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Clinical characteristics and outcomes in carbohydrate antigen 19-9 negative pancreatic cancer

World Journal of Clinical Oncology 2022年第7期13卷 630-640页

作者： Daniel Vasile Balaban Flavius Stefan Marin George Manucu Andreea Zoican Marina Ciochina Victor Mina Cristina Patoni Catalina Vladut Sandica Bucurica Raluca Simona Costache florentina ionita-radu Mariana Jinga Department of Gastroenterology Carol Davila University of Medicine and PharmacyDr.Carol Davila Central Military Emergency University HospitalBucharest 020021Romania Department of Gastroenterology and Digestive Oncology Hôpital CochinParis 75014France Department of Gastroenterology Carol Davila University of Medicine and PharmacyProf Dr.Agrippa Ionescu Clinical Emergency HospitalBucharest 020021Romania

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a leading cause of death from cancer *** markers like carbohydrate antigen 19-9(CA 19-9)have been proven valuable as a diagnostic tool and a predictor for tumor staging and response to *** To delineate the phenotype of normal CA 19-9 PDAC according to clinical features,disease staging and prognosis as compared with high CA 19-9 PDAC *** We performed a retrospective single-center analysis of all PDAC cases admitted in our Gastroenterology department over a period of 30 mo that were diagnosed by endoscopic ultrasound-guided tissue *** were divided into two groups according to CA 19-9 levels over a threshold of 37 U/*** performed a comparison between the two groups with regard to demographic and clinical data,biomarkers,tumor staging and 6-mo *** Altogether 111 patients were recruited with 29 having documented normal CA 19-9(<37 U/mL).In the CA 19-9 negative group of patients,20.68%had elevated levels of both CEA and CA 125,13.79%for CA 125 only whilst 17.24%for CEA *** two groups had similar demographic *** pain was more frequently reported in positive vs negative CA 19-9 PDAC cases(76.83%vs 55.17%),while smoking was slightly more prevalent in the latter group(28.04%vs 31.03%).Tumors over 2 cm were more frequently seen in the positive CA 19-9 group,reflecting a higher proportion of locally advanced and metastatic neoplasia(87.7%vs 79.3%).Sixmonth survival was higher for the negative CA 19-9 group(58.62%vs 47.56%).CONCLUSION Elevated CA 19-9 at diagnosis seems to be associated with a more pronounced symptomatology,high tumor burden and poor prognosis compared to negative CA 19-9 PDAC *** and CA 125 can be adjunctive useful markers for PDAC,especially in CA 19-9 negative cases.

关键词： Pancreatic cancer Carbohydrate antigen 19-9 Survival Lewis Outcome

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