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Reduction of epinephrine in the lumbar spinal cord following repetitive blast-induced traumatic brain injury in rats

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Neural Regeneration Research 2024年第7期19卷 1548-1552页

作者： Shigeharu Tsuda Mustafa Golam Jiamei Hou Kevin K.W.Wang floyd J.Thompson Prodip Bose Brain Rehabilitation Research Center Malcom Randall VA Medical CenterNorth Florida/South Georgia Veterans Health SystemGainesvilleFLUSA Department of Anesthesiology College of MedicineUniversity of FloridaGainesvilleFLUSA Department of Emergency Medicine University of FloridaGainesvilleFLUSA Department of Neuroscience University of FloridaGainesvilleFLUSA Department of Neurology University of FloridaGainesvilleFLUSA

Traumatic brain inju ry-induced unfavorable outcomes in human patients have independently been associated with dysregulated levels of monoamines,especially epinephrine,although few preclinical studies have examined the epinephrine level in the central nervous system after traumatic brain *** has been shown to regulate the activities of spinal motoneurons as well as increase the heart rate,blood pressure,and blood flow to the hindlimb ***,the purpose of the present study was to determine the impact of repeated blast-induced traumatic brain injury on the epinephrine levels in seve ral function-s pecific central nervous system regions in *** three repeated blast injuries at 3-day intervals,the hippocampus,motor cortex,locus coeruleus,vestibular nuclei,and lumbar spinal cord were harvested at post-injury day eight and processed for epinephrine assays using a high-sensitive electrochemical detector cou pled with high-performance liquid *** results showed that the epinephrine levels were significantly decreased in the lumbar spinal cord tissues of blast-induced traumatic brain injury animals compared to the levels detected in age-and sex-matched sham *** other function-specific central nervous system regions,although the epinephrine levels were slightly altered following blast-induced tra u matic brain injury,they were not statistically *** results suggest that blast injury-induced significant downregulation of epinephrine in the lumbar spinal cord could negatively impact the motor and cardiovascular *** is the first repo rt to show altered epinephrine levels in the spinal cord following repetitive mild blast-induced traumatic brain injury.

关键词： balance blood flow cardiovascular system central nervous system epinephrine ischemic damage lumbar spinal cord muscle tone repeated blast spasticity traumatic brain injury

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Volumetric lattice Boltzmann method for pore-scale mass diffusionadvection process in geopolymer porous structures

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2126-2136页

作者： Xiaoyu Zhang Zirui Mao floyd W.Hilty Yulan Li Agnes Grandjean Robert Montgomery Hans-Conrad zur Loye Huidan Yu Shenyang Hu Purdue University IndianapolisIN46202USA Pacific Northwest National Laboratory RichlandWA99352USA CEA DESISECDMRCUniv.MontpellierMarcouleFrance Department of Chemistry and Biochemistry University of South CarolinaColumbiaSC29208USA

Porous materials present significant advantages for absorbing radioactive isotopes in nuclear waste *** improve absorption efficiency in nuclear waste treatment,a thorough understanding of the diffusion-advection process within porous structures is essential for material *** this study,we present advancements in the volumetric lattice Boltzmann method(VLBM)for modeling and simulating pore-scale diffusion-advection of radioactive isotopes within geopolymer porous *** structures are created using the phase field method(PFM)to precisely control pore *** our VLBM approach,we introduce a concentration field of an isotope seamlessly coupled with the velocity field and solve it by the time evolution of its particle population *** address the computational intensity inherent in the coupled lattice Boltzmann equations for velocity and concentration fields,we implement graphics processing unit(GPU)*** of the developed model involves examining the flow and diffusion fields in porous ***,good agreement is observed for both the velocity field from VLBM and multiphysics object-oriented simulation environment(MOOSE),and the concentration field from VLBM and the finite difference method(FDM).Furthermore,we investigate the effects of background flow,species diffusivity,and porosity on the diffusion-advection behavior by varying the background flow velocity,diffusion coefficient,and pore volume fraction,***,all three parameters exert an influence on the diffusion-advection *** background flow and diffusivity markedly accelerate the process due to increased advection intensity and enhanced diffusion capability,***,increasing the porosity has a less significant effect,causing a slight slowdown of the diffusion-advection process due to the expanded pore *** comprehensive parametric study provides valuable insights into the kinetics of isotope

关键词： Volumetric lattice Boltzmann method(VLBM) Phase field method(PFM) Pore-scale diffusion-advection Nuclear waste treatment Porous media flow Graphics processing unit(GPU) parallelization

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BDS-3 B1C/B2a长基线相对定位研究

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测绘通报 2024年第8期 31-36,53页

作者：方卓王立诗云 MICHAEL floyd 南京数维测绘有限公司江苏南京211808 中铁四院集团南宁勘察设计院有限公司广西南宁430007 麻省理工学院地球、大气与行星科学系马萨诸塞州剑桥02139

