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Molecular Plant 2012年第1期5卷 85-97页

作者： Nan-Nan gu Yan-Chun Zhang Hong-quan Yang National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200032China Plant Science Institute School of Agriculture and BiologyShanghai Jiaotong UniversityShanghai 200240China

CRYPTOCHROMES （CRYs） are photolyase-like ultraviolet-A/blue light photoreceptors that mediate various light responses in plants. The signaling mechanism of Arabidopsis CRYs （CRY1 and CRY2） involves direct CRY-COP1 interaction. Here, we report that CRY1G380R, which carries a Gly-to-Arg substitution of the highly conserved G380 in the photo-lyase-related （PHR） domain of Arabidopsis CRY1, shows constitutive CRY1 photoreceptor activity in Arabidopsis. Transgenic plants overexpressing CRY1G380R display a constitutively photomorphogenic （COP） phenotype in darkness, as well as a dramatic early flowering phenotype under short-day light conditions （SD）. We further demonstrate that CRY1G380R expression driven by the native CRY1 promoter also results in a COP phenotype in darkness. Moreover, over- expression of either the Arabidopsis homolog CRY2G377R or the rice ortholog OsCRYlbG388R of CRY1G380R in Arabidopsis results in a COP phenotype in darkness. Cellular localization studies indicate that CRY1G380R co-localizes with COP1 in the same nuclear bodies （NBs） in vivo and inhibits the nuclear accumulation of COP1 in darkness. These results suggest that the conserved G380 may play a critical role in regulating the photoreceptor activity of plant CRYs and that CRY1G380R might constitutively phenocopy the photo-activated CRY1 in darkness and thus constitutively mediate CRY1 signaling.

关键词： Arabidopsis CRY1 CRy1G380R COP phenotype COP1.

D-band frontier: A new hydrogen evolution reaction activity descriptor of Pt single-atom catalysts

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Journal of Energy Chemistry 2022年第9期31卷 203-209,I0007页

作者： guangming Zhan Yancai Yao Fengjiao quan Huayu gu Xiao Liu Lizhi Zhang Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Institute of Applied & Environmental Chemistry College of Chemistry Central China Normal UniversityWuhan 430079HubeiChina School of Environmental Science and Engineering Shanghai jiao Tong UniversityShanghai 200240China

Hydrogen evolution reaction(HER) is crucial for achieving sustainable development and carbon neutrality, and thus demands efficient catalysts, which necessitates fundamental theory to relieve trial-and-error experiment. To fast screen HER candidates, most studies focus on d-band center(ε)associated with the Gibbs energy of H* adsorption(ΔG). Unfortunately, εrule is not applicable to Pt single atoms on transition metal disulfides(Pt_(1)/TMDs) because of the additional contributions from p states of S atom. Here, we propose a new HER descriptor — d-band frontier(d) by defining the weight of d-band in the energy range of [-1.0 eV, 1.0 eV] of Pt single atoms. This dis exactly correlated with the ΔGof Pt_(1)/TMDs, and thus perfectly describes the structure–activity relationship, as validated by systematical experimental evidences. Moreover, this ddescriptor can be extended to Pt single atoms anchored on other supports(e.g., CN, C, MoO, and CoO), indicating its promising generality.

关键词： Hydrogen evolution reaction Single atoms Transition metal disulfides Descriptor

Hybrid tri-memristor hyperchaotic map and application in Wasserstein Generative Adversarial Nets

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Science China(Technological Sciences) 2024年第6期67卷 1855-1865页

作者： gu Yang BAO Han YU XiHong HUA ZhongYun BAO BoCheng XU quan School of Microelectronics and Control Engineering Changzhou UniversityChangzhou213159China School of Computer Science and Technology Harbin Institute of TechnologyShenzhen518055China

Inspired by basic circuit connection methods,memristors can also be utilized in the construction of complex discrete chaotic *** investigate the dynamical effects of hybrid memristors,we propose two hybrid tri-memristor hyperchaotic(HTMH)mapping structures based on the hybrid parallel/cascade and cascade/parallel operations,*** the HTMH mapping structure with hybrid parallel/cascade operation as an example,this map possesses a spatial invariant set whose stability is closely related to the initial states of the *** distributions and bifurcation behaviours dependent on the control parameters are explored with numerical ***,the memristor initial offset-boosting mechanism is theoretically demonstrated,and memristor initial offset-boosting behaviours are numerically *** results clarify that the HTMH map can exhibit hyperchaotic behaviours and extreme multistability with homogeneous coexisting infinite *** addition,an FPGA hardware platform is fabricated to implement the HTMH map and generate pseudorandom numbers(PRNs)with high ***,the generated PRNs can be applied in Wasserstein generative adversarial nets(WGANs)to enhance training stability and generation capability.

