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四川生理科学杂志 1993年第4期15卷 42-46页

作者： floyd e. bloom 刘应兵

要保持有才华的研究者的最高才能水准,关键在于能够招收、培训和保持住一支最优秀的神经科学的年轻学生队伍。本文强调训练者在注重贯常的实验技能训练之外,也需要重视科学相关技能的训练。这种技能训练可能有助于保持住显然在长时期内... 详细信息

要保持有才华的研究者的最高才能水准,关键在于能够招收、培训和保持住一支最优秀的神经科学的年轻学生队伍。本文强调训练者在注重贯常的实验技能训练之外,也需要重视科学相关技能的训练。这种技能训练可能有助于保持住显然在长时期内都是珍贵财富的这支队伍的生命力。

关键词：神经科学家学生队伍技能训练神经科学研究细胞内第二信使研究计划神经遗传学研究基金资助培训者资助情况

Fundame.tal Ne.roscie.ce 2nd

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2003年

作者： Larry Squire.Darwin Be.g floyd e. bloom Sascha du Lac Anirvan Ghosh Larry R. Squire.Nicholas C. Spitze. Susan K. McConne.l Jame. L. Robe.ts Michae. J. Zigmond

ISBN: (纸本)9780126603033;9780080521800

With ove. 300 training programs in ne.roscie.ce.curre.tly in e.iste.ce. de.and is gre.t for a compre.e.sive.te.tbook that both introduce. graduate.stude.ts to the.full range.of ne.roscie.ce. from mole.ular biology to clinical scie.ce. but also assists instructors in offe.ing an in-de.th course.in ne.roscie.ce.to advance. *** se.ond e.ition of Fundame.tal Ne.roscie.ce.accomplishe. all this and more. The.thoroughly re.ise. te.t fe.ture. ove. 25% ne. mate.ial including comple.e.y ne. chapte.s, illustrations, and a CD-ROM containing all the.figure. from the.te.t. More.concise.and manage.ble.than the.pre.ious e.ition, this book has be.n re.oole. to be.te. se.ve.its audie.ce.in the.ne.roscie.ce.and me.ical *** Fe.ture.• Logically organize. into 7 se.tions, with uniform e.iting of the.conte.t for a''one.voice.'fe.l throughout all 54 chapte.s• Include. nume.ous te.t boxe. with concise. de.aile. de.criptions of spe.ific e.pe.ime.ts, disorde.s, me.hodological approache., and conce.ts• We.l-illustrate. with ove. 850 full color figure., also include. on the.accompanying CD-ROM

关键词： Ne.roscie.ce.

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

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感谢记忆

世界科学 2000年第9期 9-9页

作者： floyd e. bloom,陈伟京

这是Ｓｃｉｅｎｃｅ杂志前任主编离任时的一篇精彩演讲，他特别对因特网时代的期刊定位发表了看法，值得一读。

关键词：因特网互联网络期刊报刊主编编辑人员

Alte.e. le.kocyte.ge.e.e.pre.sion afte. traumatic spinal cord injury:clinical implications

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Ne.ral Re.e.e.ation Re.e.rch 2018年第9期13卷 1524-1529页

作者： Paige.e.He.man Ona bloom The.Fe.nste.n Institute.for Me.ical Re.e.rch Northwell Health De.artme.ts of Physical Me.icine.and Re.abilitation Molecular MedicineDonald and Barbara Zucker School of Medicine at Hofstra Northwell

In addition to change. in motor and se.sory function, individuals with spinal cord injury （SCI） e.pe.ie.ce.immunological change.. The.e.change. are.clinically significant, as infe.tions are.the.le.ding cause.of de.th for this population. Along with incre.se. infe.tions, inflammation is commonly obse.ve. in pe.sons with SCI, whe.e.it may promote.many common me.ical conse.ue.ce.. The.e.include.e.e.ate. risk of cardio- vascular dise.se. impaire. wound he.ling, diabe.e. and ne.ropathic pain. It has also be.n propose. that chronic inflammation dampe.s ne.rological re.ove.y. In orde. to ide.tify the.ape.tic strate.ie. to im- prove.immune.function, we.ne.d a gre.te. unde.standing of the.mole.ular change. that occur in immune.ce.ls afte. SCI. The.purpose.of this mini-re.ie. is to discuss two re.e.t studie. that use. functional ge.om- ics to inve.tigate.ge.e.e.pre.sion in circulating le.kocyte. isolate. from pe.sons with SCI. In the.future. the.mole.ular pathways that are.alte.e. afte. SCI may be.targe.e. to improve.immunological function, as we.l as ove.all he.lth and functional re.ove.y, afte. SCI.

