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Lyell Syndrome with Fatal Outcome in Two Pregnant Women Receiving Antiretroviral Therapy in Guinea Conakry

Journal of Cosmetics, Dermatological Sciences and Applications 2013年第2期3卷 135-138页

作者： Mohamed Cissé Mohamed Maciré Soumah Thierno Mamadou Tounkara Boh Fanta Diané fodé bangaly sack Houleymatou Baldé Amara Camara Aissata Dabo Camara Alhousseini Doumbouya Dermatology-STD Donka Teaching Hospital Gamal Abdel Nasser University of Conakry Conakry Guinea Infectious and Tropi- cal Diseases Donka Teaching Hospital Gamal Abdel Nasser University of Conakry Conakry Guinea

An old woman, 28 years old, weighing 74 kg was referred for skin detachment associated with bubbles and mucosal erosions. This clinical picture had occurred 15 days after the institution of a triple combination: AZT (300 mg) + 3TC (150 mg) and nevirapine (200 mg), during a pregnancy of 20-week gestation. The woman was in her third gestation. The second case is aged 26, weighing 65 kg. This clinical picture had occurred 20 days after the administration of a triple therapy combination: AZT (300 mg) + 3TC (150 mg) and nevirapine (200 mg), during a pregnancy of 32-week gestation. It was the fourth gestation. The birth of a stillborn had occurred the day before his admission into our service. The diagnosis of Toxic Epidermal Necrolysis with nevirapine was selected on the basis of the clinical and anamnestic arguments. The biological tests showed the following results: transaminases (ALT and AST) were within normal limits, blood glucose, and urea > 10 mmol/l. The evolution was marked by the patient death to Day 9 (D9) and at D2 of hospitalization. Discussion: NET and the SJS have been reported in pregnant women as potentially dangerous complications that are often associated with suspected drugs. Among these drugs, antiretroviral drugs, prescribed to pregnant women to prevent mother to child transmission of HIV are often reported. Our case is an illustration of the problem of HIV management in pregnant women. It also focuses on the association between pregnancy and Toxic Epidermal Necrolysis. Nevirapine is an effective drug in the regimens proposed in the management of HIV patients in limited resources countries. But the high frequency of toxidermia with this drug should lead to its replacement by other antiretrovirals least providers of toxidermia as anti proteases in the context of PMTCT programs.

关键词： Lyell Pregnant Women Nevirapine Fatal Outcome

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Landscape architecture and novel ecosystems:ecological restoration in an expanded field

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Ecological Processes 2013年第1期2卷 393-401页

作者： Catharina sack Faculty of Architecture Landscape and Visual ArtsUniversity of Western AustraliaM43335 Stirling HighwayCrawleyWA 6009Australia

Within the continuum of natural-to-novel ecosystems−i.e.,from the‘pristine’to the greatly intervened−this paper emphasizes the role of design within highly modified ecosystems in areas of *** is argued that,as certain landscapes(particularly urbanized ones)can never be restored to original levels of historical ecological fidelity,they should be treated as both cultural and ecological *** is then proposed that these anthropogenic landscapes would be ready canvases for designed(or planned)novel ecosystems that could be inculcated with ecological function and systems delivery,yet having profound aesthetic *** on this landscape architecture perspective,it is suggested that ecologists may not have fully explored cultural interventions in restoring landscapes,especially within the agency of design.A design strategy for the biological hotspot of Perth in southwestern Australia is then provided as a relevant example of how novel ecosystems can be *** an acute and novel approach to modifying current development practices,Perth’s biodiversity is on track for considerable *** this exploratory backdrop,it is elaborated how neo-baroque design strategies can be used for structuring ecological systems to create resilient and productive novel ecosystems grounded in a critical and autochthonous aesthetic of botanical complexity.

