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Role of <i>Helicobacter pylori</i>Infection in Recurrent Abdominal Pain of the Child in Brazzaville

Open Journal of Pediatrics 2020年第4期10卷 587-599页

作者： Ollandzobo Ikobo Lucie Charlotte Ahombo Niotsebe Lydie Bénédicte Mongo-Onkouo Arnaud Ahoui Apendi Clausina Rochelvie Itoua Ngaporo Ngala Akoa Mimiesse Mounanou Jile florent Tchidjo Ngamo Lynda Déby Gassaye Mabiala Babela Jean Robert Atipo Ibara Blaise Irénée Ibara Jean-Rosaire Faculty of Health Sciences Marien Ngouabi University of Brazzaville Brazzaville Congo Infants Pediatric ward Brazzaville University Teaching Hospital Brazzaville Congo Gastroentérology and Internal Medicine Ward Brazzaville University Teaching Hospital Brazzaville Congo

The Helicobacter pylori (Hp) infection is a public health problem, especially in developing countries. However, the responsibility of Hp for the occurrence of recurrent abdominal pain is still unclear. Objectives: To determine the prevalence of Helicobacter pylori (Hp) infection in children with recurrent abdominal pain (RAP) in Brazzaville and to establish the relationship between Hp infection and RAP. Patients and Methods: We conducted a cross-sectional case-control study, between March and September 2018, including 106 children with RAP and 218 children without RAP, aged 2 to 17 years old, received in health centres in Brazzaville. All the children were subjected to detection of Hp fecal antigen by qualitative immuno-chromatography in the faeces. Results: The prevalence of Hp infection among children with RAP in Brazzaville was 43.4%. The female sex was most represented in both populations, with a sex ratio of 0.84 in the infected population. Compared with controls, these were children with a mean age of 8.13 ± 4.57 years. Infected children with RAP were unschooled in 66.7% (n = 31) of cases (p < 0.05). Those using potty were 63% (n = 29). Handwashing before meals and after using the toilet was not done in 66.7% (n = 31) and 56.5%

关键词： Helicobacter pylori Recurrent Abdominal Pain Fecal Antigen Child Brazzaville

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华伦天奴从巴黎开始进军男装

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纺织服装周刊 2013年第4期 59-页

作者： florent Gilles

1月22日,有财大气粗的新老板(卡塔尔皇室控制的Mayhoola投资公司),又有Maria Grazia Chiuri和Pierpaolo Piccioli这两位天才设计师执掌,华伦天奴公司将全面发展男装系列,并将陆续在各大城市开设男装店,首先打响头炮的将是巴黎。品牌总... 详细信息

1月22日,有财大气粗的新老板(卡塔尔皇室控制的Mayhoola投资公司),又有Maria Grazia Chiuri和Pierpaolo Piccioli这两位天才设计师执掌,华伦天奴公司将全面发展男装系列,并将陆续在各大城市开设男装店,首先打响头炮的将是巴黎。品牌总部就位于巴黎著名的凡登广场。

关键词：男装华伦巴黎法国

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Viral Hepatitis B: Seroprevalence and Genetic Diversity in Blood Donors North of Congo

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Open Journal of Gastroenterology 2019年第12期9卷 239-245页

作者： Arnaud Mongo-Onkouo Amelia Dzia Lepfoundzou Dinghat Ornela Marlyne Yvonne Ahoui Apendi Clausina Philestine Jile florent Mimiesse Monamou Ngala Akoa Itoua-Ngaporo Rody Stéphane Ngami Mouakosso Marlyse Ngalessami Céline Sandra Adoua Deby Gassaye Blaise Irénée Atipo Ibara Jean-Rosaire Ibara Department of Hepatogastroenterology and Internal Medicine Of Brazzaville Universty Hospital Center Brazzaville Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Cong Department of Metabolic Diseases of Brazzaville University Hospital Center Brazzaville Congo

