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A comprehensive evaluation of sexual and reproductive outcomes following robot-assisted retroperitoneal lymph node dissection for nonseminomatous germ cell tumor

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Asian Journal of Andrology 2022年第6期24卷 579-583页

作者： fra.cesco A Mistretta Ottavio de Cobelli Paolo Verze fra.cesco botticelli Letizia Jannello Stefano Luzzago Gabriele Cozzi Roberto Bianchi Ettore Di Trapani Matteo Ferro Giovanni Cordima Danilo Bottero Deliu Victor Matei Vincenzo Mirone Gennaro Musi Department of Urology European Institute of OncologyIRccSMilan 20141Italy Department of Oncology and Hemato-Oncology University of MilanMilan 20122Italy Department of Urology University of NaplesFederico IlNaples 80138Italy

Sexual disorders following retroperitoneal pelvic lymph node dissection(RPLND)for testis tumor can affect the quality of life of *** aim of the current study was to investigate several different andrological outcomes,which may be influenced by robot-assisted(RA)*** January 2012 to March 2020,32 patients underwent RA-RPLND for stage I nonseminomatous testis cancer or postchemotherapy(PC)residual *** unilateral RPLND nerve-sparing template was always *** variables of interest were erectile dysfunction(ED),premature ejaculation(PE),dry ejaculation(DE),or orgasm ***,fertility as well as the fecundation process(sexual intercourse or medically assisted procreation[MAP])was *** patients(31.3%)presented an andrological disorder of any type after *** was present in 4(12.5%)patients,DE(International Index of Erectile Function-5[IIEF-5]<25)in 3(9.4%)patients,and ED in 3(9.4%)*** PE or orgasmic alterations were *** median age at surgery,body mass index(BMI),number of nodes removed,scholar status,and preoperative risk factor rates were identified between *** all these 10 patients,6(60.0%)were treated at the beginning of our robotic experience(2012-2016).Of all 32 patients,5(15.6%)attempted to have a child after *** of these 5 patients have successfully fathered children,but 2(40.0%)required a *** conclusion,a nonnegligible number of andrological complications occurred after RA-RPLND,mainly represented by ejaculation disorders,but ED occurrence and overall sexual satisfaction deficit should be definitely *** negative impact on fertility was described after RA-RPLND.

关键词： andrology lymph node excision nonseminomatous germ cell tumor robotics testicular cancer

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促肾上腺皮质激素对隔-海马胆碱能神经元的跨突触性调节

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国外医学(分子生物学分册) 1981年第4期 187-188页

作者： botticelli 叶智文

隔区内的各种神经介质,包括P-物质,β-内啡肽可能是通过对胆碱能神经元胞体发挥作用而影响隔-海马神经元的活动。促肾上腺皮质激素(ACTH 1—24)和α-促黑色细胞素(α-MSH),在一定程度上也影响隔-海马神经元乙酰胆碱(ACh)的转换。这种影... 详细信息

隔区内的各种神经介质,包括P-物质,β-内啡肽可能是通过对胆碱能神经元胞体发挥作用而影响隔-海马神经元的活动。促肾上腺皮质激素(ACTH 1—24)和α-促黑色细胞素(α-MSH),在一定程度上也影响隔-海马神经元乙酰胆碱(ACh)的转换。这种影响在切断海马的传入纤维后也不被阻断,从而推论:这些神经介质直接作用于海马。实验表明:ACTH是通过隔区内肽能神经元而影响隔-海马胆碱能神经元活动的。

关键词：海马胆碱能神经元促肾上腺皮质激素海马神经元突触

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Clinical Safety of New Tri-Phasic Oral Contraceptive Pill

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Journal of Reproduction and Contraception 1991年第1期3卷 25-30页

作者： N.Mereuri G.Brilli A.C.Mancini G.botticelli G.Fabbri A.D.Genazzani F.Petraglia A.Volpe A.R.Genazzani Dept.Obst.Gynecol. UniversityofModenaViadelP02207141100ModenaItaly Dept.Obst.Gynecol. UniversityofCagliareItaly

The aim of our study was to evaluate the metabolic and clinical effects of a contraceptive treatment with a new tri-phasic formulation of ethynyl-estradiol (35μg) and norethisterone (0.5-1mg) in fertile *** this purpose 20 healthy fertile women (19-32years) volunteered to follow this ***-density lipoprotein cholesterol,low-density lipoprotion cholesterol,fibrinogen concentration and antithrombin Ⅲ were measured by enzymatic method and fibrinopeptides A,by *** patients were treated for 6 cycles and they were studied before and after 1,3, and 6 cycles of *** all patients both the length of the menstrual cycle,and bleeding,acne and seborrhea and side effects were *** contraceptive therapy with this new formulation resulted very effective,without significant metabolic changes and with very few side effects.

关键词：三相口服避孕药丸药物安全性临床试验药物代谢动力学育龄女性

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