检索结果-南通市图书馆

Cellular & Molecular Immunology 2019年第7期16卷 671-673页

作者： Hussein Issaoui Nour Ghazzaui Mélissa Ferrad françois Boyer Yves Denizot UMR CNRS 7276 INSERM U1262Equipe Labellisée LIGUE 2018University of LimogesCBRSrue Pr.Descottes87025 LimogesFrance

After encountering antigen,B-cells undergo class switch recombination(CSR)that substitutes the constant(C)μgene with Cγ,Cε,or Cα,thereby generating IgG,Ige,and IgA antibodies with new effector functions but the same antigenic specificity.1 The DNA-editing enzyme activation-induced deaminase(AID)is required for CSR by targeting specific DNA switch(S)regions preceding the C region,except Cδ.2 Sμis the donor region,while Sγ,ε,αare the acceptor *** is controlled in cis by the immunoglobulin heavy chain(IgH)3’regulatory region(3’RR).3 The 3’RR is essential to poise AID on the S acceptor *** CSR IgH,intrachromosomal interactions(schematized in Fig.1a)are found between the 3’RR and the intronic eμenhancer.1,4 Looping allows transcriptional binding activators to enhancers to facilitate ***,CSR is only modestly influenced by eμdeletion.5–7 During CSR,two different DNA repair pathways take place:the classical nonhomologous end joining(c-NHeJ)and the alternative end joining(A-eJ)pathways.

关键词： joining thereby generating

An Infinite Family of Number Fields with No Inert Primes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Pure Mathematics 2022年第12期12卷 744-756页

作者： françois e.manue. tanoé UFR Mathematics and Computer Science Félix Houphouet-BOIGNY University Abidjan Ivory Coast

The goal of this paper is to show that there are infinitely many number fields K/Q, for which there is no inert prime p ∈ N*, i.e. ∀p ∈ N* a prime number, prime ideal of K such that where: Zk is the Dedekind domain of the integer elements of K. To prove such a result, consider for any prime p, the decomposition into a product of prime ideals of Zk, of the ideal . From this point, we use on the one hand: 1) The well- known property that says: If , then the ideal pZk decomposes into a product of prime ideals of Zk as following: . (where:;is the irreducible polynomial of θ, and, is its reduction modulo p, which leads to a product of irreducible polynomials in Fp[X]). It is clear that because if is reducible in Fp[X], then consequently p is not inert. Now, we prove the existence of such p, by proving explicit such p as follows. So we use on the other hand: 2) this property that we prove, and which is: If , is an irreducible normalized integer polynomial, whose splitting field is , then for any prime number p ∈ N: is always a reducible polynomial. 3) Consequently, and this closes our proof: let’s consider the set (whose cardinality is infinite) of monogenic biquadratic number fields: . Then each fθ(X) checks the above properties, this means that for family M, all its fields, do not admit any inert prime numbers p ∈ N. 2020-Mathematics Subject Classification (MSC2020) 11A41 - 11A51 - 11D25 - 11R04 - 11R09 - 11R11 - 11R16 - 11R32 - 11T06 - 12e05 - 12F05 -12F10 -13A05-13A15 - 13B02 - 13B05 - 13B10 - 13B25 -13F05

关键词： Fields extensions Splitting Fields Polynomials Finite Fields extensions Polynomials of Fp[X] Dedekind Ring Ramification Theory Monogeneity Quadratic & Biquadratic Fields Irreducible Polynomials of Degree 3 & 4

Characterization of Particle emissions of Turbocharged Direct Injection Gasoline engine in Transients and Hot Start Conditions

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2021年第6期30卷 2056-2070页

作者： Vincent BeRTHOMe David CHALeT Jean-françois HeTeT ecole Centrale de Nantes LHEEA Lab.(ECN/CNRS)Nantes 44300France