关键词： Landscape architecture Novel ecosystem design OCBIL landscapes Urban ecology Translational strategies

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Differential Privacy via a Truncated and Normalized Laplace Mechanism

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Journal of Computer Science & Technology 2022年第2期37卷 369-388页

作者： William Croft Jorg-Rudiger sack Wei Shi School of Computer Science Carleton UniversityOttawa K1S 5B6Canada School of Information Technology Carleton UniversityOttawa K1S 5B6Canada

When querying databases containing sensitive information,the privacy of individuals stored in the database has to be *** guarantees are provided by differentially private mechanisms which add controlled noise to the query ***,most such mechanisms do not take into consideration the valid range of the query being ***,noisy responses that fall outside of this range may potentially be *** rectify this and therefore improve the utility of the mechanism,the commonly-used Laplace distribution can be truncated to the valid range of the query and then ***,such a data-dependent operation of normalization leaks additional information about the true query response,thereby violating the differential privacy ***,we propose a new method which preserves the differential privacy guarantee through a careful determination of an appropriate scaling parameter for the Laplace *** adapt the privacy guarantee in the context of the Laplace distribution to account for data-dependent normalization factors and study this guarantee for different classes of range constraint *** provide derivations of the optimal scaling parameter(i.e.,the minimal value that preserves differential privacy)for each class or provide an approximation *** a result of this work,one can use the Laplace distribution to answer queries in a range-adherent and differentially private *** demonstrate the benefits of our proposed method of normalization,we present an experimental comparison against other range-adherent *** show that our proposed approach is able to provide improved utility over the alternative mechanisms.

关键词： differential privacy Laplace mechanism query range constraint

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Being accompanied to liver discharge clinic: An easy measure to identify potential liver transplant candidates among those previously considered ineligible

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World Journal of Hepatology 2019年第4期11卷 370-378页

作者： Jordan sack Nilofar Najafian Angela DeLisle Simona Jakab Department of Internal Medicine Yale University School of Medicine Northeast Medical Group Yale New Haven Health Section of Digestive Diseases Yale University School of Medicine

BACKGROUND Patients with cirrhosis deemed ineligible for liver transplantation are usually followed in general hepatology or gastroenterology clinics, with the hope of reevaluation once they meet the appropriate criteria. Specific strategies to achieve liver transplant eligibility for these patients have not been *** To assess clinical and sociodemographic factors associated with future liver transplant eligibility among patients initially considered *** This is a retrospective study of patients with cirrhosis considered non-transplant eligible, but without absolute contraindications, who were scheduled in our transitional care liver clinic(TCLC) after discharge from an inpatient liver *** candidacy was assessed 1 year after the first scheduled TCLC *** on clinical and sociodemographic factors were *** Sixty-nine patients were identified and the vast majority were Caucasian men with alcoholic cirrhosis. 46 patients(67%) presented to the first TCLC visit. Seven of 46 patients that showed to the first TCLC visit became transplant candidates,while 0 of 23 patients that no-showed did(15.2% vs 0%, P = 0.08). Six of 7 patients who showed and became transplant eligible were accompanied by family orfriends at the first TCLC appointment, compared to 13 of 39 patients who showed and did not become transplant eligible(85.7% vs 33.3%, P = 0.01).CONCLUSION Patients who attended the first post-discharge TCLC appointment had a trend for higher liver transplant eligibility at 1 year. Being accompanied by family or friends during the first TCLC visit correlated with higher liver transplant eligibility at 1 year(attendance by family or friends was not requested). Patient and family engagement in the immediate post-hospitalization period may predict future liver transplant eligibility for patients previously declined.

