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Targeted therapy in advanced metastatic colorectal cancer: Current concepts and perspectives

World Journal of Gastroenterology 2014年第20期20卷 6102-6112页

作者： florian Hohla Thomas Winder Richard Greil Ferenc G Rick Norman L Block rew V Schally Ⅲrd Medical Department with Hematology Medical Oncology Hemostasis Rheumatology and Infectious Diseases Oncologic Center Center for Clinical Cancer and Immunology Trials Laboratory of Immunological and Molecular Cancer Research Paracelsus Medical University of Salzburg A-5020 Salzburg Austria Department of Oncology Medical University of Zurich 8091 Zurich Switzerland Endocrine Polypeptide and Cancer Institute Veterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education Miami FL 33125 United States Department of Urology Florida International University Herbert Wertheim College of Medicine Miami FL 33199 United States Divisions of Hematology/Oncology and Endocrinology Department of Pathology and Department of Medicine Miller School of Medicine University of Miami Miami FL 33136 United States

The introduction of new cytotoxic substances as well as agents that target vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) signaling has improved clinical outcome of patients with metastatic colorectal cancer (mCRC). In this review we summarize the most relevant clinical data on VEGF and EGFR targeting regimens in mCRC. The effects of available treatment strategies for mCRC are often temporary, with resistance and disease progression developing in most patients. Thus, new treatment strategies are urgently needed. Some GI peptides including gastrin and gastrin releasing peptide, certain growth factors such as insulin-like growth factor-I and II and neuropeptides such as growth hormone releasing hormone (GHRH) are implicated in the growth of CRC. Experimental investigations in CRC with antagonistic analogs of bombesin/gastrin-releasing peptide, GHRH, and with cytotoxic peptides that can be targeted to peptide receptors on tumors, are summarized in the second part of the review.

关键词： Colorectal cancer Targeted treatment Vascular endothelial growth factor Epidermal growth factor receptor Peptide receptors Gastrin-releasing peptide Growth hormone releasing hormone Luteinizing hormone-releasing hormone Cytotoxic analogs

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The 3-60 criteria challenge established predictors of postoperative mortality and enable timely therapeutic intervention after liver resection

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 111-124页

作者： Georg P.Gyoeri David Pereyra Eva Braunwarth Markus Ammann Philipp Jonas florian Offensperger florian Klinglmueller Ruth Baumgartner Sandra Holzer Michael Gnant Friedrich Laengle Stefan Staettner Thomas Gruenberger Patrick Starlinger Department of Surgery General HospitalMedical University of ViennaViennaAustria Department of Surgery Medical University of InnsbruckInnsbruckAustria Department of Surgery State Hospital Wiener NeustadtWiener NeustadtAustria Department of Surgery Kaiser Franz Josef HospitalViennaAustria Core Unit for Medical Statistics and Informatics Medical University of ViennaViennaAustria

Background:To date,definitions of liver dysfunction(ld)after hepatic resection rely on late postoperative time ***,the used parameters are markedly influenced by perioperative ***,we aimed to establish a very early postoperative score to predict postoperative ***:Liver related parameters were evaluated after liver resection in a retrospective evaluation cohort of 228 colorectal cancer patients with liver metastasis(mCRC)and subsequent validation in a prospective set of 482 consecutive patients from 4 independent institutions undergoing hepatic resection was ***:C-reactive protein(CRP,AUC=0.739,Pld and mortality(Pld[3-60 criteria:total positive patients:26 patients(70%mortality detected),odds ratio(OR):48.8;International Study Group for Liver Surgery:total positive patients:43(70%mortality detected),OR:23.3;Peak7:total positive patients:9(30%mortality detected),OR:27.8;50-50:total positive patients:9(30%mortality detected),OR:27.8].These results could be validated in a multi-center analysis and ultimately the 3-60 criteria remained an independent predictor of postoperative mortality upon multivariable ***:The 3-60 criteria on POD1 predict postoperative ld and mortality early after liver resection with a comparable or better accuracy than established criteria,allowing for immediate identification of high-risk patients.

关键词： Liver surgery liver dysfunction(ld) mortality C-reactive protein(CRP) AntithrombinⅢ-activity(ATⅢ)

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