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Modulating effects of acyl-CoA synthetase 5-derived mitochondrial Wnt2B palmitoylation on intestinal Wnt activity

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World Journal of Gastroenterology 2014年第40期20卷 14855-14864页

作者： Christina klaus Ursula Schneider Christian Hedberg Anke k Schütz Jürgen Bernhagen Herbert Waldmann Nikolaus Gassler Elke kaemmerer Institute of Pathology RWTH Aachen University 52074 Aachen Germany Department of Chemical Biology Max Planck Institute of Molecular Physiology 44227 Dortmund Germany Department of Biochemistry and Molecular Cell Biology RWTH Aachen University 52074 Aachen Germany Department of Pediatrics RWTH Aachen University 52074 Aachen Germany

AIM: To investigate the role of acyl-CoA synthetase 5 (ACSL5) activity in Wnt signaling in intestinal surface epithelia.

关键词： Acyl-CoA synthetases Wnt signaling Palmitoylation Intestinal barrier Carcinogenesis

Dietary supplementation of sulfur amino acids improves intestinal immunity to Eimeria in broilers treated with anti-interleukin-10 antibody

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Animal Nutrition 2022年第3期10卷 382-389页

作者： Zhouzheng Ren Jiakun Yan Rose Whelan Xujie Liao Daniel E.Bütz Maria k.Arendt Mark E.Cook Xiaojun Yang Thomas D.Crenshaw College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxiChina Department of Animal Sciences University of WisconsinMadisonWIUSA Evonik Operations GmbH Hanau-WolfgangGermany

Oral antibody to interleukin-10(anti-IL-10)enhances the intestinal immune defense against *** sulfur amino acids methionine and cysteine(MtC)play essential roles in inducing and maintaining protective immune responses during intestinal ***,increased dietary MtC may support the anti-IL-10-induced intestinal immunity to ***(n=640)were arranged in a 2×2×2 factorial design with 2 levels of each of the 3 main factors:dietary standardized ileal digestible(SID)MtC levels(0.6%or 0.8%),dietary anti-IL-10 supplementation(with or without),and coccidiosis challenge(control or challenge).Briefly,the broilers were supplied with either 0.6%or 0.8%SID MtC,each with or without anti-IL-10(300 mg/kg),from d 10 to *** d 14,broilers from each diet were gavaged with either PBS or *** resulting Eimeria infection induced fecal oocyst shedding and intestinal *** fed 0.8%SID MtC(main effects,P≤0.05)had decreased feed-to-gain ratio,increased duodenum and cecum luminal anti-Eimeria IgA titers,and decreased fecal oocyst counts,when compared to 0.6%SID *** supplementation of anti-IL-10(main effects,P≤0.05)increased cecum luminal total IgA concentration and decreased cecum ***(P≤0.05)were detected for growth performance and cecum luminal IFN-γ.Briefly,the highest body weight gain and feed intake were reached in PBS-gavaged broilers fed 0.8%SID MtC with no anti-IL-10 and in Eimeria-challenged broilers fed 0.8%SID MtC with *** Eimeria-infected broilers,anti-IL-10 increased intestinal luminal IFN-γ and body weight gain only at 0.8%SID ***,anti-IL-10 increased intestinal luminal IFN-γ levels,decreased cecum lesions and restored growth only when fed with adequate amounts of sulfur amino *** findings underscore the importance of providing sufficient essential nutrients to support the anti-IL-10 induced immunity against coccidiosis.

关键词： Chicken Coccidiosis Egg yolk antibody Interleukin-10 Sulfur amino acid

Arterial thrombosis in the context of HCV-associated vascular disease can be prevented by protein C

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Cellular & Molecular Immunology 2017年第12期14卷 986-996页

作者： Philipp Blüm Joachim Pircher Monika Merkle Thomas Czermak Andrea Ribeiro Hanna Mannell Florian krötz Alexander Hennrich Michael Spannagl Simone köppel Erik Gaitzsch Markus Wörnle Medizinische klinik und Poliklinik IV InnenstadtKlinikum der Universität München80336 MünchenGermany Walter Brendel Centre of Experimental Medicine and Munich Heart Alliance Ludwig Maximilians University München80336 MünchenGermany Medizinische klinik und Poliklinik I Klinikum der Universität München80336 MünchenGermany Abteilung für Transfusionsmedizin Zelltherapeutika und HämostaseologieKlinikum der Universität München80336 MünchenGermany