关键词： traumatic spinal cord injury inflammation immune.ce.ls functional ge.omics ge.e.e.pre.sion autoimmunity microarray chronic spinal cord injury

COVID-19 Vaccine.Allocation: Mode.ing He.lth Outcome. and e.uity Implications of Alte.native.Strate.ie.

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e.gine.ring 2021年第7期7卷 924-935页

作者： Maddale.a Fe.ranna Danie. Cadare.te.David e.bloom Harvard T.H.Chan School of Public He.lth BostonMA 02115USA

Give. the.scarcity of safe.and e.fe.tive.COVID-19 vaccine.,a chie. policy que.tion is how to allocate.the. among diffe.e.t sociode.ographic *** pape. e.aluate. COVID-19 vaccine.prioritization strate.ie. propose. to date.focusing on the.r state. goals;the.me.hanisms through which the.se.e.te. allocations affe.t the.course.and burde. of the.pande.ic;and the.main e.ide.iological,e.onomic,logistical,and political issue. that arise.whe. se.ting the.prioritization *** pape. use. a simple.age.tratifie. susce.tible.e.pose.–infe.tious–re.ove.e. mode. applie. to the.Unite. State. to quantitative.y asse.s the.pe.formance.of alte.native.prioritization strate.ie. with re.pe.t to avoide. de.ths,avoide. infe.tions,and life.ye.rs *** de.onstrate.that prioritizing e.se.tial worke.s is a viable.strate.y for re.ucing the.numbe. of case. and ye.rs of life.lost,while.the.large.t re.uction in de.ths is achie.e. by prioritizing olde. adults in most sce.arios,e.e. if the.vaccine.is e.fe.tive.at blocking viral *** re.arding this prope.ty and pote.tial de.ays in dose.de.ive.y re.nforce.the.call for prioritizing olde. ***,we.inve.tigate.the.stre.gth of the.e.uity motive.that would support an allocation strate.y attaching absolute.priority to e.se.tial worke.s for a vaccine.that re.uce. infe.tionfatality risk.

关键词： Vaccine.allocation COVID-19 e.uity Se.R mode.

Age.as a pre.ictor of clinical outcome. and de.e.minant of the.ape.tic me.sure. for e.e.ge.cy me.ical se.vice. tre.te. cardioge.ic shock

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Journal of Ge.iatric Cardiology 2023年第1期20卷 1-10页

作者： Xiaoman Xiao Jason e.bloom e.ily Andre. Luke.P Dawson Ziad Ne.me.Michae. Ste.he.son David Ande.son Himawan Fe.nando Same. Noaman She.le. Cox William Chan David M Kaye.Kare. Smith Dion Stub De.artme.t of Cardiology Alfred Health55 Commercial RoadMelbourneAustralia Bake. He.rt and Diabe.e. Institute 75 Commercial RoadMelbourneAustralia De.artme.t of Cardiology Western HealthFurlong RoadSt AlbansAustralia Ambulance.Victoria 31 Joseph StreetBlackburnAustralia School of Public He.lth and Pre.e.tive.Me.icine Monash University553 St Kilda RoadMelbourneAustralia De.artme.t of Parame.icine Monash UniversityMcMahons RoadFrankstonAustralia

BACKGROUND The.impact of age.on outcome. in cardioge.ic shock(CS)is poorly de.cribe. in the.pre.hospital *** asse.se. the.impact of age.on outcome. of patie.ts tre.te. by e.e.ge.cy me.ical se.vice.(e.S).Me.HODS This population-base. cohort study include. conse.utive.adult patie.ts with CS transporte. to hospital by *** linke. patie.ts we.e.stratifie. into te.tile. by age.18-63,64-77,and>77 ye.rs).Pre.ictors of 30-day mortality we.e.asse.se. through re.re.sion *** primary outcome.was 30-day all-cause.*** A total of 3523 patie.ts with CS we.e.succe.sfully linke. to state.he.lth *** ave.age.age.was 68±16 ye.rs and 1398(40%)we.e.*** patie.ts we.e.more.like.y to have.comorbiditie. including pre.e.isting coronary arte.y dise.se.hype.te.sion,dyslipide.ia,diabe.e. me.litus,and ce.e.rovascular *** incide.ce.of CS was significantly gre.te. with incre.sing age.incide.ce.rate.pe. 100,000 pe.son ye.rs 6.47[95%CI:6.1-6.8]in age.18-63 ye.rs,34.34[32.4-36.4]in age.64-77 ye.rs,74.87[70.6-79.3]in age.77 ye.rs,Pe.e.was a ste.-wise.incre.se.in the.rate.of 30-day mortality with incre.sing age.*** adjustme.t,compare. to the.lowe.t age.te.tile.patie.ts age.>77 ye.rs had incre.se. risk of 30-day mortality(adjuste. hazard ratio=2.26[95%CI:1.96-2.60]).Olde. patie.ts we.e.le.s like.y to re.e.ve.inpatie.t coronary *** Olde. patie.ts with e.S-tre.te. CS have.significantly highe. rate. of short-te.m *** re.uce. rate. of invasive.inte.ve.tions in olde. patie.ts unde.score.the.ne.d for furthe. de.e.opme.t of syste.s of care.to improve.outcome. for this patie.t group.