Reducing pollutant emissions,particularly soot particles emitted by internal combustion engines,is a major challenge for car *** this paper,the experimental setup is a turbocharged three-cylinders gasoline direct injection engine installed on a HORIBA dynamic test driven by a HORIBA STARS *** particle-measuring device is a Pegasor Particles Sensor that measures the current carried by previously electrically charged *** hot engine stabilized tests,with lambda parameter lower or equal to one,have very low emission levels,unlike dynamic *** a consequence,the present paper deals with experiments in transient *** diesel engine,cycle tests show that particulate emissions vary *** understand the phenomenon,a simple transient was created and reproduced a hundred times in order to obtain enough data to analyze and compare these different *** transient starts from idle to reach the speed of 2000 r/min and 60 N·m in 5 *** reach this point,it is necessary to stay in full load for about 3 *** maximum deviations of particles reaches 85%with the standard deviationσ=18%.The cylinder pressure sensor shows significant variations at the very beginning of each transient,i.e.,during the first 500 *** kind of result was observed for Worldwide harmonized Light vehicles Test Cycles(WLTC)with a maximum deviations of particles reaching 75%withσ=30%,on Real Drive emissions Cycle(RDe)with a maximum deviations of particles reaching 45%withσ=22%and for a 300 s Mini-Cycle with a maximum deviations of particles reaching 70%withσ=17%.The Mini-cycle is made up of the five largest accelerations of the WLTP cycle.A complete analysis highlights the importance of filling the first engine *** depends on the opening speed of the throttle,the position of the crankshaft at the beginning of the transient,and the acceleration of the first ***,the NO_(x) sensor shows very slight variations between each *** a consequence,i

关键词： particles gasoline engine cycle-to-cycle variations transients oil consumption

Describing failure in geomaterials using second-order work approach

在线全文

学校读者我要写书评

暂无评论

Water Science and engineering 2015年第2期8卷 89-95页

作者： franois Nicot Félix Darve Institut de Recherche en Sciences et Technologies de l'environnement et de l'Agriculture(IRSTeA) Erosion Torrentielle Neige et Avalanches (ETNA)Geomechanics GroupGrenoble 38402 France Université Joseph Fourier (UJF)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS) Laboratoire SolsSolides Structures et RisquesGrenoble 38041 France

Geomaterials are known to be non-associated materials. Granular soils therefore exhibit a variety of failure modes, with diffuse or localized kinematical patterns. In fact, the notion of failure itself can be confusing with regard to granular soils, because it is not associated with an obvious phenomenology. In this study, we built a proper framework, using the second-order work theory, to describe some failure modes in geomaterials based on energy conservation. The occurrence of failure is defined by an abrupt increase in kinetic energy. The increase in kinetic energy from an equilibrium state, under incremental loading, is shown to be equal to the difference between the external second-order work,involving the external loading parameters, and the internal second-order work, involving the constitutive properties of the material. When a stress limit state is reached, a certain stress component passes through a maximum value and then may decrease. Under such a condition, if a certain additional external loading is applied, the system fails, sharply increasing the strain rate. The internal stress is no longer able to balance the external stress, leading to a dynamic response of the specimen. As an illustration, the theoretical framework was applied to the well-known undrained triaxial test for loose soils. The influence of the loading control mode was clearly highlighted. It is shown that the plastic limit theory appears to be a particular case of this more general second-order work theory. When the plastic limit condition is met, the internal second-order work is nil. A class of incremental external loadings causes the kinetic energy to increase dramatically, leading to the sudden collapse of the specimen, as observed in laboratory.