为了验证北斗三号卫星导航系统(BDS-3)B1C/B2a长基线相对定位的精度,本文首先对2023年DOY(304~313)澳大利亚地区8个MGEX测站连续10 d观测数据进行质量分析;然后使用改进的GAMIT10.76软件对观测数据进行长基线相对定位解算;最后评估BDS-3... 详细信息

为了验证北斗三号卫星导航系统(BDS-3)B1C/B2a长基线相对定位的精度,本文首先对2023年DOY(304~313)澳大利亚地区8个MGEX测站连续10 d观测数据进行质量分析;然后使用改进的GAMIT10.76软件对观测数据进行长基线相对定位解算;最后评估BDS-3和GPS不同频点信号组合数据质量和双频无电离层线性组合基线解算,以及网平差的精度。试验结果表明,B1C/B2a、B1C/B2b和B1C/B3I频点信号组合数据质量、载噪比和伪距多路径误差基本相当,优于L1/L2;B1C/B2a的标准化均方根(NRMS)略优于B1C/B2b和L1/L2,显著优于B1C/B3I;B1C/B2a和B1C/B2b模糊度固定率基本相当,显著优于B1C/B3I,差于L1/L2。试验结果进一步表明,B1C/B2a相对于B1C/B3I的基线分量东(E)、北(N)和天顶(U)3方向标准差(STD)均值和三维点位误差均值分别降低了29.4%、27.0%、30.0%和41.0%。

关键词：北斗三号卫星导航系统频点信号数据质量相对定位

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肾素血管紧张素醛固酮系统抑制剂与新型冠状病毒肺炎感染或住院治疗:一项队列研究

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中华高血压杂志(中英文) 2022年第2期 200-200页

作者： Dublin S Walker RL floyd js Shortreed SM Fuller S Albertson-Junkans L Harrington LB Greenwood-Hickman MA Green BB Psaty BM 袁源郑武洪

Am J Hypertens,2021,34(4):339-347.血管紧张素转换酶抑制药(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体阻滞药(angiotensin receptor blocker,ARB)可能增加新型冠状病毒肺炎(corona virus disease 2019,COVID-19)感染风险或影响疾病的严重程度。先前的研究尚未明确药物剂量对上述风险的影响。方法:本研究为回顾性队列研究,纳入年龄≥18岁且在2020年2月29日之前在美国综合保健系统中注册4个月以上的人群。根据药店数据确认ACEI或ARB当前使用情况,估算药物每日剂量并进行标准化处理。

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Stop flow lithography synthesis of non-spherical metal oxide particles

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Particuology 2014年第3期12卷 91-97页

作者： David Baah Tobias Donnell Julaunica Tigner Tamara floyd-Smith Materials Science & Engineering Department Tuskegee UniversityTuskegeeAL 36088USA Chemical Engineering Department Tuskegee UniversityTuskegeeAL 36088USA

Non-spherical micron and hand-sized particles and their composites have become essential in select application areas of optics, wear resistance, personnel protection, chemical mechanical polishing, and biomedicine. In this paper, the synthesis of composite and ceramic non-spherical particles using stop flow lithography is reported. Precursor suspensions of poly（ethylene glycol） diacrylate, 2-hydroxy- 2-methylpropiophenone and SiO2 or Al2O3 are prepared. The precursor suspension flows through a microfluidic device mounted on an upright microscope and is polymerized in an automated process. A photomask patterned with transparent geometric features, which define the cross-sectional shapes of the particles, masks the UV light to synthesize micron sized particles. Particles with axial dimensions ranging from 35 to 167μm were synthesized. Control of device channel depth and objective lens magnification enables the manipulation of the particle size. Composite particles in triangular, square, pentagonal, hexagonal, and circular cross sections were synthesized. Subsequently, the transformation of the composite particles into the corresponding metal oxide particles was achieved through polymer burn-offand sintering.

关键词： Microfluidics Stop flow lithography Electron microscopy

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Expansion properties for finite subdivision rules I Dedicated to the Memories of William P. Thurston and Lei Tan

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Science China Mathematics 2018年第12期61卷 2237-2266页

作者： William J.floyd Walter R.Parry Kevin M.Pilgrim Department of Mathematics Virginia Tech Department of Mathematics and Statistics Eastern Michigan University Department of Mathematics Indiana University

Among Thurston maps (orientation-preserving, postcritically finite branched coverings of the 2-sphere to itself), those that arise as subdivision maps of a finite subdivision rule form a special family. For such maps, we investigate relationships between various notions of expansion—combinatorial, dynamical, algebraic,and coarse-geometric.

关键词： finite subdivision rule expanding map postcritically finite Thurston map

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