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Pharmacokinetics of traditional Chinese syndrome and recipe:a hypothesis and its verification(Ⅰ)

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World Journal of Gastroenterology 2000年第3期6卷 384-391页

作者： Xi Huang Ping Ren Ai Dong Wen Li Li Wang Li Zhang Feng Gao Laboratory of Clinical Pharmacology of Chinese Medicine,Xijing Hospital,The fourth military medical university,Xi’an 710032,Shaanxi Province,China Department of Pharmacy,Xijing Hospital,The fourth military medical university,Xi’an 710032,Shaanxi Province,China Department of Physiology,The fourth military medical university,Xi’an 710032,Shaanxi Province,China 第四军医大学陕西西安

AIM To propose a hypothesis defining theabsorption,distribution,metabolism andelimination of traditional Chinese recipe（TCR）-component in blood of healthy subjects andpatients,and estimate its *** The pharmacokinetics（PK）of samedose of drug was studied in the animal model oftraditional Chinese syndrome（S）and *** classification,terminology,concept and significance of the hypothesis wereset forth with evidence provided in the *** hypotheses consisted of traditionalChinese syndrome PK（S-PK）and traditionalChinese recipe PK（R-PK）.Firstly,the observedtetramethylpyrazine（TMP）PK in healthy,chronically reserpinized rats（rat model ofspleen deficiency syndrome,RMSDS）andRMSDS treated with Sijunzi decoction（SJZD）forconfirmation were used to verify S-PK; secondly,the ferulic acid（FA）PK in healthy andhigh molecular weight dextran（HMWD）-inducedrabbit model with blood stasis syndrome（RDBSS）was also used to verify S-PK;andlastly,TMP PK parameters in serum of healthyrats after orally taken Ligusticum wallichii（LW）,LW and Salvia miltiorrhiza（LW&SM）decoctions were compared to verify *** The apparent first-order absorption[Ka,（13.61±2.56）h-1,area under the blooddrug concentration-time curve[AUC,（24.88±9.76）μg.h-1mL-1],maximum drug concentration[Cmax,（4.82±1.23）μg·mL-1]of serum TMP inRMSDS were increased markedly（P-1,AUC=（5.20±2.57）μg·h-1·mL-1,Cmax=（2.33±1.77）μg·mL-1]of healthy rats（HR）.Theapparent first-order rate constant for α and βdistribution phase[α=（0.38±0.09）h-1,β=（0.06±0.03）h-1,the apparent first-orderintercompartmental transfer rate constants[K10=（0.24±0.07）h-1,K12=（0.11±0.02）h-1,K21=（0.11±0.02）h-1]of serum TMP in RMSDS weredecreased significantly（P10

关键词： traditional Chinese syndrome/recipe Chinese medicine pharmacokinetics blood stasis spleen deficiency hypothesis

Construction and Activity Assay of the Activating Transcription Factor 3 Reporter Vector pATF/CRE-luc

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Acta Biochimica et Biophysica Sinica 2006年第1期38卷 58-62页

作者： Jun-Qing XU~(1,2),Jing-Lan DENG~1,You-Sheng WU~2,Han-Yan FU~2,Rui-Hua WANG~2,Jian ZHANG~2, Fan LU~(2*),and Zhong-Liang ZHAO~(2*) ~1 Department of Naclear Medicine,Xijing Hospital,fourth military medical university,Xi'an 710032,China ~2 Department of Biochemistry and Molecular Biology,fourth military medical university,Xi'an 710032,China Department of Biochemistry and Molecular Biology Fourth Military Medical University Xi''an 710032 China

Activating transcription factor 3 (ATF3),a member of the activating transcription factor/cAMPresponsive element binding protein (ATF/CREB) family of transcription factors,is induced by manyphysiological *** investigate the activity of ATF/CREB in cells with physiological stresses,we developeda practical reporter vector,the plasmid pATF/CRE-luc,bearing activating transcription factor/cAMP responsiveelement (ATF/CRE) binding *** plasmid was constructed by inserting three repeats of the ATF/CREbinding element into the plasmid pG51uc,replacing the GAL-4 binding *** plasmids pACT/ATF3 andpATF/CRE-luc were transfected into HeLa and NIH3T3 cells,respectively,and the results showed that theexpression of luciferase .was increased in a dose-dependent manner on plasmid pACT/*** datasuggested that the plasmid pATF/CRE-luc could be used as a sensitive and convenient reporter system ofATF3 activity.