关键词： Failure in geomaterials Undrained triaxial loading path Second-order work Kinetic energy Plastic limit condition Control parameter

A Formal Passage From a System of Boltzmann equations for Mixtures Towards a Vlasov-euler System of Compressible Fluids

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2019年第1期35卷 158-173页

作者： Laurent DeSVILLeTTeS fran?ois GOLSe Valeria RICCI Université Paris Diderot Sorbonne Paris Cité Institut de Mathématiques de Jussieu-Paris Rive GaucheUMR CNRS 7586 CNRS Sorbonne Universités UPMC Univ CMLS Ecole polytechnique et CNRS Université Paris-Saclay Dipartimento di Matematica e Informatica Università degli Studi di Palermo

A formal asymptotics leading from a system of Boltzmann equations for mixtures towards either Vlasov-Navier-Stokes or Vlasov-Stokes equations of incompressible fluids was established by the same authors and etienne Bernard in: A Derivation of the Vlasov-Navier-Stokes Model for Aerosol Flows from Kinetic Theory Commun. Math. Sci., 15: 1703–1741(2017) and A Derivation of the Vlasov-Stokes System for Aerosol Flows from the Kinetic Theory of Binary Gas Mixtures. KRM, 11: 43–69(2018). With the same starting point but with a different scaling, we establish here a formal asymptotics leading to the Vlasov-euler system of compressible fluids. explicit formulas for the coupling terms are obtained in two typical situations: for elastic hard spheres on one hand, and for collisions corresponding to the inelastic interaction with a macroscopic dust speck on the other hand.

关键词： Vlasov-euler system Boltzmann equation Hydrodynamic limit Aerosols Sprays Gas mixture

Pythagorician Divisors and Applications to Some Diophantine equations

在线全文

学校读者我要写书评

暂无评论

Advances in Pure Mathematics 2023年第2期13卷 35-70页

作者： françois e.manue. tanoé Prosper Kouadio Kimou UFR Mathématiques et Informatique. Université Félix Houphouë t BOIGNY Abidjan C&#244te D’ivoire Laboratoire d’Informatique et de Mathématiques Appliquées. Institut Polytechnique Félix Houphouë t BOIGNY Yamoussoukro C&#244te D’ivoire

We consider the Pythagoras equation X2 +Y2 = Z2, and for any solution of the type (a,b = 2sb1 ≠0,c) ∈ N*3, s ≥ 2, b1odd, (a,b,c) ≡ (±1,0,1)(mod 4), c > a , c > b, and gcd(a,b,c) = 1, we then prove the Pythagorician divisors Theorem, which results in the following: , where (d,d′′) (resp. (e,en)) are unique particular divisors of a and b, such that a = dd′′ (resp. b = ee′′ ), these divisors are called: Pythagorician divisors from a, (resp. from b). Let’s put λ ∈{0,1}, defined by: and S = s -λ (s -1). Then such that . Moreover the map is a bijection. We apply this new tool to obtain a new classification of the primitive, positive and non-trivial solutions of the Pythagoras equations: a2 + b2 = c2 via the Pythagorician parameters (d,e,S ). We obtain for (d, e) fixed, the equivalence class of any Pythagorician solution (a,b,c), checking , namely: . We also update the solutions of some Diophantine equations of degree 2, already known, but very important for the resolution of other equations. With this tool of Pythagorean divisors, we have obtained (in another paper) new recurrent methods to solve Fermat’s equation: a4 + b4 = c4, other than usual infinite descent method;and to solve congruent numbers problem. We believe that this tool can bring new arguments, for Diophantine resolution, of the general equations of Fermat: a2p + b2p = c2p and ap + bp = cp. MSC2020-Mathematical Sciences Classification System: 11A05-11A51-11D25-11D41-11D72.