Introduction: Viral hepatitis B is the most formidable and confusing of all viral hepatitis, given its cirrhogenic and carcinogenic potential. The objective of the study is to characterize the molecular profile of hepatitis virus B in northern Congo. Materials and Methods: This was a descriptive and cross-sectional study that was carried out between January and September 2014, that is 9 months, in the establishments of the National Center for Blood Transfusion (CNTS) of the 4 departments of the north of the Congo. Epidemiological, serological and molecular variables (HBsAg, HBV DNA, genotypes and subtypes) were studied. The HBs antigen was searched by rapid test and confirmed by ELISA. For all positive donors, conventional and specific gene extraction and amplification techniques were performed for the identification of genotypes and subtypes from the serum. Results: A total of 892 donors were included. The average age was 35.36 ± 12.36 years with extremes ranging from 18 to 65 years old. The sex ratio (M/F) was 3.3. The prevalence of HBV was 8.6%. The viral DNA of HBV was amplified in 83.1%. Four genotypes were found: E (40.6%), A (3.1%), B (3.1%) and C (1.6%). Two cases of co-infection were identified: E/A (15.6%) and B/C (1.6%). Subgenotypes A1, B2 and C1 were highlighted. Conclusion: The prevalence of HBV is high, HBV infection remains a major public health problem for blood donors in Congo. Genotypes E, A, B, C as well as subtypes A1, B2, C1 have been identified in northern Congo.

关键词： HBV Molecular Biodiversity Subgenotypes North Congo

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走向“双碳” 一个攸关人类命运的课题

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环球人文地理 2022年第9期 44-53页

作者：史英静林文强石耀臣 Allen 崔缘陈健邱新生一路无话118 刘嘉烨 florent isaac74

2020年，我国明确了碳达峰、碳中和的目标；2021年，正式开启“双碳”元年。生态恢复、节能减排、发展新能源……时至今日，作为世界第二大经济体的中国，交出了一张怎样的答卷？又面临着怎样的困难？2021年11月，第26届联合国气候变化...

2020年，我国明确了碳达峰、碳中和的目标；2021年，正式开启“双碳”元年。生态恢复、节能减排、发展新能源……时至今日，作为世界第二大经济体的中国，交出了一张怎样的答卷？又面临着怎样的困难？2021年11月，第26届联合国气候变化大会上，世界气象组织发布了关于2021年全球气候状况的临时报告。报告数据显示，2020年全球温室气体浓度已达到新高，2021年仍在继续增长。这意味着，全球气候变暖在不断加剧。气候变暖不仅融化极地冰川，也带来了更多极端天气，全球各地难有幸免：暴雪低温天气影响全美；极端高温在美国加州、土耳其和希腊等地引发了重大森林火灾；蒙古国连续遭遇强沙尘暴和暴风雪……

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Dysregulated Hematopoiesis in Bone Marrow Marks Severe COVID-19

Dysregulated Hematopoiesis in Bone Marrow Marks Severe COVID...

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第十四届全国免疫学学术大会

作者： Xin Wang Wen Yanling Xiaowei Xie Liu Yang Xiaohua Tan Qingxian Cai Yawen Zhang Lin Cheng Gang Xu Shengyuan Zhang Haiyan Wang Lanlan Wei Xian Tang Furong Qi Juanjuan Zhao Jing Yuan Lei Liu Ping Zhu florent Ginhoux Shuye Zhang Tao Cheng Zheng Zhang Institute for Hepatology National Clinical Research Center for Infectious Disease Shenzhen Third People's Hospital State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Diseases Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Department of Oncology and Hematology Shenzhen Third People's Hospital Department of Hepatology Shenzhen Third People's Hospital Department for Infectious Diseases Shenzhen Third People's Hospital Singapore Immunology Network (SIgN) Agency for Science Technology and Research (A*STAR) Shanghai Public Health Clinical Center Fudan University

Severe coronavirus disease 2019(COVID-19) is often indicated by lymphopenia and increased myelopoiesis;however, the underlying mechanism is still unclear, especially the alteration of hematopoiesis. It’s important to explore to what extent and how hematopoietic stem cells contribute to the impairment of peripheral lymphoid and myeloid compartments in COVID-19 patients. In this study, we used a single-cell RNA sequence to assess bone marrow mononuclear cells from COVID-19 patients with peripheral blood mononuclear cells as control. The Results showed that the hematopoietic stem cells in these patients were mainly in the G1 phase and prone to apoptosis, with immune activation and obvious anti-viral response being identified. Importantly, we found a significant accumulation of immature myeloid progenitors and a dramatic reduction of lymphoid progenitors in severe cases, along with the upregulation of transcription factors(such as SPI1, LMO4, ETS2, FLI1, and GATA2) that are important for the hematopoietic stem cell or multipotent progenitor to differentiate into downstream progenitors, indicating a dysregulated hematopoiesis in patients with severe COVID-19.

