检索结果-南通市图书馆

Research 2024年第1期6卷 825-826页

作者： Huan Miao Bowen Li Zehua Wang Jinming Mu Yanlin Tian Binhua Jiang Shaohua Zhang Xia Gong Guanghou Shui Sin Man lam State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China LipidALL Technologies Company Limited Changzhou 213022Jiangsu ProvinceChina

Main Text In the Research Article“Lipidome Atlas of the Developing Heart Uncovers Dynamic Membrane Lipid Attributes Underlying Cardiac Structural and Metabolic Maturation”[1],there was an error in *** authors mistakenly repeated the chord diagram designated for P7 with that from *** figure amendment did not affect the in-text discussion of the figure,which was focused on changes between P0 and P21,and did not alter the *** 2B has now been corrected in the PDF and HTML(full text).

关键词： Atlas Dynamic HTML

Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaemic lesions at 1 month: the ATTUNE study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2024年第1期9卷 30-37,I0034页

作者： Angelos Sharobeam Longting Lin Christina lam Carlos Garcia-Esperon Yash Gawarikar Ronak Patel Matthew Lee-Archer Andrew Wong Michael Roizman Amanda Gilligan Andrew Lee Kee Meng Tan Susan Day Christopher Levi Stephen M Davis Mark Parsons Bernard Yan Melbourne Brain Centre at Royal Melbourne Hospital ParkvilleVictoriaAustralia University of New South Wales South Western Sydney Clinical School LiverpoolNew South WalesAustralia Department of Neurology John Hunter HospitalNewcastleNew South WalesAustralia Department of Neurology Calvary Public HospitalCanberraAustralian Capital TerritoryAustralia Department of Neurology Northern Hospital EppingEppingVictoriaAustralia Department of Neurology Royal Brisbane and Women's HospitalHerstonQueenslandAustralia The University of Queensland School of Medicine HerstonQueenslandAustralia Neurosciences Clinical Institute Epworth HealthcareRichmondVirginiaAustralia Department of Neurology Austin HealthUniversity of MelbourneHeidelbergVictoriaAustralia Flinders University College of Medicine and Public Health AdelaideSouth AustraliaAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia The University of Sydney Northern Clinical School St LeonardsNew South WalesAustralia Department of Neurology and Neurophysiology Liverpool HospitalLiverpoolNew South WalesAustralia

Background The optimal time to commence anticoagulation in patients with atrial fibrillation(AF)after ischaemic stroke or transient ischaemic attack(TIA)is unclear,with guidelines differing in recommendations.A limitation of previous studies is the focus on clinically overt stroke,rather than radiologically obvious diffusion-weighted imaging ischaemic *** aimed to quantify silent ischaemic lesions and haemorrhages on MRI at 1month in patients commenced on early(5mL,regardless of anticoagulation *** Commencing anticoagulation<4days after stroke or TIA is associated with fewer ischaemic lesions at 1month in AF *** is no increased rate of haemorrhage with early *** results suggest that early anticoagulation after mild-to-moderate acute ischaemic stroke associated w

关键词： patients lesions ischaemic

Tuberculosis Diagnosis and Visualization with a Large Vietnamese X-Ray Image Dataset

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intelligent Automation & Soft Computing 2024年第2期39卷 281-299页

作者： Nguyen Trong Vinh lam Thanh Hien Ha Manh Toan Ngo Duc Vinh Do Nang Toan Faculty of Information Technology Lac Hong UniversityBien HoaDong Nai76120Vietnam Institute of Information Technology Vietnam Academy of Science and TechnologyHanoi10072Vietnam Faculty of Information Technology Hanoi University of IndustryHanoi11915Vietnam

