检索结果-南通市图书馆

cD4^(+)T cells produce IFN-I to license cDc1s for induction of cytotoxic T-cell activity in human tumors

cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël c.de Groot Marij J.P.Welters Tom de Wit ellen schrama Hans van Eenennaam saskia J.santegoets Timo Oosenbrug Annemarthe van der Veen Joris L.Vos charlotte L.Zuur Noel F.c.c.de Miranda Heinz Jacobs sjoerd H.van der Burg Jannie Borst Yanling Xiao department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOs B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands department of Otorhinolaryngology Leiden University Medical center LeidenThe Netherlands department of Pathology Leiden University Medical CenterLeidenThe Netherlands

cD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDc1s)to induce cD8^(+)cytotoxic T lymphocyte(cTL)anticancer responses,as proven in mouse *** recently identified cDc1s with a transcriptomic imprint of cD4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDc1 licensing by cD4^(+)T cells in *** cD4^(+)T cells produce IFNβvia the sTING pathway,which promotes MHc-I antigen(cross-)presentation by cDc1s and thereby improves their ability to induce cTL anticancer *** cooperation with cD40 ligand(L),IFNβalso optimizes the costimulatory and other functions of cDc1s required for cTL response ***-I-producing cD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to cTLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDcs and tumor-reactive cD8^(+)T *** agreement with this scenario,the presence of IFN-I-producing cD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： cD4^(+)T-cell help cDc1 licensing IFN-I signaling cD40 costimulation (cross-)presentation cTL priming Tumor control

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A tribo-chemical view on astringency of plant-based food substances

引用

friction 2024年第7期12卷 1392-1407页

作者： samuel s.GAMANIel Paloma s.DUEÑAs ROBLEs Hans TROMP els H.A.de HOOG sissi de BEER Emile van der HEIde Laboratory for surface Technology and Tribology Faculty of Engineering TechnologyUniversity of TwenteEnschede 7522 LWthe Netherlands NIZO Food Research B.V. Ede6710 BAthe Netherlands department of Molecules and Materials MEsA+Institute for Nanotechnology University of TwenteEnschede 7500 AEthe Netherlands

consumption of plant-based food products having high composition of polyphenols leads to the sensation of *** sliding oral surfaces,friction is an essential property during the oral perception of roughness and dryness which are attributes associated with *** factors including the chemical composition of interacting layers,structure and operation of interfaces have an effect on the astringency development *** manner of interactions occurring at oral interfaces suggest there is a system dependence of astringency and highlights the importance of adopting a tribosystems *** measurement techniques have shown an existing relationship between salivary protein-polyphenol interaction and an astringent ***,the tribo-chemistry involved in this multifaceted sensation remains largely unexplored in a comprehensive *** this review the underlying tribo-chemical processes useful in understanding the mechanism of astringency are highlighted and discussed considering current techniques employed to investigate astringency *** of lubrication on oral surfaces owing to the tribo-chemical interactions involving saliva and astringent plant proteins requires subsequent deformations of oral tissues which are significant enough to induce strains at mechanoreceptor locations,leading to the sensation of *** is proposed that micro-scale contact modelling on the interaction of food particles/aggregates,boundary layers and oral surfaces shows potential in addressing the knowledge gap between tribo-chemical measurement techniques and panel tests,making it possible to attain a predictor for astringency.

关键词： oral lubrication astringency tribo-chemistry tribology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Public perception of connected and automated vehicles:Benefits,concerns,and barriers from an Australian perspective

Journal of Intelligent and Connected Vehicles

引用

Journal of Intelligent and connected Vehicles 2024年第2期7卷 108-128页

作者： Ali Matin Hussein dia department of civil and construction Engineering Swinburne University of TechnologyMelbourne 3122Australia

This study investigates the attitudes and concerns of the Australian public toward connected and autonomous vehicles(cAVs),and the factors influencing their willingness to adopt this *** a comprehensive survey,a diverse group of respondents provided valuable insights toward various cAV scenarios such as riding in a vehicle with no driver,self-driving public transport,self-driving taxis,and heavy vehicles without *** results highlight the significant impact of safety concerns about automated vehicles on individuals’attitudes across all *** levels of concern were associated with more negative attitudes,and a strong correlation between concerns and opposition underlines the necessity of addressing these apprehensions to build public trust and promote cAV ***,nearly 70%of respondents felt uncomfortable driving next to a cAV,but they displayed more confidence in adopting automated public transport in the near ***,around 40%of participants indicated a strong willingness to purchase a cAV,primarily driven by the desire to reduce their carbon footprint and safety ***,respondents with health conditions or disability exhibited heightened interest(almost double those without health conditions)in cAV *** differences emerged in attitudes and preferences toward cAVs,with women expressing a greater level of concern and perceiving higher barriers to cAV *** emphasizes the importance of employing targeted approaches to address the specific concerns of different *** study also underscores the role of trust in technology as a significant barrier to cAV deployment,ranking high among respondents’*** overcome these challenges and facilitate successful cAV deployment,various strategies are suggested,including live demonstrations,dedicated routes for automated public transport,adoption incentives,and addressing liability *** findings from this st

