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Efficient robust supervisors for discrete event systems

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Science in china(Series F) 2009年第7期52卷 1075-1083页

作者： EcONOMAcOS christoforos E. KOUMBOULIS fotis N. Department of Automation Halkis Institute of Technology

This paper is a sequel to a previous publication by the same authors, in which an efficient modular solution to a robust supervisory control problem for discrete event systems modeled by finite automata with prefix-closed specification languages has been presented. This solution is based on a general recursive robust control scheme, which has been successfully applied to a number of problems. The additional contributions of the present paper are：（a） a slight generalization of the problem assumptions; （b） an alternative derivation of some of the results and an alternative formulation of the controller; （c） a detailed description of a very efficient on-line implementation algorithm; and （d） an illustrative practical example.

关键词： robust supervisory control uncertain discrete event systems modular supervisory control on-line supervisory controller

Hemobilia as the initial manifestation of cholangiocarcinoma in a hemophilia B patient

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World Journal of Gastroenterology 2008年第26期14卷 4241-4244页

作者： Anastassios c Manolakis Andreas N Kapsoritakis Antonis D Tsikouras fotis D Tsiopoulos Athanassios K Psychos Spyros P Potamianos Department of Gastroenterology University of ThessalySchool of Medicine Larissa 41447Greece

Hemobilia is a rare manifestation of hemophilia and is usually iatrogenic following liver biopsy. There are only few reports of spontaneous hemobilia in hemophilia patients. cholangiocarcinoma is a well-established cause of hemobilia. We describe a case of a 70-year-old male, with known haemophilia B and a past history of papillotomy, who presented with classical symptoms of hemobilia. The initial diagnostic work-up failed to demonstrate a potential cause of bleeding other than the coagulopathy. Three months later, he was readmitted to our hospital with a second episode of hemobilia. During the second work-up, a cholangiocarcinoma was diagnosed both by imaging studies and by a significant elevation of cancer antigen 19-9. Although hemobilia could be attributed to hemophilia, especially in a patient with previous papillotomy, an underlying malignancy of the biliary tree should be suspected.

关键词： Hemobilia Hemophilia cholangiocarcinoma cancer antigen 19-9 cholangiopan-creatography

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量子力学意义初现

意林文汇 2018年第15期 48-51页

作者： Bernardo Kasttup Henry P.Stapp Menas c.kafatos 马瑗不详

近一个世纪以来,物理学家们一直想知道量子力学最反直觉的预测是否是真的。而直到近几年,才有了可行的、回答这个问题所需的技术,一系列实验结果随之涌现,其中包括2007年和2010年发表的令人震惊的研究成果,而今年5月发表的一项令人印象... 详细信息

近一个世纪以来,物理学家们一直想知道量子力学最反直觉的预测是否是真的。而直到近几年,才有了可行的、回答这个问题所需的技术,一系列实验结果随之涌现,其中包括2007年和2010年发表的令人震惊的研究成果,而今年5月发表的一项令人印象深刻的测试则带来了该领域研究的高潮——其表明量子力学的关键预测是正确的。

关键词：量子力学意义物理学家研究成果预测

From Quanta to Qualia： How a Paradigm Shift Turns Into Science

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Journal of Philosophy Study 2014年第4期4卷 287-301页

作者： Deepak chopra Menas c. kafatos University of california San Diego chapman University

Ever since the development of quantum mechanics in the first part of the 20th century, a new world view has emerged. Today, the physicalist objective assumption that objects exist independently of acts of observation has been challenged. The repercussions of this radical challenge to our common-sense perception of the world are far-reaching, although not yet generally realized. Here we argue that there is a complementary view to the way science which is being practiced, and that consciousness itself is primary and qualia form the foundation of experience. We outline the arguments of why the new science of qualia will tie objects that are being perceived to the subjective experience, through the units of subjective experience called qualia. If there is a reality that exists outside of perceptions in consciousness, it is indeed inconceivable. The reason is that once one subtracts everything that one can sense, imagine, feel, or think about, there＇s nothing left. Since qualia are subjective, they challenge the dominant world view of science as practiced today, which is reductionist, objective, and mathematical. Our view is a natural continuation of the quantum world view. We outline what the steps will have to be in order to fully develop the science of qualia.

关键词： consciousness quanta qualia Quantum Theory complementarity recursion

chimera RNA interference knockdown of γ-synuclein in human cortical astrocytes results in mitotic catastrophe

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Neural Regeneration Research 2020年第10期15卷 1894-1902页

作者： Timmy Le cynthia L.Winham fotis Andromidas Adam c.Silver Evan R.Jellison Aime A.Levesque Andrew O.Koob Graduate Program in Neuroscience Biology DepartmentUniversity of HartfordWest HartfordCTUSA Department of Immunology UCONN Health CenterFarmingtonCTUSA

