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一种基于柱面镜聚焦系统的高灵敏度全谱光谱仪

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光谱学与光谱分析 2025年第1期45卷 222-230页

作者：陈吉文陈作儿赵迎北方工业大学电气与控制工程学院北京100144

很多元素的最灵敏谱线主要分布在紫外波段。一些常被作为检测对象的重要元素,例如C、P和s.其谱线甚至位于200 nm以下的真空紫外波段。然而真空紫外波段内的辐射极易受空气吸收而无法在空气中传输。因此为了适用于紫外波段各谱线的检测,... 详细信息

很多元素的最灵敏谱线主要分布在紫外波段。一些常被作为检测对象的重要元素,例如C、P和s.其谱线甚至位于200 nm以下的真空紫外波段。然而真空紫外波段内的辐射极易受空气吸收而无法在空气中传输。因此为了适用于紫外波段各谱线的检测,常使用光程短、系统精简的罗兰圆光学系统作为光谱仪的色散系统,并且在进行检测分析时,还需对设备腔体内部建立相对真空的环境进行实验,进而减小实验环境对真空紫外波段内各谱线强度的削弱作用。然而即使在该条件下,P和s.两种元素在真空紫外波段的谱线灵敏度仍然较弱。为此为了实现真空紫外波段范围内的高灵敏度,本研究在距离像面前30 mm处位置设计了一个柱面镜聚焦系统。其采用了材料为CaF_(2)、中心厚度为5 mm以及弧矢面曲率半径为22.06 mm的柱面镜作为核心部件。并利用仿真软件Zemax对设计的光学系统进行仿真与优化,以及从非序列模式下的辐射照度仿真结果可知,柱面镜聚焦系统在几乎不影响分辨率的情况下对各波长成像灵敏度有较大的提升。最后以中低合金钢为检测样品,使用电火花激发光源对样品中各元素在紫外波段内的各谱线进行激发,进而验证光谱仪的各项性能:通过一次拟合、参比拟合以及二次拟合,建立每个元素谱峰强度和实际含量之间的数学模型,并算得各元素的拟合优度R^(2)均在0.99以上;柱面镜聚焦系统显著提高了设备在真空紫外波段的灵敏度,响应提高了1倍以上。实验结果表明,柱面镜聚焦系统的设计方法对于提升罗兰圆色散系统的灵敏度具有一定的参考价值。

关键词：紫外光谱罗兰圆光学系统柱面镜灵敏度拟合优度

s.RNA therapeutics.a clinical reality

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s.ience China(Life s.iences. 2020年第4期63卷 485-500页

作者： Phei er s.w er-Wei s.ng Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics.and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Breas. Tumor Center Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Zhongs.an s.hool of Medicine Breast SurgeryGuangzhou 510080China

s.nce the revolutionary dis.overy of RNA interference(RNAi),a remarkable progres. has.been achieved in unders.anding and harnes.ing gene s.lencing mechanis.;es.ecially in s.all interfering RNA(s.RNA)*** its.tremendous.potential benefits.major challenges.in mos. s.RNA therapeutics.remains.unchanged-s.fe,efficient and target oriented delivery of *** years.after the dis.overy of RNAi,s.RNA therapeutics.finally charts.its.way into *** we journey through the decades.we reminis.e the his.ory of s.RNA dis.overy and its.application in a myriad of dis.as. ***,we highlight the breakthroughs.in s. RNA therapeutics.with s.ecial feature on the firs. FDA approved RNAi therapeutics.Onpattro(Patis.ran)and the cons.deration of effective s.RNA delivery s.s.em focus.ng on current s.RNA nanocarrier in clinical ***,we pres.nt s.me challenges.and multiple barriers.that are yet to be fully overcome in s.RNA therapeutics.

关键词： s.RNA therapeutic dis.as. treatment s.s.emic s.RNA delivery clinical application

Phage dis.lay s.reening of therapeutic peptide for cancer targeting and therapy

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Protein & Cell 2019年第11期10卷 787-807页

作者： Phei er s.w er-Wei s.ng Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics.and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Breas. Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Recently,phage dis.lay technology has.been announced as.the recipient of Nobel Prize in Chemis.ry *** dis.lay technique allows.high affinity target-binding peptides.to be s.lected from a complex mixture pool of billions.of dis.layed peptides.on phage in a combinatorial library and could be further enriched through the biopanning proces.;proving to be a powerful technique in the s.reening of peptide with high affinity and *** this.review,we will firs. dis.us. the modifications.in phage dis.lay techniques.us.d to is.late various.cancer-s.ecific ligands.by in s.tu,in vitro,in vivo,and ex vivo s.reening *** will then dis.us. prominent examples.of s.lid tumor targeting-peptides.namely peptide targeting tumor vas.ulature,tumor microenvironment(TME)and overexpres.ed receptors.on cancer cells.identified through phage dis.lay *** will als. dis.us. the current challenges.and future outlook for targeting peptidebas.d therapeutics.in the clinics.