关键词： memristor hybrid tri-memristor map spatial invariant set hyperchaos extreme multistability generative adversarial nets

The effects of clay minerals and organic matter on nanoscale pores in Lower Paleozoic shale gas reservoirs, guizhou, China

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Acta Geochimica 2018年第6期37卷 791-804页

作者： Yuantao gu quan Wan Wenbin Yu Xiaoxia Li Zhongbin Yu State Key Laboratory of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences School of Resource and Environment Henan University of Engineering

In organic-rich gas shales, clay minerals and organic matter(OM) have significant influences on the origin, preservation, and production of shale gas. Because of the substantial role of nanoscale pores in the generation,storage, and seepage of shale gas, we examined the effects of clay minerals and OM on nanoscale pore distribution characteristics in Lower Paleozoic shale gas *** the Niutitang and Longmaxi shales as examples, we determined the effects of clay minerals and OM on pores through sedimentation experiments. Field emission–scanning electron microscopy combined with low-pressure N2 adsorption of the samples before and after sedimentation showed significant differences in pore location and pore size distribution between the Niutitang and Longmaxi shales. Nanoscale pores mostly existed in OM in the Longmaxi shale and in clay minerals or OM–clay composites in the Niutitang shale. The distribution differences were attributed largely to variability in thermal evolution and tectonic development and might account for the difference in gas-bearing capacity between the Niutitang and Longmaxi reservoirs. In the nanoscale range, mesopores accounted for 61–76% of total nanoscale pore *** developed nanoscale pores in OM were distributed in a broad size range in the Longmaxi shale, which led to good pore connectivity and gas *** narrow pores(i.e., pores \ 20 nm) in OM–clay composites were found in the Niutitang shale, and might account for this shale's poor pore connectivity and low gas production efficiency. Enhancing the connectivity of the mesopores(especially pores \ 20 nm and those developed in OM–clay composites) might be the key to improving development of the Niutitang shale. The findings provide new insight into the formation and evolutionary mechanism of nanoscale pores developed in OM and clay minerals.

关键词： Nanoscale pore Clay minerals Organic matter OM-clay composites Pore distribution characteristics Pore connectivity

Huangqin Decoction Attenuates DSS-Induced Mucosal Damage and Promotes Epithelial Repair via Inhibiting TNF-α-Induced NF-κB Activation

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Chinese Journal of Integrative Medicine 2022年第2期28卷 124-129页

作者： gu Li-mei LI Hui XIA Jun-quan PAN Cheng-yu gu Chao TIAN Yao-zhou Gastroenterology Department Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing(210028)China Gastroenterology Department Jiangsu Province Hospital on Integration of Chinese and Western MedicineNanjing(210028)China Jiangsu Province Academy of Traditional Chinese Medicine Nanjing(210028)China

Objective:To investigate the protective effect of Chinese herbal formula Huangqin Decoction(HQD)on ulcerative colitis mouse model induced by dextran sulphate sodium(DSS)and human intestinal epithelial cell injury induced by tumour necrosis factor-α(TNF-α).Methods:In vivo,30 male C57BL/6 mice were divided into 5 groups using a random number table(n=6 per group),including control,DSS,5-aminosalicylic acid(5-ASA),HQD low-(HQD-L)and high-dose(HQD-H)*** colitis mouse model was established by 3%(w/v)DSS water for 5 ***,mice in the HQD-L,HQD-H and 5-ASA groups were administrated with 100,200 mg/kg HQD or 100 mg/kg 5-ASA,respectively,once daily by *** 9 days of administration,the body weight,disease activity index(DAI)score and colon length of mice were measured,the pathological changes of colons were analyzed by hematoxylin-eosin staining(HE)staining,and the levels of serum interleukin(IL)-6,IL-1βand TNF-αwere measured by enzyme linked immunosorbent *** vitro,the human colon epithelial normal cells(FHC cells)were exposed to HQD(0.6 mg/mL)for 12 h and then treated with TNF-α(10 ng/mL)for 24 *** tight junction(TJ)protein expression levels of Claudin-4 and Occludin,and the protein phosphorylation levels of p65 and inhibitor of nuclear factor kappaB(NF-κB)-α(IκBα)were measured by Western ***:In vivo,compared with the DSS group,HQD-H treatment attenuated the weight loss and reduced DAI score of mice on the 8th day(Pgulated Occludin and Claudin-4 protein expressions and inhibited p-p65 and p-IκBαlevel