关键词： Bone Marrow COVID-19 Hematopoiesis Hematopoietic Stem Cells Granulocyte-Monocyte Progenitors Differentiation Emergency Myelopoiesis

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Factors associated with mortality in congenital malformations of the gastrointestinal tract in a tertiary center in Senegal

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World Journal of Pediatric Surgery 2023年第1期6卷 24-29页

作者： Tshibwid A Zeng Papa Alassane Mbaye Doudou Gueye Ndèye Fatou Seck Ibrahima Bocar Wellé Rosalie Niang Youssouph Diedhiou Mbaye Fall Ndèye Aby Ndoye Aloïse Sagna Oumar Ndour Gabriel Ngom Department of Pediatric Surgery Albert Royer National Children’s Hospital CenterUniversitéCheikh Anta Diop Facultéde Medecine Pharmacie d'Odonto-StomatologieDakarSenegal Department of Pediatric Surgery Aristide Le Dantec University Teaching HospitalUniversitéCheikh Anta Diop Facultéde Medecine Pharmacie d'Odonto-StomatologieDakarSenegal

Objective Patients with congenital malformations(CMs)of the gastrointestinal tract(GIT)have a very high ***,the literature on the factors associated with mortality in these patients is scarce in sub-Saharan *** aim of this study is to identify independent risk factors for mortality in patients with CMs of the GIT at our pediatric surgical *** We conducted a retrospective analysis of cases with CMs of the GIT managed at a tertiary center from 2018 to *** were subdivided into two groups based on the outcomes,and variables with a significant difference were analyzed by logistic *** Our review included 226 patients,63 of whom died(27.88%).Patient age ranged from 0 to 15 *** into account statistical significance,mortality was more frequent in neonates than in older patients(57.30%vs 6.15%),in patients coming out of the Dakar area than in those from the Dakar area(43.75%vs 19.18%),in patients with abnormal prenatal ultrasound than in those with normal ultrasound(100%vs 26.67%),in premature children than in those born at term(78.57%vs 21.87%),in patients with an additional malformation than in those with an isolated malformation(69.23%vs 25.35%),and in those with intestinal,esophageal,duodenal and colonic atresia than in those with other diagnoses(100%,89%,56.25%and 50%,respectively).Referred patients died more than those who changed hospitals or came from home(55.29%vs 25%and 9.09%,respectively).On multivariable logistic regression,two independent factors of mortality were identified:presence of associated malformation[odds ratio(OR)=13.299;95%Confidence interval(CI)1.370 to 129.137]and diagnosis of esophageal atresia(OR=46.529;95%CI 5.828 to 371.425).Conclusion The presence of an associated malformation or diagnosis of esophageal atresia increases mortality in patients with CMs of the GIT in our environment.

关键词： mortality diagnosis congenital

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PCR-ELISA法检测烟曲霉和黄曲霉有助于提高IA的早期诊断率

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中国处方药 2006年第3期5卷 51-51页

作者： florent M Katsahian S Vekhoff A 邓妍（编译）

背景：现在实验室和放射学中缺乏用于诊断侵袭性曲霉感染（IA）的敏感性和特异性较高的方法。我们预期评价用PCR—ELISA方法对血液中的烟曲霉和黄曲霉DNA进行每两周的测定，以评价它的诊断价值。

关键词：早期诊断率 ELISA法检测黄曲霉烟曲霉 PCR 侵袭性曲霉感染 ELISA方法 IA 诊断价值敏感性

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基于有限元方法的塔机桁架结构屈曲分析

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中国工程机械学报 2013年第3期11卷 187-189,204页

