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作者： Federico Saenz-frances Martha cecilia Bermúdez-Vallecilla lara Borrego-Sanz luis jaez J osé Marìa Martinez-de-la-casa laura Morales-ferna.dez Enrique Santos-Bueso Julián ga.cia-Sanchez Julián ga.cia-Feijoo Department of Ophthalmology Hospital Clínico San CarlosUniversidad Complutense de Madrid Instituto de Tecnologìa del conocimiento Universidad Complutense de Madrid

·AIM: To anatomically locate the points of minimum corneal thickness and central corneal thickness(pupil center) in relation to the corneal apex.·METHODS: Observational, cross-sectional study, 299 healthy volunteers. Thickness at the corneal apex(AT),minimum corneal thickness(MT) and corneal thickness at the pupil center(PT) were determined using the pentacam. Distances from the corneal apex to MT(MD)and PT(PD) were calculated and their quadrant position(taking the corneal apex as the reference) determined:point of minimum thickness(Mc) and point of central thickness(Pc) depending on the quadrant position. Two multivariate linear regression models were constructed to examine the influence of age, gender, power of the flattest and steepest corneal axes, position of the flattest axis, corneal volume(determined using the Pentacam)and PT on MD and PD. The effects of these variables on Mc and Pc were also determined in two multinomial regression models.·RESUlTS: MT was located at a mean distance of 0.909 mm from the apex(79.4% in the inferior-temporal quadrant). PT was located at a mean distance of 0.156 mm from the apex. The linear regression model for MD indicated it was significantly influenced by corneal volume(B =-0.024; 95% cI:-0.043 to-0.004). No significant relations were identified in the linear regression model for PD or the multinomial logisticregressions for Mc and Pc.·cONclUSION: MT was typically located at the inferiortemporal quadrant of the cornea and its distance to the corneal apex tended to decrease with the increment of corneal volume.

关键词： cornealthickness anatomy glaucoma

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一组孤立性房颤患者行导管射频消融术1年后左侧心腔重构发生逆转

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世界核心医学期刊文摘(心脏病学分册) 2006年第4期 51-51页

作者： Reant P. lafitte S. jas P. 尹涛 Hopital cardiologique du Haut-leveque Service Pr Roudaut Avenue de Magellan 33604 Bordeaux-Pessac france Dr.

Background -Isolated atrial fibrillation(AF)is associated with mild enlargement of the left atrium(lA)and left ventricular(lV)diastolic dysfunction. The impact of ablation of isolated AF on left chamber size and function is unclear, and whether diastolic dysfunction is the cause or the consequence of AF remains unknown. The objective of this prospective study was to evaluate the impact of sinus rhythm restoration by catheter ablation on lV diastolic dysfunction, lA morphology, and mechanical function. Methods and Results -Forty-eight patients with isolated AF were studied by serial echocardiographic studies at baseline and at 1-, 3-, 6-, 9-, and 12-month intervals after radiofrequency ablation. lA dimensions and mechanical function and lV systolic and diastolic functions were evaluated at each time interval. Diastolic function was assessed with conventional Doppler parameters and new indexes such as tissue Doppler imaging, mitral flow propagation velocity, and combined criteria. lV diastolic dysfunction was present in paroxysmal and chronic AF patients with a reduction of tissue Doppler imagin g lateral early diastolic peak velocity in 37%(Pctively, compared with healthy control subjects. At the end of the follow-up, lA area decreased significantly by 18%(Pl and 23%(Pchronic AF patients. Diastolic function improved significantly with an increa se in lateral early diastolic peak velocity of 29%(Pl AF an d 46%(Pchronic AF patients. A significant increase in lV ejection fra ction was also noted for both groups: 7.7%and 18.8%, respectively. conclusions -This study demonstrates reverse morphological remodeling of the lA and improv ement of lV diastolic and systolic functions after restoration of sinus rhythm b y ablation for isolated AF. Because patients with isolated AF have none of the t raditional causes of lV diastolic dysfunction, our findings suggest that AF may be partly t

关键词：房颤舒张功能心房纤颤孤立性心腔患者

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