关键词： Huangqin Decoction ulcerative colitis tumour necrosis factor-α nuclear factor kappaB pathway tight conjunction protein Chinese medicine

Recent advances in chiral aggregation-induced emission fluorogens

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Engineered Regeneration 2022年第3期3卷 323-338页

作者： Rui Hu Yuncong Yuan Meijia gu You-quan Zou Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of EducationSchool of Pharmaceutical SciencesWuhan UniversityWuhanChina College of Life Sciences Wuhan UniversityWuhanChina TaiKang Center for Life and Medical Sciences Wuhan UniversityWuhanChina

Over the past decade,aggregation-induced emission(AIE)molecules have played a pivotal role in bioimaging,anti-microbial,and photodynamic therapy,and have been at the forefront of several disciplines *** combined with chiral moieties,they can easily collide with dazzling sparks and exhibit exceptional and unique *** the application of chiral recognition and measurement of enantiomeric excess,it can identify chi-ral molecules visually based on color change and precipitation reaction,quantitatively analyze chiral molecules while determining the enantiomeric composition based on the fluorescence intensity change at different wave-lengths,and obtain two parameters about chiral molecules from one measurement,thereby demonstrating its high selectivity,sensitivity and accuracy in chiral *** the field of organic circularly polarized lu-minescent(CPL)materials,the asymmetry(g lum)of common organic light emitting elements is usually between 10−5 and 10−2,whereas the CPL asymmetry factor(g lum)of chiral AIE fluorogens(AIEgens)can reach 1.42,which is very close to the theoretical value of ***,the combination of chiral elements and luminescent groups promotes their adoption in the field of organic CPL *** we have summarized the recent applications of chiral AIEgens in both chiral molecule recognition and circularly polarized organic light-emitting diode(CP-OLED)in order to provide future researchers with a more comprehensive and detailed understanding of chiral AIEgens and to encourage more scientists to contribute to the development of AIEgens.

关键词： Aggregation-induced emission Chiral AIE fluorogens Recognition Circularly polarized luminescent

Correlations between hippocampal functional connectivity,structural changes,and clinical data in patients with relapsing-remitting multiple sclerosis:a case-control study using multimodal magnetic resonance imaging

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Neural Regeneration Research 2022年第5期17卷 1115-1124页

作者： Xin-quan gu Ying Liu Jie-Bing gu Lin-Fang Li Ling-Ling Fu Xue-Mei Han China-Japan Union Hospital of Jilin University ChangchunJilin ProvinceChina First Department of Neurology China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina Cardre’s Ward Changchun Central hospitalChangchunJilin ProvinceChina

Multiple sclerosis is associated with structural and functional brain alterations leading to cognitive impairments across multiple domains including attention,memory,and the speed of information *** hippocampus,which is a brain important structure involved in memory,undergoes microstructural changes in the early stage of multiple *** this study,we analyzed hippocampal function and structure in patients with relapsing-remitting multiple sclerosis and explored correlations between the functional connectivity of the hippocampus to the whole brain,changes in local brain function and microstructure,and cognitive function at *** retrospectively analyzed data from 20 relapsing-remitting multiple sclerosis patients admitted to the Department of Neurology at the China-Japan Union Hospital of Jilin University,China,from April 2015 to November *** healthy volunteers were recruited as the healthy control *** participants were evaluated using a scale of extended disability status and the Montreal cognitive assessment within 1 week before and after head diffusion tensor imaging and functional magnetic resonance *** with the healthy control group,the patients with relapsing-remitting multiple sclerosis had lower Montreal cognitive assessment scores and regions of simultaneously enhanced and attenuated whole-brain functional connectivity and local functional connectivity in the bilateral *** diffusion tensor imaging data showed that,compared with the healthy control group,patients with relapsing-remitting multiple sclerosis had lower hippocampal fractional anisotropy values and higher mean diffusivity values,suggesting abnormal hippocampal *** left hippocampus whole-brain functional connectivity was negatively correlated with the Montreal cognitive assessment score(r=-0.698,P=0.025),and whole-brain functional connectivity of the right hippocampus was negatively correlated with extended disability stat

