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Interendoscopist variability in proximal colon polyp detection is twice higher for serrated polyps than adenomas

World Journal of Gastroenterology 2016年第38期22卷 8549-8557页

作者： Jean-françois Bretagne Stéphanie Hamonic Christine Piette Jean-françois Viel Guillaume Bouguen Service des maladies de l'appareil digestif hopital PontchaillouCentre hospitalo-universitaire de Rennes35033 RennesFrance Service d'épidémiologie et de santé publique Centre hospitalo-universitaire de Rennes35033 Rennes France Association pour le dépistage des cancers en Ille et Vilaine 35033 RennesFrance

AIM To assess the interendoscopist variability in the detection of colorectal polyps according to their location and histological *** This study was a retrospective analysis of prospectively collected data from a regional colorectal cancer(CRC) screening program; 2979 complete colonoscopies from 18 endoscopists were included. Variability in performance between endoscopists for detection of at least one adenoma(A), one proximal adenoma(PA), one distal adenoma(DA), and one proximal serrated polyp(PSP) was assessed by using multilevel logistic regression *** The observed detection rates among the 18 endoscopists ranged from 24.6% to 47.6%(mean = 35.7%) for A, from 19.1% to 39.0%(mean = 29.4%) for DA, from 6.0% to 22.9%(mean = 12.4%) for PA, and from 1.3% to 19.3%(mean = 6.9%) for *** adjusting for patient-level variables(sex, age), the interendoscopist detection rates variability achieved a significant level for A, PA, and PSP but not for DA(P = 0.03, P = 0.02, P = 0.02 and P = 0.08, respectively). This heterogeneity, as measured by the variance partition coefficient, was approximately threefold higher for PA(6.6%) compared with A(2.1%), and twofold higher for PSP(12.3%) compared with *** These results demonstrate significant interendoscopist variability for proximal polyp particularly for serrated p o l y p s, b u t n o t f o r d i s t a l a d e n o m a d e t e c t i o n. These findings contribute to explain the decreased effectiveness of complete colonoscopies at preventing proximal CRCs and the need to carefully assess the proximal colon during scope procedure.

关键词： Colonoscopy Colorectal cancer Adenoma Serrated polyp Proximal polyp Detection rate Quality performance

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Roadside vehicle particulate matter concentration estimation using artificial neural network model in Addis Ababa,Ethiopia

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Journal of Environmental Sciences 2021年第3期33卷 428-439页

作者： Solomon Neway Jida Jean-françois Hetet Pascal Chesse Awoke Guadie Research Laboratory in Hydrodynamics Energetics&Atmospheric Environment(LHEEA)École Centrale de NantesNantes 44300France Department of Mechanical Engineering Faculty of Mechanical&Production EngineeringInstitute of TechnologyArba Minch UniversityArba Minch 21Ethiopia Key Laboratory of Environmental Biotechnology Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China Department of Biology College of Natural SciencesArba Minch UniversityArba Minch 21Ethiopia

Currently,vehicle-related particulate matter is the main determinant air pollution in the urban *** study was designed to investigate the level of fine(PM_(2.5))and coarse particle(PM_(10))concentration of roadside vehicles in Addis Ababa,the capital city of Ethiopia using artificial neural network *** train,test and validate the model,the traffic volume,weather data and particulate matter concentrations were collected from 15 different sites in the *** experimental results showed that the city average 24-hr PM_(2.5)concentration is 13%-144%and 58%-241%higher than air quality index(AQI)and world health organization(WHO)standards,*** PM_(10)results also exceeded the AQI(54%-65%)and WHO(8%-395%)*** model runs using the Levenberg-Marquardt(Trainlm)and the Scaled Conjugate Gradient(Trainscg)and comparison were performed,to identify the minimum fractional error between the observed and the predicted *** two models were determined using the correlation coefficient and other statistical *** Trainscg model,the average concentration of PM_(2.5)and PM_(10)exhaust emission correlation coefficient were predicted to be(R^(2)=0.775)and(R^(2)=0.92),*** Trainlm model has also well predicted the exhaust emission of PM_(2.5)(R~2=0.943)and PM_(10)(R^(2)=0.959).The overall results showed that a better correlation coefficient obtained in the Trainlm model,could be considered as optional methods to predict transport-related particulate matter concentration emission using traffic volume and weather data for Ethiopia cities and other countries that have similar geographical and development settings.

