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2010年广东省药师周大会

作者： Fang Yuan1a,j.e Chen 2a,Wen-j.n Wu 3,Su-zhen Chen 1,Xue-ding Wang 1 and Min Huang 1 1 Institute of Clinical Pharmacology,School of Pharmaceutical Sciences,Sun Yat-sen University,74 Zhongshan Road II,Guangzhou 510080,P.R.China,and 2 Department of Pharmacy,the First Affiliated Hospital,Sun Yat-sen University,58 Zhongshan Road II,Guangzhou 510080,China,and 3 Institution of Chinese Medical Science,University of Macau,Av.Padre Tomás Pereira S.j.,Taipa,Macao,P.R.China.

Matrine and oxymatrine are the maj.r bioactive compounds extracted from the root of Sophorae flavescens Ait,which have been widely used in traditional Chinese *** obj.ctive of the study was to investigate the effects of matrine or oxymatrine on hepatic cytochrome P450 (CYP450) and the underlying molecular *** (15,75 and 150 mg kg-1 ) or oxymatrine (36,180 and 360 mg kg-1) had been administrated to rats for 14 days and the activities of CYP450 were measured by the quantication of the metabolites from multiple CYP450 probe substrates,using validated liquid chromatography coupled with liquid chromatography-tandem mass spectrometry detection (LC-MS/MS) and High Performance Liquid Chromatography methods (HPLC).The mRNA and protein expression level of CYPs were determined by quantitative real-time reverse-transcription polymerase chain reaction and western blotting analysis *** between matrine or oxymatrine and human constitutive androstane (car),pregnane X receptor (PXR) were evaluated by means of reporter gene assay in CV-1 *** study showed that matrine and oxymatrine signicantly induced the activity and gene expression of CYP2B1 in a dose-dependent manner;Matrine (150 mg kg-1) slightly induced the mRNA and protein expression of CYP2E1 and mildly inhibited the mRNA and protein expression of CYP3A1 in *** or oxymatrine could activate human car and induce the CYP2B reporter construct in CV-1 *** results revealed that matrine and oxymatrine can induce the activity and expression of CYP2B1/2 in rats,and the underlying mechanism may be related to the activation of car.

关键词： Matrine Oxymatrine cytochrome P450 CYP2B1/2 induction.

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In Vitro Konstruktion und Erfolgreiche Transplantation von Kryokonservierten Membran-Zel-Transplantaten(MZT) auf Vollhautwunden Athymischer Nacktmuse

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暨南大学学报(自然科学与医学版) 1998年第6期 158-158页

作者： Kopp, j. 1,2) j.ao, X.Y. 1,3) Chen, Y.L. 1,2) Stark, G.B. 1,2,3) (1) Abteilung Plastische und Handchirurgie, Chirurgische Universiltsklinik, freiburg l. Brsg, Germany 2) Verbrennungszentrum, Changhai Hosptital, Second Military Medical University, Shanghai,P.R. China) 3) Abteilung Plastische Chirurgie, Changhai Hospital, Second Militray Medical University, Shanghai, P.R.China)

Ｋｏｐｐ，Ｊ１，２）Ｊｉａｏ，Ｘ．Ｙ．１，３）Ｃｈｅｎ，Ｙ．Ｌ．１，２）Ｓｔａｒｋ，Ｇ．Ｂ．１，２，３）（１）ＡｂｔｅｉｌｕｎｇＰｌａｓｔｉｓｃｈｅｕｎｄＨａｎｄｃｈｉｒｕｒｇｉｅ，ＣｈｉｒｕｒｇｉｓｃｈｅＵｎｉｖｅ... 详细信息

Ｋｏｐｐ，Ｊ１，２）Ｊｉａｏ，Ｘ．Ｙ．１，３）Ｃｈｅｎ，Ｙ．Ｌ．１，２）Ｓｔａｒｋ，Ｇ．Ｂ．１，２，３）（１）ＡｂｔｅｉｌｕｎｇＰｌａｓｔｉｓｃｈｅｕｎｄＨａｎｄｃｈｉｒｕｒｇｉｅ，ＣｈｉｒｕｒｇｉｓｃｈｅＵｎｉｖｅｒｓｉｌｔｓｋｌｉｎｉｋ，Ｆｒｅｉ...

关键词： In Vitro Erfolgreiche Athymischer

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j.NO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop j.ão Pedro Athayde Marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Buscemi j.se Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos frédéric Druillole 杜然杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Agnese Giaz Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Christian Grewing Vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher caren Hagner 韩然 Yang Han Muhammad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice j.lmini Kuo-Lun j.n Ignacio j.ria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile j.llet j.ri j.utsenvaara Sirichok j.ngthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China University of Science and Technology ShanghaiChina University of Science and Technology of China HefeiChina j.int Institute for Nuclear Research DubnaRussia INFN Sezione di Milano and Dipartimento di Fisica dell Universitàdi Milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand Ij.Lab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and University of Milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of Roma Tre and INFN Sezione Roma Tre RomaItaly Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beij.ng Institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The j.angmen Underground Neutrino Observatory(j.NO)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with j.NO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of j.NO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories j.NO liquid scintillator detector

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