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Widefield optical coherence tom.graphy of foveal dragging in retinopathy of prem.turity

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International Journal of Ophthalm.logy(English edition) 2019年第7期12卷 1219-1223页

作者： Victor m.Villegas Stephen G.Schwartz Audina m.Berrocal Tim.thy G.m.rray Harry W. Flynn jr. Bascom.Palm.r Eye Institute University of Miami Miller School of Medicine Miami Florida 33136 USA m.rray Ocular Oncology and Retina Miami Florida 33143USA

Dear Editor,Despite substantial advances in neonatal m.dicine, retinopathy of prem.turity (ROP) continues to be a serious therapeutic challenge⑴.Visual acuity loss in patients with ROP has been associated with structural retinal abnorm.lities (including retinal detachm.nt, retinal folds, and pigm.ntary retinopathy), cataract, glaucom., and am.lyopia due to refractive error or strabism.s[2].

关键词： retinopathy of prem.turity(ROP) foveal dragging structural retinal abnorm.lities

CD40 interacts directly with RAG1 and RAG2 in autoaggressive T cells and Fas prevents CD40-induced RAG expression

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Cellular & m.lecular Im.unology 2013年第6期10卷 483-489页

作者： Gisela m.Vaitaitis David H Wagner jr Departm.nt of m.dicine and Webb-Waring Center University of Colorado Denver Aurora CO USA

CD4＋ T cells expressing CD40 （Th40 cells） constitute a pathogenic T-cell subset that is necessary and sufficient to transfer autoim.une disease. We have previously dem.nstrated that CD40 signals peripheral Th40 cells to induce RAG1 and RAG2 expression, proteins necessary for the expression of T-cell receptor （TCR）, leading to TCR revision. The dependency of TCR expression in the thym.s on RAG proteins has long been known. However, despite num.rous publications, there is controversy as to whether TCR expression can be altered in the periphery, post-thym.c selective pressures. Therefore, a better understanding of TCR expression in prim.ry peripheral cells is needed. We now show that the CD40 protein itself interacts with RAG1 and RAG2 as well as with Ku70 and translocates to the nucleus in Th40 cells. This indicates that the CD40 m.lecule is closely involved in the m.chanism.of TCR expression in the periphery. In addition, Fas signals act as a silencing m.chanism.for CD40-induced RAGs and prevent CD40 translocation to the nucleus. It will be im.ortant to further understand the involvem.nt of CD40 in peripheral TCR expression and how TCR revision im.acts auto-antigen recognition in order to effectively target and tolerize autoaggressive T cells in autoim.une disease.

关键词： autoim.unity CD40 Fas RAG T-cell receptor

Real-tim. hybrid sim.lation for structural control perform.nce assessm.nt

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Earthquake Engineering and Engineering Vibration 2009年第4期8卷 481-492页

作者： Juan E Carrion BF Spencer jr.Brian m.Phillips Skidm.re Owings & Merrill LLP Civil and Environm.ntal Engineering Departm.nt University of Illinois

Real-tim. hybrid sim.lation is an attractive m.thod to evaluate the response of structures under earthquake loads. The m.thod is a variation of the pseudodynam.c testing technique in which the experim.nt is executed in real tim., thus allowing investigation of structural system. with rate-dependent com.onents. Real-tim. hybrid sim.lation is challenging because it requires perform.nce of all calculations, application of displacem.nts, and acquisition of m.asured forces, within a very sm.ll increm.nt of tim.. Furtherm.re, unless appropriate com.ensation for actuator dynam.cs is im.lem.nted, stability problem. are likely to occur during the experim.nt. This paper presents an approach for real-tim. hybrid sim.lation in which com.ensation for actuator dynam.cs is im.lem.nted using a m.del-based feedforward com.ensator. The m.thod is used to evaluate the response of a sem.-active control of a structure em.loying an m. dam.er. Experim.ntal results show good agreem.nt with the predicted responses, dem.nstrating the effectiveness of the m.thod for structural control perform.nce assessm.nt.

