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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien francesca Cicchetti frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal dOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

A verification framework for spatio-temporal consistency language with CCSL as a specification language

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frontiers of Computer Science 2020年第1期14卷 105-129页

作者： Yuanrui ZHANG frédéric MALLET Yixiang CHEN MoE Engineering Research Center for Software/Hardware Co-design Technology and Application East China Normal UniversityShanghai 200062China University Nice Sophia Antipolis I3SUMR 7271 CNRSINRIA06900 Sophia AntipolisFrance

The Spatio-Temporal Consistency Language(STeC)is a high-level modeling language that deals natively with spatio-temporal behaviour,i.e.,behaviour relating to certain locations and *** restriction by both locations and time is of first importance for some types of real-time *** is a formal specification language based on logical *** is used to describe some crucial safety properties for real-time systems,due to its powerful expressiveness of logical and chronometric time *** consider a novel verification framework combining STeC and CCSL,with the advantages of addressing spatio-temporal consistency of system behaviour and easily expressing some crucial time *** propose a theory combining these two languages and a method verifying CCSL properties in STeC *** adopt UPPAAL as the model checking tool and give a simple example to illustrate how to carry out verification in our framework.

关键词： spatio-temporal consistency real-time systems spatio-temporal systems high-level modelling language clock constraint specification model checking verification framework

High temperature X-ray diffraction study of the formation of Na_(2)Ti_(3)O_(7) from a mixture of sodium carbonate and titanium oxide

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Journal of Energy Chemistry 2022年第2期31卷 210-218页

作者： Caroline Piffet Bénédicte Vertruyen frédéric Hatert Rudi Cloots frédéric Boschini Abdelfattah Mahmoud GREENMAT CESAM Research UnitChemistry DepartmentUniversity of Liège4000 LiègeBelgium Laboratory of Mineralogy Geology Research UnitUniversity of Liège4000 LiègeBelgium

Na2Ti3O7 has attracted much attention in the field of anode materials for Na-ion batteries thanks to its non-toxicity and very low working potential of 0.3 V vs Na0/Na+.Building a clearer picture of its formation from cheap Na_(2)CO_(3) and TiO_(2) starting materials is therefore of obvious ***,we report new insights from an in-situ high temperature X-ray diffraction study conducted from room temperature to 800°C,complemented by ex-situ *** were thereby able to position the previously reported Na_(4)Ti_(5)O_(12) and Na_(2)Ti_(6)O_(13) intermediate phases in a reaction scheme involving three successive steps and temperature *** and/or broadening of a subset of the Na_(2)Ti_(6)O_(13) reflections suggested a combination of intra-layer disorder with the well-established ordering of successive *** in-situ study was carried out on reproducible mixtures of Na_(2)CO_(3) and TiO_(2) in 1:3 molar ratio prepared by spraydrying of mixed aqueous ***-phase Na_(2)Ti_(3)O_(7) was obtained after only 8 h at 800°C in air,instead of a minimum of 20 h for a conventional solid-state route using the same *** analysis revealed~15 mm diameter granules made up from rectangular rods of a fewmm length presenting electrochemical properties in line with *** the absence of grinding or formation of intimate composites with conductive carbon,the specific capacity of 137 m Ah/g at C/5 decreased at higher rates.

关键词： Formation mechanism High temperature XRd Na_(2)Ti_(3)O_(7) Spray-drying synthesis Na-ion batteries

Anisotropic modelling of Opalinus Clay behaviour: from triaxial tests to gallery excavation application

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第3期9卷 53-66页

作者： francois Bertrand frédéric Collin Université de Liège Département ArGEnCo/Géomécanique Allée de la découverte 9 4000 Liège Belgium F.R.I.A Fonds de la Recherche Scientifique e FNRS Brussels Belgium

deep repository in geological formations is the preferential solution considered in many countries to manage high-level nuclear wastes. In Switzerland, the Opalinus Clay is a candidate host rock. In this context, in situ and laboratory tests are conducted on Opalinus Clay to demonstrate the feasibility of deep disposal in this argillaceous formation. This paper presents a constitutive model able to fit the experimental data obtained from some triaxial tests conducted by Jahns(2013) on cores from borehole Schlattingen SLA-1. The elasto-plastic behaviour of Opalinus Clay is reproduced thanks to a druckerPrager model, taking into account the anisotropy behaviour of this sedimentary rock. The objective is to employ a single set of parameters representative of the material. In a second version of the model, the stress-dependence of the elastic properties and damage are taken into account. Finally, the parameters calibrated with experimental tests are used to simulate the excavation of a gallery with a second gradient approach.

