检索结果-南通市图书馆

Histone variants:critical determinants in tumour heterogeneity

Frontiers of Medicine 2019年第3期13卷 289-297页

作者： Tao Wang florent chuffart Ekaterina Bourova-Flin Jin Wang Jianqing Mi Sophie Rousseaux Saadi Khochbin CNRS UMR 5309 InsermU1209University of Grenoble AlpesInstitute for Advanced Biosciences38706GrenobleFrance State Key Laboratory for Medical Genomics and Department of Hematology Shanghai Institute of HematologyCollaborative Innovation Center of Systems BiomedicinePole Sino-Francais des Sciences du Vivant et GenomiqueRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China

Malignant cell transformation could be considered as a series of cell reprogramming events driven by oncogenic transcription factors and upstream signalling *** plasticity and dynamics are critical determinants in the control of cell *** increase in chromatin dynamics could therefore constitute an essential step in driving oncogenesis and in generating tumour cell heterogeneity,which is indispensable for the selection of aggressive properties,including the ability of cells to disseminate and acquire resistance to *** supply and dosage,as well as histone variants,are the best-known regulators of chromatin *** facilitating cell reprogramming,histone under-dosage and histone variants should also be crucial in cell transformation and tumour *** we summarize and discuss our knowledge of the role of histone supply and histone variants in chromatin dynamics and their ability to enhance oncogenic cell reprogramming and tumour heterogeneity.

关键词： cancer-testis TH2B TH2A HIT H1.0 H1F0 linker histones

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

引用

Frontiers of Medicine 2022年第3期16卷 442-458页

作者： Mengping Xi Shanshan Guo Caicike Bayin Lijun peng florent chuffart Ekaterina Bourova-Flin Sophie Rousseaux Saadi Khochbin Jian-Qing Mi Jin Wang Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Pôle de Recherches Sino-Français en Science du Vivant et Génomique Shanghai 200025China CNRS UMR 5309/INSERM U1209/UniversitéGrenoble Alpes/Institute for Advanced Biosciences 38706 La TroncheFrance

T-cell acute lymphoblastic leukemia(T-ALL)is one of the most dangerous hematological malignancies,with high tumor heterogeneity and poor *** than 60%of T-ALL patients carry NOTCH1 gene mutations,leading to abnormal expression of downstream target genes and aberrant activation of various signaling *** found that chidamide,an HDAC inhibitor,exerts an antitumor effect on T-ALL cell lines and primary cells including an anti-NOTCH1 *** particular,chidamide inhibits the NOTCH1-MYC signaling axis by down-regulating the level of the intracellular form of NOTCH1(NICD1)as well as MYC,partly through their ubiquitination and degradation by the proteasome *** also report here the preliminary results of our clinical trial supporting that a treatment by chidamide reduces minimal residual disease(MRD)in patients and is well *** results highlight the effectiveness and safety of chidamide in the treatment of T-ALL patients,including those with NOTCH1 mutations and open the way to a new therapeutic strategy for these patients.

关键词： T-cell acute lymphoblastic leukemia HDAC inhibitor chidamide NOTCH1 MYC ubiquitination

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：