检索结果-南通市图书馆

Dual regulatory role for phosphatase and tensin homolog in specification of intestinal endocrine cell subtypes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第14期18卷 1579-1589页

作者： Sébastien AB Roy Marie-Josée Langlois Julie C Carrier franois boudreau Nathalie Rivard Nathalie Perreault Canadian Institutes of Health Research Team on Digestive Epithelium Department of Anatomy and Cell BiologyFaculty of Medicine and Health SciencesUniversité de SherbrookeSherbrooke J1H 5N4QCCanada Canadian Institutes of Health Research Team on Digestive Epithelium Service of GastroenterologyFaculty of Medicine and Health SciencesUniversité de SherbrookeSherbrooke J1H 5N4QCCanada

AIM:To investigate the impact of phosphatase and tensin homolog(Pten) in the specification of intestinal enteroendocrine ***:Using the Cre/loxP system,a mouse with conditional intestinal epithelial Pten deficiency was *** mutant mice and controls were sacrificed and small intestines collected for immunofluorescence and quantitative real-time polymerase chain *** was collected on 16 h fasted mice by cardiac ***-linked immunosorbent assay was used to measure blood circulating ghrelin,somatostatin(SST) and glucose-dependent insulinotropic peptide(GIP) ***:Results show an unexpected dual regulatory role for epithelial Pten signalling in the specification/differentiation of enteroendocrine cell subpopulations in the small *** data indicate that Pten positively regulates chromogranin A(CgA) expressing subpopulations,including cells expressing secretin,ghrelin,gastrin and cholecystokinin(CCK).In contrast,Pten negatively regulates the enteroendocrine subtype specification of non-expressing CgA cells such as GIP and SST expressing ***:The present results demonstrate that Pten signalling favours the enteroendocrine progenitor to specify into cells expressing CgA including those producing CCK,gastrin and ghrelin.

关键词： Phosphatase and tensin homolog Enteroendocrine cells Intestinal epithelial cell specification Chromogranin A

Experimental and Numerical Analysis of a PCM-Integrated Roof for Higher Thermal Performance of Buildings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第2期33卷 522-536页

作者： SIMON françois RUIZ-VALERO Letzai GIRARD Aymeric GALLEGUILLOS Hector Centro de Desarrollo Urbano Sustentable(CEDEUS) Pontificia Universidad Católica de Chile7500000SantiagoChile Facultad de Ciencias e Ingeniería Pontificia Universidad Católica Madre y Maestra(PUCMM)10103Santo DomingoDominican Republic LMGC IMT Mines AlesUniv MontpellierCNRS30100AlèsFrance Facultad de Ingeniería y Ciencias Universidad Adolfo Ibañez2520000Viña del MarChile Centro de Desarrollo Energético Antofagasta(CDEA) Universidad de Antofagasta1240000AntofagastaChile

Phase change materials(PCMs) designate materials able to store latent *** change state from solid to liquid over a defined temperature *** process is reversible and can be used for thermo-technical *** present paper aims to study the thermal performance of an inorganic eutectic PCM integrated into the rooftop slab of a test room and analyze its potential for building thermal *** experiment is conducted in two test rooms in Antofagasta(Chile) during summer,fall,and *** PCM is integrated into the rooftop of the first test room,while the roof panel of the second room is a sealed air *** work introduces a numerical model,which is built using the finite difference method and used to simulate the rooms' thermal *** thermal simulations of the PCM room are performed for other Chilean locations to evaluate and compare the capability of the PCM panel to store latent heat thermal energy in different *** show that the indoor temperature of the PCM room in Antofagasta varies only 21.1℃±10.6℃,while the one of the air-panel room varies 28.3℃±18.5℃.Under the experiment's conditions,the PCM room's indoor temperature observes smoother diurnal fluctuations,with lower maximum and higher minimum indoor temperatures than that of the air-panel *** simulations in other cities show that the PCM panel has a better thermal performance during winter,as it helps to maintain or increase the room temperature by some degrees to reach comfort *** demonstrates that the implementation of such PCM in the building envelope can effectively reduce space heating and cooling needs,and improve indoor thermal comfort in different climates of Chile.

关键词： phase change material thermal energy storage building space heating and cooling energy efficiency designbuilder

Improving the utility of locally differentially private protocols for longitudinal and multidimensional frequency estimates

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Digital Communications and Networks 2024年第2期10卷 369-379页

作者： Héber H.Arcolezi Jean-françois Couchot Bechara Al Bouna Xiaokui Xiao Inria andÉcole Polytechnique(IPP) PalaiseauFrance Femto-ST Institute Univ.Bourg.Franche-ComtéUBFCCNRSBelfortFrance TICKET Lab. Antonine University Hadat-BaabdaBaabdaLebanon School of Computing National University of SingaporeSingaporeSingapore