关键词： Opalinus Clay Schlattingen Constitutive modelling Anisotropy dilatancy Localisation Tunnel excavation

does gastric atrophy exist in children?

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World Journal of Gastroenterology 2006年第39期12卷 6274-6279页

作者： Georges dimitrov frédéric Gottrand Gastroenterology hepatology and nutrition Unit Clinic of Pediatrics H?pital J de Flandre CHRU de Lille et Faculté de Médecine Université de Lille 2 Lille France

Several clinical reports confirmed that gastric atrophy is a pathology not only limited to adult patients. In pediatrics, it is most olden described in association with a H pylori infection but this bacteria does not seem to be the only etiological factor of this preneoplastic state in children. The frequency of gastric atrophy and intestinal metaplasia in children are unknown because they are not systematically sought during upper gastrointestinal endoscopy. The lack of specific histological classification of children＇s gastropathies makes their diagnosis difficult for pathologists. Based on our knowledge to date, we think that it is necessary to describe, in detail, the natural course of this lesion during childhood. A close and prolonged clinical and endoscopic follow-up is important for children with gastric atrophy.

关键词： Gastric atrophy Gastritis H pylori Intestinal metaplasia Gastric cancer Children

Soil-Structure Interaction Effects on dynamic Behaviour of Transmission Line Towers

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Computers, Materials & Continua 2022年第1期70卷 1461-1477页

作者： Abir Jendoubi frédéric Legeron Facultéde Génie Universitéde SherbrookeQuébecJ1K 2R1Canada Parsons Abu DhabiP.O.5498UAE

As inferred from earthquake engineering literature,considering soil structure interaction(SSI)effects is important in evaluating the response of transmission line towers(TLT)to dynamic loads such as impulse *** proposed study investigates the dynamic effects of SSI on TLT *** and non-linearmodels are *** the linearmodel,the soil is represented by complex impedances,dependent of dynamic frequency,determined from numerical *** nonlinearmodel considers the soil non-linear behavior in its material constitutive law and foundation uplift in a non-linear time history *** simplified structure behavior of a typical lattice transmission tower is *** analysis of frequency and time domain are followed through varying soil stiffness and damping *** different shock durations are *** soil-structure system with equivalent dynamic properties is *** behaviors achieved utilizing a rigid and a flexible base for the structures is compared to estimate the impact of taking SSI into account in the *** current mainstream approach in structural engineering,emphasizing the importance of the SSI effect,is illustrated using an example where the SSI effect could be detrimental to the ***,the non-linear analysis results are analyzed to show the linear approach’s limitations in the event of grand deformations.

关键词： Tower shock loads non-linear dynamic soil-structure interaction

Aminopeptidase A and dipeptidyl peptidase 4:a pathogenic duo in Alzheimer’s disease?

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Neural Regeneration Research 2022年第10期17卷 2215-2217页

作者： frédéric Checler Audrey Valverde UniversitéCôte d’Azur INSERMCNRSIPMCteam labelled“Laboratory of Excellence(LABEX)DistAlz”ValbonneFrance

The etiology of Alzheimer’s disease is far from being completely *** approaches have helped in this matter and have greatly supported the view that theβ-amyloid precursor protein(βAPP)could be at the center of gravity of the ***,mutations responsible for autosomal dominant aggressive forms of Alzheimer’s disease(Ad)are all harbored by eitherβAPP itself or by its cleaving enzyme presenilins 1/2 referred to asγ-*** was therefore convincing to note that fully independent gene products harboring Ad-linked mutations,all concur to modulateβAPP proteolytic *** genetic clues combined with a bulk of anatomical observations and cellular manipulations pointed to the role of amyloid-β(Aβ),the main biochemical component of senile plaques that accumulate at late stages of ***,a series of clinical trials designed to either abolish Aβproduction or neutralize it once produced have consistently failed(Checler et al.,2021).

关键词： Alzheimer Aβ senile