assuming R_(in)=R_(isco),we find the spin of AT2019 wey to be a*~0.97,which is close to the extreme and an inner disk inclination angle of i~22°.Additionally,according to our adopted models,AT2019 wey tends to have a relatively high iron abundance of AFe~5A_(Fe,■)and a high disk ionization state of logξ~3.4.

关键词： NuSTAR black hole physics X-rays binaries-stars individual AT2019wey

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Phytoclimatic Dynamics of Mediterranean Forests under Climate Change. A Case Study in a Southern European <i>Pinus sylvestris</i>L. Stand

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American Journal of Plant Sciences 2013年第3期4卷 655-662页

作者： javier M. García-López Carmen Allué Regional Government of Castilla y León Environmental Service Burgos Spain Regional Government of Castilla y León Environmental Service Burgos Spain.

Some effects of climate change on the composition and competitive capacity of southern European Pinus sylvestris L. forests in the Mediterranean basin were evaluated. The variation over the period 1910-2008 through 30-year mobile averages of a Phytoclimatic Suitability Index (PSI) of the main tree species of the forest cover are used to indicate the competitive hierarchy of Pinus sylvestris and Fagus sylvatica L. The methodology was applied at a specific location on the Spanish south-facing slopes of the Pyrenees mountain range in the Iberian Peninsula, where the increase in the average temperature was 1.4?C in the period of observation. The results indicated that the apparent equilibrium between the two species studied changed from the 1934-1963 average. Due to the loss of competitive capacity of Scots pine with respect to European beech, particularly from the years 1970-1999, the model predicted an inversion of the situation as it was up until now, so that beech had a higher PSI than pine. The phytoclimatic approach proposed here offers new methodological horizons for the study of the effects of climate change on the future of the forests.

关键词： Biodiversity Complexity Suitability Competition Phytoclimatology Scots Pine European Beech

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Diversity and Taxonomy of Basidiomycetous Fungi at the Northeastern Side of Quezon Protected Landscape,Southern Luzon,Philippines

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Journal of Agricultural Science and Technology(A) 2020年第1期10卷 1-11页

作者： Felimon Pacle Brazas Jr Liwayway Perlado Taglinao Arianne Grace Mapacpac revilla RaymundoFajardo javier Edwin Roces Tadiosa Department of Liberal Arts Education and SciencesSan Pedro College of Business AdministrationSan Pedro City4023LagunaPhilippines Department of Biological Sciences College of Arts and SciencesCavite State UniversityIndang 4122CavitePhilippines Senior High School Department Dasmariñas East Integrated High SchoolSan SimonDasmariñas City4115CavitePhilippines Science Department College of ScienceBulacan State UniversityGuinhawa St.Malolos City3000BulacanPhilippines College of Science and Computer Studies-Graduate Studies De La Salle UniversityDasmariñas City4115CavitePhilippines

The present study was conducted primarily,to determine the diversity of basidiomycetous fungi and their taxonomy,in the northeastern side of Quezon Protected Landscape,bordering the municipalities of Pagbilao,Padre burgos and Atimonan in Quezon province,Southern *** quadrats measuring 10 m×15 m with an interval of 50 m were established from a transect line set up from the baseline to the peak of the *** of basidiomycetous fungi were pre-identified in the ***,form,texture,size,color and other noteworthy characteristics were recorded during the time of *** of identities was done using published textbooks,literature and consultation with mycology expert.A total of 863 individuals of basidiomycetous fungi were collected and identified belonging to 19 different families,31 genera and 53 *** family has the highest number of species representing 30%of the total number of individuals *** of the species belong to Hexagonia and Polyporus *** current research revealed that most of the substrates used by these fungal organisms are woody substrate,specifically rotten *** results of Shannon-Wiener diversity index showed that the area has a high basidiomycetous fungal *** was also a high species richness of these fungal organisms,but there was a low dominance and the species were not evenly distributed in the *** this area is open for hikers,it is recommended that a continuous monitoring of the macrofungi community be done for sustainability and conservation.