Hepatitis C virus(HCV)infection is a major problem *** is not limited to liver disease but is frequently complicated by immune-mediated extrahepatic manifestations such as glomerulonephritis or vasculitis.A fatal complication of HCV-associated vascular disease is ***:polyribocytidylic acid(poly(I:C)),a synthetic analog of viral RNA,induces a Toll-like receptor 3(TLR3)-dependent arteriolar thrombosis without significant thrombus formation in venules in *** procoagulant effects are caused by increased endothelial synthesis of tissue factor and PAI-1 without platelet *** addition to human umbilical endothelial cells(HUVEC),human mesangial cells(HMC)produce procoagulatory factors,cytokines and adhesion molecules after stimulation with poly(I:C)or HCV-containing cryoprecipitates from a patient with a HCV infection as *** protein C(APC)is able to prevent the induction of procoagulatory factors in HUVEC and HMC in vitro and blocks the effects of poly(I:C)and HCV-RNA on the expression of cytokines and adhesion molecules in HMC but not in *** vivo,protein C inhibits poly(I:C)-induced arteriolar ***,endothelial cells are de facto able to actively participate in immune-mediated vascular thrombosis caused by viral ***,we provide evidence for the ability of protein C to inhibit TLR3-mediated arteriolar thrombosis caused by HCV infection.

关键词： hepatitis C thrombosis toll-like receptor 3

Epidemiology and injury patterns of aerial sports in Switzerland

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World Journal of Orthopedics 2020年第2期11卷 107-115页

作者： Henrik Constantin Bäcker J Turner Vosseller Aristomenis k Exadaktylos Carsten Perka Lorin Michael Benneker Fabian Götz krause Moritz Caspar Deml Department of Orthopaedic Surgery and Traumatology InselspitalUniversity Hospital BernUniversity BernBern 3010Switzerland Department of Orthopaedic Surgery New York Presbyterian/Columbia University Medical CenterNew YorkNY 10032United States Department of Orthopaedic Surgery and Traumatology University Hospital BerlinCharitéBerlinBerlin10117Germany Department of Emergency Medicine InselspitalUniversity Hospital BernUniversity BernBern3010Switzerland

BACkGROUND Airborne sports have become more popular in recent *** number of accidents has increased linearly as athletes take increasingly greater risks to experience the adventurous spirit of this kind of *** To investigate the variety of injuries in airborne sport accidents,as well as which acute treatment these patients receive,both before and after admission to a levelone-trauma *** We performed a retrospective chart analysis at a major level-one-trauma center in Switzerland for 235-patients who were admitted following airborne sports injuries between 2010 and ***’demographic data,injury patterns,emergency primary care procedures and intra-hospital care were *** Overall,718-injuries in 235-patients were identified;the spine was the most commonly affected region with 46.5%of injuries(n=334/718)in *** 69-patients(15.5%),the(non-spine)thorax was affected,followed by the lower and upper extremity,pelvis,head/face and abdominal ***-patients had to be intubated at the trauma *** patients were resuscitated after onset of ***-patients died in the resuscitation *** 116-cases,surgery was indicated including 55-emergency *** 19 patients(8.1%)were transferred to the intensive care *** Paragliders are most commonly affected,although the highest injury severities were identified for Building,Antenna,Span and Earth-jumping *** responders,treating physicians and pilots should be aware of the risk for potentially serious and life-threatening injury with an in-hospital mortality of 0.9%.

关键词： Airborne sport Sport injuries Trauma Spine Pelvis Emergency medicine Paragliding Parachuting Delta-flying

Evaluation of Ultrasound-based Surveillance for Hepatocellular Carcinoma in Patients at Risk:Results From a German Multicenter Retrospective Cohort Study

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 626-637页

作者： Johannes Gillessen Philipp Reuken Peter-Marton Hunyady Matthias Christian Reichert Lucian Lothschütz Fabian Finkelmeier Matthias Nowka Gabriel Allo Fabian kütting Martin Bürger Dirk Nierhoff Hans-Michael Steffen Christoph Schramm University Hospital Cologne Department of Gastroenterology and HepatologyCologneGermany University Hospital Jena Department of Internal Medicine IV-GastroenterologyHepatologyInfectious DiseaseJenaGermany University Hospital fra.kfurt Department of Internal Medicine 1-Gastroenterology und HepatologyPulmonology und AllergologyEndocrinologyFrankfurtGermany Department of Medicine II Saarland University Medical CenterHomburgGermany Department of Gastroenterology and Hepatology University Hospital of EssenEssenGermany