This paper investigates the problem of collecting multidimensional data throughout time(i.e.,longitudinal studies)for the fundamental task of frequency estimation under Local Differential Privacy(LDP)*** to frequency estimation of a single attribute,the multidimensional aspect demands particular attention to the privacy ***,when collecting user statistics longitudinally,privacy progressively ***,the“multiple”settings in combination(i.e.,many attributes and several collections throughout time)impose several challenges,for which this paper proposes the first solution for frequency estimates under *** tackle these issues,we extend the analysis of three state-of-the-art LDP protocols(Generalized Randomized Response–GRR,Optimized Unary Encoding–OUE,and Symmetric Unary Encoding–SUE)for both longitudinal and multidimensional data *** the known literature uses OUE and SUE for two rounds of sanitization(***),i.e.,L-OUE and L-SUE,respectively,we analytically and experimentally show that starting with OUE and then with SUE provides higher data utility(i.e.,L-OSUE).Also,for attributes with small domain sizes,we propose Longitudinal GRR(L-GRR),which provides higher utility than the other protocols based on unary ***,we also propose a new solution named Adaptive LDP for LOngitudinal and Multidimensional FREquency Estimates(ALLOMFREE),which randomly samples a single attribute to be sent with the whole privacy budget and adaptively selects the optimal protocol,i.e.,either L-GRR or *** shown in the results,ALLOMFREE consistently and considerably outperforms the state-of-the-art L-SUE and L-OUE protocols in the quality of the frequency estimates.

关键词： Local differential privacy Discrete distribution estimation Frequency estimation Multidimensional data Longitudinal studies

A mediation system for continuous spatial queries on a unified schema using Apache Spark

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Big Earth Data 2024年第1期8卷 115-141页

作者： Thi Thu Trang Ngo françois Pinet David Sarramia Myoung-Ah Kang UniversitéClermont Auvergne ISIMAAubièreFrance UniversitéClermont Auvergne INRAEUR TSCFClermont-FerrandFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance

Recent advances in big and streaming data systems have enabled real-time analysis of data generated by Internet of Things(IoT)systems and sensors in various *** this context,many applications require integrating data from several heterogeneous sources,either stream or static *** such as Apache Spark are able to integrate and process large datasets from different ***,these frameworks are hard to use when the data sources are heterogeneous and *** address this issue,we propose a system based on mediation techniques for integrating stream and static data *** integration process of our system consists of three main steps:configuration,query expression and query *** the configuration step,an administrator designs a mediated schema and defines mapping between the mediated schema and local data *** the query expression step,users express queries using customized SQL grammar on the mediated ***,our system rewrites the query into an optimized Spark application and submits the application to a Spark *** results are continuously returned to *** experiments show that our optimizations can improve query execution time by up to one order of magnitude,making complex streaming and spatial data analysis more accessible.

关键词： Streaming data streaming data integration mediator geospatial data continuous queries

Template-free nanostructured particle growth via a one-pot continuous gradient nanoprecipitation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aggregate

Aggregate 2024年第1期5卷 409-418页

作者： Xie Cheng Shuai Wang Julien Bernard françois Ganachaud Xibo Yan School of Chemical Engineering and Technology Tianjin UniversityTianjinChina College of Food Science and Engineering Tianjin University of Science and TechnologyTianjinChina Universitéde Lyon CNRSUniversitéClaude Bernard Lyon 1INSA-LyonUniversitéJean MonnetUMR5223Ingénierie des Matériaux PolymèresVilleurbanne CedexFrance

Engineered nanoparticles have emerged as new types of materials for a wide range of applications from therapeutics to ***,fabricating nanomaterials presenting complex inner morphologies and shapes in a simple manner remains a great ***,we report the template-free one-pot continuous gradient nanoprecipitation of different types of non-compatible polymers to spontaneously form nanostructured *** continuous addition of antisolvent induces precipitation and(re)organization of polymer chains at the forming particle interface,ultimately and naturally developing complex inner morphologies and shapes while particle *** low-energy-cost bottom-up assembly approach applies to various functional polymers,possibly embedded with metal nanoparticles,for continuous growth into well-organized *** crosslinking of the particles and core removal allows both confirming the building process and leading to hollow or multivoid nanomaterials.

关键词： aggregation nanoprecipitation phase diagrams polymeric nanoparticles self-assembly

Energy Planning of Beijing Towards Low-carbon,Clean and Efficient Development in 2035

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2024年第3期10卷 913-928页

作者： Chengzhou Li Ningling Wang Xiaohu Shen Yumeng Zhang Zhiping Yang Xiaofeng Tong françois Maréchal Ligang Wang Yongping Yang Institute of Energy Power Innovation North China Electric Power UniversityBeijing 102206China School of Energy Power and Mechanical Engineering and National Research Center for Thermal Power Engineering and TechnologyNorth China Electric Power UniversityBeijing 102206China Industrial Process and Energy Systems Engineering Swiss Federal Institute of Technology in LausanneSionSwitzerland

