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Medicinal mushrooms in supportive cancer therapies:an approach to anti-cancer effects and putative mechanisms of action

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Fungal Diversity 2012年第4期55卷 1-35页

作者： Dilani D.De Silva Sylvie Rapior françoise fons Ali H.Bahkali Kevin D.Hyde Institute of Excellence in Fungal Research Mae Fah Luang University333 M.1 T.Tasud Muang DistrictChiang Rai 57100Thailand e-mail:kdhyde3@*** School of Science Mae Fah Luang University333 M.1 T.Tasud Muang DistrictChiang Rai 57100Thailand Department of Botany Faculty of ScienceUniversity of PeradeniyaPeradeniya 20500Sri Lanka Faculty of Pharmacy University Montpellier 1UMR 5175 CEFEBP 1449115avenue Charles-Flahault34093Montpellier Cedex 5France Botany and Microbiology Department College of ScienceKing Saud UniversityRiyadh 11442Saudi Arabia

Medicinal mushrooms have been valued as natural sources of bioactive compounds since times immemorial and have been recognized as potential immunomodulating and anti-cancer *** consumption has consistently been shown to have beneficial effects on human *** is a generic term for several types of diseases that can be chronic and are responsible for a large number of deaths *** there has been considerable progress in modern cancer therapy research,difficulties in understanding the molecular behavior of various types of cancers and the numerous side effects experienced by patients from treatments means that this whole subject area is still ***,biological immunotherapy using natural bioactive compounds as supportive treatments in conventional cancer therapies has become in *** metabolites isolated from medicinal mushrooms have shown potential successes in cancer treatment as biological immunotherapeutic agents that stimulate the immune system against cancer *** also act as an effective source of anti-cancer agents,capable of interfering with cellular signal transduction pathways linked to cancer development and *** this review we compile available data on the characteristics of medicinal mushrooms that appear to be particularly effective as biological immunotherapeutic *** consideration is given to biological constituents and the putative mechanisms of action by which bioactive compounds act on the human *** is also given to the benefits that have been claimed for the use of mushrooms in treating cancer and the future prospects of using medicinal mushrooms as potent supportive candidate bioagents for treatment of cancers is discussed.

关键词： Medicinal mushrooms Cancer Anti-cancer Immunomodulation Bioactive metabolites

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The Art of Conversing

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空中英语教室（高级版．彭蒙惠英语） 2016年第3期 26-27,44,45页

作者： Mary fons

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Pancreatic adenosquamous carcinoma and intraductal papillary mucinous neoplasm in a CDKN2A germline mutation carrier

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World Journal of Gastrointestinal Oncology 2017年第9期9卷 390-396页

作者： Fernando Martínez de Juan María Reolid Escribano Carmen Martínez Lapiedra Fernanda Maia de Alcantara María Caballero Soto Ana Calatrava fons Isidro Machado Gastroenterology and Digestive Endoscopy Department Valencian Institute of Oncology Digestive Surgery Department Valencian Institute of Oncology Pathology Department Valencian Institute of Oncology

A 69-year-old woman from a kindred with familial atypical multiple mole melanoma and carrier of a germline mutation in CDKN2A, presented with abdominal pain caused by a solid-cystic pancreatic mass. The patient had an abdominal computed tomography three years before in which there was no evidence of pancreatic lesion. The endoscopic ultrasound guided fine needle aspiration showed adenocarcinoma with squamous component. After surgical resection the final diagnosis was adenosquamous pancreatic carcinoma(ASPC) arising in an intraductal papillar mucinous neoplasm(IPMN). Adenosquamous carcinomas are uncommon in the pancreas and have rarely been described in association with IPMNs. It has worse prognosis than the ordinary pancreatic ductal adenocarcinoma and some distinct features. We review the clinical, imaging, pathologic and molecular aspects of ASPC. Differential diagnosis with contamination, squamous metaplasia and pancreatic metastases from a distant squamous carcinoma is discussed. Besides, the case is an accelerated model of the adenoma(IPMN)-carcinoma sequence probably due to the CDKN2A ger-mline mutation. Somatic CDKN2A mutations are commonevents in the early steps of sporadic pancreatic cancer, but germline mutation carriers have a significantly higher risk of pancreatic carcinoma.

关键词： Intraductal papillary mucinous neoplasia Melanoma-pancreatic cancer syndrome Adenosquamous carcinoma Pancreatic carcinoma CDKN2A

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基于FPGA的汽车ECU设计

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中国电子商情(基础电子) 2012年第9期 66-70页

作者： francisco fons Mariano fons 西班牙塔拉戈纳Rovirai Virgili大学

当今的汽车制造商正在把越来越多的高级功能添加到汽车电子控制单元(ECU)中,以改善驾驶体验,增强安全性,当然还期望超过同类竞争产品的销量。在这种情况下,汽车开放系统架构(AUTOSAR)计划和功能安全国际标准ISO26262正在快速成为汽车EC... 详细信息

当今的汽车制造商正在把越来越多的高级功能添加到汽车电子控制单元(ECU)中,以改善驾驶体验,增强安全性,当然还期望超过同类竞争产品的销量。在这种情况下,汽车开放系统架构(AUTOSAR)计划和功能安全国际标准ISO26262正在快速成为汽车ECU设计的技术和架构基础。我们推出了一种具有开创性的方法,即使用可编程FPGA器件而非基于MCU的平台作为ECU的基础,设计出一款能够同时满足AUTOSAR和ISO 26262标准的汽车ECU。我们

关键词： ECU MCU AUTOSAR FPGA 可编程逻辑器件软件组件软件工具汽车

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基于SRAM并部分可重配置的FPGA设计ECU

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中国电子商情(基础电子) 2012年第10期 38-39页

作者： francisco fons Mariano fons 西班牙塔拉戈纳Rovirai Virgili大学

在运行时可重配置硬件上进行ECU设计采用基于SRAM并具备运行时部分可重配置功能的FPGA设计ECU,能够为汽车设计人员提供更多优势。事实上,其中的一大优势是如果FPGA包含有不必在启动时(如在ECU唤醒或加电)配置的部分可重配置区域,可以缩... 详细信息

在运行时可重配置硬件上进行ECU设计采用基于SRAM并具备运行时部分可重配置功能的FPGA设计ECU,能够为汽车设计人员提供更多优势。事实上,其中的一大优势是如果FPGA包含有不必在启动时(如在ECU唤醒或加电)配置的部分可重配置区域,可以缩短系统启动时间。不支持动态部分可重配置的FPGA在加电时需要配置所有的FPGA资源,但运行时可重配置FPGA只需下载部分位流进行部分重配置。

关键词：可重配置运行时 ECU SRAM FPGA

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