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Molecular Plant 2017年第1期10卷 216-218页

作者： frédéric chaux Xenie Johnson Pascaline Auroy Audrey Beyly-Adriano Isabelle Te Stéphan Cuiné Gilles Peltier CEA CNRS Aix-Marseille Université Institut de Biosciences et Biotechnologies Aix-Marseille UMR 7265 Laboratoire de Bioénergétique et Biotechnologie des Bactéries et Microalgues CEA Cadarache Saint-Paul-lez-Durance 13108 France

dear Editor,In natural environments, photosynthetic organisms experience frequent changes in the light supply, requiring modulation of light harvesting and electron transfer reactions to avoid mismatch between light conversion and metabolic reactions that may result in the production of harmful reactive oxygen species. They have thus evolved photoprotective regulatory mechanisms including the dissipation of excess energy （or non-photochemical quench-ing, NPQ）,

关键词： Controlling Photoinhibition Chlamydomonas

The Impact of Recent Reforms and determinants of Pharmaceutical Industry Patent Application in China

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The Impact of Recent Reforms and Determinants of Pharmaceuti...

作者： Felix Andres Conde chaux 上海交通大学

学位级别：硕士

China`s State Intellectual Property Office in 2015 became the first office to receive over a million patent applications in a single *** office received almost as many applications as the leaders in IP area combined(Japan,the Republic of Korea and U.S.).On the other hand,China`s pharmaceutical market became the world 2nd(regarding industry value),coming from the 9th place,in the period between 2005 to 2016,according to a IMS Health *** on a patent search and literature research,this study carefully analyzes the impact of recent reforms in the patent applications from pharmaceutical industry in China,identifies the principal fields of technology developed,leading inventors and companies patenting products in the country,and a trend in the applications after two major reforms in the patent ***,based on a questionnaire and interviews to 18 companies with operations in China,the study identifies the factors that companies in pharmaceutical industry considered the most important for their IP strategy and patent application;it has been found that(i) partnership(ii) exclusivity and(iii) licensing opportunities are the factors that influence those decisions in the ***,it has been found that companies are satisfied with the IPR system and found it userfriendly,as well as helpful to the industry growth.

关键词： Intellectual Property Patent Law IP strategy Pharmaceutical Industry

Thedual pathogenesisofpenileneoplasia: The heterogeneous morphology of human papillomavirus-relatedtumors

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Asian Journal of Urology 2022年第4期9卷 349-358页

作者： Alcides chaux diego F.Sanchez Maria Jose Fernandez-Nestosa Sofia Canete-Portillo Ingrid M.Rodriguez Giovanna A.Giannico Antonio L.Cubilla department of Scientific Research School of Postgraduate Studies Norte UniversityAsuncionParaguay InstitutodePatologiae Investigacion AsuncionParaguay Polytechnic School National University of AsuncionSan LorenzoParaguay department of Pathology University of Alabama at BirminghamBirminghamALUSA School of Medicine National University of AsuncionSan LorenzoParaguay department of Pathology Microbiologyand ImmunologyVanderbilt University Medical CenterNashvilleTNUSA

Objective:Penile neoplasia,usually of squamous histogenesis,is currently classfied into human papillomavirus(HPV)-related or-dependent and non-HPV-related or-indepen *** are distinct morphological differences among the two *** research studies on penile cancer from Northern countries showed that the presence of HPV is corre lated with a better prognosis than virus negative people,while studies in Southern countries had not confirmed,perhaps due to differences in staging or ***:We focused on the description of the *** carcinomas of the *** approach was to describe common clinical features followed by the pathological features of each entity or subtype stressing the characteristics for differential diagnosis,HPV genotypes,and prognostic features of the invasive *** structure was followed for penile intraepithelial neoplasia,except for prognosis because of the scant evidence ***:Most of HPV-related lesions can be straightforwardly recognized by routine hematoxylin and eosin stains,but in some cases surrogate p16 immunohistochemical staining or molecular methods such as in situ hybridization or polymerase chain reaction can be ***,there are eight tumor invasive variants associated with HPV,as follows:basaloid,warty,warty-basaloid,papillary basaloid,clear cell,medullary,lymphoepithelioma-like,and giant condylomas with malignant ***:This review presents and describes the heterogeneous clinical,morphological,and genatypic features of the HPV-related subtypes of invasive and non-invasive penile neoplasia.