关键词： Addis Ababa Artificial neural network PM prediction Roadside emission

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GENERALIZATION OF THE INTERACTION BETWEEN HAAR APPROXIMATION AND POLYNOMIAL OPERATORS TO HIGHER ORDER METHODS

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Analysis in Theory and Applications 2006年第4期22卷 301-318页

作者： fran ois Chaplais école Nationale Supérieure des Mines de Paris France

In applications it is useful to compute the local average empirical statistics on u. A very simple relation exists when of a function f（u） of an input u from the local averages are given by a Haar approximation. The question is to know if it holds for higher order approximation methods. To do so, it is necessary to use approximate product operators defined over linear approximation spaces. These products are characterized by a Strang and Fix like condition. An explicit construction of these product operators is exhibited for piecewise polynomial functions, using Hermite interpolation. The averaging relation which holds for the Haar approximation is then recovered when the product is defined by a two point Hermite interpolation.

关键词： Strang and Fix conditions product approximation Hermite interpolation wavelets

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Interaction between a diesel-fuel spray and entrained air with single- and double-injection strategies using large eddy simulations

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Propulsion and Power Research 2020年第1期9卷 37-50页

作者： Jonathan Brulatout françois Garnier Patrice Seers Mechanical Engineering Department École de Technologie Supérieure1100 Notre-Dame Street WestMontrealH3C 1K3Canada

Interaction between fuel and air in a combustion chamber is one of the main drivers of the mixing ***,flow visualizations are limited by high droplet density in the ***,the ability of large eddy simulations(LES)to resolve large scales of flow offers good perspectives on capturing flow structures issued from the interaction between the Lagrangian(fuel droplets)and Eulerian(ambient gas)*** study examined these interactions first during a single injection using 3D and 2D criteria for both *** for the 3D criteria,the spray shape was analyzed in parallel to the Q-criteria applied to the Eulerian phase,making it possible to relate the spray deformations to some specific Eulerian ***,2D criteria were the fuel mass-fraction field and Eulerian streamlines,both taken in the mid-plane of the *** last analysis allows for identifying certain mechanisms involved in the Eulerian phase’s structure generation and relates it to high fuel-concentration areas in the fuel mass-fraction visualizations.

关键词： Diesel fuel spray Large eddy simulation Multiple injection Coherent structures Lagrangian-Eulerian interaction Air-spray interactions

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Severe acute respiratory syndrome coronavirus-2-related and imputable deaths in children:results from the French pediatric national registry

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World Journal of Pediatrics 2024年第6期20卷 611-620页

作者： Marguerite Lockhart-Bouron Noemie Vanel Michael Levy Anais R.Briant Etienne Javouhey Sophie Breinig Julia Dina Marion Caseris francois Angoulvant Stephane Leteurtre Morgan Recher David W.Brossier Univ.Lille CHU LilleULR 2694-METRICS:Evaluation Des Technologies de Sante Et Des Pratiques Medicales59000LilleFrance Pediatric Intensive Care Unit CHU de MarseilleMarseilleFrance Pediatric Intensive Care Unit CHU Robert-DebreAssistance Publique Hopitaux de ParisParisFrance UniversitéParis-Cite ParisFrance Biostatistics and Clinical Research Unit CHU de Caen Normandie14000CaenFrance Pediatric Intensive Care Hospices Civils de LyonLyonFrance Neonatal andPediatric IntensiveCare Unit Children's HospitalToulouseFrance Virology Department INSERM U1311 DynamicureUniv CAEN NormandieCHU de Caen14000 CaenFrance Medical School Universite Caen Normandie14000 CaenFrance Department of Pediatrics CHU Robert-DebréAssistance Publique Hopitaux de ParisParisFrance Department Women-Mother-Child Service of PediatricsLausanne University Hospital(CHUV)LausanneSwitzerland Pediatric Intensive Care Unit Réanimation Et Soins Intensifs PéediatriquesCHU de CAENAvenue de La Cote de Nacre14000 CaenFrance CHU Sainte Justine Research Center MontréalCanada