作者：秦仙蓉孚罗特刘应花洪颖张氢同济大学机械与能源工程学院上海201804

以塔式起重机的金属结构为主要研究对象,借助有限元平台,从简单杆件的分析入手获得了可行的线性屈曲与非线性屈曲分析的方法与流程,进而以此为基础从不同侧面对塔机桁架结构的屈曲问题进行了详细分析.研究结果表明:考虑载荷偏心和初始... 详细信息

以塔式起重机的金属结构为主要研究对象,借助有限元平台,从简单杆件的分析入手获得了可行的线性屈曲与非线性屈曲分析的方法与流程,进而以此为基础从不同侧面对塔机桁架结构的屈曲问题进行了详细分析.研究结果表明:考虑载荷偏心和初始位移非线性屈曲分析的结果要比线性特征值屈曲分析的结果更符合实际状态.在塔机上计算时只考虑5%的载荷偏心就使结果比原来小了33%,而在实际情况中由于小车轨道不平、风载荷等原因引起的载荷偏心可能会更严重.

关键词：特征值屈曲非线性屈曲塔机桁架结构

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我对中国市场发展绝对有信心

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中国检验检疫 2019年第6期 6-6页

作者：孟立国米其林集团

5年前,我在中国内陆城市搭乘一辆汽车,车辆行驶在一条新建的高速公路上,但车载导航却显示车辆处于野外。车是一年前买的,当时这里还是一片荒野。另外,中国在不到10年的时间里建造了超过2万公里的高铁。中国的变化在我眼里是一种巨变,我... 详细信息

5年前,我在中国内陆城市搭乘一辆汽车,车辆行驶在一条新建的高速公路上,但车载导航却显示车辆处于野外。车是一年前买的,当时这里还是一片荒野。另外,中国在不到10年的时间里建造了超过2万公里的高铁。中国的变化在我眼里是一种巨变,我总是着迷于中国的快速发展。

关键词：中国市场信心内陆城市高速公路车载导航车辆汽车

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Maternal and Fetal Outcomes of COVID-19 Pregnant Women Followed Up at a Tertiary Care Unit: A Descriptive Study

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Open Journal of Obstetrics and Gynecology 2020年第10期10卷 1482-1491页

作者： Madye A. Ngo Dingom Eugène Sobngwi Félix Essiben Antoinette N. Assiga Yves F. Wasnyo Anicet Ngate Jean C. Katte Junie Y. Ngaha Philemon Nsem Charles E. Sone Brigitte Wandji Gilles T. Libend Jean J. Bissemou Filbert E. Eko florent Y. Fouelifack Glwadys Ngono Jeanne Fouédjio Rebecca Tonye Pierre Ongolo-Zogo Pierre J. Fouda Robinson E. Mbu Obstetrics and gynecology Unit Yaounde Central Hospital Yaounde Cameroon COVID 19 Unit Yaounde Central Hospital Yaounde Cameroon Department of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon Department of Public Health University of Exeter Exeter UK Department of Obstetrics and Gynecology Higher Institute of Medical Technology of Nkolondom Yaoundé Cameroon

Background: The SARS-CoV-2 and associated corona virus disease COVID-19 have been declared a pandemic having a poor prognosis among individuals with debilitating conditions and those who are immune-compromised. Current evidence is however limited on maternal and fetal transmission and pregnancy outcomes. We aimed to describe the pattern of SARS-CoV-2 infection and outcomes in a group of pregnant women followed up at a tertiary care unit in Cameroon. Methods: This was an observational study conducted over a period of 3 months (April 1 to June 30, 2020) at the Yaounde Central Hospital. All pregnant women who were tested positive for SARS-CoV-2 and who provided a signed written informed consent were included in the study. Results: Out of 83 pregnant women who presented with symptoms suspicious of COVID-19, 25 were tested positive. The median age of these women was 31 (27 - 35) years. A total of 76% consulted within 6 days of onset of symptoms and 68% had a gestational age greater than 28 weeks. The most common presenting complaint was fever (88%)

关键词： COVID-19 Pregnancy Mortality Outcomes

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