关键词： asse.se. se.vice. shock

Toxicity of a se.food toxin， domoic acid， in the.re.ina via modulation of the.NRF2 and NF-κB pathways

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Food Scie.ce.and Human We.lne.s 2024年

作者： Gabrie. Mbuta Tchive.e.e.e.Yanqun Cao Mohammad Almarhoun Xinzhi Zhou Agostinho Francisco Cachapa Se.asti?o Tumitangua Jame. Re.lly Patricia e.Martin Xinhua Shu De.artme.t of Biological and Biome.ical Scie.ce. Glasgow Cale.onian Unive.sity De.artme.t of Marine.Biology Faculty of Natural Scie.ce Unive.sity of Namibe Puai Me.ical School Shaoyang Unive.sity De.artme.t of Vision Scie.ce Glasgow Cale.onian Unive.sity

Domoic acid (DA)， a biotoxin， is produce. by se.e.al spe.ie. of marine.dinoflage.late.and diatom during harmful algal bloom e.e.ts. DA is a ne.rotoxin， in humans and non-human primate.， oral e.posure.to DA re.ults in gastrointe.tinal e.fe.ts， while.DA at highe. dose. le.ds to ne.rological symptoms， se.zure. and me.ory de.icie.cy. e.posure.of humans to DA occurs mainly through consumption of contaminate. se.foods containing an accumulation of the.toxin. Pre.iously， it was uncle.r if DA can have.toxic e.fe.ts on the.re.ina. We.asse.se. the.toxicity of DA in human re.inal ce.ls (ARPe.19) and in ze.rafish e.bryos. DA significantly lowe.e. ARPe.19 ce.l viability dose.de.e.de.tly， and de.re.se. anti-oxidative.capacity， incre.se. inflammation， and promote. ce.l de.th， possibly through modulating the.NRF2 and NF-κB signalling pathways. Ze.rafish e.bryos e.pose. to DA for four days from one.day post fe.tilization (dpf) had an incre.se.in mortality and a de.re.se.in both hatching and he.rtbe.t rate.and e.hibite. morphological abnormalitie.. DA tre.tme.t also significantly downre.ulate. e.pre.sion of antioxidant ge.e. and upre.ulate. e.pre.sion of inflammation me.iators， as we.l as causing photore.e.tor de.th in ze.rafish e.bryos. The.re.ults de.onstrate.that consuming se.food containing DA will have.pote.tial toxic e.fe.ts in human re.inas.

关键词：

What to e.t:e.ide.ce.for Se.e.tive.Autophagy in Plants

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Journal of Inte.rative.Plant Biology 2012年第11期54卷 907-920页

作者： Brice.e.floyd Ste.hanie.C.Morriss Gustavo C.MacIntosh Diane.C.Bassham De.artme.t of Ge.e.ics Development and Cell BiologyIowa State UniversityAmes IA 50011USA De.artme.t of Bioche.istry Biophysics and Molecular BiologyIowa State UniversityAmes IAUSA

Autophagy is a macromole.ular de.radation pathway by which ce.ls re.ycle.the.r conte.ts as a de.e.opme.tal proce.s, house.e.ping me.hanism, and re.ponse.to e.vironme.tal stre.s. In plants, autophagy involve. the.se.ue.tration of cargo to be.de.rade., transport to the.ce.l vacuole.in a double.e.brane.bound autophagosome. and subse.ue.t de.radation by lytic e.zyme..

关键词： Autophagy de.radation stre.s vacuole.

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