关键词： Pythagoras equation Pythagorician Triplets Diophantine equations of Degree 2 Factorisation-Gcd-Fermat’s equations

experimental and Numerical Analysis of a PCM-Integrated Roof for Higher Thermal Performance of Buildings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第2期33卷 522-536页

作者： SIMON françois RUIZ-VALeRO Letzai GIRARD Aymeric GALLeGUILLOS Hector Centro de Desarrollo Urbano Sustentable(CeDeUS) Pontificia Universidad Católica de Chile7500000SantiagoChile Facultad de Ciencias e Ingeniería Pontificia Universidad Católica Madre y Maestra(PUCMM)10103Santo DomingoDominican Republic LMGC IMT Mines AlesUniv MontpellierCNRS30100AlèsFrance Facultad de Ingeniería y Ciencias Universidad Adolfo Ibañez2520000Viña del MarChile Centro de Desarrollo energético Antofagasta(CDeA) Universidad de Antofagasta1240000AntofagastaChile

Phase change materials(PCMs) designate materials able to store latent *** change state from solid to liquid over a defined temperature *** process is reversible and can be used for thermo-technical *** present paper aims to study the thermal performance of an inorganic eutectic PCM integrated into the rooftop slab of a test room and analyze its potential for building thermal *** experiment is conducted in two test rooms in Antofagasta(Chile) during summer,fall,and *** PCM is integrated into the rooftop of the first test room,while the roof panel of the second room is a sealed air *** work introduces a numerical model,which is built using the finite difference method and used to simulate the rooms' thermal *** thermal simulations of the PCM room are performed for other Chilean locations to evaluate and compare the capability of the PCM panel to store latent heat thermal energy in different *** show that the indoor temperature of the PCM room in Antofagasta varies only 21.1℃±10.6℃,while the one of the air-panel room varies 28.3℃±18.5℃.Under the experiment's conditions,the PCM room's indoor temperature observes smoother diurnal fluctuations,with lower maximum and higher minimum indoor temperatures than that of the air-panel *** simulations in other cities show that the PCM panel has a better thermal performance during winter,as it helps to maintain or increase the room temperature by some degrees to reach comfort *** demonstrates that the implementation of such PCM in the building envelope can effectively reduce space heating and cooling needs,and improve indoor thermal comfort in different climates of Chile.

关键词： phase change material thermal energy storage building space heating and cooling energy efficiency designbuilder

Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第1期20卷 22-30页

作者： Jean-Philippe Babeu franois Boudreau Département d’ Anatomie et de Biologie Cellulaire Faculté de Médecine et des Sciences de la SantéUniversité de SherbrookeSherbrooke J1E 4K8QuébecCanada

Hepatocyte nuclear factor 4-alpha (HNF4-α) is a nuclear receptor regulating metabolism, cell junctions, differentiation and proliferation in liver and intestinal epithelial cells. Mutations within the HNF4A gene are associated with human diseases such as maturity-onset diabetes of the young. Recently, HNF4A has also been described as a susceptibility gene for ulcerative colitis in genome-wide association studies. In addition, specific HNF4A genetic variants have been identified in pediatric cohorts of Crohn’s disease. Results obtained from knockout mice supported that HNF4-α can protect the intestinal mucosae against inflammation. However, the exact molecular links behind HNF4-α and inflammatory bowel diseases remains elusive. In this review, we will summarize the current knowledge about the role of HNF4-α and its isoforms in inflammation. Specific nature of HNF4-α P1 and P2 classes of isoforms will be summarized. HNF4-α role as a hepatocyte mediator for cytokines relays during liver inflammation will be integrated based on documented examples of the literature. Conclusions that can be made from these earlier liver studies will serve as a basis to extrapolate correlations and divergences applicable to intestinal inflammation. Finally, potential functional roles for HNF4-α isoforms in protecting the intestinal mucosae from chronic and pathological inflammation will be presented.