关键词： Penile neoplasia Squamous cell carcinoma Human papillomavirus Carcinoma in situ Penile intraepithelial neoplasia

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蔗糖工业中的环境保护

产业与环境 1992年第4期14卷 51-59,60页

作者： didier chaux 刘云清 7 rue Carnot 91120 PalaiseauFrance

由于牵涉到未来的发展战略和前景,在发展中国家,蔗糖工业具有重要意义。本文的作者分析了引起污染的各种原因:通过大气（酸雨）、副产物和污水。他指出了此行业中不同的预防措施和实施的主要处理。在与糖精制造工业有关的各种环境风险... 详细信息

由于牵涉到未来的发展战略和前景,在发展中国家,蔗糖工业具有重要意义。本文的作者分析了引起污染的各种原因:通过大气（酸雨）、副产物和污水。他指出了此行业中不同的预防措施和实施的主要处理。在与糖精制造工业有关的各种环境风险中,最具危险的是蒸馏残液。目前的处理技术既能实现环境保护,同时又能提供有利的商业机会。

关键词：制糖蔗糖工业环境保护

心肌不同步是严重左室收缩功能障碍致慢性心力衰竭患者在动力性运动过程中功能性二尖瓣反流严重程度的决定性因素

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世界核心医学期刊文摘（心脏病学分册） 2006年第8期2卷 22-23页

作者： Ennezat P.V. Maré chaux S. Le Tourneau T. 杨海涛 Intensive Care Unit University Hospital Bd Pr Jules Leclercq 59 000 Lille France

Aims: Functional mitral regurgitation(MR) and myocardial asynchronism occur commonly in patients with dilated cardiomyopathy and affect adversely their prognosis and symptoms. The aim of this study was to evaluate the mechanisms of changes in MR severity during dynamic exercise in patients with chronic heart failure(CHF). Methods and results: Seventy patients with CHF due to left ventricular(LV) systolic dysfunction [LV ejection fraction(EF)d functional MR were studied. All were in sinus rhythm. Medications were left unchanged for the study. Each patient performed a maximal symptom-limited exercise test with continuous 2d-doppler echocardiography. Mitral regurgitant volume(RV) and effective regurgitant orifice(ERO) were determined at rest and during exercise. LV asynchrony using doppler tissue imaging and interventricular asynchrony using conventional pulsed-doppler were evaluated at rest. Resting LV EF averaged 25± 8% . Mean resting LV and interventricutar mechanical delays were 56± 50 and 43± 37 ms, respectively. The overall median values for mitral ERO and RV did not significantly change during dynamic exercise(11 [7-16] vs. 11 [6-21] mm2 and 14 [10- 22] vs. 12 [9-23] mL, respectively). However, changes in mitral ERO and RV were individually variable and significantly correlated with the degree of LV asynchronism(r=0.66, Pd r=0.66, Pduring dynamic exercise. LV asynchronism at rest substantially contributes to worsening of functional MR during dynamic exercise in patients with CHF due to LV systolic dysfunction.