Background Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)is responsible for an important mortality rate *** aimed to evaluate the actual imputability of SARS-CoV-2 on the mortality rate associated with SARS-CoV-2-related illnesses in the pediatric intensive care unit(PICU).Secondary objectives were to identify risk factors for *** This national multicenter comparative study comprised all patients under 18 years old with positive SARS-CoV-2 polymerase chain reactions(PCRs)[acute corona virus disease 2019(COVID-19)or incidental SARS-CoV-2 infection]and/or pediatric inflammatory multisystem syndrome(PIMS)recorded in the French PICU registry(PICURe)between September 1,2021,and August 31,*** patients were classified and compared according to their living status at the end of their PICU *** patients were evaluated by four experts in the field of pediatric infectiology and/or pediatric intensive *** imputability of SARS-CoV-2 as the cause of death was classified into four categories:certain,very probable,possible,or unlikely,and was defined by any of the first three *** There were 948 patients included of which 43 died(4.5%).From this,26 deaths(67%)could be attributed to SARS-CoV-2 infection,with an overall mortality rate of 2.8%.The imputability of death to SARS-CoV-2 was considered certain in only one case(O.1%).Deceased patients suffered more often from comorbidities,especially heart disease,neurological disorders,hematological disease,cancer,and *** of the deceased patients were admitted for pediatric inflam-matory multisystem syndrome(PIMS).Mortality risk factors were male gender,cardiac comorbidities,cancer,and acute respiratorydistress *** SARS-CoV-2 mortality in the French pediatric population was *** though the imputability of SARS-Cov-2 on mortality was considered in almost two-thirds of cases,this imputability was considered certain in only one case.

关键词： Death Pediatric intensive care unit SARS-CoV-2

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Azoximer bromide and hydroxyapatite:promising immune adjuvants in cancer

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Cancer Biology & Medicine 2023年第12期20卷 1021-1034页

作者： Jean-françois Rossi Patrick Frayssinet Maksim Matciyak Nikolai Tupitsyn Institut du Cancer Avignon-Provence Sainte Catherine–Department of Hematology-BiotherapyAvignon 84918France University of Montpellier UFR MédecineMontpellier 34090France HASTIM Inc. Rue de CauletToulouse 31300France Petrovax NPO Pharm Moscow 123112Russia Laboratory of Immunology of Hematopoiesis N.N.Blokhin Cancer Research Center(RCRC)Moscow 123112Russia

Immune adjuvants are immune modulators that have been developed in the context of infectious *** is currently a growing interest in immune adjuvants due to the development of immunotherapy against *** adjuvant mechanisms of action are focused on the initiation and amplification of the inflammatory response leading to the innate immune response,followed by the adaptive immune *** main activity lies in the support of antigen presentation and the maturation and functions of dendritic *** immune adjuvants are associated with a vaccine or incorporated into the new generation of m RNA *** immune adjuvants are used as ***(HA)ceramics and azoximer bromide(AZB)are overlooked molecules that were used in early clinical trials,which demonstrated clinical efficacy and excellent tolerance *** combined in an autologous vaccine was previously developed in the veterinary field for use in canine spontaneous ***,an original immune modulator derived from a class of heterochain aliphatic polyamines that is licensed in Russia,the Commonwealth of Independent States,and Slovakia for infectious and inflammatory diseases,is and now being developed for use in cancer with promising *** two immune adjuvants can be combined in various immunotherapy strategies.

关键词： Immune adjuvants cancer azoximer bromide hydroxyapatite Toll receptor agonists immunotherapy

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In vitro immunotoxicity of untreated and treated urbanwastewaters using various treatment processes to rainbow trout leucocytes

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Journal of Environmental Sciences 2013年第7期25卷 1400-1407页

作者： franois Gagné Marlène Fortier Michel Fournier Shirley-Anne Smyth Emerging Methods Aquatic Contaminants Research Division Water Science and Technology Environment Canada105 McGill Street Montral Qubec Canada INRS-Institut Armand-Frappier 531 boul.des Prairies Laval Qubec Canada Effluents and Wastewaters Aquatic Contaminants Research Division Water Science and Technology Environment Canada867 Lakeshore Road BurlingtonOntario Canada

Municipal effluents are known to impede the immune system of aquatic organisms. The purpose of this studywas to examine the immunotoxicity of urbanwastewaters before and after 6 treatment processes from 12 cities toward trout leucocytes. Freshly prepared trout leucocyteswere exposed to increasing concentrations of solid phase （C18） extracts ofwastewaters for24 hr at 15°C. Immunocompetencewasdetermined by following changes in leucocyte viability and the proportion of cells able to ingest at least one （immunoactivity） and at least three （immunoefficiency） fluorescent beads. The influentswere treated by sixdifferent treatment strategies consisting of facultative aerated lagoons, activated sludge, biological aerated filter, biological nutrient removal, chemically-assisted physical treatment and trickling filter/solid contact. Water quality parameters of thewastewaters revealed that the plants effectively removed total suspended solids and reduced the chemical oxygendemand. The results revealed that the effluents＇ immunotoxic propertieswere generally more influenced by the properties of the untreatedwastewaters than by the treatment processes. About half of the incoming influentsdecreased leucocyte viabilitywhile4 treatment plantswere able to reduce toxicity. The influents readily increased phagocytosis activity for 8/12 influentswhile itwasdecreased in4/12 influents. This increasewas abolished for4/12 of the effluents using treatments involving biological and oxidative processes. In conclusion, municipal effluents have the potential to alter the immune system in fish and more researchwill be needed to improve the treatments ofwastewaters to better protect the quality of the aquatic environment.