关键词： connected and automated vehicles(cAVs) autonomous vehicles public acceptance stakeholder consultations road safety

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nonlinear wave dispersion in monoatomic chains with lumped and distributed masses:discrete and continuum models

引用

Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 633-648页

作者： E.GHAVANLOO s.el-BORGI school of Mechanical Engineering Shiraz UniversityShiraz 71963-16548Iran Mechanical Engineering Program Texas A&M University at QatarDoha 23874Qatar

The main objective of this paper is to investigate the influence of inertia of nonlinear springs on the dispersion behavior of discrete monoatomic chains with lumped and distributed *** developed model can represent the wave propagation problem in a non-homogeneous material consisting of heavy inclusions embedded in a *** inclusions are idealized by lumped masses,and the matrix between adjacent inclusions is modeled by a nonlinear spring with distributed ***,the model is capable of depicting the wave propagation in bi-material bars,wherein the first material is represented by a rigid particle and the second one is represented by a nonlinear spring with distributed *** discrete model of the nonlinear monoatomic chain with lumped and distributed masses is first considered,and a closed-form expression of the dispersion relation is obtained by the second-order Lindstedt-Poincare method(LPM).Next,a continuum model for the nonlinear monoatomic chain is derived directly from its discrete lattice model by a suitable continualization *** subsequent use of the second-order method of multiple scales(MMs)facilitates the derivation of the corresponding nonlinear dispersion relation in a closed *** novelties of the present study consist of(i)considering the inertia of nonlinear springs on the dispersion behavior of the discrete mass-spring chains;(ii)developing the second-order LPM for the wave propagation in the discrete chains;and(iii)deriving a continuum model for the nonlinear monoatomic chains with lumped and distributed ***,a parametric study is conducted to examine the effects of the design parameters and the distributed spring mass on the nonlinear dispersion relations and phase velocities obtained from both the discrete and continuum *** parameters include the ratio of the spring mass to the lumped mass,the nonlinear stiffness coefficient of the spring,and the wave amplitude.

关键词： nonlinear mass-spring chain discrete model continuum model LindstedtPoincare method(LPM) method of multiple scales(MMs) dispersion phase velocity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Geochemistry and depositional environment of fuchsite quartzites from sargur Group,western Dharwar craton,India

引用

Acta Geochimica 2024年第3期43卷 555-570页

作者： c.s.sindhuja G.Harshitha c.Manikyamba k.s.V.subramanyam csIR(council of scientific and Industrial Research)-National Geophysical Research Institute(NGRI) Uppal RoadHyderabad 500007India

Meso-Neoarchean fuchsite quartzites are present in different stratigraphic positions of Dharwar craton including the oldest(~3.3 Ga)sargur Group of western Dharwar *** present study deals with the petro-graphic and geochemical characteristics of the fuchsite quartzites from the Ghattihosahalli belt to evaluate their genesis,depositional setting and the enigma involved in the ancient sedimentation *** major mineral assemblages include quartz,fuchsite,and feldspars along with accessory kyanite and *** geochemical com-positions are characterized by high siO_(2),Al_(2)O_(3),low MgO,caO,strongly enriched cr(1326–6899 ppm),Ba(1165–3653 ppm),sr(46–210 ppm),V(107–868 ppm)and Zn(11–158 ppm)contents compared to the upper continental crust(Ucc).The Ucc normalized rare earth element(REE)patterns are characterized by depleted light REE[(La/sm)Ucc=0.33–0.95]compared to heavy REE[(Gd/Yb)_(Ucc)=0.42–1.65]with conspicuous positive Eu-anomalies(Eu/Eu^(*)=1.35–18.27)characteristic of hydrothermal solutions evidenced through the interlayered *** overall major and trace element systematics reflect a combined mafic-felsic provenance and suggest their deposition at a passive continental margin *** comprehensivefield,petrographic,and geo-chemical studies indicate that these quartzites are infiltrated by cr-richfluids released during high-grade metamorphism of associated ultramafic *** sargur and the subse-quent Dharwar orogeny amalgamated diverse lithounits from different tectonic settings,possibly leading to the release of cr-richfluids and the formation of fuchsite quartzite during or after the *** sug-gest a pre-existing stable crust prior to the sargur Group and the link between orogenic events and various mineral deposits in the Dharwar craton.