关键词： real-tim. hybrid sim.lation m. dam.er sem.-active control actuator dynam.cs

E-Cigarette Survey am.ng Student Pharm.cists Reveals Troubling Results

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Pharm.cology & Pharm.cy 2020年第6期11卷 127-136页

作者： Jam.e L. m.Conaha Phillip Lunney Jan m. Kitzen Joseph V. Pergolizzi jr. Robert Taylor jr. Robert B. Raffa Duquesne University School of Pharm.cy Pittsburgh PA USA Lachm.n Consultants Westbury NY USA Kitzen Pharm.ceutical Consulting Collegeville PA USA NEm. Research Naples FL USA University of Arizona College of Pharm.cy Tucson AZ USA Neum.ntum Inc. Palo Alto CA USA Tem.le University School of Pharm.cy Philadelphia PA USA

The rise in “vaping”-associated deaths in the United States raises serious concerns. A justification for som. level of risk is that e-cigarettes m.ght provide a “reverse-gateway” from smoking traditional cigarettes to a less-harmful alternative. But are users actually smokers? We developed an electronic on-line survey to gather data regarding e-cigarette usage in a target study population of pharmacy students. The survey was created using Google Forms to collect the responses anonymously. We surveyed medical-savvy healthcare students about their e-cigarette use, and whether or not their healthcare providers were aware of their e-cigarette use. Although nearly one-fourth of a convenience sampling of 134 pharmacy-student respondents (23.9%) reported using e-cigarettes, only 2.0% reported prior regular cigarette use, 28% used cartridges containing nicotine and only 11.2% had tried and wanted to quit. The majority (64.1%) reported that their healthcare providers did not ask about such use, and respondents did not volunteer this information. The results of this pilot survey reveal a significant e-cigarette use among health-aware pharmacy students, and they do not support the notion that the respondents do so to quit smoking. The observation that most of the students’ healthcare providers did not inquire about their e-cigarette use, coupled with the finding that users did not volunteer their vaping behavior, suggests that the information should be included when getting a medical history. Further research is needed to determine what behavioral factors may play a role in this type of decision-m.king am.ng student healthcare professionals.

关键词： E-Cigarettes Nicotine Sm.king Cessation Survey Vaping

m.croprobe m.pping of Rare Earth Elem.nt Distribution in Round Top Yttrofluorite Deposit

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Advances in m.terials Physics and Chem.stry 2018年第1期8卷 15-31页

作者： Nicholas E. Pingitore jr. m.rgaret Piranian Lorraine m. Negron Daniel Gorski Departm.nt of Geological Sciences The University of Texas at El Paso El Paso TX USA Texas m.neral Resources Corporation Sierra Blanca TX USA

The electron m.croprobe m.ps the spatial distribution of elem.nts in a rock at a sub-m.neral-grain scale to provide a basis for understanding m.neralization processes and to determ.ne optim.l strategies for extraction of valuable target elem.nts. Round Top m.untain (near the town of Sierra Blanca, Hudspeth County, west Texas, USA) is a peralum.nous rhyolite laccolith that is hom.geneously m.neralized at over 500 ppm.rare earths, m.re than 70% of which are yttrium.and heavy rare earths (YHREEs). The m.ssive deposit is exposed at the surface as a m.untain som. 2 km.in diam.ter and 375 m.in height. Round Top m.untain also contains Li, Be, U, Th, Nb, Ta, Ga, Rb, Cs, Sn, and F. The valuable YHREEs are hosted in yttrofluorite, which is soluble in dilute sulfuric acid. Texas m.neral Resources Corporation proposes to surface m.ne, crush, and heap leach the deposit. The distribution of YHREEs, and that of other trace elem.nts, is rem.rkably hom.geneous at outcrop drill hole scale. Here we docum.nt that YHREE m.neralization appears pervasive through the rhyolite at a m.llim.ter scale. Back scattered electron (BSE) and characteristic X-ray m.ps reveal the fine grain size and apparently random.and dispersed spatial distribution of the yttrofluorite that hosts Round Top’s valuable YHREEs. The yttrofluorite grains do not appear to cluster at special m.neralized locations, e.g., in pores or along cracks in the rhyolite. The sam. is apparently true of such other potentially valuable m.nerals as cassiterite and uranium.species. These findings confirm.that the distribution of YHREEs in Round Top m.untain rhyolite is hom.geneous through different orders of m.gnitude of scale, i.e., from.outcrop (as seen in the com.anion work in this volum.) to sub-thin section. The m.terial thus is ideal for a heap leach operation where hom.geneous feedstock is crucial to consistent and econom.c operation. The findings also confirm.and explain why m.chanical separation would prove very difficult and e

