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Commentary on:“Human umbilical cord Wharton’s jelly-derived mesenchymal stem cell transplantation could improve diabetic intracavernosal pressure”

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Asian Journal of Andrology 2022年第2期24卷 226-227页

作者： fotios dimitriadis Vasileios Palapelas Athanasios Zachariou Ioannis Sokolakis Department of Urology Aristotle UniversitySchool of MedicineThessalonikiGreece 3^(rd)Department of Obstetrics and Gynecology Aristotle UniversitySchool of MedicineThessalonikiGreece Department of Urology Ioannina UniversitySchool of MedicineIoanninaGreece Department of Urology Martha-Maria Hospital NurembergNurembergGermany

The article by Wu et al.1 is an interesting and meticulous work investigating the role of human umbilical cord Wharton’s jelly-derived mesenchymal stem cells(hWJ-MSCs)in the treatment of erectile dysfunction(ED)in th... 详细信息

关键词： diabetic al jelly

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mpact of antioxidants on seminal vesicles function ind fertilizing potential in diabetic rats

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Asian Journal of Andrology 2017年第6期19卷 639-646页

作者： Panagiota Tsounapi Masashi Honda fotios dimitriadis Bunya Kawamoto Katsuya Hikita Kuniyasu Muraoka Motoaki Saito Nikolaos Sofikitis Atsushi Takenaka Division of Urology Department of Surgery Tottori University School of Medicine 36-1 Nishimachi Yonago 683-8503 Japan Department of Urology University of Ioannina School of Medicine P.O. Box 1186 45110 Ioannina Greece Department of Pharmacology Kochi University Kochi Medical School Nankoku 783-8505 Japan.

Diabetes mellitus significantly affects the male reproduction and sexual function. In the present study, we investigated the diabetes-induced dysfunction of seminal vesicles （SVs） in the diabetes-rat model and the role of antioxidants. Streptozotocin-induced diabetes after 4 weeks caused smaller size of the organs, hypercontractility, histological abnormalities, increased concentrations of malondialdehyde in the serum and tissue, overexpression of oxidative stress markers, and cleaved caspase-3 as identified by immunohistochemistry in the SVs. In addition, diabetes resulted in deceased levels of serum testosterone and no newborns after the mating studies. Antioxidants significantly normalized all the above parameters, except for the severely decreased serum testosterone levels and the negative outcome of the mating studies. The present study gives evidence for the important role of diabetes-induced oxidative stress in the function and structure of these androgen-dependent organs. Antioxidants may be a promising supplementary therapy for diabetic male patients to alleviate ejaculatory disorders but alone is not efficient treatment for the mitigation of infertility.

关键词： diabetes mellitus male infertility oxidative stress seminal vesicles seminiferous epithelium smooth muscle cellcontractions

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Effect of testosterone replacement treatment on constitutional and sexual symptoms in type 2 diabetic men. need for rules

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Asian Journal of Andrology 2015年第2期17卷 217-218页

作者： fotios dimitriadis Nikolaos Sofikitis Department of Urology University of Ioannina Medical School Ioannina Greece.

In a recent publication, Gianatti and colleagues investigated the effect of testosterone treatment in obese, aging men with type 2 diabetes （T2D） with mild to moderate symptoms, a modest reduction in testosterone levels, mild to moderate aging male symptoms, and erectile dysfunction？ The authors could not show any significant improvement in constitutional or sexual symptoms in this group of men. This randomized double-blind, parallel, and placebo-controlled trial among other critically emphasizes the increased testosterone prescriptions worldwide and together with other corroborating or contradictory studies awakes the need for guidelines in the androgen replacement treatment.

关键词： QUALITY-OF-LIFE DEPRESSIVE SYMPTOMS ANDROGEN DEFICIENCY METABOLIC SYNDROME HYPOGONADAL MEN ADULT MEN THERAPY METAANALYSIS UNDECANOATE DYSFUNCTION

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