关键词：慢性心力衰竭患者左室收缩功能障碍扩张型心肌病患者二尖瓣反流运动过程严重程度动力性功能性决定性因素慢性心力衰竭(CHF)

A modified clinicopathological tumor staging system for survival prediction of patients with penile cancer

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Cancer Communications 2018年第1期38卷 726-735页

作者： Zai-Shang Li Antonio Augusto Ornellas Christian Schwentner Xiang Li Alcides chaux Georges Netto Arthur LBurnett Yong Tang JiunHung Geng Kai Yao Xiao-Feng Chen Bin Wang Hong Liao Nan Liu Peng Chen Yong-Hong Lei Qi-Wu Mi Hui-Lan Rao Ying-Ming Xiao Qi-Lin Wang Zi-Ke Qin Zhuo-Wei Liu Yong-Hong Li Zi-Jun Zou Jun-Hang Luo Hui Li Hui Han Fang-Jian Zhou department of Urology Shenzhen People’s HospitalThe Second Clinical College of Jinan UniversityShenzhen 518060GuangdongP.R.China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhou 510060GuangdongP.R.China department of Urology Sun Yat-sen University Cancer Center651 Dongfeng RoadEast Guangzhou 510060GuangdongP.R.China department of Urology Brazilian National Institute of Cancer and Hospital Mário KröeffRio de Janeiro 20230-130Brazil Section of Urology National Institute of CancerRio de JaneiroBrazil department of Urology Diakonie Klinikum Stuttgart70174 StuttgartGermany Urological department Urological InstituteWest China Hospital of Sichuan UniversityChengdu 610041SichuanP.R.China department of Scientific Research Norte University1001-1925 AsunciónParaguay department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA department of Urology Johns Hopkins UniversityBaltimoreMD 21218USA department of Urology Affiliated Cancer Hospital of Guangxi Medical UniversityNanning 530021GuangxiP.R.China department of Urology Kaohsiung Medical University HospitalKaohsiungTaiwan 807China department of Urology The First People’s Hospital of ChenzhouChenzhou 423000HunanP.R.China department of Urology Cancer Center of Guangzhou Medical UniversityGuangzhou 510000GuangdongP.R.China department of Urology Sichuan Cancer HospitalChengdu 610041SichuanP.R.China department of Urology Oncological Surgery Chongqing Cancer Hospital&Institute&Cancer CenterChongqing 400040China department of Urology Affiliated Tumor Hospital of Xinjiang Medical UniversityUrumqi 830011XinjiangP.R.China department of Urology Yunnan Provincial Tumor HospitalThe Third Affiliated Hospital of Kunming Medical UniversityKunming 650118YunnanP.R.China department of Urology Dongguan People’s HospitalDongguan 523059GuangdongP.R.China department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdo

Background:The 8th American Joint Committee on Cancer tumor-node-metastasis(AJCC-TNM)staging system is based on a few retrospective single-center *** aimed to test the prognostic validity of the staging system and to determine whether a modified clinicopathological tumor staging system that includes lymphovascular emboliza-tion could increase the accuracy of prognostic prediction for patients with stage T2-3 penile ***:A training cohort of 411 patients who were treated at 2 centers in China and Brazil between 2000 and 2015 were staged according to the 8th AJCC-TNM staging *** internal validation was analyzed by bootstrap-corrected C-indexes(resampled 1000 times).data from 436 patients who were treated at 15 centers over four conti-nents were used for external ***:A survivorship overlap was observed between T2 and T3 patients(P=0.587)classified according to the 8th AJCC-TNM staging *** embolization was a significant prognostic factor for metastasis and survival(all Pd on the multivariate analysis,only lymphovascular embolization showed a significant influ-ence on cancer-specific survival(CSS)(hazard ratio=1.587,95%confidence interval=1.253-2.011;P=0.001).T2 and T3 patients with lymphovascular embolization showed significantly shorter CSS than did those without lymphovascu-lar embolization(Pdified clinicopathological staging system was proposed,with the T2 and T3 categories of the 8th AJCC-TNM staging system being subdivided into two new categories as follows:t2 tumors invade the corpus spongiosum and/or corpora cavernosa and/or urethra without lymphovascular invasion,and t3 tumors invade the corpus spongiosum and/or corpora cavernosa and/or urethra with lymphovascular *** modified staging system involving lymphovascular embolization showed improved prognostic stratification with significant differences in CSS among all categories(all Pd exhibited higher accur