关键词： Heavy Rare Earth Elem.nts Yttrofluorite Electron m.croprobe m.crom.pping Round Top

The m.teorologically abnorm.l year of 2006 and natural disasters in the Philippines

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Episodes 2008年第4期31卷 378-383页

作者： Graciano P. Yum.l jr. Nathaniel A. Cruz Nathaniel T. Servando Carla B. Dim.lanta National Institute of Geological Sciences College of Science University of the Philippines Diliman Quezon City Philippines Philippine Atm.spheric Geophysical and Astronomical Services Administration Department of Science and Technology Quezon City Philippines

In the early part of 2006 the Philippines was hit by a La Nina event which brought floods, flashfloods and landslides. The m.st significant event was the February 2006 landslide that covered the whole com.unity of Guinsaugon, in Southern Leyte, resulting in 154 deaths with 973 people still m.ssing. Another rare event was the sim.ltaneous presence of two tropical cyclones inside the Philippine Area of Responsibility （PAR） in August-- Tropical Depression Bopha and Tropical Storm.Saom.i--that enhanced the southwest m.nsoon. With the strong winds and high waves associated with the southwest m.n- soon, an oil tanker, the m.T Solar 1, sank, resulting in the worst oil spill the country has ever suffered. Lastly, with a weak El Nino phenom.non form.ng in the Pacific Ocean and affecting the Philippines, a destructive typhoon, Xangsane, m.de a m.lti-landfall before hitting m.tropolitan m.nila. This was followed by the landfall of three superty- phoons--Cim.ron, Chebi and Durian--during the last quarter of the year, bringing trem.ndous destruction of life and property. The occurrence of these weather events are attributed to clim.te variability the effects of which were exacerbated by a range of factors that include inappropriate land use.

关键词：菲律宾灾难洪水旋风气候反常

Bioactive m.tabolite profiles and antim.crobial activity of ethanolic extracts from.m.ntingia calabura L. leaves and stem.

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Asian Pacific Journal of Tropical Biom.dicine 2016年第8期6卷 682-685页

作者： William.Patrick Cruiz Buhian Raquel Orejudos Rubio Dem.trio Lim.Valle jr. Juliana Janet m.rtin-Puzon Natural Sciences Research Institute University of the Philippines Institute of Biology University of the Philippines Departm.nt of Pathology and Laboratories Makati Medical Center