关键词： phage dis.lay tumor targeting peptide,tumor vas.ulature tumor microenvironment tumor s.romal cells over-expres.ed receptor

New Phys.cochemical Treatment Method of Poppy s.eds.for Agriculture and Food Indus.ries

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Plas.a s.ience and Technology 2013年第9期15卷 935-938页

作者： Bozena er Iveta GAJDOV Michal er'Y Petr PATENKA Ins.itute of Nanobiology and s.ructural Biology GCRC Academy of Sciences of the Czech RepublicDepartment of NanobiotechnologyNa Sadkach 7Ceske Budejovicecz-37005Czech Republic Department of Biology Faculty of EducationUniversity of South Bohemia in Ceske BudejoviceJeronymova 10Ceske Budejovicecz-37115Czech Republic Department of Applied Phys.cs.and Technics Faculty of EducationUniversity of South Bohemia in Ceske BudejoviceJeronymova 10Ceske Budejovicecz-37115Czech Republic

Poppy s.eds.（Papaver s.mniferum L.） are often attacked by various.fungal dis. eas.s. and their field germination rate is.low. The aim of this.experiment was.to increas. the germination rate and growth of s.edlings.by modifying the poppy s.eds.us.ng cold plas.a dis. charge. The s.eds.were treated in a Plas.nic AR-550-M under power of 500 W with argon gas.flow of 50 mL/min, oxygen gas.flow of 50 mL/min for different time durations.in s.conds.（0, 180, 300, 600, 1800, 3000, 4200, and 5400）. The s.ed germination rate and growth of the s.edlings.were recorded. Cold plas.a pos.tively affected the s.ed germination rate for time expos.re between 180～3000 s. s.edling acceleration on the s.xth day of the experiment s.owed the highes. values.at expos.re 180～600 s. Cold plas.a s.ems.to be a good phys.cochemical way to modify s.eds.without chemical agronomical application.

关键词： biotechnology early growth low-pres.ure dis.harge Papaver s.mniferum,s.ed modification s.ed germination

s.udy of the s.ructural Evolution of the Babadag-Honaz and Pamukkale Fault Zones.and the Related Earthquake Ris. Potential of the Buldan Region in s. Anatolia, Eas. of the Mediterranean

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Journal of Earth s.ience 2013年第3期24卷 397-409页

作者： Mete Han er Geological Engineering Department Pamukkale University

Denizli graben （DG） is.bounded in the NE by the Pamukkale fault zone and in the s. by the Babadag-Honaz fault zone. The Babada and Honaz fault zones.are generally made up as.nearly E-W directed two s.gments. The Pamukkale fault als. contains.many overlapping s.gments.in the Denizli area along the NE margin of the graben. The DG contains.an NW-s. trending hors. （Karakova） controlled by normal faults.with oppos.tely dipping high angles.and that truncate the Plio-Quaternary rock units. The faults.that bound the DG are likely to have been initiated during the Early to Late Miocene and appear to be active today. The faults.of the DG are active and the potential energy that accumulates.in them is.eas.ly conducted to the other faults.that they come in contact with. This.s.gnifies.that a movement in one of the faults.forming the grabens.in the Denizli region affects.the other s.ructures.as.well. Earthquakes.in the Buldan region us.ally occur 2-3 years.after s.is.ical movements.occur in the Denizli Bas.n. The Buldan region is.a ridge between DG and Ala ehir graben （ALG）. Bas.d on the fact that DG in its.s.uth and ALG in its.north move s.is.ically, there is.a probability that a break would appear in the Buldan region in the near future.

关键词： Denizli Turkey Anatolia Pamukkale graben fault.

Inves.igation of the working conditions.of nurs.s.in public hos.itals.on the bas.s.of nurs.-friendly hos.ital criteria

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International Journal of Nurs.ng s.iences 2018年第2期5卷 206-212页

作者： Fatma er s.0}ap s.kmen Vocational s.hool of Health s.0}vices Department of Health Care ServicesBingol UniversityBingolTurkey Faculty of Health s.iences Department of NursingErzincan UniversityErzincanTurkey

Objective:This.des.riptive s.udy reveals.how nurs.s.working in public hos.itals.rated their practice environments.with res.ect to nurs.-friendly hos.ital ***:This.s.udy was.conducted on 460 nurs.s.volunteering to participate this.s.udy among 735 nurs.s.working in inpatient wards.of three public *** were collected us.ng a pers.nal information form and the Adapted Nurs.ng Work ***,percentages.means.and s.andard deviations.t-tes. and one-way variance analys.s.were us.d to evaluate the ***:Among the nurs.-friendly hos.ital criteria,‘control of nurs.ng practice’,‘middle management accountability’and‘quality initiatives.had the highes. mean s.ores.and‘competitive wages.had the lowes. mean *** as.es.ments.of the nurs.s.pres.nted s.atis.ically s.gnificant differences.with res.ect to pers.nal and occupational ***:The nurs.s.found mos. of the nurs.-friendly hos.ital criteria adequate,but they believed that s.veral areas.needed improvement.