关键词： Dharwar craton Ghattihosahalli Fuchsite quartzite Provenance depositional setting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Large magnetocaloric effect and magnetic properties of EuRhO3

引用

Journal of Rare Earths 2024年第9期42卷 1724-1729页

作者： M.Lassri M.sajieddine A.elouafi A.el Hachmi s.el Ouahbi R.Moubah Laboratory of Energy and Materials Engineering (LGEM) University of Sultan Moulay SlimaneFaculty of Science and Technology (FST) Institute of Applied Physics (IAP)-school of Industrial Management (EMINEs) Mohammed Ⅵ Polytechnic University National school of Applied sciences (ENsA) University of Sultan Moulay Slimane Laboratory of Mechanics Production and Industrial Engineering (LMPGI)Higher School of Technology of Casablanca (ESTC)University of Hassan Ⅱ Casablanca Laboratory of Radiation on Matter and Instrumentation (LRMI) Faculty of Science and Technology (FST) SettatHassan Ⅰ University Laboatory of Physics of Advanced Materials and Thermic (LPMAT) Faculty of Science Ain Chock (FSAC)University of Hassan Ⅱ Casablanca

We report on the structural,magnetic,and magnetocaloric properties of *** oxidation states of Eu and Rh ions were studied using X-ray photoelectron spectroscopy（XPs）.It is found that the Eu ions are mainly in the divalent oxidation state while the Rh ions have+4 ***3powders are found to be antiferromagnetic with a second order magnetic transition at Neel temperature（TN=2.9 k）.Analysis of the magnetic susceptibility versus temperature data in terms of the curie=Weiss law:(χ=c/（T-θW）) for T>TN,yields θW=-3.1 k and effective magne tic moment ■,which is close to the theoretical value ■.The magnetic entropy change(-ΔsM),was determined by em ploying the thermodynam ic Maxwell's *** μ0H=5 T and near TN,■ and relative cooling power（RcP） exhibit large values of 33.7 J/（kg·k） and 238 J/kg,*** large magnitude of-ΔsMand RcP show that the EuRhO3compound could be a potential candidate to be used in cryogenic magnetic refrigeration.

关键词： X-ray photoelectron spectroscopy cryogenic magnetic refrigeration Magnetic properties Magnetocaloric effect Rare earths

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Adsorption of yttrium(Y^(3+)) and concentration of rare earth elements from phosphogypsum using chitin and chitin aerogel

引用

Journal of Rare Earths 2024年第4期42卷 775-782页

作者： Glaydson s.dos Reis diana Pinto sabrina F.Lütke Eder c.Lima Luis F.O.silva Irineu A.s.de Brum Guilherme L.Dotto department of Forest Biomaterials and Technology Biomass Technology centre Swedish University of Agricultural SciencesUmeaE13Swedn Universidad de La costa Calle 58#55-66080002BarranquillaAtlanticoColombia Research Group on Adsorptive and catalytic Process Engineering(ENGEPAc) Federal University of Santa MariaAv.Roraima100079705900Santa MariaRSBrazil Institute of chemistry Federal University of Rio Grande do Sul90040060Porto AlegreBrazil

chitin powder and chitin-aerogel were prepared from shrimp wastes and used to uptake Y^(3+)from aqueous solutions and concentrate this rare earth element from phosphogypsum(PG).chitin aerogel displays a specific surface area of 945 m^(2)/g,while chitin powder is 3.6 m^(2)/g,which largely influences its adsorption *** the adsorption in synthetic solutions,the effect of pH on Y^(3+)removal is strong for chitin powder *** contrast,no big pH influence was detected for chitin *** interactions and chelation can highlight the proposed mechanism of Y^(3+)on chitin adsorbents for the powder and ***,in addition to these interactions,pore filling/pore diffusion is the main mechanism of Y^(3+)removal in the chitin *** aerogel is efficient in concentrating 8 times the Y^(3+)from PG,a very complex *** complex chitin aerogel-Y^(3+)can be a secondary source of rare earth elements for other applications.