关键词： cognitive impairment diffusion tensor imaging fractional anisotropy functional connectivity functional magnetic resonance imaging hippocampus local consistency low frequency oscillation amplitude mean diffusivity multiple sclerosis neurodegeneration

PEG-grafted PVA Membrane and Its Blood Compatibility

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Chemical Research in Chinese Universities 2011年第6期27卷 1078-1082页

作者： JIN gu YAO Qi-zhi DONG Li-quan MA Feng Department of Chemistry University of Science and Technology of China Hefei 230026 P. R. China

Preparation and blood compatibility of different shape polyvinyl alcohol（PVA） membrane were investigated. Firstly, the tabular and tubular[polytetrafluoroethylene（PTFE） capillary as supporter] PVA membranes were prepared; then, methoxy polyethylene glycol（mPEG） was grafted onto the surface of the PVA membranes. The effects of the shape, structure and properties of the membrane surface on blood compatibility were studied in detail. The experiment results show that mPEG modified PVA membranes, especially mPEG modified tubular membrane, could availably repel the adhesion of the platelets. In addition, the anticoagulant mechanism of mPEG with a steric repulsion effectiveness was confirmed further via different grafting methods.

关键词： Polyvinyl alcohol(PVA) Polyethylene glycol(PEG) Membrane Platelet Adhesion

Environment-Stable CoxNiy Encapsulation in Stacked Porous Carbon Nanosheets for Enhanced Microwave Absorption

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Nano-Micro Letters 2020年第8期12卷 172-183页

作者： Xiaohui Liang Zengming Man Bin quan Jing Zheng Weihua gu Zhu Zhang guangbin Ji College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211100People’s Republic of China Department of Chemistry and Materials Science College of ScienceNanjing Forestry UniversityNanjing 210037People’s Republic of China

Magnetic/dielectric@porous carbon composites,derived from metal–organic frameworks(MOFs)with adjustable composition ratio,have attracted wide attention due to their unique magnetoelectric *** addition,MOFs-derived porous carbon-based materials can meet the needs of lightweight *** paper reports a simple process for synthesizing stacked CoxNiy@C nanosheets derived from CoxNiy-MOFs nanosheets with multiple interfaces,which is good to the microwave *** CoxNiy@C with controllable composition can be obtained by adjusting the ratio of Co^2+ and Ni^2+.It is supposed that the increased Co content is benefit to the dielectric and magnetic ***,the bandwidth of CoNi@C nanosheets can take up almost the whole Ku ***,this composite has better environmental stability in air,which characteristic provides a sustainable potential for the practical application.

关键词： MOFs CoxNiy@C nanosheets Multiple interfaces Microwave absorption Environmental stability

Verification of a self-developed CFD-based multi-physics coupled code MPC-LBE for LBE-cooled reactor

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Nuclear Science and Techniques 2021年第5期32卷 84-100页

作者： Zhi-Xing gu Qing-Xian Zhang Yi gu Liang-quan Ge guo-Qiang Zeng Mu-Hao Zhang Bao-Jie Nie College of Nuclear Technology and Automation Engineering Chengdu University of TechnologyChengdu 610059China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China

To perform an integral simulation of a pool-type reactor using CFD code,a multi-physics coupled code MPC-LBE for an LBE-cooled reactor was proposed by integrating a point kinetics model and a fuel pin heat transfer model into self-developed CFD *** code verification,a code-to-code comparison was employed to validate the CFD ***,a typical BT transient benchmark on the LBE-cooled XADS reactor was selected for verification in terms of the integral or system *** on the verification results,it was demonstrated that the MPC-LBE coupled code can perform thermal-hydraulics or safety analyses for analysis for processes involved in LBE-cooled pool-type reactors.

关键词： LBE-cooled pool-type reactor Computational fluid dynamics Multi-physics coupling code Safety analysis code Verification