关键词： ATF/CRE luciferase gene pG51uc reporter system

Reduced cell death by inosine pretreatment after photochemically induced cerebral ischemia in adult rats

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Progress in Natural Science:Materials International 2008年第12期18卷 1513-1518页

作者： Zhongliang WU~(a,1) Fei Liu~(a,1) Yazhou Wang~a Xiying Jiao~a Ming Shi~a Qingbo Zhao~b Gong Ju~a Siwei You~a a Institute of Neurosciences,The fourth military medical university,17 Changlexi Road,Xi’an 710032,China b Department of Biostatisties,The fourth military medical university,17 Changlexi Road,Xi’an 710032,China Institute of Neurosciences The Fourth Military Medical University 17 Changlexi Road Xi’an 710032 China Department of Biostatistics The Fourth Military Medical University 17 Changlexi Road Xi’an 710032 China

Protective effect of inosine against cell death after photochemically induced focal cerebral ischemia was investigated in adult rats. Intraperitoneal injection of inosine was started 24 h before operation and continued till the animals were *** TUNEL method and Nissl staining were used to identify apoptosis and necrosis,***-positive cells were located in the transitional zone between the necrotic core and normal *** mean maximum area of the necrotic cores and mean number of TUNEL-positive cells 24 h after operation were reduced significantly in the inosine-treated rats when compared with those in the saline-treated control animals. We suggest that inosine can significantly reduce both necrosis and apoptosis following cerebral ischemia induced by photothrombosis in adult rats.

关键词： Cell death Cerebral infarction Inosine Photothrombosis Rat

Antioxidative activities of the aqueous extracts of Puerariae and Notoginseng

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生物物理学报 2009年第S1期25卷 395-396页

作者： Wang Xin, Hai ChunXu, Liang Xin, Li Yuliang Department of Toxicology,School of military Preventive Medicine, the fourth military medical university, Xi’an 710032, China

AIM:To study the antioxidative activities of the aqueous extracts of Puerariae and Notoginseng in several models in vitro and their dose-effect relationships.

关键词： Puerariae Notoginseng chemiluminescence antioxidative activities LPO

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MODULATION OF SYMPATHETIC NERVE ON POLYMODAL NOCICEPTORS IN RATS

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针刺研究 1989年第Z1期 101-102页

作者： Zhu Jun Hu sanjue Fan Jinzhi Department of Physiology, the fourth military medical university Xian, China

Single fiber rcording technique and tail flick test of rat were used in thepresent study. The unit discharges evoked by mechanical stimuli and tail flicklatency responsed to noxious heat stimuli as indices of the activity of polymodalnociceptor were examined during and after sympathetic stimulation. Stimula-tion of the peripheral end of the lumbosaeral sympathetic trunk increased thedischarges of polymodal nociceptors at first and then inhibited markedly. Thedepression of the unit discharges lasted for more than ten min. Injection of

关键词： MODULATION OF SYMPATHETIC NERVE ON POLYMODAL NOCICEPTORS IN RATS test

MODULATION OF ACUPUNCTURE AND SYMPATHETIC NERVE ON PERIPHERAL NOCICEPTORS

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针刺研究 1989年第Z1期 98-100页

作者： Hu Sanjue Chen min Zhu Jun Jiang Shujun Department of Physiology the fourth military medical university, Xian, China

Since the centrifugal inhibitory effect of acupuncture on nociceptors wasfound in 1982, we have systematically studied the regularity of this action andits pathways using dissected technique of nerve fine bundles at nociceptor *** main results and conclusions are as follons: 1. Electrical stimulation of the lateral hypothelamic area could inhibitthe peripheral noxious afferents through the adrenal gland-sympathetic system,indicating that the lateral hypothalamic area is one of the centres originatingthe centrifugal inhibitory effect on nociceptors.