关键词： Rare earths sustainable material chitin powder chitin porous aerogel Yttrium adsorption and recovery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Landau quantization effects on damping kawahara solitons in electron–positron–ion plasma in rotating ionized medium

引用

communications in Theoretical Physics 2024年第10期76卷 143-152页

作者： E I el-Awady s Hussain N Akhtar department of Physics Faculty of Science Port Said University Theoretical Physics Division (TPD) PINSTECH

For the dynamics of three-dimensional electron–positron–ion plasmas, a fluid quantum hydrodynamic model is proposed by considering Landau quantization effects in dense ***–neutral collisions in the presence of the coriolis force are also considered. The application of the reductive perturbation technique produces a wave evolution equation represented by a damped korteweg–de Vries equation. This equation, however, is insufficient for describing waves in our system at very low dispersion coefficients. As a result, we considered the highest-order perturbation, which resulted in the damped kawahara equation. The effects of the magnetic field, Landau quantization, the ratio of positron density to electron density, the ratio of positron density to ion density, and the direction cosine on linear dispersion laws as well as soliton and conoidal solutions of the damped kawahara equation are explored. The understanding from this research can contribute to the broader field of astrophysics and aid in the interpretation of observational data from white dwarfs.

关键词： coriolis force kawahara equation Landau quantization magnetoplasmas quantum plasma solitary and cnoidal waves

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Radiative heat transfer analysis of a concave porous fin under the local thermal non-equilibrium condition:application of the clique polynomial method and physics-informed neural networks

引用

Applied Mathematics and Mechanics(English Edition) 2024年第9期45卷 1613-1632页

作者： k.cHANDAN k.kARTHIk k.V.NAGARAJA B.c.PRAsANNAkUMARA R.s.VARUN kUMAR T.MUHAMMAD Amrita school of Artificial Intelligence Amrita Vishwa VidyapeethamBengaluru 560035KarnatakaIndia department of studies in Mathematics Davangere UniversityDavangere 577002KarnatakaIndia computational science Lab Amrita School of EngineeringAmrita Vishwa VidyapeethamBengaluru 560035KarnatakaIndia department of Pure and Applied Mathematics School of Mathematical SciencesSunway UniversityPetaling Jaya 47500Malaysia department of Mathematics College of ScienceKing Khalid UniversityAbha 61413Saudi Arabia

The heat transfer through a concave permeable fin is analyzed by the local thermal non-equilibrium(LTNE)*** governing dimensional temperature equations for the solid and fluid phases of the porous extended surface are modeled,and then are nondimensionalized by suitable dimensionless ***,the obtained nondimensional equations are solved by the clique polynomial method(cPM).The effects of several dimensionless parameters on the fin's thermal profiles are shown by graphical ***,the current study implements deep neural structures to solve physics-governed coupled equations,and the best-suited hyperparameters are attained by comparison with various network *** results of the cPM and physicsinformed neural network(PINN)exhibit good agreement,signifying that both methods effectively solve the thermal modeling problem.

关键词： heat transfer fin porous fin local thermal non-equilibrium(LTNE)model physics-informed neural network(PINN)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multiple scales method for analyzing a forced damped rotational pendulum oscillatorwithgallows

引用

communications in Theoretical Physics 2024年第5期76卷 58-67页

作者： Haifa A Alyousef Alvaro H salas B M Alotaibi s A el-Tantawy department of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia department of Mathematics and statistics Universidad Nacional de ColombiaFIZMAKO Research GroupColombia department of Physics Faculty of SciencePort Said UniversityPort Said 42521Egypt Research center for Physics(RcP) Department of PhysicsFaculty of Science and ArtsAl-MikhwahAl-Baha UniversityAl-Baha 1988Saudi Arabia

This study reports the analytical solution for a generalized rotational pendulum system with gallows and periodic excited *** multiple scales method(MsM)is applied to solve the proposed *** types of rotational pendulum oscillators are studied and talked about in *** include the forced damped rotating pendulum oscillator with gallows,the damped standard simple pendulum oscillator,and the damped rotating pendulum oscillator without *** MsM first-order approximations for all the cases mentioned are derived in *** obtained results are illustrated with concrete numerical *** first-order MsM approximations are compared to the fourth-order Runge-kutta(Rk4)numerical ***,the maximum error is estimated for the first-order approximations obtained through the MsM,compared to the numerical approximations obtained by the Rk4 ***,we conducted a comparative analysis of the outcomes obtained by the used method(MsM)and He-MsM to ascertain their respective levels of *** proposed method can be applied to analyze many strong nonlinear oscillatory equations.

关键词： rotational pendulum system multiple scales method approximate solution damped oscillations forced pendulum with gallows he-multiple scales method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：