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SurePath、ThinPrep和传统细胞学3种方法常规筛查阴性后的宫颈癌发病率的研究：基于人群研究

英国医学杂志中文版 2018年第3期21卷 177-177页

作者： Kirsten Rozemeijer Steffie K Naber Corine Penning Lucy H Overbeek Caspar W N Looman Inge M C M de Kok Suzette M Matthijsse Matejka Rebolj folkert j van Kemenade Marjolein van Ballegooijen 张雪芳王淑珍不详首都医科大学附属北京朝阳医院妇产科

摘要目的比较3种不同筛查方法即传统细胞学、液基细胞学（Sure Path和Thin Prep）检测阴性后72个月内宫颈癌的累积发病率。设计以人群为基础的回顾性队列研究。背景从2000年1月-2013年3月在荷兰全国范围内网络登记的有组织病理学或细... 详细信息

摘要目的比较3种不同筛查方法即传统细胞学、液基细胞学（Sure Path和Thin Prep）检测阴性后72个月内宫颈癌的累积发病率。设计以人群为基础的回顾性队列研究。背景从2000年1月-2013年3月在荷兰全国范围内网络登记的有组织病理学或细胞病理学情况的宫颈癌数据。

关键词：细胞学屏蔽学习人口癌症样品

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Emerging roles of the intestine in control of cholesterol metabolism

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World journal of Gastroenterology 2006年第40期12卷 6429-6439页

作者： janine K Kruit Albert K Groen Theo j van Berkel folkert Kuipers Department of Pediatrics Center for Liver Digestive and Metabolic Diseases University Medical Center Groningen Groningen The Netherlands Department of Experimental Hepatology Academic Medical Center Amsterdam The Netherlands Division of Biopharmaceutics Leiden/Amsterdam Center for Drug Research Leiden University Leiden The Netherlands

The liver is considered the major “control center” for maintenance of whole body cholesterol homeostasis. This organ is the main site for de novo cholesterol synthesis, clears cholesterol-containing chylomicron remnants and low density lipoprotein particles from plasma and is the major contributor to high density lipoprotein (HDL; good cholesterol) formation. The liver has a central position in the classical definition of the reverse cholesterol transport pathway by taking up periphery-derived cholesterol from lipoprotein particles followed by conversion into bile acids or its direct secretion into bile for eventual removal via the feces. During the past couple of years, however, an additional important role of the intestine in maintenance of cholesterol homeostasis and regulation of plasma cholesterol levels has become apparent. Firstly, molecular mechanisms of cholesterol absorption have been elucidated and novel pharmacological compounds have been identified that interfere with the process and positively impact plasma cholesterol levels. Secondly, it is now evident that the intestine itself contributes to fecal neutral sterol loss as a cholesterol-secreting organ. Finally, very recent work has unequivocally demonstrated that the intestine contributes significantly to plasma HDL cholesterol levels. Thus, the intestine is a potential target for novel anti-atherosclerotic treatment strategies that, in addition to interference with cholesterol absorption, modulate direct cholesterol excretion and plasma HDL cholesterol levels.

关键词：胆固醇物质代谢病理治疗临床

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Pharmacomicrobiomics： a novel route towards personalized medicine？

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Protein & Cell 2018年第5期9卷 432-445页

作者： Marwah Doestzada Arnau Vich Vila Alexandra Zhernakova Debby P.Y. Koonen Rinse K. Weersma Daan j. TOUW folkert Kuipers Cisca Wijmenga jingyuan Fu Departments of Genetics University Medical Center Groningen PO Box 30001 9700 RB Groningen The Netherlands Departments of Paediatrics University Medical Center Groningen PO Box 30001 9700 RB Groningen The Netherlands Departments of Gastroenterology & Hepatology University Medical Center Groningen PO Box 30001 9700 RB Groningen The Netherlands Departments of Clinical Pharmacy & Pharmacology University Medical Center Groningen PO Box 30001 9700 RB Groningen The Netherlands Departments of Laboratory Medicine University Medical Center Groningen PO Box 30001 9700 RB Groningen The Netherlands K.G. jebsen Coeliac Disease Research Centre Department of Immunology University of Oslo P.O. Box 1072 Blindern 0316 Oslo Norway

Inter-individual heterogeneity in drug response is a serious problem that affects the patient＇s wellbeing and poses enormous clinical and financial burdens on a societal level. Pharmacogenomics has been at the forefront of research into the impact of individual genetic background on drug response variability or drug toxicity, and recently the gut microbiome, which has also been called the second genome, has been recog- nized as an important player in this respect. Moreover, the microbiome is a very attractive target for improving drug efficacy and safety due to the opportunities to manipulate its composition. Pharmacomicrobiomics is an emerging field that investigates the interplay of microbiome variation and drugs response and disposi- tion （absorption, distribution, metabolism and excretion）. In this review, we provide a historical overview and examine current state-of-the-art knowledge on the complex interactions between gut microbiome, host and drugs. We argue that combining pharmacogenomics and pharmacomicrobiomics will provide an important foundation for making major advances in personalized medicine.

关键词： gut microbiome drug metabolism personalized medicine

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