Tuberculosis is a dangerous disease to human life,and we need a lot of attempts to stop and reverse ***,in theCOVID-19 pandemic,access to medical services for tuberculosis has become very *** late detection of tuberculosis could lead to danger to patient health,even *** one of the countries heavily affected by the COVID-19 pandemic,andmany residential areas as well as hospitals have to be isolated for a long *** demands a fast and effective tuberculosis diagnosis solution to deal with the difficulty of accessingmedical services,such as an automatic tuberculosis diagnosis *** our study,aiming to build that system,we were interested in the tuberculosis diagnosis problem from the chest X-ray images of Vietnamese *** chest X-ray image is an important data type to diagnose tuberculosis,and it has also received a lot of attention from deep learning *** paper proposed a novel method for tuberculosis diagnosis and visualization using the deeplearning approach with a large Vietnamese X-ray image *** detail,we designed our custom convolutional neural network for the X-ray image classification task and then analyzed the predicted result to provide visualization as a *** prove the performance of our network model,we conducted several experiments to compare it to another study and also to evaluate it with the dataset of this *** support the implementation,we built a specific annotation system for tuberculosis under the requirements of radiologists in the Vietnam National Lung Hospital.A large experiment dataset was also from this hospital,and most of this data was for training the convolutional neural network *** experiment results were evaluated regarding sensitivity,specificity,and *** achieved high scores with a training accuracy score of 0.99,and the testing specificity and sensitivity scores were over *** on the X-ray image classification result,we visualize pr

关键词： Tuberculosis classification Vietnamese chest X-ray deep learning

Predicting 3D Radiotherapy Dose-Volume Based on Deep Learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intelligent Automation & Soft Computing 2024年第2期39卷 319-335页

作者： Do Nang Toan lam Thanh Hien Ha Manh Toan Nguyen Trong Vinh Pham Trung Hieu Institute of Information Technology Vietnam Academy of Science and TechnologyHanoi10072Vietnam Faculty of Information Technology Lac Hong UniversityBien HoaDong Nai76120Vietnam

Cancer is one of the most dangerous diseaseswith *** of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill from doctors and *** our study,we focused on the 3D dose prediction problem in radiotherapy by applying the deeplearning approach to computed tomography(CT)images of cancer *** image data has more complex characteristics than normal image data,and this research aims to explore the effectiveness of data preprocessing and augmentation in the context of the 3D dose prediction *** proposed four strategies to clarify our hypothesis in different aspects of applying data preprocessing and *** strategies,we trained our custom convolutional neural network model which has a structure inspired by the U-net,and residual blocks were also applied to the *** output of the network is added with a rectified linear unit(Re-Lu)function for each pixel to ensure there are no negative values,which are absurd with radiation *** experiments were conducted on the dataset of the Open Knowledge-Based Planning Challenge which was collected from head and neck cancer patients treatedwith radiation *** results of four strategies showthat our hypothesis is rational by evaluating metrics in terms of the Dose-score and the Dose-volume histogram score(DVH-score).In the best training cases,the Dose-score is 3.08 and the DVH-score is *** addition,we also conducted a comparison with the results of another study in the same context of using the loss function.

关键词： CT image 3D dose prediction data preprocessing augmentation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

苏格兰的跨年夜

中学生英语 2024年第5期 36-39页

作者： Kenny lam 长庚(选译) 不详

"Hogmanay"是苏格兰人所说的新年前夜——12月31日,是标志着新年到来的重要夜晚。它的起源可以追溯到维京人在12月下旬举行的冬至庆祝活动。

关键词：维京人苏格兰人庆祝活动新年

Caveolin‑1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2024年第2期11卷 206-227页

作者： Guang-Hui Deng Chao-Feng Wu Yun-Jia Li Hao Shi Wei-Chao Zhong Mu-Keng Hong Jun-Jie Li Jia-Min Zhao Chang Liu Meng-Chen Qin Zhi-Yun Zeng Wei-Min Zhang Ken Kin lam Yung Zhi-Ping Lv Lei Gao Department of Gastroenterology Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Department of Hepatology Cancer CenterIntegrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033GuangdongChina Department of Biology Hong Kong Baptist UniversityKowloon TongKowloonHong Kong SAR 999077China