关键词： Cirrhosis Transitional clinic Transplant listing Support Family

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Future technology-enabled care for diabetes and hyperglycemia in the hospital setting

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World Journal of Diabetes 2019年第9期10卷 473-480页

作者： Alex Renato Montero Jeffrey S Dubin Paul sack Michelle F Magee MedStar Diabetes Institute WashingtonDC 20010United States Department of Medicine MedStar Georgetown University HospitalWashingtonDC 20007United States MedStar Washington Hospital Center WashingtonDC 20010United States MedStar Union Memorial Hospital BaltimoreMD 21218United States MedStar Health Research Institute WashingtonDC 20010United States

Patients with diabetes are increasingly common in hospital settings where optimal glycemic control remains *** technology-enabled support systems are being designed,adapted and evaluated to meet this *** pump use,increasingly common in outpatients,has been shown to be safe among select *** pump protocols and provider training are needed to optimize pump use in the *** glucose monitoring(CGM)has been shown to be comparable to usual care for blood glucose surveillance in intensive care unit(ICU)settings but data on cost effectiveness is *** use in non-ICU settings remains investigational and patient use of home CGM in inpatient settings is not recommended due to safety *** to unstructured insulin prescription,a continuum of effective electronic medical record-based support for insulin prescription exists from passive order sets to clinical decision support to fully automated electronic Glycemic Management *** efficacy and cost among these systems remains *** array of novel platforms are being evaluated to engage patients in technology-enabled diabetes education in the *** hold tremendous promise in affording universal access to hospitalized patients with diabetes to effective self-management education and its attendant short/long term clinical benefits.

关键词： Diabetes Inpatients Continuous subcutaneous insulin infusion Continuous glucose monitoring Clinical decision support Patient education Self-management

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A new method for internal cardioversion in patients with persistent atrial fibrillation

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Chinese Medical Journal 2002年第2期 139-141页

作者：周京敏 Stefan sack Frank Heinzel Peter Hunold Nicklas Dagres Raimund Erbel 葛均波 Department of Cardiology Zhongshan Hospital Shanghai Institute of Cardiovascular Diseases Fudan University Department of Cardiology University Essen Hospital Essen 45122 Germany

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Medical genetics /

Medical genetics /

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1999年

作者： sack George H.

来源：畅想之星图书光盘版（南... 评论

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用一支针管笔“行走江湖”

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视野 2015年第13期 50-51页

作者： sack

sack的作品探讨建筑作为一种灵活的媒介能够表达现实与抽象之间的独特的空间，以及创造意义的能力是在不断变化的。

关键词：江湖针管

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欧洲门窗设施的能耗分析

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中国建筑金属结构 2006年第12期 11-13,17页

作者： Nobert sack 德国罗森海姆门窗设施检测鉴定局

一、序言提高能耗效率不仅对欧洲来说是一个中心任务,也是全球环境、气候和各国经济面临的一个全球性挑战.降低建筑物的能量需求具有重要意义,例如德国从前通过修订相应的建筑物热防护要求大大降低了建筑物的能耗.

关键词：能耗分析设施门窗建筑物能耗效率全球环境能量需求热防护

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Coronary microvascular dysfunction exists early after hearttransplantationand normalisation during followup :serial assessment with intracoronaryFlo Wire

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Chinese Medical Journal 1999年第9期112卷 81-81页

作者： JGe DWelge AJeremias GGorge FLiu Ssack CReidemeister RErbel Department of Cardiology University-GHS Essen Germany Department of Cardiac Surgery University-GHS Essen Germany

In order to assess the vascular integrity after heart transplantation (HTx), intracoronary Doppler was performed in 13 patients within 3 months after HTx and at one year follow up in all the 3 epicardial coronary arteries (LAD, LCX, and RCA) For intracoronary Doppler flow mapping, a 0 014 inch,15 MHz FloWire (Cardiometrics) was used Coromary flow velocity reserve (CFR) was derived by calculating the ratio between average peak flow velocity (APV) at baseline and after intracoronary adenosine injection (LAD and LCX, 18?μg; RCA, 12?μg) All patients were found to have relatively normal coronary angiograms within 3 months and at one year follow up CFVR was increased significantly in LAD (2 87±0 59 vs 3 63±0 91, P 0 05) Reduction of CFR exists within 3 months after HTx and normalises within one year This indicates that microvascular dysfunction especially in LAD and LCX exists early after HTx which will be normalised at 1 year CFR of the RCA seems to recover early HTx

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