Background and Aims:Hepatocellular carcinoma(HCC)surveillance in patients at risk is strongly recommended and usually performed by ultrasound(US)semiannually with or without alfa-fetoprotein(AFP)*** pa-rameters except for surveillance intervals have not been strictly *** aimed to evaluate surveillance success and risk factors for surveillance ***:Patients with≥1 US prior to HCC diagnosis performed at four tertiary referral hospitals in Germany between 2008 and 2019 were retrospectively *** success was defined as HCC detection within Milan ***:Only 47%of 156 patients,median age 63(interquartile range:57-70)years,56%male,and 96%with cirrhosis,received recom-mended surveillance modality and *** fail-ure occurred in 29%and was significantly associated with lower median model for end-stage liver disease(MELD)score odds ratio(OR)1.154,95%confidence interval(CI):1.027-1.297,p=0.025)and HCC localization within right liver lobe(OR:6.083,95%CI:1.303-28.407,p=0.022),but not with AFP≥200μg/*** with surveillance failure had sig-nificantly more intermediate/advanced tumor stages(93%vs.6%,pk frequently fails and its failure is associated with unfavorable patient-related *** MELD score and HCC lo-calization within right liver lobe were significantly associated with surveillance failure.

关键词： Hepatocellular carcinoma Surveillance success Screening Ultra-sound.

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丘脑梗塞的影象诊断

放射学实践 1990年第4期5卷 154-156页

作者： G.F.Gtz k.Mathias H.Lincke 徐霓霓 Institut fr Strahlendiagnostik und Neurologische klinik der Stdtischen kliniken Dortmund 北京宣武医院

血管造影术作为CT检查的补充对丘脑梗塞的定位具有很大意义。要准确判断结果则首先应精通椎-基底动脉区的供血情况。

关键词：丘脑梗塞血管造影 CT

肝血管瘤诊断方法的改进:快速动态连续CT扫描

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放射学实践 1992年第4期7卷 152-155页

作者： J.Gaa M.Schütz H.k.Deininger 刘建斌 Strahleninstitut der Stadtischen kliniken Darmstadt. Grafenstraβe 9 6100 Darmstadt FRG 中国康复研究中心

一种与血供相关的CT增强扫描法,可对肝血管瘤作出较肯定的诊断,前提是要有正确的造影剂注射技术和拥有高空间分辨率的CT机。

关键词：肝脏肿瘤 CT 血管瘤

Haptotropic Migration of Metal Templates on Arene Surfaces

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复旦学报（自然科学版） 2007年第5期46卷 863-页

作者： k.H.Dtz H.C.Jahr J.Bennewitz J.Dubarle-offner kekulé Institute of Organic Chemistry and Biochemistry Rheinische Friedrich-Wilhelms-University

1 Results The chromium-templated benzannulation of arylcarbenes by alkynes provides a direct regio- and diastereoselective access to densely functionalized chromium arenes[1]. The chromium fragment undergoes a haptotropic migration along the π-face of the fused arenes which can be controlled by thermodynamics,by the substitution pattern of the arene and by the metal coligand sphere(See Scheme 1).The controlled regioselective labeling of benzene rings can be exploited in diastereoselective C-C bond forma...

关键词： organometallic switches haptotropic metal migration metal arenes heterobimetallic arenes

The archaeogenomic validation of Saint Ladislaus'relic provides insights into theárpád dynasty's genealogy

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Journal of Genetics and Genomics 2023年第1期50卷 58-61页

作者： Gergely I.B.Varga Lilla Alida kristóf kitti Maár Luca kis Oszkár Schütz Orsolya Váradi Bence kovács Alexandra Gînguță Balázs Tihanyi Péter L.Nagy Zoltán Maróti Emil Nyerki Tibor Török Endre Neparáczki Department of Archaeogenetics Institute of Hungarian ResearchH-1014 BudapestHungary Doctoral School of History University of SzegedSzegedHungary Department of Genetics University of SzegedH-6726 SzegedHungary Department of Biological Anthropology University of SzegedH-6726 SzegedHungary Department of Molecular Biology and Biotechnology Faculty of Biology and GeologyBabes-Bolyai University400006 Cluj-NapocaRomania Praxis Genomics LLC AtlantaUSA Department of Pediatrics and Pediatric Health Center University of SzegedH-6725 SzegedHungary

The house of Arp ad ruled Hungary for more than four centuries,establishing dynastical relationships with numerous European nobleand ruling houses,and giving many Catholic saints and blesseds to the Catholic *** were one of the significant dynasties of Medieval Europe(krist o and Makk,1996).The knight-king Saint Ladislaus I(c.1040-1095,reign:1077-1095)is one of the most outstanding kings of this *** addition to the hand relic(the Holy Right)of king Saint Stephanus I(c.975-1038,reign:1000/1001-1038),the skull relic in the Saint Ladislaus’Herma(Fig.1A-1C)preserved in the Cathedral of Gy or,is one of the most important relics for Hungarians(klaniczai,2000).

关键词： relic provides insights into the The archaeogenomic validation of Saint Ladislaus d dynasty’s genealogy