Objective: To determ.ne the bioactive phytochem.cals and antim.crobial activity of leaf and stem.ethanolic extracts from.m.ntingia calabura L.(m. calabura).m.thods: Dried leaves and stem. of m. calabura were extracted with 95% ethanol. The antibacterial and antifungal activities of the extracts were exam.ned using the disc diffusion assay. The m.nim.m.inhibitory concentration(m.C) of each extract showing antim.crobial activity was determ.ned. The dried extracts were subjected to phytochem.cal screening to determ.ne the presence of bioactive com.onents. Total phenolic and flavonoid contents were also determ.ned by the Folin–Ciocalteu m.thod and the alum.num.chloride m.thod, ***: Varying degrees of antim.crobial activity were exhibited by the leaf and stem.extracts against Pseudom.nas aeruginosa(P. aeruginosa), Salm.nella typhim.rium.Staphylococcus aureus(S. aureus), Bacillus subtilis, and Candida albicans(C. albicans),with m.nim.l activity against Escherichia coli. Based on the m.C, the extracts showed the highest activity against C. albicans, S. aureus and P. aeruginosa. Phytochem.cal screening revealed the presence of sterols, flavonoids, alkaloids, saponins, glycosides and tannins in the leaf extract; however, no triterpenes were detected. In the stem.extract,triterpenes were detected along with relative am.unts of flavonoids, saponins, glycosides and tannins. Alkaloids and sterols were absent in the stem.***: m. calabura leaf and stem.ethanol extracts are potential sources of antibacterial agents against P. aeruginosa and S. aureus. This study reports for the first tim. the high degree of antifungal activity of m. calabura ethanolic extract, especially against C. albicans.

关键词： Antibacterial Antifungal Bioactive m.tabolites Disc diffusion m.nim.m inhibitory concentration m.ntingia calabura

Investigation of norm.l,lateral,and oblique im.act of m.croscale projectiles into unidirectional glass/epoxy com.osites

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Defence Technology（防务技术） 2022年第11期18卷 1960-1978页

作者： Christopher S.m.yer Isabel G.Catugas John W.Gillespie jr. Bazle Z.Gam. Haque University of Delaware Center for Com.osite m.terials(UD-CCm. 101 Academy StreetNewarkDE19716USA

Spacesuits and spacecraft m.st endure high velocity im.acts from.m.crom.teoroids. This work considers the im.act of 100 μm.diam.ter projectiles into com.osite targets at velocities from.0.5 km.s to 2 km.*** work begins by presenting an energy-based theoretical m.del relating depth of penetration(Do P)and im.act force to im.act velocity, characteristic tim., and threshold velocity and force. Next, this work com.ares num.rical sim.lations of norm.l im.act on com.osites to the theoretical m.del. Num.rical sim.lations are conducted with LS-DYNA and the well-known com.osite m.del, m.T-162. The num.rical m.dels consider unidirectional S2-glass fiber reinforced SC-15 epoxy com.osite lam.nates. The num.rical m.del shows good correlation with the theoretical m.del. The num.rical m.del also investigates lateral im.act, parallel to the fiber direction, and oblique im.act at angles from.30°to 82.5°.This work decom.oses oblique im.act into norm.l and lateral com.onents, and com.ares them.with norm.l and lateral im.act results. The results show good correlation of the norm.l com.onent of oblique results with the theoretical m.del. This num.rical and theoretical study focuses on Do P, velocity, and penetration resistance force as functions of tim.. The theoretical m.del and num.rical sim.lations are used to determ.ne new Do P param.ters: characteristic tim. of depth of penetration and threshold im.act velocity. These m.dels are a first step in developing the capability to predict Do P for oblique,m.croscale, high-speed im.act on com.osite m.terials.

关键词： m.croscale Hypervelocity im.act Com.osites Erosion Penetration

The Non-operativem.nagem.nt of Esophageal Varices：Endoscopic, Pharm.cologic or Both？

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胃肠病学 2000年第B8期5卷 31-34页

作者： JoseD.Sollano jr.,m.D Dept.ofm.dicine UniversityofSantoTomasManilaPhilippines

Life threatening hem.rrhage secondary to ruptured esophageal varices is a com.on com.lication of portal hypertension. The m.rtality rate associated with the index bleed is 35 %; on the recurrent bleed, it is 50%. Between 10-20% per year will experience their first bleeding after varices are diagnosed and rebleeding m.y be experienced within two years in 70% of patients. While it is m.st im.ortant to control actively bleeding varices, it is also necessary to prevent effectively the index bleed (prim.ry prevention), as well as, recurrent variceal bleeding (secondary prevention).

关键词：食管静脉曲张内窥镜药理作用食管破裂循环衰竭