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with disordered lipid and iron *** previous study has substantiated the pivotal role of Caveolin-1(Cav-1)in protecting hepatocytes and mediating iron metabolism in the *** study aimed to explore the specific mechanisms underlying the regulation of iron metabolism by Cav-1 in ***:Hepatocyte-specific Cav-1 overexpression mice and knockout mice were used in this ***-1-knockdown of RAW264.7 cells and mouse primary hepatocytes were performed to verify the changes in ***,a high-fat diet and palmitic acid plus oleic acid treatment were utilized to construct a NAFLD model in vivo and in vitro,respectively,while a high-iron diet was used to construct an in vivo iron overload ***,iron concentration,the expression of Cav-1 and iron metabolism-related proteins in liver tissue or serum were detected using iron assay kit,Prussian blue staining,Western blotting,immunofluorescence staining,immunohistochemical staining and *** related indicators of lipid metabolism and oxidative stress were evaluated by the corresponding reagent kit and ***:Significant disorder of lipid and iron metabolism occurred in *** expression of Cav-1 was decreased in NAFLD hepatocytes(P<0.05),accompanied by iron metabolism ***-1 enhanced the iron storage capacity of hepatocytes by activating the ferritin light chain/ferritin heavy chain pathway in NAFLD,subsequently alleviating the oxidative stress induced by excess ferrous ions in the ***,CD68^(+) CD163^(+) macrophages expressing Cav-1 were found to accelerate iron accumulation in the liver,which was contrary to the effect of Cav-1 in *** correlations were also observed between the serum Cav-1 concentration and the serum iron-related protein levels in NAFLD patients and healthy volunteers(P<0.05).Conclusions:These findings confirm that Cav-1 is an essential target protein that reg

关键词： Caveolin-1 Nonalcoholic fatty liver disease Iron metabolism Ferritin Oxidative stress

Assessment of Sericin Biosorbent for Selective Dye Removal

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2012年第3期20卷 426-432页

作者： CHEN Xinqing lam Koon Fung MAK Shuk fong CHING Wai Kwong NG Tsz Nok YEUNG King Lun Department of Chemical and Biomolecular Engineering Division of Environment the Hong Kong University of Science and TechnologyHong KongChina

The silk sericin is the main residue in silk production and it is found to be a low cost and efficient bio-sorbent. In this study, sericin was characterized with various techniques including SEM （scanning electron micro- scope）, XRD, N2 physisorption, FTIR （Fourier transformed infrared spectroscopy） and XPS （X-ray photoelectron spectroscopy）. The nitrogen content of sericin was ca. 8.5 mmol.g-1 according to elemental analysis. Dye adsorption by sericin biosorbent was investigated with the acid yellow （AY）, methylene blue （MB） and copper （II） phthalocyanine-3,4＇4＂4＇＂-tetrasulfonic acid （CuPc） dyes from water. Sericin displayed large capacity for AY andCuPc adsorption with adsorption capacities of respectively 3.1 and 0.35 mmol.g-1, but it did not adsorbed methyl- ene blue dye. This selectivity is due to the basicity of amide groups in seriein biosorbents.

关键词： dye adsorption silk protein biosorbent

THREE NOVEL FOXL2 GENE MUTATIONS IN CHINESE PATIENTS WITH BLEPHAROPHIMOSIS-PTOSIS-EPICANTHUS INVERSUS SYNDROME

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2006年第1期119卷 49-52页

作者： OR SIU-fong JUNE TONG MING-FOR TONY LO FAI-MAN IVAN lam TAK-SUM STEPHEN CLINICAL GENETIC SERVICE DEPARTMENT OF HEALTH HONG KONG SAR CHINA

Blepharophimosis-ptosis-epicanthus inversus Psyndrome （BPES, OMIM # 110100） is a rare autosomal dominant disorder affecting the eyelid and ovarian development. When co-occurred together, it is type Ⅰ and when only the eyelid abnormalities are present, it is type Ⅱ. Both types had been mapped to the same locus 3q23 on the basis of cytogenetic rearrangements 1-3 and linkage analyses. 4-6 Subsequently,

