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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 33-34页

作者： Campos S.H forjaz v Kozak L.R M. Castelo-Branco 王大江 Institute of Biomedical Research in Light and Image Faculty of Medicine University of Coimbra Az. de Sta Comba Celas 3000- 354 Coimbra Portugal.Dr

Objectives: To quantify chromatic dysfunction in Best disease to reassess the classic categorization of macular chromatic damage and to investigate psychophysical and clinical correlations. Methods: Color-contrast discrimination was measured using 2 different psychophysical strategies in age-matched control (n=41) and patient (n=34) eyes. The first strategy measured performance along 3 main confusion lines (testing cone function), and the second evaluated discrimination ellipses (modified Cambridge Color Test). The main outcome measures were chromatic discrimination variables (confusion line length, ellipse length, angle, and axis ratio) and visual acuity (vA). Results: Significant loss of performance was seen in all color axes in our patients, and it increased monotonically with staging, becoming significant in Fishman stages 2 and 3. The classically assumed preferential type I red-green deficit was true only for stage 4. Substantial chromatic dysfunction occurred even with relatively preserved vA despite that negative correlations between all test variables and vA reached statistical significance. Partial correlation analysis showed that protan/deutan loss was related to vA independent of tritan loss. Statistically significant positive correlations were also found between lesion size and chromatic dysfunction. Conclusions: Chromatic discrimination is often impaired in Best disease, even when vA is still spared. Our quantitative psychophysical approach shows that the classic categorization as a type I red green deficit is valid only for disease stage 4.

关键词：黄斑营养不良 Best 色觉障碍定量研究心理物理学方法分辨力辨色障碍经典分类颜色对比红绿

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