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中国疼痛医学杂志 2024年第4期30卷 251-254页

作者： Sendel M Dunst A forsten pointer j 贺婷(译) 郑拥军(校) 不详复旦大学附属华东医院

辣椒素是瞬时受体电位香草酸亚型1(transient receptor potential vanilloid 1,TRPV1)的激动剂,用于外周神经病理性疼痛的局部治疗。其作用机制是皮肤痛觉感受器可逆的去功能化和变性及随后的再生。该研究假设伤害性传入的一个亚类,肽... 详细信息

辣椒素是瞬时受体电位香草酸亚型1(transient receptor potential vanilloid 1,TRPV1)的激动剂,用于外周神经病理性疼痛的局部治疗。其作用机制是皮肤痛觉感受器可逆的去功能化和变性及随后的再生。该研究假设伤害性传入的一个亚类,肽能血管活性伤害感受器的功能加速恢复是辣椒素镇痛的潜在原因。在非干预性探索性试验中,23名患有外周神经病理性疼痛的病人接受了1次局部高浓度辣椒素治疗。评估基线疼痛等级、共病和生活质量。在受影响的皮肤中进行功能性激光散斑对比分析(热诱发神经源性血管舒张以评估肽能伤害感受器的功能特性)和定量感觉测试。治疗4周后,再次进行功能性激光散斑对比分析和问卷调查。在第2、10和12周进行电话随访。局部辣椒素治疗诱导疼痛强度显著降低,最大值出现在第4周。同时,热诱发的神经源性血管舒张平均值与治疗前相似。一半的病人不仅显示出功能恢复,而且显示出血管舒张的改善,表明神经纤维的再生。在第4周,热诱发的神经源性血管扩张改善病人比恶化的病人疼痛减轻更多。血管舒张程度与疼痛减轻显著相关。表明肽能感受器的再生可能是辣椒素诱导镇痛的机制,辣椒素对这些纤维的疾病缓解作用在应用4周后已经发生。

关键词：伤害感受器痛觉感受器疼痛减轻血管舒张辣椒素神经病理性疼痛激光散斑血管扩张

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Evaluation of operator visibility in three different cabins type Far-East combine harvesters

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International journal of Agricultural and Biological Engineering 2016年第4期9卷 33-44页

作者： Dae H.Lee Yong j.Kim Chang H.Choi Sun O.Chung Yo S.Nam jin H.So Department of Biosystems Machinery Engineering Chungnam National UniversityDaejeon 305-764Republic of Korea Department of Bio-mechatronic Engineering Sungkyunkwan UniversitySuwon 440-746Republic of Korea TYM R&D Center Tong Yang Moolsan Co.Ltd.Gongju 314-862Republic of Korea

The purpose of this study was to develop and evaluate a visibility evaluation system for the cabin type Far-East combine *** human field of view has been classified into five levels(perceptive,effective,stable gaze,induced,and auxiliary)depending on the rotation of the human head and *** divider,reaper lever,gearshift,dashboard,and conveying component were considered as major viewpoints of the cabin type Far-East combine *** visibility of the cabin type Far-East combine harvester was evaluated quantitatively using viewpoints and human field of view *** visibility evaluation system for the cabin type Far-East combine harvester consisted of a laser pointer,stepping motors to control the directions of the view,gyro sensors to measure horizontal and vertical angles,and I/O interface to acquire the *** visibility evaluation tests were conducted at different postures(‘sitting straight’,‘sitting with a 15°tilt’,‘standing straight’,and‘standing with a 15°tilt’)for three cabin type Far-East combine *** LSD(least significant difference)multiple comparison tests showed that the visibilities of viewpoints differed significantly as the operator's posture *** results showed that the posture while standing with a 15°tilt provided the best *** average visibility scores at sitting postures were 22.3(straight)and 24.4(15°tilt),and the scores at standing postures were 18.7(straight)and 29.5(15°tilt).Also,the average visibility scores were observed in order from highest to lowest as reaper lever(44.6),divider(28.7),dashboard(23.1),conveying part(12.2),and gearshift lever(10.1).Most viewpoints of the cabin type Far-East combine harvester were out of the stable gaze field of the view *** of the cabin type Far-East combine harvester design will be required to enhance the visibility during harvesting operation and to improve safety and convenience of farmers.

关键词： combine harvester cabin operator visibility field of view evaluation system ergonomics safety and comfort

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绿色激光指示器诱发的视网膜病变:临床病理研究

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世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 28-28页

作者： Robertson D.M. McLaren j.W. Salomao D.R. Link T.P. 杨秀梅 Mayo Clinic 200 First St SW Rochester MN 55905 United States Dr.

Objective: To report retinopathy following exposure to light from a commercially available class 3A green laser pointer. Methods: A 55-year-old woman with a ring melanoma was scheduled for enucleation. The eye (visual acuity 20/ 20) had a healthy-appearing macular retina. The retina was exposed to light from a commercially available class 3A green laser: 60 seconds to the fovea, 5 minutes to a site 5°below the fovea, and 15 minutes to a site 5°superior to the fovea. Color photographs were obtained before and after exposure. The eye was enucleated 20 days after exposure. Results: Laser power measurements averaged less than 5 mW. Retinopathy was observed 24 hours after laser exposure. This was characterized by a yellowish discoloration at the level of the retinal pigment epithelium (RPE) in the subfoveal region and at the site superior to the macula where the retina received 15 minutes of laser exposure. Each site developed granular changes at the level of the RPE within 5 days of exposure. Histologic study showed RPE damage in the exposed subfoveal and parafoveal regions. Conclusion: A class 3A green laser pointer caused visible retinopathy in the human eye with exposures as short as 60 seconds.

关键词：视网膜病变临床病理研究激光指示器中心凹视网膜区域眼球摘除术黑色素瘤颗粒样表现正常绿色激光

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