关键词： Atimonan basidiomycetous diversity Hexagonia macrofungi northeastern side Quezon Protected Landscape Polyporaceae

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Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in Murine Model

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Chinese Journal of Integrative Medicine 2020年第11期26卷 812-818页

作者： Juan Luis Santiago Eva Maria Galan-Moya Jose Ramon Munoz-Rodriguez Miguel Angel de la Cruz-Morcillo fran.isco javier Redondo-Calvo Ignacio Gracia-Fernandez Peter M.Elias Jose Manuel Perez-Ortiz Mao-Qiang Man Dermatology Service Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Research Unit Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Oncology Laboratory Centro Regional de Investigaciones BiomedicasUniversidad de Castilla-La ManchaAlbacete(02008)Spain Instituto de Tecnologia Quimica y Medioambiental Universidad de Castilla-La ManchaCiudad Real(13004)Spain Dermatology Service Vetera ns Affairs Medical Centerand Department of DermatologyUniversity of CaliforniaSan FranciscoCA(94121)USA Dermatology Hospital Southern Medical UniversityGuangzhou(510091)China

Objective To determine whether topical applications of thiosulfinate-enriched Allium sativum extract(TASE)can accelerate acute cutaneous wound healing(WH)in a murine *** Keratinocyte viability and in vitro wound closure were assessed in keratinocyte *** of topical TASE(0.5μg/mL of allicin in 97%ethanol)on acute cutaneous WH were determined in a murine model of acute cutaneous *** mice were alternately assigned to the vehicle-and TASE-treated groups(n=6 per group).Expression levels of mRNA for keratinocyte differentiation marker-related proteins(filaggrin,loricrin and involucrin)and lipid synthetic enzymes(elongation of very long chain fatty acids protein 4(ELOVL4),fatty acid synthase(FA2H),3-hydroxy-3-methyl-glutaryl-coenzyme A reductase(HMGCoA),and serine palmitoyltransferase(SPT))were assessed using real-time quantitative polymerase chain reaction on day 3 and 8 after wounding,while transepidermal water loss(TEWL)rates were measured in wounded *** TASE accelerated WH both in vivo(40%vs.22%reduction in wound area,P<0.01)and in vitro(90%vs.65%reduction in wound area,P<0.01).Moreover,topical applications of TASE upregulated the expression levels of epidermal mRNA for ELOVL4,HMGCoA,SPT,filaggrin,loricrin and involucrin(P<0.05 ***-treated controls)on day 3 after ***,TASE significantly lowered TEWL rates in comparison with vehicle alone on day 8(33.06±2.09 g/(m^2·h)vs.24.60±2.04 g/(m^2·h),P<0.01).Conclusions Topical applications of TASE stimulated keratinocyte proliferation and formation of epidermal permeability barrier function,leading to acceleration of acute cutaneous *** products containing TASE could be used to manage acute cutaneous WH.

关键词： Allium sativum thiosulfinate wound healing permeability barrier keratinocytes proliferation

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Spanish National Monuments with Traditional Timber Roofs： Restoration versus Reconstruction

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Journal of Civil Engineering and Architecture 2011年第9期5卷 828-834页

作者： javier Garabito Jose Carlos Garabito Victor Echarri Angel Rodriguez Jesus Gadea Veronica Calderon Department of Building Construction University of Burgos Spain Department of Civil Engineering University of Burgos Spain Department of Building Construction University of Alicante Spain

We prioritize interventions in the roof structure in order to prevent subsequent deterioration of the monument. This presentation refers to interventions in two Spanish National Monuments： the Collegiate Church of Roa de Duero and San Esteban＇s church of Los Balbases. The Collegiate Church was built during the 16th century. It is considered the jewel of the villa. It is a ＂hallenkirche＂ model with three big naves of the same height covered by beautiful starry vaults. The intervention consisted of restoring the wooden roof structure, preserving the original 16th centary structure, by replacing the damaged elements. It was restored according to archaeological criteria. San Esteban＇s church is a 13 century Gothic style church with a Latin cross plan. It has three naves with a transept of great slenderness. It preserves Romanesque remains. Opposite to the previous intervention we decided to rebuild the roof because the former roof was totally distorted due to bad executed works during the past Century. In this way we regain the original shape of the church. These interventions aim to improve constructive and structural conditions as well as retrieve the image of both monuments. We have studied the visual impact of interventions through virtual recreations. The intervention criteria are very different, restoration versus structttral reconstruction.

关键词： Restoration roof timber structure heritage laminated wood.

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