关键词： Penile neoplasms Lymph node metastasis Staging Lymph node excision Prognosis

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阴茎癌改良临床病理肿瘤分期预后意义分析

癌症 2019年第6期38卷 261-271页

作者： Zai-Shang Li Antonio Augusto Ornellas Christian Schwentner Xiang Li Alcides chaux Georges Netto Arthur L.Burnett Yong Tang Jiun Hung Geng Kai Yao Xiao-Feng Chen Bin Wang Hong Liao Nan Liu Peng Chen Yong-Hong Lei Qi-Wu Mi Hui-Lan Rao Ying-Ming Xiao Qi-Lin Wang Zi-Ke Qin Zhuo-Wei Liu Yong-Hong Li Zi-Jun Zou Jun-Hang Luo Hui Li Hui Han Fang-Jian Zhou 深圳市人民医院泌尿外科暨南大学第二临床学院广东深圳518060 department of Urology Johns Hopkins UniversityBaltimoreMD 21218USA 广西医科大学附属肿瘤医院泌尿外科广西南宁530021 高雄医科大学附属医院泌尿外科台湾高雄807 郴州市第一人民医院泌尿外科湖南郴州423000 广州医科大学肿瘤中心泌尿外科广东广州510000 四川省肿瘤医院泌尿外科四川成都610041 重庆市肿瘤医院&肿瘤研究所&癌症中心泌尿肿瘤外科重庆400040 新疆医科大学附属肿瘤医院泌尿外科新疆乌鲁木齐830011 云南省肿瘤医院昆明医科大学第三附属医院泌尿外科云南昆明650118 东莞市人民医院泌尿外科广东东莞523059 中山大学肿瘤防治中心华南肿瘤学国家重点实验室肿瘤医学协同创新中心广东广州 510060 中山大学肿瘤防治中心病理科广东广州510060 中山大学附属第一医院泌尿外科广东广州510000 香港中文大学病理学系香港999077 中山大学肿瘤防治中心泌尿外科广东广州510060 department of Urology Brazilian National Institute of Cancer and Hospital Mario KroeffRio de Janeiro 20230-130Brazil Section of Urology National Institute of CancerRio de Janeiro Brazil department of Urology Diakonie Klinikum StuttgartGermany 四川大学华西医院泌尿外科四川成都610041 department of Scientific Research Norte University1001-1925 AsuncionParaguay department of Pathology Johns Hopkins UniversityBaltimoreMD21218USA

背景与目的第8版美国癌症联合会-TNM(American Joint Committee on Cancer tumor–node–metastasis,AJCC-TNM)分期基于的是一些回顾性单中心研究。本研究旨在分析分期的预后价值,并探讨加入脉管癌栓的改良的临床病理肿瘤分期能否提高... 详细信息

背景与目的第8版美国癌症联合会-TNM(American Joint Committee on Cancer tumor–node–metastasis,AJCC-TNM)分期基于的是一些回顾性单中心研究。本研究旨在分析分期的预后价值,并探讨加入脉管癌栓的改良的临床病理肿瘤分期能否提高对T2–3期阴茎癌患者预后预测的准确性。方法根据第8版AJCC-TNM分期对2000年至2015年在中国和巴西2个中心接受治疗的411例患者所组成的训练队列进行分期。采用C-indexes一致性系数进行预测模型的评估,Bbootstrap再抽样法(1000次)进行模型验证。采用来自4个大洲15个中心接受治疗的436例患者的数据进行外部验证。结果根据第8版AJCC-TNM分期的T2和T3期患者有存活率重叠(P=0.587)。脉管癌栓是转移和生存的重要预后因素(均P dex,0.739 vs. 0.696)。以上结果在外部验证队列中得到了确认。结论 T2–3期阴茎癌是异质性的,加入脉管癌栓的改良临床病理分期比第8版AJCC-TNM分期对阴茎癌患者的预后预测能力更强。

关键词：阴茎肿瘤淋巴结转移分期淋巴结清扫预后