Energy transition towards clean,efficient energy supply has been a common sense of the government and public in ***,lacking reasonable planning will lead to undisciplined development,resource waste,and excessive *** this context,this paper investigates potential pathways of Beijing energy transition towards a high-level low-carbon,clean and efficient energy system in 2035 with an extended energysocpe ***,based on available data,future energy demands are predicted by a newly proposed hybrid forecasting method,which combines the traditional regression model,grey model,and support vector machine model with an entropy-based weighted ***,the superstructure-based optimization model is employed to investigate the system configuration and operation strategy of the future Beijing energy ***,the uncertainty impact of electricity price,natural gas price,hydrogen price,and the capital expenditures of electrolyzer and steam methane reforming for hydrogen applications are *** forecasting results show that all walks of life will witness a continuously increasing energy demand in multiple sectors of Beijing towards *** planning results suggest that the imported electricity and natural gas will dominate the energy supply of Beijing in 2035 with a contribution of 86%of the energy resources consumption of 384 ***,the energy system presents a high end-use electrification level of 65%and high penetration of efficient technologies,which supply 119 TWh via combined heat and power,26 TWh via heat pump and 95 TWh via district heating *** energy use of various sectors of energy resources,technologies and end-use are closely *** will have an increased penetration in the private mobility sector,but the locally generated hydrogen is mainly from steam methane reforming technology.

关键词： Energy transition energy planning carbonneutral demand forecasting energyscope

Characterisation of the granular dynamics at the interface between a pipe and a granular flow in a rotating drum

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第3期86卷 117-125页

作者： francois Rioual Paule Emmanuelle Eva Gbehe Research Unit FRISE National Research Institute for Agriculture Food and the Environment1 Rue Pierre Gilles De Gennes92160AntonyFrance

A new mobile bed heat exchanger is presented in this work which is composed of a flowing granular material in a rotating drum and a cylindrical pipe with potential interest in different energy applications as cooling,heating or heat recovery *** optimal design of the device requires a characterisation of the phenomena involved at the interface between the granular flow and the *** process is modelled by the discrete element method and a global classification of the flow patterns around the pipe is presented with respect to the three main control parameters of the problem:the Froude number,the diameter ratio and the relative filling height of the *** second part is devoted to the characterisation of the structure of the flow at the interface(velocity field,density field)in particular in a so-called Biflow regime where granular motion occurs above as well as below the pipe which is favourable to transfer by convection.A typical behavior at the interface with the pipe consists of a zone I with high velocities of particles at the top of the pipe,a second zone with quasistatic particles or low velocity particles at the front and at the bottom of the pipe and a last zone ll of depletion of particles at the back of the *** Froude number has a limited effect on the features of this structure on the first layer in the range of Froude numbers considered whereas the relative height is a more determinant parameter to control the relative magnitude of velocities in zone I and zone Il as well as the extent of the depletion *** first hydrodynamical characterisation can shed light on the dynamical regimes with improved transfer between the particles and the pipe boundary.

关键词： Granular flow Transfer Heat exchange Mobile bed Boundary condition

Les hérauts de l'éradication Réunis à Yaounde le 6 mars dernier,1l pays africains ont joint leurs forces dans le but de mettre fin aux décès causés par le paludisme d'ici 2030

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国与非洲（法文版） 2024年第5期16卷 44-45页

作者： franÇois ESSOMBA 不详

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于指针神经网络的细粒度缺陷定位

软件学报 2024年第4期35卷 1841-1860页

作者：王尚文刘逵林博黎立 Jacques KLEIN Tegawendéfrançois BISSYANDÉ 毛晓光国防科技大学计算机学院湖南长沙410073 南京航空航天大学计算机科学与技术学院江苏南京210016 Monash University Clayton VIC 3800Australia University of Luxembourg Luxembourg L-1359Luxembourg

软件缺陷定位是指找出与软件失效相关的程序元素.当前的缺陷定位技术仅能产生函数级或语句级的定位结果.这种粗粒度的定位结果会影响人工调试程序和软件缺陷自动修复的效率和效果.专注于细粒度地识别导致软件缺陷的具体代码令牌,为代码... 详细信息

软件缺陷定位是指找出与软件失效相关的程序元素.当前的缺陷定位技术仅能产生函数级或语句级的定位结果.这种粗粒度的定位结果会影响人工调试程序和软件缺陷自动修复的效率和效果.专注于细粒度地识别导致软件缺陷的具体代码令牌,为代码令牌建立抽象语法树路径,提出基于指针神经网络的细粒度缺陷定位模型来预测出具体的缺陷代码令牌和修复该令牌的具体操作行为.开源项目中的大量缺陷补丁数据集包含大量可供训练的数据,且基于抽象语法树构建的路径可以有效捕获程序结构信息.实验结果表明所训练出的模型能够准确预测缺陷代码令牌并显著优于基于统计的与基于机器学习的基线方法.另外,为了验证细粒度的缺陷定位结果可以贡献于缺陷自动修复,基于细粒度的缺陷定位结果设计两种程序修复流程,即代码补全工具去预测正确令牌的方法和启发式规则寻找合适代码修复元素的方法,结果表明两种方法都能有效解决软件缺陷自动修复中的过拟合问题.

关键词：缺陷定位缺陷自动修复神经网络