关键词： municipal effluents fish leucocytes viability phagocytosis

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Microstructure and texture evolution of nonoriented silicon steel during the punching process

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International Journal of Minerals,Metallurgy and Materials 2022年第11期29卷 2064-2071页

作者： Xiang Fang Wei Wang françois Brisset Anne-Laure Helbert Thierry Baudin School of Automotive Engineering Wuhan University of TechnologyWuhan 430070China Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan University of TechnologyWuhan 430070China Hubei Research Center for New Energy&Intelligent Connected Vehicle Wuhan University of TechnologyWuhan 430070China Institut de Chimie Moléculaire et des Matériaux d’Orsay UniversitéParis-SaclayCNRS91405 OrsayFrance

The iron core of a motor is mainly manufactured from rolled nonoriented silicon steel using a punching process that leads to deformation and texture evolution at the cutting *** to this process,circular samples of nonoriented silicon steel were prepared by punching using blunt punch *** this work,two positions along the rolling and transverse directions at the cutting edge were *** main mechanisms of deformation for both positions are dislocation slip and formation of shear *** two mechanisms lead to similar texture evolutions for both *** dislocation slip leads to the formation of the{221}component in the unbending area(200μm away from the cutting edge)and intermediate continuum-bent ***,the evolution of the texture from the{111}γfiber to the{110}fiber was observed at the extremity of the cutting edge with the formation of shear bands.

关键词： microstructure texture nonoriented silicon steel punching

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Learning-Based Metaheuristic Approach for Home Healthcare Optimization Problem

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Computer Systems Science & Engineering 2023年第4期45卷 1-19页

作者： Mariem Belhor Adnen El-Amraoui Abderrazak Jemai françois Delmotte Univ.Artois LGI2A LaboratoryUR 3926Technoparc FUTURA 62400BéthuneFrance Univ.Carthage SERCOM LaboratoryEPTMarsa2078Tunisia Univ.Manouba National School of Computer ScienceManouba2010Tunisia

This research focuses on the home health care optimization problem that involves staff routing and scheduling *** considered problem is an extension of multiple travelling salesman *** consists of finding the shortest path for a set of caregivers visiting a set of patients at their homes in order to perform various tasks during a given ***,a mixed-integer linear programming model is proposed to minimize the overall service time performed by all caregivers while respecting the workload balancing ***,when the time horizon become large,practical-sized instances become very difficult to solve in a reasonable computational ***,a new Learning Genetic Algorithm for mTSP(LGA-mTSP)is proposed to solve the ***-mTSP is composed of a new genetic algorithm for mTSP,combined with a learning approach,called learning *** refers to that caregivers’productivity increases as they gain more *** curves approach is considered as a way to save time and *** results show the efficiency of the proposed approach and the impact of learning curve strategy to reduce service times.

关键词： Home healthcare scheduling and routing problem optimization multiple travelling salesman problem learning curves genetic algorithm

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Applying chemical engineering concepts to non-thermal plasma reactors

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Plasma Science and Technology 2018年第6期20卷 161-171页

作者： Pedro AFFONSO NOBREGA Alain GAUNAND VANDad ROHANI fran?ois CAUNEAU Laurent FULCHERI MINES ParisTech PSL Research UniversityPERSEE-Centre for ProcessesRenewable Energy and Energy Systems MINES ParisTech PSL Research UniversityCTP-Centre for Thermodynamics of p Processes

Process scale-up remains a considerable challenge for environmental applications of non-thermal *** the impact of reactor hydrodynamics in the performance of the process is a key step to overcome this *** this work,we apply chemical engineering concepts to analyse the impact that different non-thermal plasma reactor configurations and regimes,such as laminar or plug flow,may have on the reactor *** do this in the particular context of the removal of pollutants by non-thermal plasmas,for which a simplified model is *** generalise this model to different reactor configurations and,under certain hypotheses,we show that a reactor in the laminar regime may have a behaviour significantly different from one in the plug flow regime,often assumed in the non-thermal plasma *** the other hand,we show that a packed-bed reactor behaves very similarly to one in the plug flow *** those results,the reader will find in this work a quick introduction to chemical reaction engineering concepts.

关键词： non-thermal plasma chemical engineering dielectric barrier discharge(DBD) corona discharge plug flow reactor volatile organic compounds

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