关键词： Hepatocyte nuclear factor 4-alpha Inflammatory bowel diseases Colitis-associated cancer Gastrointestinal tract Intestinal epithelium barrier Inflammation

Interendoscopist variability in proximal colon polyp detection is twice higher for serrated polyps than adenomas

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第38期22卷 8549-8557页

作者： Jean-françois Bretagne Stéphanie Hamonic Christine Piette Jean-françois Viel Guillaume Bouguen Service des maladies de l'appareil digestif hopital PontchaillouCentre hospitalo-universitaire de Rennes35033 RennesFrance Service d'épidémiologie et de santé publique Centre hospitalo-universitaire de Rennes35033 Rennes France Association pour le dépistage des cancers en Ille et Vilaine 35033 RennesFrance

AIM To assess the interendoscopist variability in the detection of colorectal polyps according to their location and histological *** This study was a retrospective analysis of prospectively collected data from a regional colorectal cancer(CRC) screening program; 2979 complete colonoscopies from 18 endoscopists were included. Variability in performance between endoscopists for detection of at least one adenoma(A), one proximal adenoma(PA), one distal adenoma(DA), and one proximal serrated polyp(PSP) was assessed by using multilevel logistic regression *** The observed detection rates among the 18 endoscopists ranged from 24.6% to 47.6%(mean = 35.7%) for A, from 19.1% to 39.0%(mean = 29.4%) for DA, from 6.0% to 22.9%(mean = 12.4%) for PA, and from 1.3% to 19.3%(mean = 6.9%) for *** adjusting for patient-level variables(sex, age), the interendoscopist detection rates variability achieved a significant level for A, PA, and PSP but not for DA(P = 0.03, P = 0.02, P = 0.02 and P = 0.08, respectively). This heterogeneity, as measured by the variance partition coefficient, was approximately threefold higher for PA(6.6%) compared with A(2.1%), and twofold higher for PSP(12.3%) compared with *** These results demonstrate significant interendoscopist variability for proximal polyp particularly for serrated p o l y p s, b u t n o t f o r d i s t a l a d e n o m a d e t e c t i o n. These findings contribute to explain the decreased effectiveness of complete colonoscopies at preventing proximal CRCs and the need to carefully assess the proximal colon during scope procedure.

关键词： Colonoscopy Colorectal cancer Adenoma Serrated polyp Proximal polyp Detection rate Quality performance

What is artificial meat and what does it mean for the future of the meat industry?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2015年第2期14卷 255-263页

作者： Sarah P F Bonny Graham e Gardner David W Pethick Jean-franois Hocquette School of Veterinary and Life Sciences Murdoch UniversityMurdoch W.A. 6150 Australia INRA UMR1213 Recherches sur les HerbivoresSaint-Genès Champanelle F-63122 France Clermont Université Vet Agro Sup UMR1213 Recherches sur les HerbivoresSaint-Genès Champanelle F-63122 France

The meat industry cannot respond to increases in demand by ever increasing resource use. The industry must find solutions to issues regarding animal welfare, health and sustainability and will have to do so in the face of competition from emerging non-traditional meat and protein products in an increasingly complex regulatory environment. These novel meat and protein products, otherwise known as ‘artificial meat＇ are utilising ground breaking technologies designed to meet the issues facing the conventional meat industry. These artificial meats, in vitro or cultured meat and meat from genetically modified organisms have no real capacity to compete with conventional meat production in the present environment. However, meat replacements manufactured from plant proteins and mycoproteins are currently the biggest competitors and are gaining a small percentage of the market. Manufactured meats may push conventional meat into the premium end of the market, and supply the bulk, cheap end of the market if conventional meat products become more expensive and the palatability and versatility of manufactured meats improve. In time the technology for other artificial meats such as meat from genetic modified organisms or cultured meat may become sufficiently developed for these products to enter the market with no complexity of the competition between meat products. Conventional meat producers can assimilate agroecology ecology concepts in order to develop sustainable animal production systems. The conventional meat industry can also benefit from assimilating biotechnologies such as cloning and genetic modification technologies, using the technology to adapt to the changing environment and respond to the increasing competition from artificial meats. Although it will depend at least partly on the evolution of conventional meat production, the future of artificial meat produced from stem cells appears uncertain at this time.

关键词： artificial meat in vitro meat meat industry consumer satisfaction sustainable production