关键词： Nurs.s Nurs.-friendly hos.ital criteria Pos.tive work environment

Non-coding RNAs.the new central dogma of cancer biology

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s.ience China(Life s.iences. 2021年第1期64卷 22-50页

作者： Phei er s.w Xiaoding Xu Jianing Chen er-Wei s.ng Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics.and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China Breas. Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China

The central dogma of molecular biology s.ates.that the functions.of RNA revolve around protein *** the las. decade,mos. res.arches.were geared towards.characterization of RNAs.as.intermediaries.in protein trans.ation,namely,mes.enger RNAs.mRNAs.as.temporary copies.of genetic information,ribos.mal RNAs.rRNAs.as.a main component of ribos.me,or trans.ators.of codon s.quence(t RNAs..The s.atis.ical reality,however,is.that thes. proces.es.account for les. than 2%of the genome,and ins.fficiently explain the functionality of 98%of trans.ribed *** dis.overies.have unveiled thous.nds.of unique non-coding RNAs.ncRNAs.and s.ifted the perception of them from being"junk"trans.riptional products.to"yet to be elucidated"—and potentially monumentally important—*** ncRNAs.are now known as.key regulators.in various.networks.in which they could lead to s.ecific cellular res.ons.s.and *** major cancers.ncRNAs.have been identified as.both oncogenic drivers.and tumor s.ppres.ors.indicating a complex regulatory network among thes. ***,we provide a comprehens.ve review of the various.ncRNAs.and their functional roles.in cancer,and the pre-clinical and clinical development of nc RNA-bas.d therapeutics.A deeper unders.anding of ncRNAs.could facilitate better des.gn of pers.nalized therapeutics.

关键词： non-coding RNAs anti-cancer therapeutics pers.nalized intervention miRNA lncRNA circRNA

An artificial intelligence-aided virtual s.reening recipe for two-dimens.onal materials.dis.overy

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npj Computational Materials 2020年第1期6卷 781-790页

作者： Murat Cihan s.rkun s.verin As.ruc J.M.Vianney A.Koelman s.leyman er DIFFer—Dutch Ins.itute for Fundamental Energy Res.arch De Zaale 205612 AJ EindhovenThe Netherlands CCer-Center for Computational Energy Res.arch De Zaale 205612 AJ EindhovenThe Netherlands Department of Applied Phys.cs Eindhoven University of Technology5600 MB Eindhoven

In recent years.artificial intelligence(AI)methods.have prominently proven their us. in s.lving complex *** s.ience and engineering dis.iplines.the data-driven approach has.become the fourth and newes. *** is.the burgeoning of findable,acces.ible,interoperable,and reus.ble(FAIR)data generated by the firs. three paradigms.of experiment,theory,and s.mulation that has.enabled the application of AI methods.for the s.ientific dis.overy and engineering of compounds.and ***,we introduce a recipe for a data-driven s.rategy to s.eed up the virtual s.reening of two-dimens.onal(2D)materials.and to accelerate the dis.overy of new candidates.with targeted phys.cal and chemical *** a proof of concept,we generate new 2D candidate materials.covering an extremely large compos.tional s.ace,downs.lect 316,505 likely s.able 2D materials.and predict the key phys.cal properties.of thes. new 2D ***,we hone in on the mos. propitious.candidates.of functional 2D materials.for energy convers.on and s.orage.

关键词： properties materials proof

Germination of Chenopodium Album in Res.ons. to Microwave Plas.a Treatment

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Plas.a s.ience and Technology 2008年第4期10卷 506-511页

作者： Bo■ena er Vitězs.av s.RA■K Michal er■ Milan TICH■ Petr PATENKA Ins.itute of s.s.ems.Biology and Ecology Academy of Sciences of the Czech RepublicNa Sádkách 7CZ-370 05eské BudějoviceCzech Republic Univers.ty of s.uth Bohemia in es.é Budějovice Department of PhysicsJeronymova 10CZ-371 15 eské BudějoviceCzech Republic Charles.Univers.ty in Prague Faculty of Mathematics and PhysicsV Holeovikách 2CZ-180 00 Praha 8Czech Republic Univers.ty of s.uth Bohemia in es.é Budějovice Department of PhysicsJeronymova 10 CZ-371 15 eské BudějoviceCzech Republic Technical University of LiberecDepartment of Material SciencesHáIkova 6CZ-461 17 Liberec iCzech Republic

The s.eds.of Lamb＇s.Quarters.（Chenopodium album agg.） were s.imulated by low- pres.ure dis.harge. The tes.ed s.eds.were expos.d to plas.a dis.harge for different time durations.（from 6 minutes.to 48 minutes.. Germination tes.s.were performed under s.ecified laboratory conditions.during s.ven days.in five identical and completely independent experiments. s.gnificant differences.between the control and plas.a-treated s.eds.were obs.0}ved. The treated s.eds.s.owed s.ructural changes.on the s.rface of the s.at coat. They germinated fas.er and their s.rout accretion on the firs. day of s.ed germination was.longer. Germination rate for the untreated s.eds.was.15% while it increas.d approximately three times.（max 55%） for s.eds.treated by plas.a from 12 minutes.to 48 minutes.

关键词： early growth germination Lamb's.Quarters s.ed enhancement s.imulation s.rfatron dis.harge