Elevated levels of γ-synuclein(γ-syn)expression have been noted in the progression of glioblastomas,and also in the cerebrospinal fluid of patients diagnosed with neurodegenerative diseases.γ-Syn can be either internalized from the extracellular milieu or expressed endogenously by human cortical ***γ-syn results in increased cellular proliferation,brain derived neurotrophic factor release and ***,the function of endogenousγ-syn in primary astrocytes,and the relationship to these two opposing disease states are unknown.γ-Syn is expressed by astrocytes in the human cortex,and to gain a better understanding of the role of endogenous γ-syn,primary human cortical astrocytes were treated with chimera RNA interference(RNAi)targeting γ-syn after release from cell *** polymerase chain reaction analysis demonstrated an increase in endogenousγ-syn expression 48 hours after release from cell synchronization,while RNAi reduced γ-syn expression to control *** of Ki67 and 5-bromodeoxyuridine showed chimera RNAi γ-syn knockdown reduced cellular proliferation at 24 and 48 hours after release from cell *** further investigate the consequence of γ-syn knockdown on the astrocytic cell cycle,phosphorylated histone H3 pSer10(pHH3)and phosphorylated cyclin dependent kinase-2 pTyr15(pcDK2)levels were observed via western blot *** results revealed an elevated expression of pHH3,but not pcDK2,indicating γ-syn knockdown leads to disruption of the cell cycle and chromosomal compaction after 48 ***,flow cytometry with propidium iodide determined that increases in apoptosis coincided with γ-syn ***,γ-syn exerts its effect to allow normal astrocytic progression through the cell cycle,as evidenced by decreased proliferation marker expression,increased pHH3,and mitotic catastrophe after *** this study,we demonstrated that the knockdown of γ-syn with

关键词： apoptosis astrocyte cell cycle glioblastomas phospho-histone H3 proliferation synuclein

current knowledge and contemporary management of non-A non-B aortic dissections

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World Journal of cardiology 2023年第5期15卷 244-252页

作者： Konstantinos c christodoulou Dimos Karangelis Gioultzan Memet Efenti Panagiotis Sdrevanos Jennifer R Browning fotis Konstantinou Efstratios Georgakarakos Fotios A Mitropoulos Dimitrios Mikroulis Department of cardiac Surgery Democritus University of ThraceUniversity Hospital of AlexandroupolisAlexandroupolis 68100Greece Department of Surgery Didimotichon General HospitalDidimotichon 68300Greece cardioiasis cardiology clinic Xanthi 67100Greece Department of Vascular Surgery University Hospital of AlexandroupolisDemocritus University of ThraceAlexandroupolis 68100Greece Department of cardiac Surgery Mitera HospitalAthens 15123Greece

Non-A non-B aortic dissection(AAD)is an infrequently documented condition,comprising of only a small proportion of all *** unique anatomy of the aortic arch and the failure of the existing classifications to adequately define individuals with non-A non-B AAD,have led to an ongoing controversy around the *** seems that the clinical progression of acute non-A non-B AAD diverges from the typical type A and B dissections,frequently leading to serious complications and thus mandating early ***,the available treatment methods in the surgical armamentarium are conventional open,endovascular techniques and combined hybrid *** optimum approach is tailored in every individual case and may be determined by the dissection’s location,extent,the aortic diameter,the associated complications and the patient’s *** management of non-A non-B dissections still remains challenging and a unanimous consensus defining the gold standard treatment has yet to be *** an attempt to provide further insight into this perplexing entity,we performed a minireview of the literature,aiming to elucidate the epidemiology,clinical course and the optimal treatment modality.

关键词： Aortic dissection Aortic disease Aortic surgery Thoracic aorta disease Aortic arch dissection

A genome-wide scan for pleiotropy between bone mineral density and nonbone phenotypes

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Bone Research 2020年第3期8卷 356-364页

作者： Maria A.christou Georgios Ntritsos Georgios Markozannes fotis Koskeridis Spyros N.Nikas David Karasik Douglas P.Kiel Evangelos Evangelou Evangelia E.Ntzani Department of Hygiene and Epidemiology Clinical and Molecular Epidemiology UnitSchool of MedicineUniversity of loanninaloanninaGreece Department of Medicine Beth Israel Deaconess Medical CenterHarvard Medical SchoolHinda and Arthur Marcus Institute for Aging ResearchHebrew SeniorLifeand the Broad Institute of MIT&HarvardCambridgeMAUSA Azrieli Faculty of Medicine Bar llan UniversitySafedIsrael Department of Epidemiology and Biostatistics Imperial College LondonLondonUK Department of Health Services Policy and PracticeCenter for Research Synthesis in HealthSchool of Public HealthBrown UniversityProvidenceRlUSA

Osteoporosis is the most common metabolic bone disorder globally and is characterized by skeletal fragility and microarchitectural *** pleiotropy occurs when a single genetic element is associated with more than one *** aimed to identify pleiotropic loci associated with bone mineral density(BMD)and nonbone phenotypes in genome-wide association *** the discovery stage,the NHGRI-EBI catalog was searched for genome-wide significant associations(P valuecluding bone-related *** was used to identify proxies of the significantly associated single nucleotide polymorphisms(SNPs)(r2=1).We then assessed putative genetic associations of this set of SNPs with femoral neck(FN)and lumbar spine(LS)BMD data from the GEFOS *** variants were claimed at a false discovery ratec markers was performed among more than 400000 UK Biobank participants of European ancestry with available genetic and heel bone ultrasound *** the discovery stage,72 BMD-related pleiotropic SNPs were identified,and 12 SNPs located in 11 loci on 8 chromosomes were replicated in the UK *** SNPs were associated,in addition to BMD,with 14 different *** pleiotropic associations were exhibited by rs479844(AP5B1,O V O L 1 genes),which was associated with dermatological and allergic diseases,and rs4072037(M U c 1 gene),which was associated with magnesium levels and gastroenterological *** conclusion,12 BMD-related genome-wide significant SNPs showed pleiotropy with nonbone *** associations can deepen the genetic understanding of bone-related diseases by identifying shared biological mechanisms with other diseases or traits.

关键词： magnesium globally Replication