关键词： blepharophimosis-ptosis-epicanthus inversussyndrome FOXL2 gene mutation multiplex ligation-dependent probe amplification

编写诗乐大音乐史的理想与实际困难:我的个人体会

在线全文

学校读者我要写书评

暂无评论

黄钟（武汉音乐学院学报） 2024年第2期 6-13,167页

作者： [美]林萃青美国密歇根大学音乐学院安娜堡MI48109 中国音乐学院

该文是作者基于在《牛津手册:中国与海外华人音乐》中发表的“中国人为什么、又如何唱《诗经》歌曲?”(Why and How Do Chinese Sing Shijing Songs?),以及正在写作的《孔子之歌:中国诗乐的大历史描述》(Confucius's Songs:A Global His... 详细信息

该文是作者基于在《牛津手册:中国与海外华人音乐》中发表的“中国人为什么、又如何唱《诗经》歌曲?”(Why and How Do Chinese Sing Shijing Songs?),以及正在写作的《孔子之歌:中国诗乐的大历史描述》(Confucius's Songs:A Global History of Chinese Shiyue)一书有关编写诗乐大音乐史的理论建构和相关思考。作者突破了对传统诗乐历史认知的框架,以“大历史”的理念观照诗乐和格里高利圣咏历史发展的异同,为当今理解诗乐提供了新路径。

关键词：诗经诗乐大历史大音乐史格里高利圣咏

三陰乳腺癌PD-L1(SP142)與CTLA-4、PTEN表達的關係研究

在线全文

学校读者我要写书评

暂无评论

镜湖医学 2024年第1期24卷 20-23,F0003页

作者：韋潔貞林文華冼麗芳陳建勇黃香婷肖剛文劍明澳門鏡湖醫院病理科中国

目的探討三陰乳腺癌PD-L1(SP142)與CTLA-4、PTEN表達的關係和意義。方法收集鏡湖醫院2008年1月~2018年6月間病理科136例乳腺癌標本,按乳腺癌分子分型分為三陰乳腺癌(TNBC)、管腔A型、管腔B型及HER2型乳腺癌,採用免疫組化檢測各型乳腺癌P... 详细信息

目的探討三陰乳腺癌PD-L1(SP142)與CTLA-4、PTEN表達的關係和意義。方法收集鏡湖醫院2008年1月~2018年6月間病理科136例乳腺癌標本,按乳腺癌分子分型分為三陰乳腺癌(TNBC)、管腔A型、管腔B型及HER2型乳腺癌,採用免疫組化檢測各型乳腺癌PD-L1(SP142)、CTLA-4和PTEN表達情況,並分析它們之間的關係。結果136例乳腺癌中,32.4%的病例PD-L1(SP142)陽性,其中48%(24/50)TNBC、11.9%(5/42)管腔A型、20%(3/15)管腔B型和41.4%(12/29)HER2型PD-L1(SP142)陽性;43.4%的病例CTLA-4陽性,其中52.0%(26/50)TNBC、31.0%(13/42)管腔A型、33.3%(5/15)管腔B型和50.9%(15/29)HER2型CTLA-4陽性;28.0%的病例PTEN陽性,其中52.0%(26/50)TNBC、31.0%(13/42)管腔A型、33.3%(5/15)管腔B型和50.9%(15/29)HER2型PTEN陽性。TNBC的PD-L1(SP142)表達與CTLA-4表達呈正相關(Spearman=0.409,P<0.05),與PTEN表達呈負相關(Spearman=-0.318,P<0.05)。結論TNBCPD-L1(SP142)與CTLA-4表達的正相關關係,提示聯合免疫治療可能使TNBC患者獲益,而TNBCPD-L1(SP142)與PTEN表達的負相關關係,提示TNBC同時遭受免疫逃逸和基因突變的雙重打擊,因此適合免疫治療和靶向PTEN聯合治療。

关键词：三陰乳腺癌 PD-L1(SP142) CTLA-4 PTEN