关键词： MODULATION OF ACUPUNCTURE AND SYMPATHETIC NERVE ON PERIPHERAL NOCICEPTORS

MY RESEARCH ACHIEVEMENTS IN THE FIELD OF NEURO-ANATOMY

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Bulletin of the Chinese Academy of Sciences 1995年第3期9卷 275-276页

作者： Ju Gong(The PLA fourth military medical university, Xi’an)

In 1929, I was born in Shanghai. I graduated from the former Hsiang Ya medical College (a Yale-affdiated medical school in China before Liberation in 1949, and the predecessor of today’s Hunan medical university) in 1952. My aspiration to be a clinical doctor was strongly influenced by my father Sophie (his pen name) whereas my devotion for all my life to neuro-anatomy resulted from the interaction between the mandatory system of work assignment by the State and my personal selfdevelopment. In the year of my graduation, the Ministry of Public Health under the National military Commission was in need of a human anatomy lecturer and asked its civil counterpart to select a nominee for the vacancy. At the time, Ihad chosen basic medical research as my career and anatomy was definitely not one of my options, nor was any of my classmates in favor of it. However, the solution to this issue was simple enough: the

关键词： MY RESEARCH ACHIEVEMENTS IN THE FIELD OF NEURO-ANATOMY

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Mechanism of exogenous nucleic acids and their precursors improving the repair of intestinal epithelium after 7-irradiation in mice

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World Journal of Gastroenterology 2000年第5期6卷 709-717页

作者： Da Xiang Cui~1 Guei Ying Zeng~2 Feng Wang~1 Jun Rong Xu~1 Dong Qing Ren~2 Yan Hai Guo~1 Fu Rong Tian~2 Xiao Jun Yan~1 Yu Hou~1 Cheng Zhi Su~1 1 Institute of Genetic Diagnosis of the fourth military medical university,Xi’an 710032,China 2 Department of Irradiation Medicine of the fourth military medical university,Xi’an 710032,China 第四军医大学陕西西安

AIM To clone expressed genes associated withrepair of irradiation-damaged mice intestinalgland cells treated by small intestinal RNA,andto explore the molecular mechanism ofexogenous nucleic acids improving repair ofintestinal *** The animal mode of test group andcontrol group was established,forty-five micebeing irradiated by γ ray were treated with smallintestinal RNA as test group,forty mice beingirradiated by γ ray were treated withphysiological saline as control group,five micewithout irradiation were used as normal control,their jejunal specimens were collectedrespectively at 6h,12h,24h,4d and 8d *** by using LD-PCR based onsubtractive hybridization,these gene fragmentsdifferentially expressed between test group andcontrol group were obtained,and then werecloned into T vectors as well as *** sequences were ***,if being new sequences,they were submitted to *** Ninety clones were associated withrepair of irradiation-damaged intestinal glandcells treated by intestinal *** clonesfrom test group of 6h,12h,24h,4d and 8dwere respectively 18,22,25,13,*** screening against GeneBank,18 of which werenew sequences,the others were dramaticallysimilar to the known sequences,mainly similarto hsp,Nmi,Dutt1,alkaline phosphatase,homeobox,anti-CEA ScFv antibody,arginine/serine kinase and BMP-4,*** genefragments were new sequences,their acceptnumbers in GeneBank were *** Ninety clones were obtained tobe associated with repair of irradiation-damagedmice intestinal gland cells treated by smallintestinal RNA,which may be related toabnormal expression of genes and matchedproteins of hsp,Nmi,Duttl,Na,K-ATPase,alkalineph-osphatase,glkA,single strandedreplicative centromeric gene as well as 18 newsequences.

关键词： radiation ionizing intestine small/injuries RNA gene expression nucleic acids/therapeutic use polymerase chain reaction repair intestinal epithelium mice

Effect of intravenous injection of lipopolysaccharide and small-dose adrenaline on the opening of blood-brain barrier

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Acta Pharmacologica Sinica 1999年第5期 83-84页

作者： KUANG Fang, WANG Bai-Ren, JU Gong (Department of Neuroimmunomodulation, Institute of Neurosciences, The fourth military medical university, Xi-an 710032, China)

It is believed that in neuroimmune communication the pro-inflammatory cytokines are key messengers for immune system to influence the brain where the cascade of neural events occurred. However, the pathway that the cytokines use to signalthe brain remains a topic of *** molecular weight of cytokines is too large to pass through blood-brain barrier (BBB) *** the. present study in order to understand whether the BBB opens when the immune system is challenged,

关键词： open BBB Effect of intravenous injection of lipopolysaccharide and small-dose adrenaline on the opening of blood-brain barrier